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Strategies for preventing the spread of antimicrobial resistance driven by social dilemma

Research Project

Project/Area Number 21H01575
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 25020:Safety engineering-related
Research InstitutionNagasaki University

Principal Investigator

ITO Hiromu  長崎大学, 熱帯医学研究所, 准教授 (80780692)

Co-Investigator(Kenkyū-buntansha) 守田 智  静岡大学, 工学部, 教授 (20296750)
山本 太郎  長崎大学, 熱帯医学研究所, 教授 (70304970)
和田 崇之  大阪公立大学, 大学院生活科学研究科, 教授 (70332450)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2023: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Keywordsゲーム理論 / 感染症 / 進化 / AI / 抗菌薬 / 薬剤耐性 / 公衆衛生 / 意思決定 / 社会的ジレンマ / 疫学
Outline of Research at the Start

抗生剤の使用と耐性菌の出現・拡散の間に起こる社会的ジレンマの存在に目を向け、Web調査と数理モデリング(マルチ・エージェント・シミュレーションの構築)を組み合わせることでヒトの行動が創り出す病原体の進化動態を理解し、耐性菌の拡散リスクを数理的に明らかにする。これにより、現代社会の一大脅威である薬剤耐性菌の世界的拡散を効果的に封じ込める戦略を総合的にデザインし、抗生剤の処方・使用方法の在り方を再検討する。

Outline of Final Research Achievements

We successfully observed and visualized the social dilemma underlying antimicrobial use, enabling international comparisons. Approximately 15-30% of respondents in eight countries/areas indicated a preference for others to refrain from using antimicrobials due to the emergence of antimicrobial resistance (AMR), while they themselves would use them freely. This highlights the presence of the social dilemma in antimicrobial use. Additionally, around half of the respondents, regardless of country/area, felt that neither they nor others should refrain from using antimicrobials, shedding light on one of the reasons behind the excessive use of antimicrobials, which promotes the emergence of AMR. This study is the first to confirm the existence of the social dilemma in the context of antimicrobial use.

Academic Significance and Societal Importance of the Research Achievements

公衆衛生に関する社会的ジレンマを調査から観測して国際比較した試みは本研究の他に例がない。故に本研究の手法は、医療の問題に深く切り込んだ社会的ジレンマの研究の中でも最先端に位置しており、ゲーム理論研究の発展に大きく寄与したと自負する。学会発表では日本ソーシャルデータサイエンス学会2024年春季研究発表会で最優秀賞を受賞し、学術的評価も高い。また、本研究が見出した「耐性菌問題は医療体制側だけのものではなく、社会全体で考えていかなければならない問題だ」という視点は、ABEMAヒルズ・ABEMA TIMES・日本経済新聞・日経産業新聞でも報じられ、社会に対する警鐘として発信することができた。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • Research Products

    (27 results)

All 2024 2023 2022 2021 Other

All Int'l Joint Research (2 results) Journal Article (8 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 8 results,  Open Access: 8 results) Presentation (13 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Remarks (4 results)

  • [Int'l Joint Research] クイーンズランド大学(オーストラリア)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] クイーンズランド大学(オーストラリア)

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Social dilemma in the excess use of antimicrobials incurring antimicrobial resistance2022

    • Author(s)
      Hiromu Ito, Takayuki Wada, Genki Ichinose, Jun Tanimoto, Jin Yoshimura, Taro Yamamoto, Satoru Morita
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 21084-21084

    • DOI

      10.1038/s41598-022-25632-1

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exploring sexual contact networks by analyzing a nationwide commercial-sex review website2022

    • Author(s)
      Ito Hiromu、Shigeta Keiko、Yamamoto Taro、Morita Satoru
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 11 Pages: e0276981-e0276981

    • DOI

      10.1371/journal.pone.0276981

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High prevalence of rheumatoid arthritis and its risk factors among Tibetan highlanders living in Tsarang, Mustang district of Nepal2022

    • Author(s)
      Arima Hiroaki、Koirala Sweta、Nema Kotaro、Nakano Masayuki、Ito Hiromu、Poudel Kapil Madi、Pandey Kishor、Pandey Basu Dev、Yamamoto Taro
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 41 Issue: 1 Pages: 12-12

    • DOI

      10.1186/s40101-022-00283-3

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Optimal strategies and cost-benefit analysis of the $${\varvec{n}}$$-player weightlifting game2022

    • Author(s)
      Cuaresma Diane Carmeliza N.、Chiba Erika、Tubay Jerrold M.、Rabajante Jomar F.、Gavina Maica Krizna A.、Yoshimura Jin、Ito Hiromu、Okabe Takuya、Morita Satoru
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 8482-8482

    • DOI

      10.1038/s41598-022-12394-z

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Individual variations and sex differences in hemodynamics and percutaneous arterial oxygen saturation (SpO2) in Tibetan highlanders of Tsarang in the Mustang district of Nepal2022

    • Author(s)
      Nishimura Takayuki、Arima Hiroaki、Koirala Sweta、Ito Hiromu、Yamamoto Taro
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 41 Issue: 1 Pages: 9-9

    • DOI

      10.1186/s40101-022-00282-4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The effect of men who have sex with men (MSM) on the spread of sexually transmitted infections2021

    • Author(s)
      Ito Hiromu、Yamamoto Taro、Morita Satoru
    • Journal Title

      Theoretical Biology and Medical Modelling

      Volume: 18 Issue: 1 Pages: 18-18

    • DOI

      10.1186/s12976-021-00148-9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analyzing Predictors of Control Measures and Psychosocial Problems Associated with COVID-19 Pandemic: Evidence from Eight Countries2021

    • Author(s)
      Jony Sheikh Saifur Rahman、Haque Ubydul、Webb Nathaniel J.、Spence Emily、Rahman Md. Siddikur、Aghamohammadi Nasrin、Lie Yongchan、Angulo-Molina Aracely、Ananth Sushmitha、Ren Xuelian、Kawachi Nobuyuki、Ito Hiromu、Ulvi Osman、Lubinda Jailos、Karamehic-Muratovic Ajlina、Maher Wasim、Ali Parveen、Rahman M. Sohel
    • Journal Title

      Behavioral Sciences

      Volume: 11 Issue: 8 Pages: 106-106

    • DOI

      10.3390/bs11080106

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Improving environment drives dynamical change in social game structure2021

    • Author(s)
      Chiba Erika、Cuaresma Diane Carmeliza N.、Rabajante Jomar F.、Tubay Jerrold M.、Areja Gavina Maica Krizna、Yamamoto Tatsuki、Yoshimura Jin、Morita Satoru、Ito Hiromu、Okabe Takuya
    • Journal Title

      Royal Society Open Science

      Volume: 8 Issue: 5 Pages: 1-7

    • DOI

      10.1098/rsos.201166

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Social dilemma in the excess use of antimicrobials incurring antimicrobial resistance2024

    • Author(s)
      Hiromu Ito
    • Organizer
      協力的AIの実現に関する日本・ベルギー二国間研究交流シンポジウム
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 薬剤耐性の出現と拡散につながる社会的ジレンマの実態調査2024

    • Author(s)
      伊東啓,和田崇之,一ノ瀬元喜,谷本潤,吉村仁,山本太郎,守田智
    • Organizer
      第3回計算社会科学会大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 薬剤耐性の出現と拡散につながる社会的ジレンマの観測手法の開発2024

    • Author(s)
      伊東啓,和田崇之,一ノ瀬元喜,谷本潤,吉村仁,山本太郎,守田智
    • Organizer
      日本オペレーションズ・リサーチ学会2024年春季研究発表会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 薬剤耐性の出現と拡散につながる社会的ジレンマの実態把握と国際比較2024

    • Author(s)
      伊東啓,和田崇之,一ノ瀬元喜,谷本潤,吉村仁,山本太郎,守田智
    • Organizer
      日本ソーシャルデータサイエンス学会2024年春季研究発表会&シンポジウム
    • Related Report
      2023 Annual Research Report
  • [Presentation] 薬剤耐性の出現と拡散につながる社会的ジレンマの観測2024

    • Author(s)
      伊東啓,和田崇之,一ノ瀬元喜,谷本潤,吉村仁,山本太郎,守田智
    • Organizer
      情報処理学会第86回全国大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Visualization of sexual contact networks by analyzing a nationwide commercial-sex review website in Japan2023

    • Author(s)
      Hiromu Ito
    • Organizer
      2023 8th China-India-Japan-Korea International Conference on Mathematical Biology
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 性風俗情報サイトの分析による性接触ネットワークの可視化2023

    • Author(s)
      伊東啓,重田桂子,山本太郎,守田智
    • Organizer
      第22回情報科学技術フォーラム
    • Related Report
      2023 Annual Research Report
  • [Presentation] 性風俗情報サイトの口コミ投稿から再構築する全国規模の性接触ネットワーク2023

    • Author(s)
      伊東啓, 重田桂子, 山本太郎, 守田智
    • Organizer
      日本オペレーションズ・リサーチ学会2023年春季研究発表会
    • Related Report
      2022 Annual Research Report
  • [Presentation] オンラインレビュー(口コミ)サイト分析による全国規模の性接触ネットワークの再構築2023

    • Author(s)
      伊東啓, 重田桂子, 山本太郎, 守田智
    • Organizer
      情報処理学会第85回全国大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 性風俗店のオンラインレビューから再構築する全国規模の性接触ネットワーク2023

    • Author(s)
      伊東啓, 重田桂子, 山本太郎, 守田智
    • Organizer
      情報処理学会第18回ネットワーク生態学シンポジウム
    • Related Report
      2022 Annual Research Report
  • [Presentation] 性風俗情報サイトのレビュー(口コミ)投稿から再構築する全国規模の性接触ネットワーク2023

    • Author(s)
      伊東啓, 重田桂子, 山本太郎, 守田智
    • Organizer
      日本ソーシャルデータサイエンス学会2023シンポジウム
    • Related Report
      2022 Annual Research Report
  • [Presentation] ソープランドの顧客レビュー(口コミ)から再構築する性接触の社会ネットワーク2023

    • Author(s)
      伊東啓, 重田桂子, 山本太郎, 守田智
    • Organizer
      第2回計算社会科学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 数理モデルから考える性感染症の社会ネットワークへの適応2021

    • Author(s)
      伊東啓
    • Organizer
      日本数理生物学会第31回大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Remarks] researchmap

    • URL

      https://researchmap.jp/hiromu_ito/

    • Related Report
      2023 Annual Research Report
  • [Remarks] 個人ホームページ

    • URL

      https://sites.google.com/view/h-ito/

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report 2021 Annual Research Report
  • [Remarks] 国際保健学分野ホームページ

    • URL

      https://www.tm.nagasaki-u.ac.jp/newrect/index.html

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report 2021 Annual Research Report
  • [Remarks] reseachmap

    • URL

      https://researchmap.jp/hiromu_ito/

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report

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Published: 2021-04-28   Modified: 2025-01-30  

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