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Evaluation of instability plaque in the patient with acute ischemic stroke with intracranial artery stenosis and investigation of related factors to persistent plaque instability.

Research Project

Project/Area Number 21K07429
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52020:Neurology-related
Research InstitutionKawasaki Medical School

Principal Investigator

Yagita Yoshiki  川崎医科大学, 医学部, 教授 (20403066)

Co-Investigator(Kenkyū-buntansha) 大山 直紀  川崎医科大学, 医学部, 准教授 (90622895)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords脳梗塞 / 頭蓋内脳動脈狭窄 / 頭蓋内動脈狭窄 / プラーク性状 / 脂質低下療法 / vessel wall imaging / MRI
Outline of Research at the Start

再発リスクの高い脳主幹動脈狭窄による脳梗塞例において、VWIによるプラーク不安定性を定性・定量的に評価する方法を確立する。また急性期から慢性期にかけてのVWI所見の経時変化を評価し、治療効果判定に使用できるか検討する。さらに入院時の患者背景やバイオマーカーのうち、プラークの不安定性が遷延することや脳梗塞再発と関連するものを同定する。本研究の成果により、脳主幹動脈狭による脳梗塞の治療成績向上が期待される。

Outline of Final Research Achievements

Ischemic stroke caused by intracranial cerebral artery stenosis has high risk of recurrence. Because atherosclerotic plaque instability is related to a high risk of recurrent stroke, plaque characterization is important for optimal therapy to prevent stroke recurrence. In this study, we investigated the time course of plaque stabilization using enhancement rate of high-resolution magnetic resonance vessel wall imaging (HR-VWI). The results showed that plaque can be stabilized in the course of clinical phase after acute ischemic stroke with medical therapy including lipid-lowering therapy. The more potent the lipid-lowering therapy could achieve earlier plaque stabilization. Our results indicate that HR-VWI is useful in the therapeutic efficacy evaluation of plaque stabilization after acute ischemic stroke caused by intracranial cerebral artery stenosis.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果により頭蓋内脳動脈のプラーク安定化の経時変化をHR-VWIで評価しうることが示された。この成果によりこれまで容易ではなかった頭蓋内脳動脈の不安定プラークの病態や不安定性に影響を与える因子の研究が格段に進むことが期待できる。またHR-VWIを指標にすることにより、頭蓋内脳動脈のプラーク安定化の治療効果が評価できる。本研究では発症時のプラーク不安定化因子よりも治療介入によってそれらをどれだけ抑制できたかがプラーク安定化に寄与することが示された。このように、より効果的な治療レジメを考えるうえで臨床的にも有用な検査法であるといえる。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (15 results)

All 2024 2023 2022 2021 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 2 results) Presentation (7 results) (of which Invited: 3 results) Remarks (1 results)

  • [Journal Article] Temporal Changes in Cerebral Blood Flow during Migraine with Aura of Alternating Left and Right Homonymous Hemianopsia2024

    • Author(s)
      Miyazato S, Oyama N, Iwamoto T, Yagita Y.
    • Journal Title

      Internal Medicine

      Volume: 63 Issue: 8 Pages: 1157-1162

    • DOI

      10.2169/internalmedicine.2114-23

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2024-04-15
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] <i>JAK2</i> V617F Mutation and Large Cerebral Artery Disease in Patients with Myeloproliferative Neoplasms2023

    • Author(s)
      Oyama N, Iwamoto T, Doyu K, Miyazato S, Okazki T, Yamada S, Kondo T, Wada H, Yagita Y.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 30 Issue: 12 Pages: 1917-1926

    • DOI

      10.5551/jat.64118

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2023-12-01
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between Carotid Bifurcation Angle and Vulnerable Plaque Volume Using Black Blood Magnetic Resonance Imaging2023

    • Author(s)
      Takai H, Matsubara S, Minami-Ogawa Y, Hirai S, Shikata E, Yagi K, Oyama N, Yagita Y, Uno M.
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 63 Issue: 10 Pages: 437-442

    • DOI

      10.2176/jns-nmc.2023-0034

    • ISSN
      0470-8105, 1349-8029
    • Year and Date
      2023-10-15
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prior direct oral anticoagulant dosage and outcomes in patients with acute ischemic stroke and non-valvular atrial fibrillation: A sub-analysis of PASTA registry study2022

    • Author(s)
      Mashiko Takafumi、Fujimoto Shigeru、Suda Satoshi、Abe Arata、Iguchi Yasuyuki、Yagita Yoshiki、Kanzawa Takao、Okubo Seiji、Todo Kenichi、Yamazaki Mineo、Nakajima Nobuhito、Kondo Kimito、Inoue Takeshi、Iwanaga Takeshi、Terasawa Yuka、Shibazaki Kensaku、Kimura Kazumi
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 434 Pages: 120163-120163

    • DOI

      10.1016/j.jns.2022.120163

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sustained atrial fibrillation is related to a higher severity of stroke in patients taking direct oral anticoagulants2022

    • Author(s)
      Hayashi Toshiyuki、Suda Satoshi、Abe Arata、Iguchi Yasuyuki、Yagita Yoshiki、Kanzawa Takao、Okubo Seiji、Fujimoto Shigeru、Kimura Kazumi
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 434 Pages: 120172-120172

    • DOI

      10.1016/j.jns.2022.120172

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Predicting hemorrhagic transformation after large vessel occlusion stroke in the era of mechanical thrombectomy2021

    • Author(s)
      Iwamoto Takanori、Kitano Takaya、Oyama Naoki、Yagita Yoshiki
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 8 Pages: e0256170-e0256170

    • DOI

      10.1371/journal.pone.0256170

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Older Thrombus Delays Reperfusion after Mechanical Thrombectomy for Ischemic Stroke2021

    • Author(s)
      Kitano Takaya、Hori Yumiko、Okazaki Shuhei、Murayama Shigeo、Morii Eiichi、Sakaguchi Manabu、Yagita Yoshiki、Shimazu Takeshi、Mochizuki Hideki、Todo Kenichi
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 122 Issue: 03 Pages: 415-426

    • DOI

      10.1055/a-1522-4507

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 頭蓋内動脈狭窄による急性期脳梗塞におけるプラーク性状の経時変化2023

    • Author(s)
      八木田佳樹、岩本高典、岡崎知子、宮里紗季、道勇慧到、大山直紀
    • Organizer
      第64回日本神経学会学術大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 脳卒中診療の進歩-急性期から再発予防まで-2023

    • Author(s)
      八木田佳樹
    • Organizer
      第68回日本内科学会四国支部生涯教育講演会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 急性期脳梗塞後の頭蓋内動脈プラーク安定化と関連する因子の検討2023

    • Author(s)
      八木田佳樹、岩本高典、岡崎知子、松崎丞、木本和希、道勇慧到、三浦人詩、大山直紀
    • Organizer
      第66回日本脳循環代謝学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 症候性頭蓋内動脈プラーク安定化と関連する因子2023

    • Author(s)
      八木田佳樹、岩本高典、岡崎知子、松崎丞、木本和希、道勇慧到、三浦人詩、大山直紀
    • Organizer
      第11回日本心血管脳卒中学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 急性期脳卒中における早期抗血小板療法の新たな可能性2023

    • Author(s)
      八木田佳樹
    • Organizer
      Stroke2024(第49回日本脳卒中学会学術集会)
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 非心原性脳梗塞急性期の抗血栓療法2023

    • Author(s)
      八木田佳樹
    • Organizer
      第48回日本脳卒中学会学術集会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 症候性頭蓋内動脈硬化プラークの不安定性と脳梗塞再発2022

    • Author(s)
      八木田佳樹
    • Organizer
      第65回日本脳循環代謝学会総会
    • Related Report
      2022 Research-status Report
  • [Remarks] 川崎医科大学脳卒中医学教室 業績一覧

    • URL

      https://m.kawasaki-m.ac.jp/stroke/work.html

    • Related Report
      2023 Annual Research Report

URL: 

Published: 2021-04-28   Modified: 2025-01-30  

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