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Examination of gastrointestinal differentiation and expression status of cancer stromal markers in extrahepatic cholangiocarcinoma

Research Project

Project/Area Number 21K06927
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 49020:Human pathology-related
Research InstitutionDokkyo Medical University

Principal Investigator

Ishida Kazuyuki  獨協医科大学, 医学部, 教授 (40444004)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2023: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords肝外胆管癌 / 胃腸分化形質 / 癌間質 / 遠位胆管癌 / 肝門部胆管癌 / 胃腸分化 / 癌関連線維芽細胞 / 胆管癌 / 胃腸分化マーカー / 腫瘍形成メカニズム
Outline of Research at the Start

胆管癌は本邦に多い悪性度が高い癌腫であり,肝外胆管癌は胃腸分化マーカーの発現により分類される.しかし,胃腸分化マーカーの発現状態の違いがどのように発癌,進展に関わっているかは不明である.我々は,胃腸分化マーカーの発現状態によって,異なるがん微小環境が形成されている可能性を考え,癌関連線維芽細胞 (CAFs),腫瘍浸潤リンパ球 (TILs),腫瘍関連マクロファージ (TAMs)の発現状態を免疫組織学的に検討し,肝外胆管癌の予後を規定する癌細胞と癌間質マーカーの組み合わせを明らかにすることを目的とする.

Outline of Final Research Achievements

To clarify the relationship between the direction of gastrointestinal differentiation and cancer stroma in hilar and distal cholangiocarcinoma, we examined the expression of cancer-associated fibroblasts (CAFs), tumor-infiltrating lymphocytes (TILs), tumor-associated macrophages (TAMs), and gastrointestinal differentiation markers. We reviewed all collected and HE specimens of surgically treated cholangiocarcinoma cases and evaluated pathological findings such as primary location, histological type, depth, vascular invasion, carcinoma in situ, budding, and marker expression. The results showed that the degree of perineural invasion (distal>hilar), vascular invasion (distal>hilar), MUC5AC expression, and TIL and TAM expression may differ by site. No relationship was found between the direction of epithelial gastrointestinal differentiation and CAFs, TILs, or TAMs.

Academic Significance and Societal Importance of the Research Achievements

胆管癌はアジアに罹患者が多く,我が国においても癌による臓器別死亡原因では第6位で,5年生存率は20%前後と膵癌に次いで悪性度が高い.本研究では肝門部胆管癌と遠位胆管癌の胃腸分化方向と癌間質との関連性を明らかにするため病理所見,癌関連線維芽細胞(CAFs), 腫瘍浸潤リンパ球(TILs), 腫瘍関連マクロファージ(TAMs), 胃腸分化マーカーの発現を検討したところ,神経浸潤の程度,脈管侵襲の程度(遠位>肝門部),MUC5ACの発現,TILsとTAMsの発現状況が部位により異なる可能性が示された.胆管癌の腫瘍発生・進展のメカニズムを解明することは,胆管癌の治療につながる重要な課題である.

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (11 results)

All 2024 2023 2022

All Journal Article (11 results) (of which Peer Reviewed: 11 results)

  • [Journal Article] Hereditary Diffuse Gastric Cancer Treated by Prophylactic Total Gastrectomy2024

    • Author(s)
      Inaba Yasunori、Goda Kenichi、Kondo Masayuki、Abe Keiichiro、Kanamori Akira、Suzuki Tsunehiro、Tominaga Keiichi、Nakagawa Masatoshi、Morita Shinji、Kojima Kazuyuki、Ishida Kazuyuki、Irisawa Atsushi
    • Journal Title

      Internal Medicine

      Volume: 63 Issue: 2 Pages: 235-239

    • DOI

      10.2169/internalmedicine.1257-22

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2024-01-15
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Superficial esophageal squamous cell carcinoma with melanocytosis that was endoscopically difficult to differentiate from malignant melanoma2024

    • Author(s)
      Horikawa Yoshinori、Goda Kenichi、Koyanagi Ryota、Kondo Masayuki、Abe Keiichiro、Kanamori Akira、Hamada Koichi、Ishida Kazuyuki、Irisawa Atsushi
    • Journal Title

      DEN Open

      Volume: 4 Issue: 1 Pages: 251-255

    • DOI

      10.1002/deo2.353

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of cytological diagnosis in pancreatic endoscopic ultrasound‐guided fine needle aspiration or biopsy: Comparison with histological diagnosis and relationship with puncture route and sample acquisition method2023

    • Author(s)
      Nagai Tamiko、Ishida Kazuyuki、Machida Hiromi、Takada‐Owada Atsuko、Onozaki Masato、Noda Shuhei、Nozawa Yumi、Takaoka Mina、Sakuma Fumi、Aoki Taku、Irisawa Atsushi
    • Journal Title

      Diagnostic Cytopathology

      Volume: 51 Issue: 8 Pages: 467-474

    • DOI

      10.1002/dc.25144

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of malignant ascites of neuroendocrine carcinoma of the gallbladder diagnosed by endoscopic ultrasound‐guided fine‐needle aspiration2023

    • Author(s)
      Ishikawa Mihoko、Ishida Kazuyuki、Machida Hiromi、Kato Hikaru、Ishizaki Satomi、Nagai Tamiko、Matsuyama Kinichi、Nozawa Yumi、Takada‐Owada Atsuko、Kaneko Yuko、Sakuma Fumi、Irisawa Atsushi
    • Journal Title

      Diagnostic Cytopathology

      Volume: 51 Issue: 10 Pages: 658-661

    • DOI

      10.1002/dc.25199

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of peripheral enhancement on contrast-enhanced computed tomography and corresponding pathological findings in colorectal liver metastases after preoperative chemotherapy2023

    • Author(s)
      Tamura Akio、Ishida Kazuyuki、Sone Misato、Yoshioka Kunihiro
    • Journal Title

      Polish Journal of Radiology

      Volume: 88 Pages: 251-255

    • DOI

      10.5114/pjr.2023.127611

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Micro-hepatocellular carcinoma with bile duct tumor thrombus mimicking intrahepatic intraductal papillary neoplasm of the bile duct: a case report2023

    • Author(s)
      Matsumoto Takatsugu、Shimizu Takayuki、Sato Shun、Tanaka Genki、Yamaguchi Takamune、Park Kyung-Hwa、Sakuraoka Yuhki、Shiraki Takayuki、Mori Shozo、Iso Yukihiro、Nemoto Takehiko、Kubota Keiichi、Nozawa Yumi、Ishida Kazuyuki、Aoki Taku
    • Journal Title

      Surgical Case Reports

      Volume: 9 Issue: 1 Pages: 67-67

    • DOI

      10.1186/s40792-023-01646-3

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pathological complete response of hepatocellular carcinoma confirmed by conversion hepatectomy following atezolizumab plus bevacizumab therapy: a case report and literature review2023

    • Author(s)
      Sato Shun、Aoki Taku、Matsumoto Takatsugu、Shiraki Takayuki、Mori Shozo、Iso Yukihiro、Nemoto Takehiko、Onishi Toshihiko、Iijima Makoto、Ishida Kazuyuki
    • Journal Title

      Clinical Journal of Gastroenterology

      Volume: 17 Issue: 2 Pages: 292-299

    • DOI

      10.1007/s12328-023-01895-7

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathological Evaluation of Resected Colorectal Liver Metastases: mFOLFOX6 Plus Bevacizumab versus mFOLFOX6 Plus Cetuximab in the Phase II ATOM Trial2022

    • Author(s)
      Takahashi Takao、Ishida Kazuyuki、Emi Yasunori、Sakamoto Michiie、Imura Johji、Aishima Shinichi、Muro Kei、Uetake Hiroyuki、Oki Eiji、Katayose Yu、Yoshida Kazuhiro、Unno Michiaki、Hyodo Ichinosuke、Tomita Naohiro、Sugihara Kenichi、Maehara Yoshihiko
    • Journal Title

      Cancers

      Volume: 14 Issue: 18 Pages: 4392-4392

    • DOI

      10.3390/cancers14184392

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Usefulness of Adding Maspin Staining to p53 Staining for EUS-FNA Specimens of Pancreatic Ductal Adenocarcinoma2022

    • Author(s)
      Fukushi Koh、Yamamiya Akira、Tominaga Keiichi、Abe Yoko、Hoshi Koki、Nagashima Kazunori、Kashima Ken、Kunogi Yasuhito、Sakuma Fumi、Yamagishi Hidetsugu、Ishida Kazuyuki、Haruyama Yasuo、Irisawa Atsushi
    • Journal Title

      Journal of Clinical Medicine

      Volume: 11 Issue: 20 Pages: 6097-6097

    • DOI

      10.3390/jcm11206097

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mixed adenoneuroendocrine carcinoma of the non-ampullary duodenum with mismatch repair deficiency: a rare case report2022

    • Author(s)
      Nozawa Yumi、Ishida Kazuyuki、Maiko Niki、Takada-Owada Atsuko、Onozaki Masato、Takaoka Mina、Matsuyama Kinichi、Sakuraoka Yuhki、Nakazato Yoshimasa、Kubota Keiichi
    • Journal Title

      Medical Molecular Morphology

      Volume: 55 Issue: 3 Pages: 258-266

    • DOI

      10.1007/s00795-022-00324-x

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of obstructive jaundice caused by metastasis of breast cancer to the intra/extrahepatic bile duct2022

    • Author(s)
      Suzuki Yuka、Hoshi Koki、Tominaga Keiichi、Inaba Yasunori、Yoshinaga Tomonori、Kojimahara Shunsuke、Maki Ryuichi、Nemoto Rena、Tetsuka Yugo、Kawata Yosuke、Yamamiya Akira、Sugaya Takeshi、Iso Yukihiro、Takada‐Owada Atsuko、Ishida Kazuyuki、Goda Kenichi、Irisawa Atsushi
    • Journal Title

      DEN Open

      Volume: 3 Issue: 1

    • DOI

      10.1002/deo2.144

    • Related Report
      2022 Research-status Report
    • Peer Reviewed

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Published: 2021-04-28   Modified: 2025-01-30  

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