• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of the function of transcription factor, IRX1, in erythropoesis

Research Project

Project/Area Number 21K07766
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52050:Embryonic medicine and pediatrics-related
Research InstitutionHirosaki University

Principal Investigator

Sato Tomohiko  弘前大学, 医学部附属病院, 助教 (70587005)

Co-Investigator(Kenkyū-buntansha) 土岐 力  弘前大学, 医学研究科, 講師 (50195731)
金崎 里香  弘前大学, 医学研究科, 助教 (60722882)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsIRX1 / ダウン症候群に伴う骨髄性白血病 / 血球分化 / 腫瘍抑制因子 / MYC / 赤血球造血 / ダウン症関連急性巨核芽球性白血病 / 赤血球分化
Outline of Research at the Start

本研究の目的は、これまで血液疾患・造血との関連が知られていない転写因子IRX1の赤血球分化における機能を明らかにすることである。
具体的にはIRX1が赤血球分化のどの段階に必要な転写因子であるかを明らかにし、その下流の伝達機構を解明する。
本研究で得られる知見は赤血球分化のメカニズム解明に寄与することが期待される。

Outline of Final Research Achievements

IRX1 mutations were found in a large scale genetic analysis of myeloid leukemia-associated with Down syndrome (ML-DS). However, IRX1 was not known to be associated with hematopoietic differentiation or cancer development; therefore, functional analysis of IRX1 was performed in this study.
This study demonstrated that IRX1 is involved in cell proliferation and erythroid/ megakaryocyte differentiation, and that IRX1 acts as a tumor suppressor in ML-DS by suppressing the MYC signaling pathway.

Academic Significance and Societal Importance of the Research Achievements

IRX1が血球分化およびがんの発症に関わることを世界で初めて証明した研究であり、血液学や腫瘍学の今後の発展に寄与する可能性がある。
また、IRX1がMYC経路を介して腫瘍抑制効果をもつことが証明できたことから、MYCがML-DSの治療標的となりうることが示され、臨床的意義も大きいと思われる。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (1 results)

All 2024

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results)

  • [Journal Article] Landscape of driver mutations and their clinical effects on Down syndrome-related myeloid neoplasms2024

    • Author(s)
      Sato Tomohiko、Yoshida Kenichi、...、Matsuo Hidemasa、...、Ito Etsuro
    • Journal Title

      Blood

      Volume: - Issue: 25 Pages: 2627-2643

    • DOI

      10.1182/blood.2023022247

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research

URL: 

Published: 2021-04-28   Modified: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi