| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2023: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2022: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2021: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
We activated the mouse habenula via chemogenetic probe and observed depressive-like reduction of the locomotor activity in the home cage and inflammatory changes in gene expression pattern. This indicated the possibility that neuronal activation led to the local inflammatory response in the habenula. We also revealed that astrocytic activation and lipopolysaccharide activated the habenular neurons via increased extracellular potassium ion in mouse. In the way of the above analyses, we published 5 articles in the international academic journals by developing a novel equipment useful for mouse behavioral analysis, unraveling evolutionarily conserved mechanism of neuroinflammation and consequences of the systemic inflammation in brain function.
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