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Establishing prognostic factors of diabetes mellitus patients using 320-row comprehensive cardiac CT

Research Project

Project/Area Number 21K07573
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionJuntendo University

Principal Investigator

Tomizawa Nobuo  順天堂大学, 医学部, 准教授 (60728509)

Co-Investigator(Kenkyū-buntansha) 藤本 進一郎  順天堂大学, 医学部, 准教授 (70385871)
三田 智也  順天堂大学, 医学部, 准教授 (90532557)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2023: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2022: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2021: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords心臓CT / 心筋血流量 / 数値流体力学 / 包括的心臓CT / 渦度 / 運動エネルギー / Renkin-Crone補正 / Maximal upslope法 / 糖尿病 / 細胞外液分画
Outline of Research at the Start

糖尿病は心血管イベントの脳卒中や虚血性心疾患などの様々な合併症を引き起こすため、早期介入を行うことで患者の生活の質を改善し、医療費を抑制することにつながる。一方、CT技術の進歩により、一度の検査で冠動脈、心筋血流、心筋遅延造影、心機能評価を行う包括的心臓CTが施行可能となった。包括的心臓CTを行うことで、冠動脈プラークや狭窄、心筋虚血、心筋線維化、収縮能・拡張能といった様々な情報を得られるため、糖尿病患者の心疾患を早期に発見することが期待される。そこで、本研究では糖尿病患者を対象として包括的心臓CTを行い、冠動脈疾患の進行や予後に関連する因子を確立することが目的である。

Outline of Final Research Achievements

The purpose of this study was to determine the factors that predict coronary artery lesion progression in patients with diabetes mellitus using comprehensive cardiac CT and computational fluid dynamics. A recently developed deep learning image reconstruction method allowed us to perform comprehensive cardiac CT with low radiation exposure. Computational fluid dynamics based on this data showed that vorticity and energy loss were related to pressure loss in coronary lesions. An observational study of patients of diabetes educational admission and underwent two coronary CT scans at 2-year intervals regarding the parameters obtained in the simulation and the presence of plaque progression showed that lesions with higher vorticity were more likely to progress.

Academic Significance and Societal Importance of the Research Achievements

本研究ではCTによる心筋血流の標準化への礎を築き、心筋血流評価を臨床で行うことが簡便にできるようになる。さらに、数値流体力学から得られるパラメータを加味することで、従来より糖尿病患者のプラーク進行を良い精度で診断できるようになる。このことから、CTを用いることで糖尿病患者のリスク層別化が容易になり、心血管イベントを起こさないように早期から介入することで予後が改善できるようになる。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (23 results)

All 2024 2023 2022 2021 Other

All Int'l Joint Research (1 results) Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (16 results) (of which Int'l Joint Research: 6 results,  Invited: 8 results)

  • [Int'l Joint Research] Lawson Health Research Institute/Charite University/Fuwai Hospital(カナダ)

    • Related Report
      2022 Research-status Report
  • [Journal Article] Super-resolution deep learning reconstruction to improve image quality of coronary CT angiography2024

    • Author(s)
      Tomizawa Nobuo、Nozaki Yui、Sato Hideyuki、Kawaguchi Yuko、Kudo Ayako、Takahashi Daigo、Takamura Kazuhisa、Hiki Makoto、Fujimoto Shinichiro、Okai Iwao、Koga Seiji、Okazaki Shinya、Kumamaru Kanako K、Minamino Tohru、Aoki Shigeki
    • Journal Title

      Radiology Advances

      Volume: - Issue: 1 Pages: 1-9

    • DOI

      10.1093/radadv/umae001

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Coronary Artery Vorticity to Predict Functional Plaque Progression in Participants with Type 2 Diabetes Mellitus2023

    • Author(s)
      Tomizawa Nobuo、Fujimoto Shinichiro、Mita Tomoya、Takahashi Daigo、Nozaki Yui、Fan Ruiheng、Kudo Ayako、Kawaguchi Yuko、Takamura Kazuhisa、Hiki Makoto、Kurita Mika、Kumamaru Kanako K.、Watada Hirotaka、Minamino Tohru、Aoki Shigeki
    • Journal Title

      Radiology: Cardiothoracic Imaging

      Volume: 5 Issue: 4

    • DOI

      10.1148/ryct.230016

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Energy loss is related to CT fractional flow reserve progression in type 2 diabetes mellitus patients2023

    • Author(s)
      Tomizawa Nobuo、Fujimoto Shinichiro、Takahashi Daigo、Nozaki Yui、Fan Ruiheng、Kudo Ayako、Kawaguchi Yuko、Takamura Kazuhisa、Hiki Makoto、Kadowaki Satoshi、Ikeda Fuki、Kumamaru Kanako K.、Watada Hirotaka、Minamino Tohru、Aoki Shigeki
    • Journal Title

      American Heart Journal Plus: Cardiology Research and Practice

      Volume: 35 Pages: 100328-100328

    • DOI

      10.1016/j.ahjo.2023.100328

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Feasibility of CT Angiography-derived Kinetic Energy of Coronary Flow to Improve the Detection of Hemodynamically Significant Coronary Stenosis2022

    • Author(s)
      Tomizawa Nobuo、Nozaki Yui、Fujimoto Shinichiro、Fan Ruiheng、Takahashi Daigo、Kudo Ayako、Kamo Yuki、Aoshima Chihiro、Kawaguchi Yuko、Takamura Kazuhisa、Hiki Makoto、Dohi Tomotaka、Okazaki Shinya、Kumamaru Kanako K.、Minamino Tohru、Aoki Shigeki
    • Journal Title

      Radiology: Cardiothoracic Imaging

      Volume: 4 Issue: 6

    • DOI

      10.1148/ryct.220147

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Coronary flow disturbance assessed by vorticity as a cause of functionally significant stenosis2022

    • Author(s)
      Tomizawa Nobuo、Nozaki Yui、Fujimoto Shinichiro、Takahashi Daigo、Kudo Ayako、Kamo Yuki、Aoshima Chihiro、Kawaguchi Yuko、Takamura Kazuhisa、Hiki Makoto、Dohi Tomotaka、Okazaki Shinya、Kumamaru Kanako K.、Minamino Tohru、Aoki Shigeki
    • Journal Title

      European Radiology

      Volume: 32 Issue: 10 Pages: 6859-6867

    • DOI

      10.1007/s00330-022-08974-2

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A phantom and in vivo simulation of coronary flow to calculate fractional flow reserve using a mesh-free model2021

    • Author(s)
      Tomizawa Nobuo、Nozaki Yui、Fujimoto Shinichiro、Takahashi Daigo、Kudo Ayako、Kamo Yuki、Aoshima Chihiro、Kawaguchi Yuko、Takamura Kazuhisa、Hiki Makoto、Dohi Tomotaka、Okazaki Shinya、Minamino Tohru、Aoki Shigeki
    • Journal Title

      The International Journal of Cardiovascular Imaging

      Volume: 38 Issue: 4 Pages: 895-903

    • DOI

      10.1007/s10554-021-02456-0

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Standardization of Myocardial Blood Flow Using Different Calculation Methods in 320-Row Dynamic Myocardial CT Perfusion.2024

    • Author(s)
      Fan R, Tomizawa N, Fujimoto S, Kawaguchi Y, Nozaki Y, Sato H, Kogure Y, Aoki S
    • Organizer
      European Congress of Radiology
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Super-resolution Deep Learning Reconstruction to Improve Image Quality of Coronary CT Angiography.2023

    • Author(s)
      Tomizawa N, Nozaki Y, Sato H, Kawaguchi Y, Kudo A, Takamura K, Hiki M, Fujimoto S, Kumamaru KK, Minamino T, Aoki S
    • Organizer
      Radiological Society of North America
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impact of Deep Learning Reconstruction in CT.2023

    • Author(s)
      Tomizawa N
    • Organizer
      Korean Society of Radiology
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Relationship Between Coronary Flow Vorticity and Functional Plaque Progression in Patients with Diabetes Mellitus.2023

    • Author(s)
      Tomizawa N, Nozaki Y, Takahashi D, Kudo A, Kawaguchi Y, Takamura K, Fujimoto S, Kumamaru KK, Minamino T, Aoki S
    • Organizer
      第82回日本医学放射線学会総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 機能的画像診断で求められる冠動脈CT2023

    • Author(s)
      富澤信夫
    • Organizer
      ラジサポ「F」web講演会 No. 11
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] ディープラーニングを応用した超改造画像再構成PIQEについて2023

    • Author(s)
      富澤信夫
    • Organizer
      Beyond Angiography Japan XXVII
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 基礎から学ぶ心臓CT2023

    • Author(s)
      富澤信夫
    • Organizer
      第42回日本画像医学会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 第42回日本画像医学会2023

    • Author(s)
      富澤信夫
    • Organizer
      Cardiac CTユーザーズミーティング
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 心臓CTを用いた機能的画像診断 ~現在地&これから~2023

    • Author(s)
      富澤信夫
    • Organizer
      第96回日本心臓血管放射線研究会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 心臓CT、FFR-CTおよび心筋血流評価における近年の動向2023

    • Author(s)
      富澤信夫
    • Organizer
      第33回日本心血管画像動態学会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] Coronary Flow Vorticity to Predict Functional Coronary Stenosis Progression in Patients with Diabetes Mellitus.2022

    • Author(s)
      Tomizawa N, Nozaki Y, Takahashi D, Kudo A, Kamo Y, Kawaguchi Y, Takamura K, Hiki M, Fujimoto S, Kumamaru KK, Minamino T, Aoki S
    • Organizer
      Radiological Society of North America
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Kinetic Energy of Coronary Flow Improves the Detection of Functionally Significant Coronary Stenosis.2022

    • Author(s)
      Tomizawa N, Nozaki Y, Fujimito S, Takahashi D, Kudo A, Kamo Y, Aoshima C, Kawaguchi Y, Takamura K, Hiki M, Kumamaru KK, Minamino T, Aoki S
    • Organizer
      Annual Meeting of Society of Cardiovascular Computed Tomography
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 粒子法による流体構造解析を用いた冠血流計算法の開発およびカテーテルFFRとの比較2022

    • Author(s)
      富澤 信夫, 野崎 侑衣, 藤本 進一郎, 高橋 大悟, 工藤 綾子, 加茂 夕紀, 青島 千紘, 川口 裕子, 高村 和久, 比企 誠, 土肥 智貴, 岡崎 真也, 南野 徹, 青木 茂樹
    • Organizer
      第32回日本心血管画像動態学会
    • Related Report
      2022 Research-status Report
  • [Presentation] Standardization of Calculation Method for Myocardial Blood Flow by using 320-Row CT Dynamic Myocardial Perfusion Imaging.2022

    • Author(s)
      Fan R, Tomizawa N, Sato H, Inage H, Yokota T, Kudo H, Kogure Y
    • Organizer
      The 78th Annual Meeting of the Japanese Society of Radiological Technology
    • Related Report
      2022 Research-status Report
  • [Presentation] CT・MRIによる循環器画像診断2022

    • Author(s)
      富澤 信夫
    • Organizer
      第12回東葛地区合同勉強会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Elevated Coronary Flow Vorticity Calculated Using A Mesh-free Simulation Is Related To Functionally Significant Coronary Stenosis2021

    • Author(s)
      Tomizawa N, Kudo A, Nozaki Y, Aoshima C, Fujimoto S, Aoki S.
    • Organizer
      RSNA 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research

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Published: 2021-04-28   Modified: 2025-01-30  

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