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Frailty Network Analysis and Identification of Prognostic Factors by Artificial Intelligence Analysis of Elderly Cohort study

Research Project

Project/Area Number 21K07372
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52010:General internal medicine-related
Research InstitutionKagoshima University

Principal Investigator

Ohishi Mitsuru  鹿児島大学, 医歯学域医学系, 教授 (50335345)

Co-Investigator(Kenkyū-buntansha) 窪薗 琢郎  鹿児島大学, 医歯学域医学系, 講師 (00598013)
川添 晋  鹿児島大学, 医歯学総合研究科, 特任講師 (00810201)
牧迫 飛雄馬  鹿児島大学, 医歯学域医学系, 教授 (70510303)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2023: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2021: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsフレイル / 予測 / 生活習慣病 / AI解析 / 口腔フレイル / 身体的フレイル / 精神的フレイル / 社会的フレイル / 予測モデル / 人工知能 / ニューラルネットワーク / 機械学習 / 高齢者コホート
Outline of Research at the Start

健康長寿・QOL保持を目指すフレイル制御のために、毎年1000名以上の高齢者を多職種・専門的・多面的に評価した高齢者コホート研究データ(垂水研究)を用いて、『フレイルを規定・悪化させている因子は何か?』、『身体的・精神的・社会的フレイルはどのように影響しあっているのか?』、『フレイル出現・悪化を予知・予防できるのか?』の3つのなぞに関して、AI(機械学習・ニューラルネットワーク)解析の手法を用いて明らかにする。

Outline of Final Research Achievements

The Tarumi Study, the subject of this research, has not progressed as planned due to the cancellation of the study in 2020 due to the new coronary disaster and the 70% reduction in the scale of the study from 2021. We prepared to conduct this study promptly after the resumption of the Tarumi Study in 2024 by analyzing the Tarumi Study 2019 data and large-scale health examination data. We reported a multidimensional analysis of frailty, including apathy and grave visit, overall frailty and satisfaction, frailty and meaningful activity, satisfaction, higher order ability, and dietary diversity, and oral frailty and protein intake, frailty, and sarcopenia. We constructed models for predicting disease onset such as hypertension, MetS, chronic kidney disease, and atrial fibrillation from large-scale health checkup data, and proved that the models have predictive power for AI analysis in hypertension and chronic kidney disease.

Academic Significance and Societal Importance of the Research Achievements

フレイル(身体的・精神的・社会的・オーラル)は密な相互関連を有し、さらに食事や栄養状態、満足度など生活そのものとも強い関連性を有することを地域住民対象のコホート研究で明らかにした。さらに生活習慣病発症を特定健診から予測ができることやAI解析によりその精度を上げることができることを示して、特定健診から生活習慣病予測を可視化して社会実装するアプリの開発のため特許申請を行った。これらのことから高齢者のフレイルの予測およびその可視化も可能であると考えており、アプリ開発を通じて社会実装にも貢献できると考えている。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (32 results)

All 2024 2023 2022 2021

All Journal Article (20 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 20 results,  Open Access: 15 results) Presentation (8 results) Book (4 results)

  • [Journal Article] Associations of eating out and dietary diversity with mild cognitive impairment among in community-dwelling older adults2024

    • Author(s)
      Kiuchi Yuto、Makizako Hyuma、Nakai Yuki、Taniguchi Yoshiaki、Akaida Shoma、Tateishi Mana、Kimura Mika、Takenaka Toshihiro、Kubozono Takuro、Tsutsumimoto Kota、Shimada Hiroyuki、Ohishi Mitsuru
    • Journal Title

      Annals of Geriatric Medicine and Research

      Volume: - Issue: 3 Pages: 266-272

    • DOI

      10.4235/agmr.23.0218

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a risk prediction score and equation for chronic kidney disease: a retrospective cohort study2023

    • Author(s)
      Kawasoe Shin、Kubozono Takuro、Salim Anwar Ahmed、Yoshimine Haruhito、Mawatari Seiichi、Ojima Satoko、Kawabata Takeko、Ikeda Yoshiyuki、Miyahara Hironori、Tokushige Koichi、Ido Akio、Ohishi Mitsuru
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 5001-5001

    • DOI

      10.1038/s41598-023-32279-z

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in Satisfaction with Meaningful Activities and Onset of Depressive Symptoms among Community-Dwelling Japanese Older Adults: A Population-Based Study Before and During the COVID-19 Pandemic2023

    • Author(s)
      Maruta Michio、Tabira Takayuki、Shimokihara Suguru、Makizako Hyuma、Ikeda Yuriko、Han Gwanghee、Akasaki Yoshihiko、Hidaka Yuma、Nakahara Rena、Kamasaki Taishiro、Kukizaki Wataru、Kubozono Takuro、Ohishi Mitsuru
    • Journal Title

      Journal of the American Medical Directors Association

      Volume: 24 Issue: 5 Pages: 702-709

    • DOI

      10.1016/j.jamda.2023.03.010

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between grave visitation and apathy among community-dwelling older adults.2023

    • Author(s)
      Hidaka Y, Tabira T, Maruta M, Hakizako H, Ikeda Y, Nakamura A, Han G, Miyata H, Shimokihara S, Akasaki Y, Kamasaki T, Kubozono T, Oishi M.
    • Journal Title

      Psychogeriatrics

      Volume: 23(3) Issue: 3 Pages: 401-410

    • DOI

      10.1111/psyg.12945

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of predictive equation and score for 5-year metabolic syndrome incidence in Japanese adults2023

    • Author(s)
      Salim Anwar Ahmed、Kawasoe Shin、Kubozono Takuro、Ojima Satoko、Kawabata Takeko、Hashiguchi Hiroshi、Ikeda Yoshiyuki、Miyata Masaaki、Miyahara Hironori、Tokushige Koichi、Nishio Yoshihiko、Ohishi Mitsuru
    • Journal Title

      PLOS ONE

      Volume: 18 Issue: 4 Pages: 0284139-0284139

    • DOI

      10.1371/journal.pone.0284139

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of Sleep Duration and Cardio-Ankle Vascular Index in Community-Dwelling Older Adults2022

    • Author(s)
      Masumitsu Tomomi、Kubozono Takuro、Miyata Masaaki、Makizako Hyuma、Tabira Takayuki、Takenaka Toshihiro、Kawasoe Shin、Tokushige Akihiro、Niwa Sayoko、Ohishi Mitsuru
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 29 Issue: 12 Pages: 1864-1871

    • DOI

      10.5551/jat.63594

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2022-12-01
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Social Frailty and Meaningful Activities among Community-Dwelling Older Adults with Heart Disease2022

    • Author(s)
      Akasaki Yoshihiko、Tabira Takayuki、Maruta Michio、Makizako Hyuma、Miyata Masaaki、Han Gwanghee、Ikeda Yuriko、Nakamura Atsushi、Shimokihara Suguru、Hidaka Yuma、Kamasaki Taishiro、Kubozono Takuro、Ohishi Mitsuru
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 19 Issue: 22 Pages: 15167-15167

    • DOI

      10.3390/ijerph192215167

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations between apathy and comprehensive frailty as assessed by the Kihon Checklist among community‐dwelling Japanese older adults2022

    • Author(s)
      Maruta Michio、Shimokihara Suguru、Makizako Hyuma、Ikeda Yuriko、Han Gwanghee、Akasaki Yoshihiko、Hidaka Yuma、Kamasaki Taishiro、Kubozono Takuro、Ohishi Mitsuru、Tabira Takayuki
    • Journal Title

      Psychogeriatrics

      Volume: 22 Issue: 5 Pages: 651-658

    • DOI

      10.1111/psyg.12867

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of blood pressure and dietary intake of Sunomono, Japanese vinegared side dishes, in community-dwelling Japanese: A cross-sectional study.2022

    • Author(s)
      Kanouchi H, Yamashita M, Kaimoto K, Kuwabara A, Kawakami Y, Takenaka S, Koriyama C, Kuwahata S, Takenaka T, Akasaki Y, Kubozono T, Miyata M, Ohishi M.
    • Journal Title

      Heliyon

      Volume: 8 Issue: 5 Pages: e09505-e09505

    • DOI

      10.1016/j.heliyon.2022.e09505

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between cognitive frailty and higher-level competence among community-dwelling older adults2022

    • Author(s)
      Wada A, Makizako H, Nakai Y, Tomioka K, Taniguchi Y, Sato N, Kiuchi Y, Kiyama R, Kubozono T, Takenaka T, Ohishi M
    • Journal Title

      Arch Gerontol Geriatr

      Volume: 99 Pages: 104589-104589

    • DOI

      10.1016/j.archger.2021.104589

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of a risk prediction score for hypertension incidence using Japanese health checkup data2022

    • Author(s)
      Kawasoe Mariko、Kawasoe Shin、Kubozono Takuro、Ojima Satoko、Kawabata Takeko、Ikeda Yoshiyuki、Oketani Naoya、Miyahara Hironori、Tokushige Koichi、Miyata Masaaki、Ohishi Mitsuru
    • Journal Title

      Hypertension Research

      Volume: 45 Issue: 4 Pages: 730-740

    • DOI

      10.1038/s41440-021-00831-x

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between apathy and satisfaction with meaningful activities in older adults with mild cognitive impairment: A?population‐based cross‐sectional study2022

    • Author(s)
      Maruta Michio、Makizako Hyuma、Ikeda Yuriko、Miyata Hironori、Nakamura Atsushi、Han Gwanghee、Shimokihara Suguru、Tokuda Keiichiro、Kubozono Takuro、Ohishi Mitsuru、Tabira Takayuki
    • Journal Title

      International Journal of Geriatric Psychiatry

      Volume: 36 Issue: 7 Pages: 1065-1074

    • DOI

      10.1002/gps.5544

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between Frequency of Going Out and Psychological Condition among Community-Dwelling Older Adults after the COVID-19 Pandemic in Japan2021

    • Author(s)
      Shimokihara S, Maruta M, Hidaka Y, Akasaki Y, Tokuda K, Han G, Ikeda Y, Tabira T
    • Journal Title

      Healthcare

      Volume: 10(3) Pages: 104665-104665

    • DOI

      10.1016/j.archger.2022.104665

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characteristics of meaningful activities in community-dwelling Japanese older adults with pre-frailty and frailty2021

    • Author(s)
      Maruta M, Makizako H, Ikeda Y, Han G, Shimokihara S, Miyata H, Tokuda K, Kubozono T, Ohishi M, Tomori K, Akaida S, Tabira T
    • Journal Title

      Archives of Gerontology and Geriatrics

      Volume: 99(5) Pages: 104616-104616

    • DOI

      10.1016/j.archger.2021.104616

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between Oral Hypofunction, and Protein Intake: A Cross-Sectional Study in Local Community-Dwelling Adults2021

    • Author(s)
      Keitaro Nishi, Hiroaki Kanouchi, Akihiko Tanaka, Maya Nakamura, Tomofumi Hamada, et.al
    • Journal Title

      Nutrients .

      Volume: 13 Issue: 12 Pages: 4377-4377

    • DOI

      10.3390/nu13124377

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Meaningful Activities and Psychosomatic Functions in Japanese Older Adults after Driving Cessation2021

    • Author(s)
      Nakamura A, Maruta M, Makizako H, Miyata M, Miyata H, Han G, Ikeda Y, Shimokihara S, Tokuda K, Kubozono T, Ohishi M, Tabira T
    • Journal Title

      Int J Environ Res Public Health

      Volume: 18(24) Issue: 24 Pages: 13270-13270

    • DOI

      10.3390/ijerph182413270

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of Oral Hypofunction with Frailty, Sarcopenia, and Mild Cognitive Impairment: A Cross-Sectional Study of Community-Dwelling Japanese Older Adults2021

    • Author(s)
      Nakamura Maya, Hamada Tomofumi, Tanaka Akihiko, et.al
    • Journal Title

      Journal of Clinical Medicine

      Volume: 10 Issue: 8 Pages: 1626-1626

    • DOI

      10.3390/jcm10081626

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Association between Dietary Variety and Physical Frailty in Community-Dwelling Older Adults2021

    • Author(s)
      Kiuchi Y, Makizako H, Nakai Y, Tomioka K, Taniguchi Y, Kimura M, Kanouchi H, Takenaka T, Kubozono T, Ohishi M
    • Journal Title

      Healthcare

      Volume: 9 Issue: 1 Pages: 32-32

    • DOI

      10.3390/healthcare9010032

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of Protein and Magnesium Intake with Prevalence of Prefrailty and Frailty in Community-Dwelling Older Japanese Women2021

    • Author(s)
      KAIMOTO Kaori、YAMASHITA Mikako、SUZUKI Taro、MAKIZAKO Hyuma、KORIYAMA Chihaya、KUBOZONO Takuro、TAKENAKA Toshihiro、OHISHI Mitsuru、KANOUCHI Hiroaki、the Tarumizu Study Diet Group
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 67 Issue: 1 Pages: 39-47

    • DOI

      10.3177/jnsv.67.39

    • NAID

      130007992421

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] The relationship between day-to-day variability in home blood pressure measurement and multiple organ function2021

    • Author(s)
      Kubozono Takuro、Akasaki Yuichi、Kawasoe Shin、Ojima Satoko、Kawabata Takeko、Makizako Hyuma、Kuwahata So、Takenaka Toshihiro、Maeda Mayuka、Fujiwara Seisuke、Miyagawa Ken、Ikeda Yoshiyuki、Ohishi Mitsuru
    • Journal Title

      Hypertension Research

      Volume: 45 Issue: 3 Pages: 474-482

    • DOI

      10.1038/s41440-021-00818-8

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] Ability of machine learning algorithms to predict chronic kidney disease using health examination data.2023

    • Author(s)
      Kawasoe S, Kubozono T, Anwar Salim, Ojima S, Kawabata T, Ikeda Y, Miyahara H, Tokushige K, Ohishi M.
    • Organizer
      第87回 日本循環器学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 健診ビッグデータの利用による心血管疾患予測の取組み2023

    • Author(s)
      川添 晋
    • Organizer
      第59回 日本循環器病予防学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 高齢者高血圧の特徴と降圧療法2022

    • Author(s)
      大石 充
    • Organizer
      第64回日本老年医学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 心不全ステージCの高齢心不全患者にFantastic Fourを使用すべきではない2022

    • Author(s)
      窪薗琢郎、大石 充
    • Organizer
      第64回日本老年医学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 高齢者における運動習慣と血管機能との関連2022

    • Author(s)
      窪薗琢郎、川添 晋、小島聡子、川畑孟子、サリムアンワー、池田義之、宮原広典、徳重浩一、大石 充
    • Organizer
      第64回日本老年医学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 低栄養は高齢者急性心筋梗塞(AMI)患者の死亡リスク因子になるか?2022

    • Author(s)
      神田大輔、池田義之、大牟禮健太、薗田剛嗣、安﨑和博、大石 充
    • Organizer
      第64回日本老年医学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 地域在住高齢者における認知的フレイルと動脈硬化度の関連2022

    • Author(s)
      赤井田将真、谷口善昭、中井雄貴、木内悠人、立石麻奈、白土大成、竹中俊宏、窪薗琢郎、大石 充、牧迫飛雄馬
    • Organizer
      第9回日本サルコペニア・フレイル学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 地域在住高齢者の動脈硬化と骨格筋量の低下は関連する2022

    • Author(s)
      谷口善昭、赤井田将真、立石麻奈、中井雄貴、木内悠人、窪薗琢郎、竹中俊宏、大石 充、牧迫飛雄馬
    • Organizer
      第9回日本サルコペニア・フレイル学会
    • Related Report
      2022 Research-status Report
  • [Book] 内科学 第12版2022

    • Author(s)
      大石 充
    • Total Pages
      2572
    • Publisher
      朝倉書店
    • ISBN
      9784254322804
    • Related Report
      2022 Research-status Report
  • [Book] フレイル対策シリーズ 循環器系と健康長寿・フレイル対策2022

    • Author(s)
      大石 充
    • Total Pages
      144
    • Publisher
      先端医学社
    • Related Report
      2022 Research-status Report
  • [Book] フレイル対策シリーズ 各論編⑤循環器系と健康長寿・フレイル対策2022

    • Author(s)
      大石 充
    • Total Pages
      146
    • Publisher
      先端医学社
    • Related Report
      2022 Research-status Report
  • [Book] 高齢者診療のための臨床検査ガイド2022

    • Author(s)
      窪薗琢郎、大石 充
    • Total Pages
      376
    • Publisher
      診断と治療社
    • ISBN
      9784787825124
    • Related Report
      2022 Research-status Report

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Published: 2021-04-28   Modified: 2025-01-30  

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