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The analysis of characteristics and pathogenesis of autoantigen in anti-p200 pemphigoid by multiple study methods

Research Project

Project/Area Number 21K08331
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53050:Dermatology-related
Research InstitutionOsaka Metropolitan University (2022-2023)
Osaka City University (2021)

Principal Investigator

Hashimoto Takashi  大阪公立大学, 大学院医学研究科, 特任教授 (20129597)

Co-Investigator(Kenkyū-buntansha) TEYE KWESI  久留米大学, 付置研究所, 助教 (30599303)
立石 千晴  大阪公立大学, 大学院医学研究科, 准教授 (40597308)
石井 文人  久留米大学, 医学部, 准教授 (80330827)
鶴田 大輔  大阪公立大学, 大学院医学研究科, 教授 (90382043)
橋本 講司  東京大学, 大学院総合文化研究科, 助教 (90802702)
平田 央  大阪公立大学, 大学院医学研究科, 講師 (00464644)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords自己免疫性水疱症 / 自己抗体 / 抗p200類天疱瘡 / ラミニンガンマ1 / ラミニンベータ4 / ファージディスプレイ法 / モノクローナル抗体 / 疾患モデル / 抗p200類天疱瘡 / ラミニンガンマ1 / 自己抗原 / 自己免疫水疱症 / p200 / ファージディスプレイ
Outline of Research at the Start

抗ラミニンγ1類天疱瘡は全身に水疱を生じる難治性表皮下自己免疫性水疱症で抗200kDaラミニンγ1自己抗体を示すが、その病原性は未だ不明で、皮膚のラミニンγ1のみに反応する機序も不明である。これらの疑問を解明するために、まずラミニンγ1ノックアウト細胞と自己抗体の反応性の比較およびリコンビナント蛋白を用いた患者血清の吸収実験を行う。次に皮膚と皮膚以外の組織の発現するラミニンγ1を比較する。また自己抗体の病原性の証明のため、患者B細胞から単離したDNAとファージディスプレイ法を用いて病原性抗ラミニンγ1抗体を取得しそれを各種疾患モデルに供する。これらの多角的研究により病因解明を目指す。

Outline of Final Research Achievements

To investigate the involvement of laminin-g1 in anti-p200 pemphigoid, we generated laminin- g1 knockout HaCaT cells by CRISPR-Cas9 method and clarified the pathogenicity of anti-laminin- g1 antibodies in patient sera using these cells.
In the course of this research project, we also found the involvement of laminin b4. Therefore, to obtain pathogenic monoclonal antibodies for both laminin g1 and laminin b4, we prepared a phage library for the phage display method using anti-p200 pemphigoid patient B cells. We will produce monoclonal antibodies for the two autoantigens and determine their pathogenicity by using various disease model experiments.

Academic Significance and Societal Importance of the Research Achievements

今回の研究の成果として、その病態がいまだ明らかでない抗p200類天疱瘡について、まず、CRISPR-Cas9法によって作成したラミニンγ1ノックアウト細胞を用いた研究で、抗ラミニンガンマ1抗体の病態への関与が確認された。また、研究の過程で、新たな自己抗原として、ラミニンベータ4が同定された。今後、ファージディスプレイ法により、2種の自己抗原のモノクローナル抗体を作製し、各種疾患モデル実験に供する予定である。本研究によって新たな自己抗原が同定され、その病原性が解明されたことは、自己免疫疾患の新しい研究に繋がる。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (141 results)

All 2024 2023 2022 2021 Other

All Int'l Joint Research (6 results) Journal Article (93 results) (of which Int'l Joint Research: 29 results,  Peer Reviewed: 93 results,  Open Access: 26 results) Presentation (33 results) (of which Int'l Joint Research: 6 results,  Invited: 4 results) Book (8 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] Hunan University of Medicine/Nanjing University/West China Hospital, Sichuan University(中国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Luebeck Univerisyt(ドイツ)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Rush University(米国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Yonsei University(韓国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Cadiz University(スペイン)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Development of novel treatment for pemphigus and confirmation of its efficacy: a randomized controlled trial of protein A-immunoadsorption therapy (Commenary)2024

    • Author(s)
      Hashimoto T, Yamagami J
    • Journal Title

      Br J Dermatol

      Volume: 4 Issue: 5 Pages: 609-609

    • DOI

      10.1093/bjd/ljae008

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sustained Clinical Remission for Five Years in Severe Epidermolysis Bullosa Acquisita Following Rituximab Infusions2024

    • Author(s)
      Koszegi B, Stone C, Ishii N, Hashimoto T, Murrel DF
    • Journal Title

      J Eur Acad Dermatol Venerol

      Volume: 15 Issue: 9

    • DOI

      10.1111/jdv.19863

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A case of anti-laminin γ1 (p200) pemphigoid developed after dipeptidyl peptidase-4 inhibitor administration2024

    • Author(s)
      Nakatani K, Noborio R, Nomura Y, Ueki Y, Kiyohara T , Hashimoto T
    • Journal Title

      J Dermatol

      Volume: 12 Issue: 6 Pages: 869-872

    • DOI

      10.1111/1346-8138.17105

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful treatment with guselkumab in a case of anti-p200 pemphigoid associated with plaque psoriasis2024

    • Author(s)
      Kitayama S, Makino T, Kataoka K, Mori S, Takemoto K, Furukawa F, Torai R, Hayashi M, Mizawa M, Ishii N, Hashimoto T, Shimizu T
    • Journal Title

      Journal der Deutschen Dermatologischen Gesellschaft (JDDG),

      Volume: 9

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Desmosomal hyper-adhesion affects direct inhibition of desmoglein interactions in pemphigus2024

    • Author(s)
      Steiner L, Fuchs M, Sigmund AM, Didona D, Hudemann C, Mobs C, Hertl M, Magin T, Hashimoto H, Waschke J, Vielmuth F
    • Journal Title

      J Invest Dermatol

      Volume: s0022-202x(24)00308 Issue: 12 Pages: 7-7

    • DOI

      10.1016/j.jid.2024.03.042

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Scarring alopecia and nail loss in a patient with epidermolysis bullosa acquisita2024

    • Author(s)
      Misaki Kusano, Takenobu Ohashi, Tomoko Hiraiwa, Toshiyuki Yamamoto
    • Journal Title

      J Dermatol

      Volume: 29 Issue: 10 Pages: 1346-8138

    • DOI

      10.1111/1346-8138.17242

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 日本皮膚科学会ガイドライン 家族性良性慢性天疱瘡診療ガイドライン 20232024

    • Author(s)
      岩田浩明, 宮内俊成,古村南夫,秋山真志,池田志斈,加賀麻弥,川上民裕, 久保宜明,久保亮治, 澤村大輔, 須賀 康, 乃村俊史, 橋本 隆, 深井和吉, 山本明美, 米田耕造
    • Journal Title

      日皮会誌:134(2)

      Volume: 134 Pages: 273-287

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of anti-p200 pemphigoid after COVID-19 vaccination2024

    • Author(s)
      Shimamoto, Someda Y, Ushimura A, Tateishi C, Hayashi D, Tsuruta D, Hashimoto T, Goto H
    • Journal Title

      Eur J Dermatol

      Volume: -

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Granular C3 dermatosis-a report of two cases and a mini-review of literature2024

    • Author(s)
      Eriko Takayama, Saki Kuwahara, Akiko Yoshioka, Chiharu Tateishi, Takashi Hashimoto
    • Journal Title

      J Dermatol

      Volume: -

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential contribution of anti-p200 autoantibodies to mucosal lesions in anti-p200 pemphigoid2023

    • Author(s)
      Gao Y, Qian H, Hashimoto T, Li X
    • Journal Title

      Front Immunol

      Volume: 14 Pages: 1118846-1118846

    • DOI

      10.3389/fimmu.2023.1118846

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anti-β4 integrin autoantibodies in patients with mucous membrane pemphigoid: a retrospective analysis from a tertiary centre in Italy2023

    • Author(s)
      Maglie R, De Almeida CV, Baffa ME, Bianchi B, Caproni M, Di Zenzo G, Li X, Hirako Y, HashimotoT, Tusa I, Lulli M, Rovida E, Antiga E
    • Journal Title

      J Eur Acad Dermatol Venereol

      Volume: 37(2) Issue: 2

    • DOI

      10.1111/jdv.18617

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Case Report: Mucous membrane pemphigoid with complicated autoantibody profile indicating the necessity of comprehensive diagnostic methods and the contribution of IgA autoantibodies2023

    • Author(s)
      Liu W, Li H, Jin Y, Cheng L, She L, Gao Y, Zhou Z, Feng S, Qian H, Hashimoto T, Li X
    • Journal Title

      Front Immunol

      Volume: 14 Pages: 1149119-1149119

    • DOI

      10.3389/fimmu.2023.1149119

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pemphigus vulgaris associated with nasoseptal perforation, ocular conjunctival herpes infection and milia2023

    • Author(s)
      Vernal S, Bueno-Filho R, Hashimoto T, Roselino AM
    • Journal Title

      An Bras Dermatol

      Volume: 98(4) Issue: 4 Pages: 550-552

    • DOI

      10.1016/j.abd.2021.09.019

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] S2k guidelines on the management of paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome initiated by the European Academy of Dermatology and Venereology (EADV)2023

    • Author(s)
      Antiga E, Bech R, Maglie R, Genovese G, Borradori L, Bockle B, Caproni M, Caux F, Chandran NS, Corra A, D'Amore F, Daneshpazhooh M, De D, Didona D, Dmochowski M, Drenovska K, Ehrchen J, Feliciani C, Goebeler M, Groves R, Gunther C, Handa S, Hofmann SC, Horvath Hashimoto T
    • Journal Title

      J Eur Acad Dermatol Venereol

      Volume: 37(6) Issue: 6 Pages: 1118-1134

    • DOI

      10.1111/jdv.18931

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Editorial: Autoimmune blistering diseases - volume II, Front Immunol,2023

    • Author(s)
      Li X, Di Zenzo G, Schmidt E, Joly P, Hashimoto T
    • Journal Title

      Front Immunol

      Volume: 14 Pages: 1175962-1175962

    • DOI

      10.3389/fimmu.2023.1175962

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Usefulness of immunofluorescence overlay antigen mapping in the identification of autoantigen in anti-p200 pemphigoid.2023

    • Author(s)
      Kitayama S, Makino T, Hayashi M, Mizawa M, Ishii N, Hashimoto T, Shimizu T.
    • Journal Title

      J Dermatol

      Volume: 50 Issue: 9 Pages: 1194-1198

    • DOI

      10.1111/1346-8138.16810

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Classification and Antigen Molecules of Autoimmune Bullous Diseases.2023

    • Author(s)
      Hashimoto T, Qian H, Ishii N, Nakama T, Tateishi C, Tsuruta D, Li X.
    • Journal Title

      Biomolecules

      Volume: 13 Issue: 4 Pages: 703-703

    • DOI

      10.3390/biom13040703

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] IgA anti-p200 pemphigoid with areolar tropism.2023

    • Author(s)
      Bujan-Bonino C, Bosch-Amate X, Hashimoto T, Ishii N, Mascaro JM Jr
    • Journal Title

      J Dtsch Dermatol Ges

      Volume: 21 Issue: 9 Pages: 1038-1040

    • DOI

      10.1111/ddg.15130

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A case of epidermolysis bullosa acquisita with IgG and IgM anti-basement membrane zone antibodies relapsed after COVID-19 mRNA vaccination.2023

    • Author(s)
      Minakawa S, Matsuzaki Y, Yao S, Sagara C, Akasaka E, Koga H, Ishii N, Hashimoto T, Sawamura D
    • Journal Title

      Front Med

      Volume: 10 Pages: 1093827-1093827

    • DOI

      10.3389/fmed.2023.1093827

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2and N-cadherin and impair cardiomyocyte cohesion2023

    • Author(s)
      Yeruva S, Stangner K, Anna Jungwirth A, Hiermaier M, Shoykhet M, Kugelmann D, Hertl M, Egami S, Ishii N, Koga H, Hashimoto T, Weis M, Beckmann BM, Biller R, Schuttler D, Kaab S, Waschke J
    • Journal Title

      Cell Mol Life Sci

      Volume: 80(8) Issue: 8 Pages: 203-203

    • DOI

      10.1007/s00018-023-04853-1

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Case Reports in Dermatology2023

    • Author(s)
      Recke A, Hashimoto T
    • Journal Title

      Front Med

      Volume: 10 Pages: 1269802-1269802

    • DOI

      10.3389/fmed.2023.1269802

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] C-type lectin receptor expression is a hallmark of neutrophils infiltrating the skin in epidermolysis bullosa acquisita2023

    • Author(s)
      Guerrero-Juarez CF, Schilf P, Li J, Zappia MP; Bao L, Patel PM; Gieseler-Tillmann J, Murthy S, Cole C, Sverdlov M, Frolov MV, Hashimoto T, Ishii N, Rulicke T, Bieber K, Ludwig RJ, Sadik CD, Amber KT
    • Journal Title

      Front Immunol

      Volume: 14 Pages: 1266359-1266359

    • DOI

      10.3389/fimmu.2023.1266359

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Case of Lamina Lucida-Type Linear IgA Disease Complicated by Colon Polyposis and Rectal Adenocarcinoma2023

    • Author(s)
      Miyazaki A, Itoi-Ochi S, Hayashi M, Ota A, Nagai K, Inoue S, Tomita N, Eguchi H, Okazaki Y, Ishida H, Hashimoto T
    • Journal Title

      Case Reports in Dermatology

      Volume: 15(1) Issue: 1 Pages: 126-132

    • DOI

      10.1159/000532104

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful treatment of ulceration in hidradenitis suppurativa with topical bucladesine: A case report2023

    • Author(s)
      Kurokawa I, Kita K, Hashimoto T
    • Journal Title

      Skin Health Disease

      Volume: 4(1) Issue: 1

    • DOI

      10.1002/ski2.321

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mucosal Fixed Drug Eruption with Oral, Conjunctival, Nasal, and Anal Lesions: A Case Report.2023

    • Author(s)
      Yoshida N, Miyagawa F, Mitsui Y, Ogawa K, Hashimoto T, Asada H
    • Journal Title

      Acta Derm Venereol

      Volume: 103 Pages: adv18295-adv18295

    • DOI

      10.2340/actadv.v103.18295

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pemphigus Autoantibodies to Desmocollin 3 but Not to Desmocollin 1 Directly Block Heterophilic Desmoglein/Desmocollin Transinteraction.2023

    • Author(s)
      Ishii K, Ishii N, Ishiko A, Hashimoto T.
    • Journal Title

      J Invest Dermatol

      Volume: - Issue: 6 Pages: 03139-1

    • DOI

      10.1016/j.jid.2023.12.004

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 後天性表皮水疱症の1例2023

    • Author(s)
      角田孝彦, 吉岡千春, 川口純之介, 泉健太郎, 石井文人, 橋本隆
    • Journal Title

      山形済生館医学雑誌(第48巻 第1号 別版)

      Volume: 48 Pages: 129-132

    • NAID

      130007851878

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Focal Acral Hyperkeratosisの1例 (2023.04)2023

    • Author(s)
      福村絵理奈, 大霜智子, 橋本 隆, 鶴田大輔
    • Journal Title

      皮膚科の臨床4月号(65巻4号)

      Volume: 65 Pages: 501-504

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 皮疹を伴った抗LAD-1抗体陽性粘膜類天疱瘡の1例2023

    • Author(s)
      松尾 彩子, 佐藤 雅子, 柳原 茂人, 遠藤 英樹, 大磯 直毅, 川田 暁, 大塚 篤司, 立石 千晴, 橋本 隆, 鶴田 大輔
    • Journal Title

      皮膚の科学(22巻2号)

      Volume: 22 Pages: 85-91

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of anti-laminin γ1 autoantibodies in anti-p200 pemphigoid by immunoblotting using cultured cells2023

    • Author(s)
      Hayashi D, Hashimoto T, Mine M, Ishii N, Izumi K, Tsuruta D
    • Journal Title

      Osaka City Medical Journal

      Volume: -

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] A life for autoimmune blistering diseases - in memoriam Detlef Zillikens2023

    • Author(s)
      Jennifer E. Hundt, Christian D. Sadik, Nina van Beek, Hauke Busch, Frederic Caux, Matthias Goebeler, Christoph M. Hammers, Karin Hartmann, Hashimoto T
    • Journal Title

      Front Immunol

      Volume: -

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IgA anti-p200 pemphigoid: A rare case of bullous disease showing areolar tropism2023

    • Author(s)
      Bujan-Bonino C, Bosch-Amate X, Hashimoto T, Ishii N, Jose M, Mascaro Jr
    • Journal Title

      Journal der Deutschen Dermatologischen Gesellschaft (JDDG)

      Volume: -

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 後天性表皮水疱症の1例2023

    • Author(s)
      角田 孝彦, 吉岡 千春, 川口 純之介, 泉 健太郎,石井 文人,橋本 隆
    • Journal Title

      山形済生館医学雑誌

      Volume: -

    • NAID

      130007851878

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Case report: Mucous membrane pemphigoid with IgG and IgA anti-laminin γ1 antibodies and IgA anti-laminin α5 antibodies2022

    • Author(s)
      Kuang W, Qian H, Zhang Q, Li W, Hashimoto T, Zeng X, Li X
    • Journal Title

      Front Immunol

      Volume: 13

    • DOI

      10.3389/fimmu.2022.903174

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of ADAM10 and ADAM17 in the Regulation of Keratinocyte Adhesion in Pemphigus Vulgaris2022

    • Author(s)
      Kugelmann D, Anders M, Sigmund AM, Egu DT, Eichkorn RA, Yazdi AS, S?rdy M, Hertl M, Didona D, Hashimoto T, Waschke J
    • Journal Title

      Front Immunol

      Volume: 13

    • DOI

      10.3389/fimmu.2022.884248

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A case of anti-BP180-type mucous membrane pemphigoid with IgG and IgA autoantibodies showing distinct reactivities2022

    • Author(s)
      Minakawa S, Matsuzaki Y, Hashimoto T, Ishii N, Nishie W, Mitsuru N, Sawamura D
    • Journal Title

      Acta Dermatovenerol Croat

      Volume: 30 Pages: 54-56

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of dipeptidyl peptidase-4 inhibitor-related anti-BP230-type bullous pemphigoid showing granular C3 dermatosis-like direct immunofluorescence staining2022

    • Author(s)
      Hashimoto T, Tsunoda T, Arai Y, Izumi K, Ishii N, Qian H, Li X, Tsuruta D
    • Journal Title

      Eur J Dermatol

      Volume: 32 Issue: 4 Pages: 549-551

    • DOI

      10.1684/ejd.2022.4316

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A case of linear IgA disease with IgA antibodies to type VII collagen demonstrated by immunofluorescence overlay antigen mapping2022

    • Author(s)
      Kitayama S, Makino T, Hayashi M, Furukawa F, Torai R, Mizawa M, Ishii N, Hashimoto T, Shimizu T.
    • Journal Title

      Eur J Dermatol.

      Volume: 32 Issue: 4 Pages: 553-554

    • DOI

      10.1684/ejd.2022.4312

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of IgG and IgA anti-laminin-332 antibody-positive mucous membrane pemphigoid with IgG and IgA anti-envoplakin and anti-periplakin antibodies2022

    • Author(s)
      Matsushima Y,Kitano M, Hayashi D,Goto H,Mine M,Yokoe T,Kondo M,Habe K, Toiyama Y, Hashimoto T, Tsuruta D, Takeuchi K and Yamanaka K
    • Journal Title

      Dermatopathology (Basel)

      Volume: 9 Issue: 3 Pages: 287-291

    • DOI

      10.3390/dermatopathology9030034

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prurigo pigmentosa clinically and immunologically mimicking autoimmune bullous disease: A case report2022

    • Author(s)
      Kita K, Kurokawa I, Hayashi D, Hashimoto T
    • Journal Title

      Front Med (Lausanne)

      Volume: 9

    • DOI

      10.3389/fmed.2022.1047870

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epidermolysis bullosa acquisita with concomitant autoantibodies to 3 subunit of laminin 3322022

    • Author(s)
      Hamaguchi M, Oiso N, Sato M, Kawada A, Tateishi C, Hashimoto T, Tsuruta D, Ohtsuka A
    • Journal Title

      J Dermatol

      Volume: - Issue: 5

    • DOI

      10.1111/1346-8138.16677

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations of autoimmune bullous diseases and autoantibodies against epidermal autoantigens in patients with inflammatory myopathy2022

    • Author(s)
      Kokubu H, Takahashi T, Tateishi C, Hashimoto T, Tsuruta D, Fujimoto N
    • Journal Title

      Mod Rheumatol

      Volume: - Issue: 6 Pages: 1207-1208

    • DOI

      10.1093/mr/roac159

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【水疱症】発症初期に抗デスモグレイン1抗体がCLEIA法で陰性を示したが,2年半後の病勢軽快期に抗体価が上昇した落葉状天疱瘡の1例2022

    • Author(s)
      見代 佳奈, 岩立 和子, 北島 真理子, 石井 文人, 橋本 隆, 末木 博彦
    • Journal Title

      皮膚科の臨床

      Volume: 64 Pages: 9-13

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【水疱症】免疫グロブリン大量静注療法を行った抗ラミニン332型粘膜類天疱瘡の1例2022

    • Author(s)
      江口 杏子, 紺野 隆之, 逸見 愛美, 荒木 勇太, 難波 広幸, 石井 文人, 橋本 隆, 鈴木 民夫
    • Journal Title

      皮膚科の臨床

      Volume: 64 Pages: 59-64

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【水疱症】後天性表皮水疱症の急性増悪に対し,ステロイドパルスと免疫グロブリン大量静注療法が有効だった1例2022

    • Author(s)
      阿部 佳奈美, 川瀬 正昭, 山田 朋子, 石井 文人, 橋本 隆, 出光 俊郎
    • Journal Title

      皮膚科の臨床

      Volume: 64 Pages: 73-77

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] 天疱瘡・類天疱瘡患者の日常生活における困難感2022

    • Author(s)
      種村 智香, 布谷 麻耶, 師岡 友紀, 川端 京子, 鶴田 大輔, 橋本 隆
    • Journal Title

      日本看護学会雑誌

      Volume: 42 Pages: 365-374

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] 尋常性乾癬の紫外線治療後に生じた表皮下水疱症の1例2022

    • Author(s)
      稲沖 真, 西島 千博, 中村 裕美, 石井 文人, 橋本 隆
    • Journal Title

      皮膚臨床

      Volume: 64 Pages: 1519-1522

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] ELISA法にて全長BP180陽性、免疫ブロット法にてBP230陽性となったDPP-4阻害薬関連類天疱瘡の1例2022

    • Author(s)
      清水 千尋, 立石 千晴, 今西 明子, 白鳥 隆宏, 前川 直輝, 鶴田 大輔, 橋本 隆, 泉 健太郎, 深井 和吉
    • Journal Title

      皮膚の科学

      Volume: 21 Pages: 34-38

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] 抗ラミニンγ1類天疱瘡と抗ラミニン332型粘膜類天疱瘡を合併した1例2022

    • Author(s)
      岩津 理世, 佐藤 雅子, 加藤 麻衣子, 柳原 茂人, 大磯 直毅, 立石 千晴, 橋本 隆, 鶴田 大輔, 川田 暁, 大塚 篤司
    • Journal Title

      皮膚の科学

      Volume: 21 Pages: 126-132

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] バルヒディオ配合錠による薬剤誘発性類天疱瘡の1例2022

    • Author(s)
      角田 孝彦,新井 陽介,川口 純之介,小関 伸,泉 健太郎,石井 文人,橋本 隆
    • Journal Title

      山形済生館医誌

      Volume: 47 Pages: 58-62

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical outcome and B‐cell kinetics in intercellular immunoglobulin A dermatosis treated with rituximab2022

    • Author(s)
      Lee Seung‐Ju、Lee Ayeong、Ishii Norito、Hashimoto Takashi、Choi Gwang Seong、Kim Soo‐Chan、Kim Jong Hoon
    • Journal Title

      The Journal of Dermatology

      Volume: 49 Issue: 1

    • DOI

      10.1111/1346-8138.16194

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Bullous pemphigoid and milia: prevalence and clinical laboratory findings in a Brazilian sample2022

    • Author(s)
      Vernal S, Oliveira de .V.E, Julio T, Bueno-Filho R, Ishii N, Hashimoto T, Roselino M.A.
    • Journal Title

      Anais Brasileiros de Dermatologia, in press

      Volume: -

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pemphigus vulgaris associated with nasoseptal perforation, ocular conjunctival herpes infection and milia.2022

    • Author(s)
      Vernal S, Bueno-Filho R, Hashimoto T, Roselino M A.
    • Journal Title

      Anais Brasileiros de Dermatologia

      Volume: -

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A case of anti-BP180-type mucous membrane pemphigoid with IgG and IgA autoantibodies showing distinct reactivities.2022

    • Author(s)
      Minakawa Satoko, Matsuzaki Yasushi, Hashimoto Takashi, Ishii Norito, Nishie Wataru, Mitsuru NAKAZAWA, Sawamura Daisuke.
    • Journal Title

      Acta DermatoVenereol Croat, in press

      Volume: -

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Overall Impairment of Quality of Life in Japanese Patients with Hidradenitis Suppurativa: Comparison with National Standard2022

    • Author(s)
      Hayama Koremasa、Fujita Hideki、Hashimoto Takashi、Terui Tadashi
    • Journal Title

      Acta Dermato-Venereologica

      Volume: 102 Pages: adv00632-adv00632

    • DOI

      10.2340/actadv.v101.1013

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Two cases of granular C3 dermatosis with intraepidermal neutrophilic and eosinophilic infiltration possibly induced by anti‐hypertensive drugs2021

    • Author(s)
      Hashimoto Takashi、Tsunoda Takahiko、Sato Fumiko、Izumi Kentaro、Nishie Wataru、Ishii Norito、Qian Hua、Li Xiaoguang、Tsuruta Daisuke
    • Journal Title

      Australasian Journal of Dermatology

      Volume: 62 Issue: 2

    • DOI

      10.1111/ajd.13563

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Autoantibodies to desmocollin 3 in pemphigus exclusively recognize calcium-dependent epitope in extracellular domain 22021

    • Author(s)
      Koga Hiroshi、Teye Kwesi、Otsuji Yoshihiko、Ishii Norito、Hashimoto Takashi、Nakama Takekuni
    • Journal Title

      Journal of Investigative Dermatology

      Volume: - Issue: 9 Pages: 2123-2131.e2

    • DOI

      10.1016/j.jid.2021.01.032

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Case of Antiplakin Dermatosis.2021

    • Author(s)
      Oiso N, Yanagihara S, Tateishi C, Ishii N, Hashimoto T, Tsuruta D, Kawada A.
    • Journal Title

      JAMA Dermatol

      Volume: 157 Issue: 5 Pages: 602-603

    • DOI

      10.1001/jamadermatol.2021.0134

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pathogenic role of ST18 in pemphigus vulgaris2021

    • Author(s)
      Hashimoto T.
    • Journal Title

      British Journal of Dermatology

      Volume: 184 Issue: 6 Pages: 1001-1002

    • DOI

      10.1111/bjd.19883

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Japanese guidelines for the management of palmoplantar keratoderma2021

    • Author(s)
      Yoneda K, Kubo A, Nomura T, Ishida-Yamamoto A, Suga Y, Akiyama M, Kanazawa N, Hashimoto T; Committee on Guidelines for the Management of PPKs
    • Journal Title

      J Dermatol.

      Volume: 48 Issue: 8

    • DOI

      10.1111/1346-8138.15850

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Granular C3 dermatosis-like immunological manifestation found in a case of acute generalized exanthematous pustulosis: Implication for the mechanism in C3 deposition to the epidermal basement membrane zone.2021

    • Author(s)
      Furukawa H, Omura R, Sugiura K, Kanazawa N, Inoue N, Qian H, Li X, Tsuruta D, Hashimoto T.
    • Journal Title

      J Dermatol.

      Volume: 48 Issue: 5

    • DOI

      10.1111/1346-8138.15853

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical and immunological findings in 55 cases of anti-laminin-332-type mucous membrane pemphigoid.2021

    • Author(s)
      Li X, Qian H, Natsuaki Y, Koga H, Kawakami T, Tateishi C, Tsuruta D, Ishii N, Hashimoto T.
    • Journal Title

      Br J Dermatol

      Volume: 185 Issue: 2 Pages: 449-451

    • DOI

      10.1111/bjd.20099

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] History, Diagnosis, Pathogenesis, and Nomenclature in Sublamina Densa-Type Linear IgA Disease2021

    • Author(s)
      Hashimoto Takashi、Yamagami Jun、Zone John J.
    • Journal Title

      JAMA Dermatology

      Volume: 157 Issue: 8 Pages: 907-909

    • DOI

      10.1001/jamadermatol.2021.0761

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Autoantibodies against the plakin family proteins as a novel marker for chronic graft-versus-host disease of the lung2021

    • Author(s)
      Kawashima Nozomu、Nishikawa Eri、Tsuchisaka Atsunari、Hashimoto Takashi、Okuno Yusuke、Hamada Motoharu、Ichikawa Daisuke、Narita Atsushi、Muramatsu Hideki、Nishio Nobuhiro、Kojima Seiji、Muro Yoshinao、Takahashi Yoshiyuki
    • Journal Title

      Bone Marrow Transplantation

      Volume: 56 Issue: 9 Pages: 2291-2294

    • DOI

      10.1038/s41409-021-01335-5

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Case of pemphigoid with antibodies to BP180 C‐terminal domain and α3 subunit of laminin‐332 associated with chronic graft‐versus‐host disease2021

    • Author(s)
      Kawashima Hiromichi、Kageji Riho、Hida Yasutoshi、Goto Tetsuya、Ishii Norito、Hashimoto Takashi
    • Journal Title

      The Journal of Dermatology

      Volume: 48 Issue: 9

    • DOI

      10.1111/1346-8138.16008

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ulnar deviation with massive palmar keratoderma in epidermolytic ichthyosis2021

    • Author(s)
      Hamada Takahiro、Ishii Norito、Koga Hiroshi、Teye Kwesi、Nagata Shuji、Matsuo Atsushi、Okada Takamitsu、Hashimoto Takashi、Nakama Takekuni
    • Journal Title

      The Journal of Dermatology

      Volume: 48 Issue: 9

    • DOI

      10.1111/1346-8138.16009

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pathogenic Activation and Therapeutic Blockage of FcαR-Expressing Polymorphonuclear Leukocytes in IgA Pemphigus2021

    • Author(s)
      Emtenani Shirin、Ghorbanalipoor Saeedeh、Mayer-Hain Sarah、Kridin Khalaf、Komorowski Lars、Probst Christian、Hashimoto Takashi、Pas Hendri H.、Mciska-Jundzi Kaja、Czajkowski Rafa、Recke Andreas、Sunderkter Cord、Schneider Stefan W.、Hundt Jennifer E.、Zillikens Detlef、Schmidt Enno、Ludwig Ralf J.、Hammers Christoph M.
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 141 Issue: 12 Pages: 2820-2828

    • DOI

      10.1016/j.jid.2021.06.007

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Human Desmocollin 3-Specific IgG Antibodies Are Pathogenic in a Humanized HLA Class II Transgenic Mouse Model of Pemphigus2021

    • Author(s)
      Hudemann Christoph、Maglie Roberto、Llamazares-Prada Maria、Beckert Benedikt、Didona Dario、Tikkanen Ritva、Schmitt Thomas、Hashimoto Takashi、Waschke Jens、Hertl Michael、Eming R?diger
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 142 Issue: 3 Pages: 915-923.e3

    • DOI

      10.1016/j.jid.2021.06.017

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A case of delgocitinib-indued anti-LAD-1 IgG-positive, anti-BP180 NC16A IgG-negative bullous pemphigoid in a patient with atopic dermatitis2021

    • Author(s)
      Asano Airi、Nakai Kozo、Hayashi Daisuke、Hashimoto Takashi、Tsuruta Daisuke
    • Journal Title

      European Journal of Dermatology

      Volume: 31 Issue: 4 Pages: 578-579

    • DOI

      10.1684/ejd.2021.4105

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intragenic copy number variation in mouse epiplakin 1 (Eppk1) and the conservation of the repeat structures in the lower vertebrates2021

    • Author(s)
      Ueo Daisuke、Furuhashi Mie、Sasaki Takashi、Kudoh Jun、Parry David A.D.、Winter David J.、Sasaki Takako、Hashimoto Takashi、Tsuruta Daisuke、Fujiwara Sakuhei
    • Journal Title

      Journal of Dermatological Science

      Volume: 103 Issue: 3 Pages: 186-189

    • DOI

      10.1016/j.jdermsci.2021.07.004

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rare case of bullous pemphigoid occurring on atrophic centers of disseminated superficial porokeratosis lesions2021

    • Author(s)
      Lee Seung Yeon、Lee Ki Hun、Ishii Norito、Hashimoto Takashi、Kim Jong Hoon、Oh Chil Hwan、Park Kun
    • Journal Title

      The Journal of Dermatology

      Volume: 48 Issue: 11

    • DOI

      10.1111/1346-8138.16083

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Symmetrical Skin Lesions on the Gluteal Region in a Patient with Anti-Laminin-332 Mucous Membrane Pemphigoid.2021

    • Author(s)
      Maki N, Demitsu T, Nagato H, Okada O, Yoneda K, Hashimoto T, Hasunuma N, Osada S, Manabe M.
    • Journal Title

      Acta Dermatovenerol Croat

      Volume: 29 Pages: 105-107

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Case of Possible Concurrence of Dermatitis Herpetiformis and Linear Immunoglobulin A / Immunoglobulin G Bullous Dermatosis.2021

    • Author(s)
      Minakawa S, Matsuzaki Y, Hashimoto T, Ishii N, Nishie W, Sawamura D
    • Journal Title

      Acta Dermatovenerol Croat

      Volume: 29 Pages: 116-117

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Case of Systemic Lupus Erythematosus with Cutaneous Leukocytoclastic Vasculitis Mimicking Bullous SLE2021

    • Author(s)
      Miyagawa F, Ogawa K, Hashimoto T, Asada H
    • Journal Title

      Case Rep Dermatol

      Volume: 13 Issue: 3 Pages: 464-469

    • DOI

      10.1159/000519022

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dipeptidyl peptidase-4 inhibitor-related bullous pemphigoid showing positive autoantibody responses to multiple epitopes2021

    • Author(s)
      Kitao Rikuma、Fukumoto Takeshi、Hashimoto Takashi、Izumi Kentaro、Jimbo Haruki、Takemori Chihiro、Nishigori Chikako
    • Journal Title

      Journal of Dermatological Science

      Volume: 103 Issue: 3 Pages: 190-192

    • DOI

      10.1016/j.jdermsci.2021.08.004

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Koebner phenomenon seen in a case of drug‐induced granular C3 dermatosis2021

    • Author(s)
      Ohata M.、Fukumoto T.、Hashimoto T.、Takemori C.、Jimbo H.、Nagai H.、Oka M.、Nishigori C.
    • Journal Title

      Clinical and Experimental Dermatology

      Volume: 47 Issue: 3 Pages: 609-611

    • DOI

      10.1111/ced.14977

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] False negative for anti‐BP180 antibody by chemiluminescent enzyme immunoassay: Dissociation from enzyme‐linked immunosorbent assay and extended antigen‐antibody reaction time2021

    • Author(s)
      Futatsuya Taketoshi、Fujii Toshiki、Nishibu Akiko、Mochizuki Takashi、Mai Yosuke、Tateishi Chiharu、Hayashi Daisuke、Hashimoto Takashi、Tsuruta Daisuke、Shimizu Akira
    • Journal Title

      The Journal of Dermatology

      Volume: 49 Issue: 4

    • DOI

      10.1111/1346-8138.16280

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] A gene-centric approach to biomarker discovery identifies transglutaminase 1 as an epidermal autoantigen2021

    • Author(s)
      Gunnarsson Hrur Ingi、Sardh Fabian、Hallgren sa、Sthle Mona、Hagforsen Eva、Bradley Maria、Edqvist Per-Henrik D.、Pontn Fredrik、Mkitie Outi、Eidsmo Liv、Norln Lars、Achour Adnane、Dahlbom Ingrid、Korponay-Szab Ilma、Agardh Daniel、Alimohammadi Mohammad、Eriksson Daniel、Hashimoto Takashi、
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 118 Issue: 51 Pages: e2100687118

    • DOI

      10.1073/pnas.2100687118

    • NAID

      120007181247

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2020447

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical, histopathological and dermoscopic features of melanotic macules of the glans penis2021

    • Author(s)
      Furukawa Hiroki、Ozawa Toshiyuki、Sowa-Osako Junko、Sakai Hiroshi、Hashimoto Takashi、Tsuruta Daisuke
    • Journal Title

      Our Dermatology Online

      Volume: 12 Issue: 1 Pages: 86-87

    • DOI

      10.7241/ourd.20211.25

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of a long-neglected basal cell carcinoma on the scalp2021

    • Author(s)
      Furukawa Hiroki、Sowa-Osako Junko、Ozawa Toshiyuki、Hashimoto Takashi、Tsuruta Daisuke
    • Journal Title

      Our Dermatology Online

      Volume: 12 Issue: 2 Pages: 206-207

    • DOI

      10.7241/ourd.20212.30

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Case Report: Variety of Target Antigens During 1 Year Follow-Up of a Patient Initially Diagnosed With Bullous Pemphigoid2021

    • Author(s)
      Qian Hua、Zhou Zhijun、Shi Luhuai、Li Huicheng、Liu Weijun、Ai Yong、Gao Yangmin、Feng Suying、Hashimoto Takashi、Li Xiaoguang
    • Journal Title

      Frontiers in Immunology in press

      Volume: 12

    • DOI

      10.3389/fimmu.2021.825226

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A case of pagetoid squamous cell carcinoma in situ: Bowen’s disease of the glans penis requiring differentiation from extramammary Paget’s disease2021

    • Author(s)
      Furukawa Hiroki、Imanishi Hisayoshi、Sowa-Osako Junko、Ozawa Toshiyuki、Hashimoto Takashi、Tsuruta Daisuke
    • Journal Title

      Our Dermatology Online

      Volume: 12 Issue: 1 Pages: 90-91

    • DOI

      10.7241/ourd.20211.27

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of Two Diagnostic Assays for Anti-Laminin 332 Mucous Membrane Pemphigoid2021

    • Author(s)
      Goletz Stephanie、Giurdanella Federica、Holtsche Maike M.、Nijenhuis Miranda、Horvath Barbara、Diercks Gilles F. H.、Zillikens Detlef、Hashimoto Takashi、Schmidt Enno、Pas Hendri H.
    • Journal Title

      Frontiers in Immunology

      Volume: 12 Pages: 773720-773720

    • DOI

      10.3389/fimmu.2021.773720

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Subunit-Specific Reactivity of Autoantibodies Against Laminin-332 Reveals Direct Inflammatory Mechanisms on Keratinocytes2021

    • Author(s)
      Bao Lei、Li Jing、Solimani Farzan、Didona Dario、Patel Payal M.、Li Xiaoguang、Qian Hua、Ishii Norito、Hashimoto Takashi、Hertl Michael、Amber Kyle T.
    • Journal Title

      Frontiers in Immunology

      Volume: 12 Pages: 775412-775412

    • DOI

      10.3389/fimmu.2021.775412

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The second study of clinical and immunological findings in anti-laminin 332-type mucous membrane pemphigoid examined at Kurume University - Diagnosis criteria suggested by summary of 133 cases.2021

    • Author(s)
      Qian H, Natsuaki Y, Koga H, Kawakami T, Tateishi C, Tsuruta D, Ishii N, Li X, Hashimoto T.
    • Journal Title

      Frontiers in Immunology

      Volume: 26 Pages: 771766-771766

    • DOI

      10.3389/fimmu.2021.771766

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 抗組織トランスグルタミナーゼ抗体陽性を示したDuhring疱疹状皮膚炎の1例2021

    • Author(s)
      見代 佳奈、佐々木 駿, 大歳 晋平, 石井 文人, 橋本 隆, 末木 博彦
    • Journal Title

      皮膚科の臨床

      Volume: 63 Pages: 1675-1675

    • NAID

      40022733769

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 濾胞性リンパ腫患者に生じた抗デスモコリン3抗体単独陽性天疱瘡の1例2021

    • Author(s)
      村上 遥子、吉田 亜希, 井上 里佳, 須永 真司, 岸 晶子, 石井 文人, 橋本 隆, 林 伸和
    • Journal Title

      皮膚科の臨床

      Volume: 63 Pages: 1670-1670

    • NAID

      40022733764

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 塩酸バンコマイシンにより誘発された線状IgA水疱性皮膚症の1例2021

    • Author(s)
      新屋 光一朗、佐々木 駿, 張田 修平, 井藤 遥, 中村 華子, 北島 真理子,渡辺 秀晃, 末木 博彦, 石井 文人, 橋本 隆
    • Journal Title

      臨床皮膚科

      Volume: 75 Pages: 779-779

    • NAID

      130004547402

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dipeptidyl Peptidase-4阻害薬長期内服後に発症した抗ラミニンγ1類天疱瘡の1例2021

    • Author(s)
      野村 史絵、西部 明子, 牛上 敢, 二ツ谷 剛俊, 池村 渓伺, 八田 順子, 望月 隆, 南部 昌之, 石井 文人, 橋本 隆
    • Journal Title

      皮膚科の臨床

      Volume: 63 Pages: 219-219

    • NAID

      40022499111

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 結節性痒疹様の臨床像を呈した抗ラミニンγ1類天疱瘡 結節型抗ラミニンγ1類天疱瘡2021

    • Author(s)
      栗田 昂幸、日野 治子, 岩渕 千雅子, 石井 文人, 橋本 隆
    • Journal Title

      臨床皮膚科

      Volume: 75 Pages: 119-119

    • NAID

      40022497185

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 最近の水疱症】抗BP180型粘膜類天疱瘡2021

    • Author(s)
      馬場 加那子、石井 健, 市村 知佳, 橋本 隆, 石井 文人, 石河 晃
    • Journal Title

      皮膚病診療

      Volume: 43 Pages: 124-124

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 前立腺癌と胆嚢癌を合併した抗ラミニンγ1類天疱瘡の1例2021

    • Author(s)
      鈴木 華織、井上 雄介, 石井 文人, 橋本 隆
    • Journal Title

      皮膚科の臨床

      Volume: 62 Pages: 1894-1894

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 後天性表皮水疱症の1例2021

    • Author(s)
      越後 岳士、碓井 雄大、筒井 清広、中村 聡、石井文人、橋本 隆
    • Journal Title

      石川県立中央病院医学誌

      Volume: 43 Pages: 21-21

    • NAID

      130007851878

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] Successful treatment of ulceration in hidradenitis   suppurativa with topical bucladesine: A caseT report2024

    • Author(s)
      Kurokawa I, Kita K, Hashimoto T
    • Organizer
      EHSF 2024 The 13th edition of the European HidradenConference
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Antigen markers in Autoimmune bullous diseases and their clinical implications2024

    • Author(s)
      Hashimoto T
    • Organizer
      CME Conference for Auto Immune Blistering Disease Foundation (AIBDF)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] テネリアによる水疱性類天疱瘡と思われる1例2023

    • Author(s)
      角田 孝彦,吉岡 千春, 東海林 眞司, 泉 健太郎, 石井 文人, 橋本 隆
    • Organizer
      第400回日本皮膚科学会山形地方会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 抗ラミニン332抗体が陽性であったBrunsting-Perry型類天疱瘡の1例2023

    • Author(s)
      森田 駿介,中嶋 千紗,大塚 篤司,橋本 隆,鶴田 大輔
    • Organizer
      第496回日本皮膚科学会大阪地方会 Web開催
    • Related Report
      2023 Annual Research Report
  • [Presentation] 水疱性類天疱瘡の鑑別を要した色素性痒疹の1例2023

    • Author(s)
      北 佳奈子,黒川 一郎,林 大輔,橋本 隆
    • Organizer
      第74回日本皮膚科学会西部支部学術大会 ハイブリッド開催
    • Related Report
      2023 Annual Research Report
  • [Presentation] DPP4阻害薬内服中に抗BP180抗体,抗デスモグレイン1抗体陽性の自己免疫性水疱症を発症した1例2023

    • Author(s)
      花本 眞未,矢村 明久,北嶋 友紀,四十万谷 貴子,寺井 沙也加,槇村 馨,清原 隆宏,橋本 隆
    • Organizer
      第493回日本皮膚科学会大阪地方会 Web開催
    • Related Report
      2023 Annual Research Report
  • [Presentation] 粘膜優位に水疱が生じた抗ラミニンγ1(p200)類天疱瘡の1例2023

    • Author(s)
      濱口 麻衣, 細本 宜志, 大原 裕士郎, 中嶋 万季, 吉岡 希, 山田 秀和, 大磯 直毅, 門田 匡史, 立石 千晴, 橋本 隆, 鶴田 大輔
    • Organizer
      第86回日本皮膚科学会東京支部学術大会 ハイブリッド開催
    • Related Report
      2023 Annual Research Report
  • [Presentation] 後天性表皮水疱症の1例2023

    • Author(s)
      角田 孝彦, 吉岡 千春, 川口 純之介, 泉 健太郎, 石井 文人, 橋本 隆
    • Organizer
      第400回日本皮膚科学会宮城地方会学術大会例会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 超高齢者に発症した抗ラミニン332型および抗BP180型合併粘膜類天疱瘡(MMP)の1例2022

    • Author(s)
      来田 英伸, 菊澤 千秋, 文 省太, 出野 りか子, 池田 彩, 小澤 健太郎, 橋本 隆
    • Organizer
      第490回日本皮膚科学会大阪地方会(Web開催)
    • Related Report
      2022 Research-status Report
  • [Presentation] 抗ラミニンα3抗体を同定し抗ラミニン332型粘膜類天疱瘡と診断した1例2022

    • Author(s)
      福満 祥子, 福本 毅, 川上 大輔, 南 祐介, 谷川 絢乃, 久保 亮治, 長井 隆行, 入谷 啓介, 橋本 隆, 平子 善章
    • Organizer
      第490回日本皮膚科学会大阪地方会(Web開催)
    • Related Report
      2022 Research-status Report
  • [Presentation] BP230抗体が単独陽性であったトラゼンタによると思われる水疱性類天疱瘡2022

    • Author(s)
      角田 孝彦, 川口 純之介, 大原 香子, 泉 健太郎, 石井 文人, 橋本 隆
    • Organizer
      第397回日本皮膚科学会福島地方会例会. 福島
    • Related Report
      2022 Research-status Report
  • [Presentation] 抗デスモグレイン1抗体の上昇が認められ臨床的に腫瘍随伴性天疱瘡が疑われた1例,2022

    • Author(s)
      井上 舞, 川村 飛翔, 佐川 展子, 蒲原 毅, 石井 文人, 橋本 隆
    • Organizer
      第902回日本皮膚科学会東京地方会(合同臨床地方会)(Web開催)
    • Related Report
      2022 Research-status Report
  • [Presentation] 後天性表皮水疱症の1例2022

    • Author(s)
      井上 舞, 川村 飛翔, 佐川 展子, 蒲原 毅, 石井 文人, 橋本 隆
    • Organizer
      第400回日本皮膚科学会宮城地方会学術大会例会
    • Related Report
      2022 Research-status Report
  • [Presentation] 天疱瘡・類天疱瘡患者の生活体験の実態―日常生活おける困惑感と対処の視点からー2022

    • Author(s)
      種村智香、川端京子、布谷麻耶、師岡友紀、鶴田大輔、橋本隆
    • Organizer
      第43回水疱症研究会 高知県高知市
    • Related Report
      2021 Research-status Report
  • [Presentation] DPP-4阻害剤による結節性類天疱瘡を疑う一例、2022

    • Author(s)
      林大輔、鶴田大輔、橋本隆
    • Organizer
      第43回水疱症研究会 高知県高知市
    • Related Report
      2021 Research-status Report
  • [Presentation] The Recent Progress in Diagnositic Methods and the Current Classification in Autoimmune Bullous Skin Diseases2021

    • Author(s)
      Takashi Hashimoto
    • Organizer
      HIFRD Chengdu, Sichuan, China
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Comparison of different assays for serum anti-type VII collagen reactivity of patients with epidermolysis bullosa acquisita2021

    • Author(s)
      M.M. Holtsche, N. van Beek, T. Hashimoto, G. Di Zenzo, D. Zillikens, C. Prost-Squarcioni, M. Titeux; A. Hovnanian, E. Schmidt, S. Goletz
    • Organizer
      The 15th Dresden Symposium on Autoantibodies
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Serological diagnosis of anti-laminin 332 mucous membrane pemphigoid using biochip mosaic and footprint immunofluorescence assays2021

    • Author(s)
      S. Goletz, F. Giurdanella, M.M. Holtsche, A.M. Nijenhuis, B. Horvath, G.F.H. Diercks, T. Hashimoto, D. Zillikens, H. H. Pas, E. Schmidt
    • Organizer
      The 15th Dresden Symposium on Autoantibodies
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Comparison of two diagnostic assays for the detection of anti-laminin 332 autoantibodies in patients with mucous membrane pemphigoid2021

    • Author(s)
      S. Goletz, F. Giurdanella, F. Giurdanella, M.M. Holtsche, A.M. Nijenhuis, B. Horvath, G.F.H. Diercks, T. Hashimoto, D. Zillikens, H. H. Pas, E. Schmidt
    • Organizer
      the International Pemphigus Pemphigoid Foundation Scientific meeting Marburg, Germany
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] バルヒディオ配合錠による薬剤誘発性類天疱瘡の1例2021

    • Author(s)
      角田孝彦、新井陽介、川口純之介、小関伸、泉健太郎、石井文人、橋本隆
    • Organizer
      日本皮膚科学会 福島地方会
    • Related Report
      2021 Research-status Report
  • [Presentation] 類天疱瘡の新規治療2021

    • Author(s)
      廣保翔、林大輔、立石千晴、橋本隆、鶴田大輔
    • Organizer
      第120回日本皮膚科学会総会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] トラゼンタによる手足型類天疱瘡の1例2021

    • Author(s)
      角田孝彦、新井陽介、泉健太郎、西江渉、石井文人、橋本隆
    • Organizer
      第120回日本皮膚科学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] CLEIA法とELISA法による抗BP180抗体価に 乖離がみられた水疱性類天疱瘡の1例2021

    • Author(s)
      二ッ谷 剛俊,藤井 俊樹,竹田 公信,西部 明子,望月 隆、清水 晶,立石 千晴,林 大輔,橋本 隆,鶴田 大輔
    • Organizer
      第120回日本皮膚科学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] LAD-1に対するIgG抗体陽性となった粘膜類天疱瘡の1例2021

    • Author(s)
      松尾彩子, 岩津理世, 佐藤雅子, 栁原茂人,遠藤英樹, 大磯直毅, 川田 暁, 大塚篤司, 立石千晴,橋本 隆,鶴田大輔
    • Organizer
      日本皮膚科学会 近畿皮膚科集談会
    • Related Report
      2021 Research-status Report
  • [Presentation] 血漿交換療法中に血小板減少を生じた水疱性類天疱瘡の1例2021

    • Author(s)
      角田孝彦、川口純之介、小幡仁子、石井文人、橋本隆
    • Organizer
      日本皮膚科学会 南東北地方会
    • Related Report
      2021 Research-status Report
  • [Presentation] LAD-1に対するIgG抗体を検出したDPP-4阻害薬関連水疱性類天疱瘡2021

    • Author(s)
      谷 直実、山田七子、石井文人、橋本 隆、山元 修
    • Organizer
      日本皮膚科学会 東部支部学会 北海道札幌
    • Related Report
      2021 Research-status Report
  • [Presentation] Focal Acral Hyperkeratosisの一例2021

    • Author(s)
      福村恵理奈、大霜智子、橋本隆、鶴田大輔
    • Organizer
      第487回 日本皮膚科学会 大阪地方会
    • Related Report
      2021 Research-status Report
  • [Presentation] DPP4阻害薬による抗ラミニンガンマ1(p200)類天疱瘡の1例2021

    • Author(s)
      中谷佳保里、上尾礼子、野村祐輝、植木瑶子、清原隆宏、橋本 隆
    • Organizer
      第72回日本皮膚科学会 中部支部学術大会 奈良県奈良市
    • Related Report
      2021 Research-status Report
  • [Presentation] 骨髄異形成症候群と大腸腺腫症を合併した線状IgA水疱性皮膚症の1例2021

    • Author(s)
      宮﨑明子、林真未、太田朝子、越智沙織、長井健悟、井上慎也、冨田尚裕、林大輔、立石千春、橋本隆、鶴田大輔
    • Organizer
      第72回日本皮膚科学会 中部支部学術大会 奈良県奈良市
    • Related Report
      2021 Research-status Report
  • [Presentation] Antibodies to desmocollin (Dsc) 3, but not Dsc1, in pemphigus sera directly block heterophilic transinteraction between desmoglein and Dsc.2021

    • Author(s)
      Ken Ishii, Norito Ishii, Akira Ishiko, Takashi Hashimoto
    • Organizer
      第46回日本研究皮膚科学会学術大会 京都
    • Related Report
      2021 Research-status Report
  • [Presentation] The presence of multiple epitopes within BP180 moleculein a case of dipeptidyl peptidase-4 inhibitor-related bullous pemphigoid2021

    • Author(s)
      Rikuma Kitao, Takeshi Fukumoto, Takashi Hashimoto, Kentaro Izumi, Haruki Jimbo, Chikako Nishigori
    • Organizer
      第46回日本研究皮膚科学会学術大会 京都
    • Related Report
      2021 Research-status Report
  • [Presentation] Cautions for discrepancy between CLEIA and ELISA and the presence of non-pathogenic antibodies are needed in pemphigus management2021

    • Author(s)
      Ai Yoshioka, Takeshi Fukumoto, Marie Ohata, Yumi Aoyama, Koji Kamiya, Takashi Hashimoto, Chikako Nishigori
    • Organizer
      第46回日本研究皮膚科学会学術大会 京都
    • Related Report
      2021 Research-status Report
  • [Presentation] Optimization of ELISAs for IgA antibodies in autoimmune bullous skin diseases2021

    • Author(s)
      Norito Ishii, Kwesi Teye, Hiroshi Koga, Takashi Hashimoto, Takekuni Nakama
    • Organizer
      第46回日本研究皮膚科学会学術大会 京都
    • Related Report
      2021 Research-status Report
  • [Book] JAYPEE BROTHERS Medical Publishers(P)Ltd.2024

    • Author(s)
      Khandpur S, Li X, Hashimoto T, Keshavamurthy V
    • Publisher
      Immunoblot Assay and Immunoprecipitation, IADVL Textbook of Pemphigus and other Autoimmune Bullous Diseases,Chapter18
    • Related Report
      2023 Annual Research Report
  • [Book] McGraw Hill Education2023

    • Author(s)
      Hashimoto T
    • Total Pages
      2
    • Publisher
      Chapter43 “Intercellular IgA dermatosis/IgA pemphigus”, Kang S et al.: Fitzpatrick's Therapeutics, A CIinician's Guide to Dermatologic Treatment: First pass pages First pass pages. Chapter 43
    • Related Report
      2023 Annual Research Report
  • [Book] McGraw Hill Education2023

    • Author(s)
      Hashimoto T
    • Publisher
      Chapter 62, Intercellular IgA dermatosis/IgA pemphigus”, 10th edition of Fitzpatrick's Ddermataology, edited by Kang S, Amagai M, Bruckner AL, Enk AH, Marglis DJ, McMichael AJ, Orringer JS
    • Related Report
      2023 Annual Research Report
  • [Book] Front Immunol2023

    • Author(s)
      Pascal Joly, Enno Schmidt, Hashimoto T, Giovanni Di Zenzo, Xiaoguang Li
    • Total Pages
      1175962
    • Publisher
      Autoimmune blistering diseases, volume II
    • Related Report
      2023 Annual Research Report
  • [Book] Frontiers Publisher2023

    • Author(s)
      Reck A, Hashimoto T
    • Publisher
      e-Book for Frontiers in Medicine, Case Reports in Dermatology,
    • Related Report
      2023 Annual Research Report
  • [Book] McGraw Hill Education2022

    • Author(s)
      Hashimoto T
    • Publisher
      Chapter 62, Intercellular IgA dermatosis/IgA pemphigus”, 10th edition of Fitzpatrick's Ddermataology, edited by Kang S, Amagai M, Bruckner AL, Enk AH, Marglis DJ, McMichael AJ, Orringer JS
    • Related Report
      2022 Research-status Report
  • [Book] Immunobullous Dermatoses2022

    • Author(s)
      Hashimoto, T., Tsuruta, D., Tateishi, C., Ishii, N., Bagherani N
    • Publisher
      Springer Nature Switzerland AG
    • ISBN
      9783319538082
    • Related Report
      2021 Research-status Report
  • [Book] Diseases of the oral mucosa2021

    • Author(s)
      Hashimoto T: (Chapter 19) ,Enno Schmidt
    • Publisher
      Springer Nature
    • Related Report
      2021 Research-status Report
  • [Patent(Industrial Property Rights)] 腫瘍随伴性天疱瘡における抗トランスグルタミナーゼ1自己抗体検出キット2021

    • Inventor(s)
      Nils Landgren、橋本 隆、Olof Kampe
    • Industrial Property Rights Holder
      Nils Landgren、橋本 隆、Olof Kampe
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2021 Research-status Report
    • Overseas

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Published: 2021-04-28   Modified: 2025-01-30  

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