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VIrome analysis of bats in Indonesia

Research Project

Project/Area Number 21K05951
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 42020:Veterinary medical science-related
Research InstitutionHokkaido University

Principal Investigator

Sawa Hirofumi  北海道大学, ワクチン研究開発拠点, 教授 (30292006)

Co-Investigator(Kenkyū-buntansha) 大場 靖子  北海道大学, 人獣共通感染症国際共同研究所, 教授 (60507169)
佐々木 道仁  北海道大学, 人獣共通感染症国際共同研究所, 講師 (70609403)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsコウモリ / ウイルス / 分離 / 単離 / インドネシア / Virome
Outline of Research at the Start

コウモリは人に致死的な肺炎、出血熱、脳炎、狂犬病 等の自然宿主と考えられている。本研究ではインドネシアで採集したコウモリの呼吸器検体を使用して、Virome解析を実施し、新規・既知のウイルスの存在を明らかにすることを計画する。本研究計画ではCOVID-19のパンデミックにより、海外における疫学活動が困難な状況において、申請者の所属施設に既に保管されているサンプルを活用する。
本研究により、コウモリの保有するウイルスの多様性に関する基礎的知見を得られると共に、公衆衛生上重要なウイルス感染症に対する対策に関する開発研究への波及が期待され、東南アジアにおける疫学研究のボトムアップをもたらす。

Outline of Final Research Achievements

Bats are considered natural hosts of viruses that cause fatal pneumonia, hemorrhagic fever, and other diseases in humans. In this research plan, we planned to determine the presence of novel and known viruses from Indonesian bats. As a result, we isolated Nelson Bay orthoreovirus, which causes pneumonia, from Indonesian bats and investigated its pathogenicity and infection status in Indonesian bats to gain insight into the prevalence of NBV in Indonesia. This study was reported in the international journal, "Virology (impact factor: 3.7)" in 2022. We also isolated mammalian orthoreoviruses and are currently submitting a paper for peer review.

Academic Significance and Societal Importance of the Research Achievements

本研究により、インドネシアのコウモリから、肺炎を惹起するNelson Bay orthoreovirus を分離してその病原性、およびインドネシアのコウモリにおける感染状況を調査して、インドネシアにおけるNBVの流行に関する知見を得た。さらに、コウモリから哺乳類オルソレオウイルスも分離し、その病原性を明らかにした。
以上の研究により、コウモリの保有するウイルスの多様性に関する基礎的知見が得られ、東南アジアにおけるウイルス感染症を対象とした疫学研究のボトムアップに貢献し、コウモリが媒介するウイルス感染症に対する公衆衛生対策にも貢献した。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (15 results)

All 2023 2022 2021 Other

All Int'l Joint Research (5 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 2 results) Remarks (3 results)

  • [Int'l Joint Research] IPB University(インドネシア)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] University College of Dublin(アイルランド)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Global Virus Network(米国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] IPB University(インドネシア)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] ボゴール農科大学(インドネシア)

    • Related Report
      2021 Research-status Report
  • [Journal Article] Isolation and characterization of an orthoreovirus from Indonesian fruit bats2022

    • Author(s)
      Intaruck Kittiya、Itakura Yukari、Kishimoto Mai、Chambaro Herman M.、Setiyono Agus、Handharyani Ekowati、Uemura Kentaro、Harima Hayato、Taniguchi Satoshi、Saijo Masayuki、Kimura Takashi、Orba Yasuko、Sawa Hirofumi、Sasaki Michihito
    • Journal Title

      Virology

      Volume: 575 Pages: 10-19

    • DOI

      10.1016/j.virol.2022.08.003

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Isolation and characterization of Mammalian Orthoreovirus from Pteropus vampyrus bats in Indonesia.2023

    • Author(s)
      Kittiya Intaruck, Mai Kishimoto, Yukari Itakurai, Koshiro Tabata, Agus Setiyono, Ekowati Handharyani, Yasuko Orba, Hirofumi Sawa, Michihito Sasaki
    • Organizer
      第70回日本ウイルス学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Isolation and characterization of Mammalian Orthoreovirus from Pteropus vampyrus bats in Indonesia.2023

    • Author(s)
      Kittiya Intaruck, Koshiro Tabata, Yukari Itakura, Nijiho Kawaguchi, Mai Kishimoto, Agus Setiyono, Ekowati Handharyani, Yasuko Orba, Hirofumi Sawa, Michihito Sasaki
    • Organizer
      第46回日本分子生物学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Characterization and seroprevalence of a new Nelson Bay orthoreovirus isolated from Indonesian fruit bats.2022

    • Author(s)
      Kittiya Intaruck, Yukari Itakura, Mai Kishimoto, Herman Moses Chambaro, Takashi Kimura, Yasuko Orba, Hirofumi Sawa, Michihito Sasaki.
    • Organizer
      The 10th Sapporo Summer Seminar for One Health (SaSSOH)
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Characterization and serological study of Nelson Bay orthoreovirus isolated from Indonesian fruit bats.2022

    • Author(s)
      Kittiya Intaruck, Yukari Itakura, Mai Kishimoto, Herman Moses Chambaro, Agus Setiyono, Ekowati Handharyani, Kentaro Uemura, Hayato Harima, Yasuko Orba, Hirofumi Sawa, Michihito Sasaki.
    • Organizer
      第69回日本ウイルス学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] Virological and serological characterization of a new Nelson Bay Orthoreovirus isolated from wild fruit bats in Indonesia2022

    • Author(s)
      Kittiya Intaruck, Yukari Itakura, Mai Kishimoto, Herman Moses Chambaro, Agus Setiyono, Ekowati Handharyani, Takashi Kimura, Yasuko Orba, Hirofumi Sawa, Michihito Sasaki.
    • Organizer
      One Health Lecture Series: InterdisciplinaryApproach Reinforces Sustainable Development Goals
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Isolation and Characterization of an Orthoreovirus from Indonesian Fruit Bats2021

    • Author(s)
      Kittiya Intaruck, Agus Setiyono, Ekowati Handharyani, Yasuko Orba, Hirofumi Sawa, Michihito Sasaki
    • Organizer
      第44回分子生物学会年会
    • Related Report
      2021 Research-status Report
  • [Remarks] 北海道大学人獣共通感染症国際共同研究所 分子病態・診断部門

    • URL

      https://www.czc.hokudai.ac.jp/pathobiol/

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
  • [Remarks] 北海道大学 ワクチン研究開発拠点

    • URL

      https://www.ivred.hokudai.ac.jp/

    • Related Report
      2023 Annual Research Report
  • [Remarks] 北海道大学 人獣共通感染症国際共同研究所 分子病態・診断部門

    • URL

      https://www.czc.hokudai.ac.jp/pathobiol/

    • Related Report
      2021 Research-status Report

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Published: 2021-04-28   Modified: 2025-01-30  

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