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Childhood obesity and chronic disease risk in adulthood

Research Project

Project/Area Number 21K02353
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 09030:Childhood and nursery/pre-school education-related
Research InstitutionMie University

Principal Investigator

Togashi Kenji  三重大学, 教育学部, 教授 (10227564)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords肥満小児 / 長期予後 / 内臓脂肪面積 / 血液生化学値 / 生活習慣病 / 肥満度 / 性差 / 小児 / 肥満 / 予後
Outline of Research at the Start

本研究は、過去に肥満を主訴として診察を受けた子どもの記録(カルテ)をもとに、郵送による予後調査(後ろ向きコホート調査)を実施し、①「初診当時の年齢、肥満の程度、予後調査時までの経過年数」と「現在(成人期)における肥満継続・解消」との関係、②「小児期の肥満に伴う病態(体型、体脂肪量、内臓脂肪量、血液生化学値等)」と「成人期の心身の健康状態」との関係を検討することで、子どもの時期における肥満形成が成人期の心身の健康状態へ与える影響について検討し、肥満の早期予防・対応の重要性を明らかにすることを目的とする。

Outline of Final Research Achievements

1)A follow-up study was conducted by mail on 1377 people who were obese in childhood, and 304 people who responded were targeted. Among those who were mildly obese in childhood, 55.9% were determined to be obese in adulthood, while 81.6% were severely obese in childhood. It was found that men were more likely to remain obese.
2)Clinical tests were conducted on 57 of the above subjects who requested retesting. The group with persistent obesity had a higher risk of lifestyle-related diseases than the group whose obesity had resolved. The correlation between laboratory test values during childhood and adulthood suggests the possibility of estimating future cardiovascular risk. These results suggest that as obesity continues for a long time, visceral fat accumulates independently of BMI, increasing the risk of lifestyle-related diseases.

Academic Significance and Societal Importance of the Research Achievements

本研究では、小児期に肥満を呈していた者を対象とし、成人期に調査紙、もしくは直接的な臨床検査を実施し、小児期の肥満が成人期の生活習慣病リスクに及ぼす影響を検討した。小児期に肥満の程度が高い者ほど、成人期に肥満を呈する確率は高く、特に小児期の高度肥満者の8割が成人期に肥満を呈していた。一方、成人期に肥満を解消すると内臓脂肪面積や血液生化学値も正常範囲内にとどまったのに対し、肥満を継続した者では生活習慣病のリスクが高い状態にあった。このように直接的に個人の小児期と成人期の情報を結びつけて生活習慣病リスクを検討した報告は国内外でも稀であり、小児期の肥満に対し早期に対応する意義を示すものである。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (13 results)

All 2024 2023 2022 2021

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (9 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results)

  • [Journal Article] Chronotype and emotional/behavioral problems mediate the association between leisure screen time and academic achievement in children2024

    • Author(s)
      Masahiro Matsui, Kaori Ishii, Koya Suzuki, Kenji Togashi
    • Journal Title

      Chronobiology International

      Volume: 41 Issue: 4 Pages: 513-520

    • DOI

      10.1080/07420528.2024.2320231

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating Extracellular Vesicles are Associated with Pathophysiological Condition Including Metabolic Syndrome-related Dysmetabolism in Children and Adolescents with Obesity2023

    • Author(s)
      Yoshinao Kobayashi; Akiko Eguchi; Koshi Imami; Mina Tempaku; Kiyora Izuoka; Takafumi Takase; Keigo Kainuma; Mizuho Nagao; Noriko Furuta; Motoh Iwasa; Hayato Nakagawa; Takao Fujisawa; Kenji Togashi
    • Journal Title

      Journal of Molecular Medicine

      Volume: 102 Issue: 1 Pages: 23-28

    • DOI

      10.1007/s00109-023-02386-5

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 子どもの体型がその後の健康に及ぼす影響2022

    • Author(s)
      冨樫健二
    • Journal Title

      こどもと発育発達

      Volume: 20(3) Pages: 181-187

    • Related Report
      2022 Research-status Report
  • [Journal Article] Protein Composition of Circulating Extracellular Vesicles Immediately Changed by Particular Short Time of High-Intensity Interval Training Exercise2021

    • Author(s)
      Kobayashi Yoshinao、Eguchi Akiko、Tamai Yasuyuki、Fukuda Sanae、Tempaku Mina、Izuoka Kiyora、Iwasa Motoh、Takei Yoshiyuki、Togashi Kenji
    • Journal Title

      Frontiers in Physiology

      Volume: 12 Pages: 1-12

    • DOI

      10.3389/fphys.2021.693007

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 子どもの肥満の現在と未来2024

    • Author(s)
      冨樫健二
    • Organizer
      第22回発育発達学会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 小学生におけるスクリーンタイムとクロノタイプ、メンタルヘルス、学力の関連性2023

    • Author(s)
      松井公宏、石井香織、江口優作、鈴木宏哉、冨樫健二
    • Organizer
      日本運動疫学会 第25回学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Chronotype and psychosocial health mediate association between screen time and academic performance in Japanese children2023

    • Author(s)
      Masahiro Matsui, Kaori Ishii, Yusaku Eguchi, Koya Suzuki, Kenji Togashi
    • Organizer
      オーストラリアスポーツ医学会
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 肥満小児の長期予後 -小児期からの経過年数の違いが予後に及ぼす影響-2023

    • Author(s)
      冨樫健二
    • Organizer
      第44回日本肥満学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 小学生における生活習慣とクロノタイプの関連2023

    • Author(s)
      松井公宏、石井香織、江口優作、鈴木宏哉、冨樫健二
    • Organizer
      日本発育発達学会 第21回大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 小児期の肥満は成人期の体型、健康状態にどのような影響を及ぼすか2022

    • Author(s)
      冨樫健二
    • Organizer
      第77回日本体力医学会大会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] ワークショップpart 1:肥満症Q&A2021

    • Author(s)
      冨樫健二
    • Organizer
      日本肥満学会 肥満症サマーセミナー
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 子どもの肥満や身体活動がその後の健康に及ぼす影響2021

    • Author(s)
      冨樫健二、笹山健作、松井公宏
    • Organizer
      第20回日本発育発達学会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] コロナ禍における小学生児童の身体活動量-性差に着目した検討-2021

    • Author(s)
      松井公宏、笹山健作、横田幸大、 西藤陽太、冨樫健二
    • Organizer
      第20回日本発育発達学会
    • Related Report
      2021 Research-status Report

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Published: 2021-04-28   Modified: 2025-01-30  

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