| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2023: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2022: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2021: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Outline of Final Research Achievements |
G protein-coupled receptors exist in equilibrium between active and inactive forms and exhibit a certain basic activity even without ligand binding. Inverse agonists exist in a wide range of potencies, from strong to weak, but the relationship between such differences in potency and structure is unknown. In this study, we determined the complex structure of the serotonin receptor with a weak inverse agonist. The results revealed that in the bound state of this inverse agonist, the structure is closer to the active conformation than to the inactive conformation.
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