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Exploratory analyses of algorithm to detect the potential adverse drug events

Research Project

Project/Area Number 21H03176
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 58010:Medical management and medical sociology-related
Research InstitutionHyogo Medical University

Principal Investigator

Morimoto Takaeshi  兵庫医科大学, 医学部, 教授 (30378640)

Co-Investigator(Kenkyū-buntansha) 作間 未織  兵庫医科大学, 医学部, 准教授 (60349587)
武内 治郎  兵庫医科大学, 医学部, 助教 (60791324)
太田 好紀  兵庫医科大学, 医学部, 特任准教授 (10516404)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2023: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2022: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2021: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywords医原性有害事象 / 医療安全 / 臨床疫学 / アルゴリズム / 機械学習 / 薬剤性有害事象
Outline of Research at the Start

本研究は、入院患者や外来患者において、日常的に発生していることが分かりつつある薬剤性有害事象について、診療中には薬剤性とは認識されず見逃されている、潜在的な薬剤性有害事象を電子カルテシステム上で自動的に予測し、検出するアルゴリズムを開発することを目的としている。研究対象施設に入院、通院している全患者を対象に前向きコホート研究を実施し、潜在的な薬剤性有害事象やそのリスク因子を解析し、そのデータを元に統計学的モデル及び機械学習を用いて、電子カルテシステム上で、潜在的な薬剤性有害事象を自動的に予測し、検出するアルゴリズムを開発する。

Outline of Final Research Achievements

We conducted a prospective cohort study to demonstrate that in-hospital mortality can be predicted using patient background and practice environment, that the effectiveness of interventions to prevent potential adverse drug events varies by drug type, and that department characteristics are associated with potential adverse drug events and medication errors. The comparison of the risk of occurrence of potential adverse drug events, which were not tested as per the package insert, as well as the validation of an algorithm that automatically suggests modifications from the electronic health record system, showed that some drugs were effective in reducing potential adverse drug events, while some drugs were not effective. Furthermore, it became clear that the algorithm should reflect the influence of the specialty as well as patient background on the risk factors for potential adverse drug events.

Academic Significance and Societal Importance of the Research Achievements

医療を含め、全ての科学技術には安全性の評価及び危険性の最小化が必要である。医療技術の発展で多くの人命が救われてきたが、一方で医療技術の高度化・複雑化により、医療そのものの危険性が高まっている。本研究課題では、潜在的な薬剤性有害事象の発生を患者背景や診療経過から予測し、電子カルテシステム上で自動的に検出できる、汎用性の高いアルゴリズムを開発することで、より効率的に薬剤性有害事象の危険性や影響を最小化できることを目指した。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • Research Products

    (34 results)

All 2024 2023 2022 2021

All Journal Article (23 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 23 results,  Open Access: 23 results) Presentation (11 results) (of which Int'l Joint Research: 11 results)

  • [Journal Article] Adverse Events in Pediatric Inpatients: The Japan Adverse Event Study2024

    • Author(s)
      Sakuma Mio、Ohta Yoshinori、Takeuchi Jiro、Yuza Yuki、Ida Hiroyuki、Bates David W.、Morimoto Takeshi
    • Journal Title

      Journal of Patient Safety

      Volume: 20 Issue: 1 Pages: 38-44

    • DOI

      10.1097/pts.0000000000001180

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Incidence of and factors associated with emergency caesarean section in pregnant women with gestational diabetes mellitus: A retrospective cohort study2024

    • Author(s)
      Nabika S, Nakamura T, Ito Y, Nagasawa A, Morimoto T
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 50 Issue: 5 Pages: 849-855

    • DOI

      10.1111/jog.15921

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anemia and Rehabilitation Outcomes in Patients Undergoing Convalescent Rehabilitation2024

    • Author(s)
      Arai H, Nozoe M, Kamiya K, Matsumoto S, Morimoto T
    • Journal Title

      Archives of Physical Medicine and Rehabilitation

      Volume: 105 Issue: 3 Pages: 539-545

    • DOI

      10.1016/j.apmr.2023.10.017

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Safety and Effectiveness of Apixaban Versus Warfarin in Japanese Patients with Nonvalvular Atrial Fibrillation Stratified by Renal Function: A Retrospective Cohort Study2023

    • Author(s)
      Morimoto T, Hoshino H, Matsuo Y, Ibuki T, Miyata K, Koretsune Y
    • Journal Title

      American Journal of Cardiovascular Drugs

      Volume: 23 Issue: 6 Pages: 721-733

    • DOI

      10.1007/s40256-023-00611-7

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Monitoring for adverse drug events of high-risk medications with a computerized clinical decision support system: a prospective cohort study2023

    • Author(s)
      Nezu Mari、Sakuma Mio、Nakamura Tsukasa、Sonoyama Tomohiro、Matsumoto Chisa、Takeuchi Jiro、Ohta Yoshinori、Kosaka Shinji、Morimoto Takeshi
    • Journal Title

      International Journal for Quality in Health Care

      Volume: 35 Issue: 4

    • DOI

      10.1093/intqhc/mzad095

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Patient-reported outcomes for quality of care among pediatric patients2023

    • Author(s)
      Sakuma Mio、Morimoto Takeshi
    • Journal Title

      International Journal for Quality in Health Care

      Volume: 35 Issue: 2

    • DOI

      10.1093/intqhc/mzad020

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of anemia on major bleeding in patients taking oral anticoagulants for nonvalvular atrial fibrillation2023

    • Author(s)
      Kinjo N, Ueda S, Uchida K, Sakakibara F, Nezu M, Arai H, Morimoto T
    • Journal Title

      Journal of Arrhythmia

      Volume: 39 Issue: 4 Pages: 556-565

    • DOI

      10.1002/joa3.12885

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prediction of ESBL-producing E coli for suspected urinary tract infection2023

    • Author(s)
      Higuchi Hiroshi、Nakamura Tsukasa、Mashino Junji、Imada Toshihiro、Morimoto Takeshi
    • Journal Title

      Urologia Journal

      Volume: 90 Issue: 1 Pages: 151-156

    • DOI

      10.1177/03915603221103438

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Statins Reduce Bleeding Risk in Patients Taking Oral Anticoagulants for Nonvalvular Atrial Fibrillation: A Retrospective Registry Study2023

    • Author(s)
      Uchida Kazutaka、Ueda Shinichiro、Sakakibara Fumihiro、Kinjo Norito、Nezu Mari、Arai Hideki、Morimoto Takeshi
    • Journal Title

      American Journal of Cardiovascular Drugs

      Volume: 23 Issue: 1 Pages: 89-99

    • DOI

      10.1007/s40256-022-00555-4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effectiveness of a computerized clinical decision support system for prevention of glucocorticoid-induced osteoporosis2022

    • Author(s)
      Morikawa Toru、Sakuma Mio、Nakamura Tsukasa、Sonoyama Tomohiro、Matsumoto Chisa、Takeuchi Jiro、Ohta Yoshinori、Kosaka Shinji、Morimoto Takeshi
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 14967-14967

    • DOI

      10.1038/s41598-022-19079-7

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between anemic status on admission and clinical outcomes of acute large vessel occlusion2022

    • Author(s)
      Fujiwara S, Sakai N, Imamura H, Ohara N, Tanaka K, Yamagami H, Matsumoto Y, Takeuchi M, Uchida K, Yoshimura S, Morimoto T
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 440 Pages: 120343-120343

    • DOI

      10.1016/j.jns.2022.120343

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between Acid-Suppressive Drugs and Clinical Outcomes in Patients with Nonvalvular Atrial Fibrillation2022

    • Author(s)
      Arai Hideki、Ueda Shinichiro、Uchida Kazutaka、Sakakibara Fumihiro、Kinjo Norito、Nezu Mari、Morimoto Takeshi
    • Journal Title

      Drugs in R&D

      Volume: 22 Issue: 3 Pages: 213-222

    • DOI

      10.1007/s40268-022-00392-5

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between dihydropyridine calcium channel blockers and ischemic strokes in patients with nonvalvular atrial fibrillation2022

    • Author(s)
      Sakakibara Fumihiro、Ueda Shinichiro、Uchida Kazutaka、Kinjo Norito、Arai Hideki、Nezu Mari、Morimoto Takeshi
    • Journal Title

      Hypertension Research

      Volume: 45 Issue: 6 Pages: 1028-1036

    • DOI

      10.1038/s41440-022-00855-x

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of prior antiplatelet therapy on outcomes of endovascular therapy for acute ischemic stroke with large vessel occlusion: Sub-analysis of the RESCUE-Japan Registry 22022

    • Author(s)
      Fujiwara S, Sakai N, Imamura H, Ohara N, Tanaka K, Yamagami H, Matsumoto Y, Takeuchi M, Uchida K, Yoshimura S, Morimoto T
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 438 Pages: 120278-120278

    • DOI

      10.1016/j.jns.2022.120278

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low Serum Total Protein at Admission Predicts in-Hospital Mortality Among General Inpatients: Historical Cohort Study2022

    • Author(s)
      Inoue Miharu、Takeuchi Jiro、Sakuma Mio、Nakamura Tsukasa、Morimoto Takeshi
    • Journal Title

      International Journal of General Medicine

      Volume: 15 Pages: 7941-7949

    • DOI

      10.2147/ijgm.s385798

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Drug-Related Pneumonitis Induced by Osimertinib as First-Line Treatment for Epidermal Growth Factor Receptor Mutation-Positive Non-Small Cell Lung Cancer: A Real-World Setting2022

    • Author(s)
      Sato Yuki,Sumikawa Hiromitsu,Shibaki Ryota,Morimoto Takeshi,Sakata Yoshihiko,Oya Yuko,Tamiya Motohiro,Suzuki Hidekazu,Matsumoto Hirotaka,Yokoi Takashi,Hashimoto Kazuki,Kobe Hiroshi,Hino Aoi,Inaba Megumi,Tsukita Yoko,Ikeda Hideki,Arai Daisuke,Maruyama Hirotaka,Hara Satoshi,Tsumura Shinsuke,Sakata Shinya,Fujimoto Daichi
    • Journal Title

      Chest

      Volume: 162 Issue: 5 Pages: 1188-1198

    • DOI

      10.1016/j.chest.2022.05.035

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epidemiology of adverse drug events and medication errors in four nursing homes in Japan : the Japan Adverse Drug Events (JADE) Study2022

    • Author(s)
      Nobutaka Ayani, Nozomu Oya, Riki Kitaoka, Akiko Kuwahara, Takeshi Morimoto, Mio Sakuma, Jin Narumoto
    • Journal Title

      BMJ Quality & Safety

      Volume: 31 Issue: 12 Pages: 878-887

    • DOI

      10.1136/bmjqs-2021-014280

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Over Half of Falls Were Associated with Psychotropic Medication Use in Four Nursing Homes in Japan: A Retrospective Cohort Study2022

    • Author(s)
      Oya Nozomu、Ayani Nobutaka、Kuwahara Akiko、Kitaoka Riki、Omichi Chie、Sakuma Mio、Morimoto Takeshi、Narumoto Jin
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 19 Issue: 5 Pages: 3123-3123

    • DOI

      10.3390/ijerph19053123

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of concomitant antiplatelet therapy on ischemic and hemorrhagic events in patients taking oral anticoagulants for nonvalvular atrial fibrillation in daily clinical practice2021

    • Author(s)
      Morimoto Takeshi、Uchida Kazutaka、Sakakibara Fumihiro、Kinjo Norito、Ueda Shinichiro
    • Journal Title

      Pharmacoepidemiology and Drug Safety

      Volume: 30 Issue: 10 Pages: 1321-1331

    • DOI

      10.1002/pds.5228

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical characteristics and factors related to antibiotic-associated diarrhea in elderly patients with pneumonia: a retrospective cohort study2021

    • Author(s)
      Takedani Yoko、Nakamura Tsukasa、Fukiwake Noriko、Imada Toshihiro、Mashino Junji、Morimoto Takeshi
    • Journal Title

      BMC Geriatrics

      Volume: 21 Issue: 1 Pages: 317-317

    • DOI

      10.1186/s12877-021-02267-x

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Burden of Preventable Adverse Drug Events on Hospital Stay and Healthcare Costs in Japanese Pediatric Inpatients: The JADE Study.2021

    • Author(s)
      Iwasaki H, Sakuma M, Ida H, Morimoto T.
    • Journal Title

      Clinical Medicine Insights: Pediatrics

      Volume: 15 Pages: 1-8

    • DOI

      10.1177/1179556521995833

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antipsychotic Polypharmacy Is Associated With Adverse Drug Events in Psychiatric Inpatients: The Japan Adverse Drug Events Study2021

    • Author(s)
      Ayani Nobutaka、Morimoto Takeshi、Sakuma Mio、Kikuchi Toshiaki、Watanabe Koichiro、Narumoto Jin
    • Journal Title

      Journal of Clinical Psychopharmacology

      Volume: 41 Issue: 4 Pages: 397-402

    • DOI

      10.1097/jcp.0000000000001416

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences in adverse drug events and medication errors among pediatric inpatients aged <3 and ≧3 years: The JADE study2021

    • Author(s)
      Takeuchi Jiro、Sakuma Mio、Ohta Yoshinori、Ida Hiroyuki、Morimoto Takeshi
    • Journal Title

      Journal of Patient Safety and Risk Management

      Volume: 26 Issue: 6 Pages: 261-266

    • DOI

      10.1177/25160435211046764

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Medical errors and error-related adverse events in pediatric inpatients in Japan: The JET Study2023

    • Author(s)
      Sakuma M, Takeuchi J, Ohta Y, Morimoto T
    • Organizer
      39th International Conference of the International Society for Quality in Health Care
    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Computerized clinical decision support system to adhere to pre-prescription examinations for high-risk drugs2023

    • Author(s)
      Nezu M, Nakamura T, Sakuma M, Morimoto T
    • Organizer
      39th International Conference of the International Society for Quality in Health Care
    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Incidence and clinical impact of delirium after transcatheter aortic valve implantation in Japan: An interim report2023

    • Author(s)
      Ayani N, Zen K, Morimoto T, Narumoto J
    • Organizer
      39th International Conference of the International Society for Quality in Health Care
    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical decision support system to reduce inappropriate medication orders in outpatient service2022

    • Author(s)
      Nakamura T, Kosaka S, Sonoyama T, Morimoto T
    • Organizer
      38th International Conference of the International Society for Quality in Health Care
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Incidence and characteristics of adverse events in pediatric inpatients in Japan: The JET Study2022

    • Author(s)
      Sakuma M, Takeuchi J, Ohta Y, Morimoto T
    • Organizer
      38th International Conference of the International Society for Quality in Health Care
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Epidemiology of unidentified adverse events in Japan: The JET Study2022

    • Author(s)
      Ohta Y, Sakuma M, Nakamura T, Morimoto T
    • Organizer
      38th International Conference of the International Society for Quality in Health Care
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical epidemiology in violence and violation in psychiatric inpatients: The GUARD Study: An interim report2022

    • Author(s)
      Ayani N, Sakuma M, Narumoto J, Morimoto T
    • Organizer
      38th International Conference of the International Society for Quality in Health Care
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical decision support system to reduce inappropriate medication orders in outpatient service2022

    • Author(s)
      Nakamura Tsukasa、Kosaka Shinji、Sonoyama Tomohiro、Morimoto Takeshi
    • Organizer
      38th International Conference of the International Society for Quality in Health Care
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Incidence and characteristics of adverse events in pediatric inpatients in Japan: The JET Study2022

    • Author(s)
      Sakuma Mio、Takeuchi Jiro、Ohta Yoshinori、Morimoto Takeshi
    • Organizer
      38th International Conference of the International Society for Quality in Health Care
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Epidemiology of unidentified adverse events in Japan: The JET Study2022

    • Author(s)
      Ohta Yoshinori、Sakuma Mio、Nakamura Tsukasa、Morimoto Takeshi
    • Organizer
      38th International Conference of the International Society for Quality in Health Care
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical epidemiology in violence and violation in psychiatric inpatients: The GUARD Study: An interim report2022

    • Author(s)
      Ayani Nobutaka、Sakuma M、Narumoto Jin、Morimoto Takeshi
    • Organizer
      38th International Conference of the International Society for Quality in Health Care
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research

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Published: 2021-04-28   Modified: 2025-01-30  

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