Study of sweat allergy development and mast cell activation mechanism

• Project/Area Number: 21K08346
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Hiroshima University
• Principal Investigator: 秀 道広 広島大学, 医系科学研究科(医), 名誉教授 (50284188)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Project Status: Granted (Fiscal Year 2022)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2023: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2021: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 汗アレルギー / コリン性蕁麻疹 / サイトカイン / 角化細胞 / 線維芽細胞 / クラウディン3 / 感作 / アジュバント / 汗 / IgE / バリア

Outline of Research at the Start

コリン性蕁麻疹の病態解明のため、表皮および汗腺のバリアを物理的な針の刺入または遺伝子工学的処理により汗腺のタイトジャンクションを障害させたマウスを作製し、ヒト汗抗原として同定されたM. globosa由来MGL_1304による汗腺を介した抗原感作の仕組みを明らかにする。また、セリンプロテアーゼ活性を持つ活性化血液凝固・線溶因子と、発汗神経から放出される神経ペプチドが、血管内皮細胞と皮膚マスト細胞に及ぼす作用を検討し、新たな蕁麻疹治療標的を探索する。

Outline of Annual Research Achievements

コリン性蕁麻疹は、我が国においては特発性の蕁麻疹、機械性蕁麻疹に次いで多い蕁麻疹の病型であるが、海外からの論文報告は限られている。研究代表者らは、コリン性蕁麻疹における汗アレルギーおよび慢性蕁麻疹における血的凝固能亢進を明らかにしてきた。本研究では、コリン性蕁麻疹における汗アレルギーによる皮膚マスト細胞の活性化と、血液凝固能亢進という特発性の蕁麻疹との共通病態に加え、発汗神経から遊離される神経ペプチドの役割に着目してコリン性蕁麻疹の病態の全容を明らかにすることを目的とし、以下のテーマで研究を進めている。
1）汗腺のバリア障害による経皮感作の解析、2)表皮の障害による経皮感作の解析、3)コリン性蕁麻疹における真皮内への汗の漏出と汗アレルギーの関係、4)コリン性蕁麻疹患者血漿の血液凝固系とC5活性化能の評価、5)発汗神経に含まれる神経ペプチドによる皮膚マスト細胞活性化とC5活性化の検討
これまでの研究で、1)ではBalb/cマウスを背景として汗腺上皮細胞のバリア機能蛋白であるclaudin-3をノックアウトしたマウスの作製に取り組み、汗管を介して外来抗原が真皮内に侵入する系統を樹立した。2)では未精製のヒト汗をオブアルブミンとともに経表皮的、またはマイクロニードルを用いて直接真皮に注射すると、IgE産生におけるアジュバント効果があること、また、未精製ヒト汗を培養角化細胞に添加して発現誘導されるトランスクリプトーム解析を行い、IL-33を含む起炎性のサイトカイン産生が誘導され、その活性は汗中に含まれるIL-1に起因することも見いだした。この効果はこれまでに報告がなく、かつ表皮角化細胞と線維芽細胞の相互作用により調節を受けることも明らかになった。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

計画していた5つのうち、最初の2つのテーマで予定していなかった成果が得られ、現在、その点を掘り下げて追求しており、今後アトピー性皮膚炎およびコリン性蕁麻疹における汗アレルギーの病態とその発症機序を分子レベルで明らかにできる可能性が浮上している。この知見は今後コリン性蕁麻疹および汗により症状が悪化することが知られているアトピー性皮膚炎の病態解明と新たなスキンケアの方法の開発にも繋がる可能性があり、3～5）の課題の停滞を補って余りある成果と言える。

Strategy for Future Research Activity

令和5年度は引き続きヒト汗によるアジュバント効果の免疫グロブリン特異性および抗原特異性について検討すると共に、ヒト汗が角化細胞および皮膚線維芽細胞のサイトカイン産生を誘導する機序と2種類の細胞の相互作用について解析する。また、汗腺のタイトジャンクションを形成するクラウディン3ノックアウトマウスを用いて汗の真皮内への漏出によるアジュバント効果を検証、解析し、得られた結果をとりまとめて成果を発表する。

Research Products

• [Journal Article] Burden of illness seen in hereditary angioedema in Japanese patients: Results from a patient reported outcome survey (2023)
  • Author(s): Yamamoto Beverley、Honda Daisuke、Ohsawa Isao、Iwamoto Kazumasa、Horiuchi Takahiko、Fukunaga Atsushi、Maehara Junichi、Yamashita Kouhei、Hide Michihiro
  • Journal Title: Intractable & Rare Diseases Research Volume: 12 Issue: 1 Pages: 35-44
  • DOI: 10.5582/irdr.2022.01130
  • ISSN: 2186-361X, 2186-3644
  • Year and Date: 2023-02-28
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and safety of omalizumab in adult patients with wheat-dependent exercise-induced anaphylaxis: Reduction of in vitro basophil activation and allergic reaction to wheat (2023)
  • Author(s): Chinuki Yuko、Kohno Kunie、Hide Michihiro、Hanaoka Keiko、Okabe Takahiro、Fukunaga Atsushi、Oda Yoshiko、Adachi Atsuko、Ugajin Tsukasa、Yokozeki Hiroo、Suzuki Ritsuro、Sugiyama Akiko、Kishikawa Reiko、Yamasaki Osamu、Morita Eishin
  • Journal Title: Allergology International Volume: 72 Issue: 3 Pages: 444-450
  • DOI: 10.1016/j.alit.2022.11.013
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy, pharmacokinetics, and safety of subcutaneous C1-esterase inhibitor as prophylaxis in Japanese patients with hereditary angioedema: Results of a Phase 3 study (2023)
  • Author(s): Fukuda Tomoo、Yamagami Keiko、Kawahata Kimito、Suzuki Yuzo、Sasaki Yoshihiro、Miyagi Takashi、Jacobs Iris、Lawo John-Philip、Glassman Fiona、Akama Hideto、Hide Michihiro、Ohsawa Isao
  • Journal Title: Allergology International Volume: 72 Issue: 3 Pages: 451-457
  • DOI: 10.1016/j.alit.2023.02.002
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Real-world safety and effectiveness of omalizumab in Japanese patients with chronic spontaneous urticaria: A post-marketing surveillance study (2023)
  • Author(s): Hide Michihiro、Fukunaga Atsushi、Suzuki Takayuki、Nakamura Noriko、Kimura Mine、Sasajima Takayoshi、Kiriyama Junna、Igarashi Atsuyuki
  • Journal Title: Allergology International Volume: 72 Issue: 2 Pages: 286-296
  • DOI: 10.1016/j.alit.2022.09.003
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Epidemiology, Management, and Treatment Access of Hereditary Angioedema in the Asia Pacific Region: Outcomes From an International Survey (2023)
  • Author(s): Li Philip H.、Pawankar Ruby、Thong Bernard Yu-Hor、Fok Jie Shen、Chantaphakul Hiroshi、Hide Michihiro、Jindal Ankur Kumar、Kang Hye-Ryun、Abdul Latiff Amir Hamzah、Lobo Rommel Crisenio M.、Munkhbayarlakh Sonomjamts、Nguyen Dinh Van、Shyur Shyh-Dar、Zhi Yuxiang、Maurer Marcus
  • Journal Title: The Journal of Allergy and Clinical Immunology: In Practice Volume: 11 Issue: 4 Pages: 1253-1260
  • DOI: 10.1016/j.jaip.2022.12.021
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Exploring biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab (B-PAD study) (2023)
  • Author(s): Nakahara T, Izuhara K, Onozuka D, Saeki H, Nunomura S, Takenaka M, Matsumoto M, Kataoka Y, Fujimoto R, Kaneko S, Morita E, Tanaka A, Hide M, Okano T, Miyagaki T, Aoki N, Nakajima K, Ichiyama S, Kido-Nakahara M, Tonomura K, Nakagawa Y, Tamagawa-Mineoka R, Masuda K, Takeichi T, Akiyama M, Ishiuji Y,et al.
  • Journal Title: Clinical & Experimental Allergy Volume: 53 Issue: 2 Pages: 233-238
  • DOI: 10.1111/cea.14267
  • Peer Reviewed / Open Access
• [Journal Article] Summary of the current status of clinically diagnosed cases of Schnitzler syndrome in Japan (2023)
  • Author(s): Takimoto-Ito R, Kambe N, Kanazawa N, Kabashima K, et al.
  • Journal Title: Allergology International Volume: 72 Issue: 2 Pages: 297-305
  • DOI: 10.1016/j.alit.2022.11.004
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] 遺伝生血管性浮腫の診断と治療 (2023)
  • Author(s): 秀 道広
  • Journal Title: 皮膚科 Volume: 3 Pages: 187-194
• [Journal Article] WAO/EAACI遺伝性血管性浮腫診療ガイドライン-2017年改訂版 (2023)
  • Author(s): 秀 道広、大澤 勲、福永 淳、山下浩平、田中 彰、鈴木大士、本田大介、田中暁生、パワンカール ルビー
  • Journal Title: アレルギー Volume: 72 Pages: 158-183
  • Peer Reviewed
• [Journal Article] Anaphylaxis due to thiamine disulfide phosphate, a derivative of vitamin B1; a case report and literature review (2022)
  • Author(s): Amano Asuka、Takahagi Shunsuke、Kinoshita Hitomi、Nakamura Rie、Ishii Kaori、Hide Michihiro
  • Journal Title: Allergology International Volume: 71 Issue: 3 Pages: 414-416
  • DOI: 10.1016/j.alit.2022.01.004
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Concise update on the pathogenesis of chronic spontaneous urticaria (CSU) (2022)
  • Author(s): Hide Michihiro、Kaplan Allen P.
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: 150 Issue: 6 Pages: 1403-1404
  • DOI: 10.1016/j.jaci.2022.08.022
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Longitudinal prevalence of atopic dermatitis among freshmen at Hiroshima University between 2002 and 2019 (2022)
  • Author(s): Kan Takanobu、Tanaka Akio、Kanamoto Mayu、Morioke Satoshi、Takahagi Shunsuke、Hide Michihiro
  • Journal Title: The Journal of Dermatology Volume: 49 Issue: 7 Pages: 724-728
  • DOI: 10.1111/1346-8138.16366
  • Peer Reviewed
• [Journal Article] Clinical course of more than 10 years in a patient with extensive skin burns who received cultured epidermal autograft transplantation (2022)
  • Author(s): Kan Takanobu、Takahagi Shunsuke、Matsubara Daiki、Murakami Emi、Kawai Mikio、Hide Michihiro、Tanaka Akio
  • Journal Title: Regenerative Therapy Volume: 19 Pages: 154-157
  • DOI: 10.1016/j.reth.2022.01.007
  • Peer Reviewed / Open Access
• [Journal Article] The expression of prolyl isomerase Pin1 is expanded in the skin of patients with atopic dermatitis and facilitates IL‐33 expression in HaCaT cells (2022)
  • Author(s): Kanamoto Mayu、Takahagi Shunsuke、Aoyama Shunya、Kido Yuri、Nakanishi Mikako、Naito Miki、Kanna Machi、Yamamotoya Takeshi、Tanaka Akio、Hide Michihiro、Asano Tomoichiro、Nakatsu Yusuke
  • Journal Title: The Journal of Dermatology Volume: 50 Issue: 4 Pages: 462-471
  • DOI: 10.1111/1346-8138.16633
  • Peer Reviewed / Open Access
• [Journal Article] Chronic spontaneous urticaria: Focus on pathophysiology to unlock treatment advances (2022)
  • Author(s): Kaplan Allen、Lebwohl Mark、Gimenez‐Arnau Ana M.、Hide Michihiro、Armstrong April W.、Maurer Marcus
  • Journal Title: Allergy Volume: 78 Issue: 2 Pages: 389-401
  • DOI: 10.1111/all.15603
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A novel detection method for cross-linking of IgE-receptors by autoantibodies in chronic spontaneous urticaria (2022)
  • Author(s): Koga Y, Yokooji T, Ogino R, Taogoshi T, Takahagi S, Ishii K, Chinuki Y, Morita E, Hide M, Matsuo H.
  • Journal Title: Allergology International Volume: 71 Issue: 1 Pages: 94-102
  • DOI: 10.1016/j.alit.2021.08.007
  • NAID: 130008145226
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Basophils activation of patients with chronic spontaneous urticaria in response to C5a despite failure to respond to IgE-mediated stimuli (2022)
  • Author(s): Matsubara Daiki、Yanase Yuhki、Ishii Kaori、Takahagi Shunsuke、Tanaka Akio、Ozawa Koichiro、Hide Michihiro
  • Journal Title: Frontiers in Immunology Volume: 13 Pages: 994823-994823
  • DOI: 10.3389/fimmu.2022.994823
  • Peer Reviewed / Open Access
• [Journal Article] Sustained safety and efficacy of ligelizumab in patients with chronic spontaneous urticaria: A one‐year extension study (2022)
  • Author(s): Maurer Marcus、Gimenez‐Arnau Ana、Bernstein Jonathan A.、Chu Chia‐Yu、Danilycheva Inna、Hide Michihiro、Makris Michael、Metz Martin、Savic Sinisa、Sitz Karl、Soong Weily、Staubach Petra、Sussman Gordon、Barve Avantika、Burciu Alis、Hua Eva、Janocha Reinhold、Severin Thomas
  • Journal Title: Allergy Volume: 77 Issue: 7 Pages: 2175-2184
  • DOI: 10.1111/all.15175
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The international WAO/EAACI guideline for the management of hereditary angioedema-The 2021 revision and update (2022)
  • Author(s): Maurer M, Magerl M, Betschel S, Aberer W, Ansotegui IJ, Aygoren-Pursun E, Banerji A, Bara NA, Boccon-Gibod I, Bork K, Bouillet L, Boysen HB, Brodszki N, Busse PJ, Bygum A, Caballero T, Cancian M, Castaldo A, Cohn DM, Csuka D, Farkas H, Gompels M, Gower R, Grumach AS, Guidos-Fogelbach G, Hide M, et al.
  • Journal Title: Allergy Volume: 77 Issue: 7 Pages: 1961-1990
  • DOI: 10.1111/all.15214
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The international WAO/EAACI guideline for the management of hereditary angioedema-The 2021 revision and update (2022)
  • Author(s): Maurer M, Magerl M, Betschel S, Aberer W, Ansotegui IJ, Aygoren-Pursun E, Banerji A, Bara NA, Boccon-Gibod I, Bork K, Bouillet L, Boysen HB, Brodszki N, Busse PJ, Bygum A, Caballero T, Cancian M, Castaldo A, Cohn DM, Csuka D, Farkas H, Gompels M, Gower R, Grumach AS, Guidos-Fogelbach G, Hide M, et al.
  • Journal Title: World Allergy Organization Journal Volume: 15 Issue: 3 Pages: 100627-100627
  • DOI: 10.1016/j.waojou.2022.100627
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ligelizumab improves angioedema, disease severity and quality-of-life in patients with chronic spontaneous urticaria (2022)
  • Author(s): Metz Martin、Bernstein Jonathan A.、Gimenez-Arnau Ana M.、Hide Michihiro、Maurer Marcus、Sitz Karl、Soong Weily、Sussman Gordon、Hua Eva、Barve Avantika、Barbier Nathalie、Balp Maria-Magdalena、Severin Thomas
  • Journal Title: World Allergy Organization Journal Volume: 15 Issue: 11 Pages: 100716-100716
  • DOI: 10.1016/j.waojou.2022.100716
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Uptake of Staphylococcus aureus by keratinocytes is reduced by interferon-fibronectin pathway and filaggrin expression (2022)
  • Author(s): Miyake Ryu、Iwamoto Kazumasa、Sakai Norio、Matsunae Kyoka、Aziz Fatkhanuddin、Sugai Motoyuki、Takahagi Shunsuke、Tanaka Akio、Hide Michihiro
  • Journal Title: The Journal of Dermatology Volume: 49 Issue: 11 Pages: 1148-1157
  • DOI: 10.1111/1346-8138.16546
  • Peer Reviewed
• [Journal Article] Minocycline‐induced anaphylaxis mediated by antigen‐specific immunoglobulin E (2022)
  • Author(s): Nakamura Rie、Tanaka Akio、Kinoshita Hitomi、Ishii Kaori、Hide Michihiro
  • Journal Title: The Journal of Dermatology Volume: 49 Issue: 2
  • DOI: 10.1111/1346-8138.16228
  • Peer Reviewed
• [Journal Article] Immunological Changes of Basophil Hyperreactivity to Sweat in Patients With Well-Controlled Atopic Dermatitis (2022)
  • Author(s): Numata Tomofumi、Takahagi Shunsuke、Ishii Kaori、Morioke Satoshi、Kan Takanobu、Mizuno Hayato、Yanase Yuhki、Kawaguchi Tomoko、Tanaka Akio、Hide Michihiro
  • Journal Title: Frontiers in Immunology Volume: 13 Pages: 883605-883605
  • DOI: 10.3389/fimmu.2022.883605
  • Peer Reviewed / Open Access
• [Journal Article] English version of Japanese guidance for the use of oral Janus kinase (JAK) inhibitors in the treatments of atopic dermatitis (2022)
  • Author(s): Saeki Hidehisa、Akiyama Masashi、Abe Masatoshi、Igarashi Atsuyuki、Imafuku Shinichi、Ohya Yukihiro、Katoh Norito、Kameda Hideto、Kabashima Kenji、Tsunemi Yuichiro、Hide Michihiro、Ohtsuki Mamitaro、Committee for reviewing the Safety of Atopic Dermatitis/Urticaria Treatment, Japanese Dermatological Association
  • Journal Title: The Journal of Dermatology Volume: 50 Issue: 1
  • DOI: 10.1111/1346-8138.16635
  • Peer Reviewed / Open Access
• [Journal Article] English Version of Clinical Practice Guidelines for the Management of Atopic Dermatitis 2021 (2022)
  • Author(s): Saeki Hidehisa、Ohya Yukihiro、Furuta Junichi、Arakawa Hirokazu、Ichiyama Susumu、Katsunuma Toshio、Katoh Norito、Tanaka Akio、Tsunemi Yuichiro、Nakahara Takeshi、Nagao Mizuho、Narita Masami、Hide Michihiro、Fujisawa Takao、Futamura Masaki、Masuda Koji、Matsubara Tomoyo、Murota Hiroyuki、Yamamoto‐Hanada Kiwako
  • Journal Title: The Journal of Dermatology Volume: 49 Issue: 10
  • DOI: 10.1111/1346-8138.16527
  • Peer Reviewed / Open Access
• [Journal Article] Executive summary: Japanese guidelines for atopic dermatitis (ADGL) 2021 (2022)
  • Author(s): Saeki Hidehisa、Ohya Yukihiro、Furuta Junichi、Arakawa Hirokazu、Ichiyama Susumu、Katsunuma Toshio、Katoh Norito、Tanaka Akio、Tsunemi Yuichiro、Nakahara Takeshi、Nagao Mizuho、Narita Masami、Hide Michihiro、Fujisawa Takao、Futamura Masaki、Masuda Koji、Matsubara Tomoyo、Murota Hiroyuki、Yamamoto-Hanada Kiwako
  • Journal Title: Allergology International Volume: 71 Issue: 4 Pages: 448-458
  • DOI: 10.1016/j.alit.2022.06.009
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] A survey on subtypes and clinical characteristics of 1061 patients with urticaria in the primary care institutes in Japan (2022)
  • Author(s): Saito R, Takahagi S, Nakano F, Furutani K, Mihara S, Numata T, Kameyoshi Y, Tanaka T, Shindo H, Niimi N, Iwamoto K, Hiragun T, Hiragun M, Tanaka A, Hide M
  • Journal Title: J Dermatol Volume: 49 Issue: 12 Pages: 1255-1262
  • DOI: 10.1111/1346-8138.16562
  • Peer Reviewed
• [Journal Article] Real‐world efficacy of proactive maintenance treatment with delgocitinib ointment twice weekly in adult patients with atopic dermatitis (2022)
  • Author(s): Suehiro Masataka、Numata Tomofumi、Murakami Emi、Takahashi Masakazu、Saito Ryo、Morioke Satoshi、Kamegashira Akiko、Takahagi Shunsuke、Hide Michihiro、Tanaka Akio
  • Journal Title: Dermatologic Therapy Volume: 35 Issue: 7
  • DOI: 10.1111/dth.15526
  • Peer Reviewed / Open Access
• [Journal Article] Clinical and histological characterization of transient dermal pain triggered by sweating stimuli (2022)
  • Author(s): Takahagi Shunsuke、Okamoto Mayumi、Ishii Kaori、Tanaka Akio、Mizuno Hayato、Harada Naoe、Yanagida Nozomi、Hide Michihiro
  • Journal Title: Allergology International Volume: 71 Issue: 3 Pages: 362-372
  • DOI: 10.1016/j.alit.2022.01.003
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of intracellular calcium mobilization induced by remimazolam, a newly approved intravenous anesthetic (2022)
  • Author(s): Urabe, T., Miyoshi, H., Narasaki, S., Yanase, Y., Uchida, K., Noguchi, S., Hide, M, Tsutsumi, M. Y. and Sakai, N.
  • Journal Title: PLos One Volume: 17 Issue: 2 Pages: e0263395-e0263395
  • DOI: 10.1371/journal.pone.0263395
  • Peer Reviewed / Open Access
• [Journal Article] Anhidrosis accompanied by cholinergic urticaria‐like rash and dermal pain in a patient with Soegren's syndrome (2022)
  • Author(s): Yanagida Nozomi、Takahagi Shunsuke、Aoyama Yumi、Tanaka Akio、Hide Michihiro
  • Journal Title: The Journal of Dermatology Volume: 印刷中 Issue: 6 Pages: 666-670
  • DOI: 10.1111/1346-8138.16365
  • Peer Reviewed
• [Journal Article] Propylthiouracil-induced Alopecia Accompanying Hypohidrosis and Onychomadesis (2022)
  • Author(s): Yanagida N, Takahagi S, Tanaka A, Hide M
  • Journal Title: Acta Derm Venereol Volume: 102 Pages: adv00763-adv00763
  • DOI: 10.2340/actadv.v102.2690
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence of immune-related adverse events and anti-tumor efficacy following immune checkpoint inhibitor therapy in Japanese patients with various solid tumors (2022)
  • Author(s): Yoshikawa Y, Imamura M, Yamauchi M, Hayes CN, Aikata H, Okamoto W, Miyata Y, Okada M, Hattori N, Sugiyama K, Yoshioka Y, Toratani S, Takechi M, Ichinohe T, Ueda T, Takeno S, Kobayashi T, Ohdan H, Teishima J, Hide M, Nagata Y, Kudo Y, Iida K, Chayama K.
  • Journal Title: BMC Cancer Volume: 22 Issue: 1 Pages: 1232-1232
  • DOI: 10.1186/s12885-022-10327-7
  • Peer Reviewed / Open Access
• [Journal Article] 汗は何のために、何が問題か ～汗とアレルギーに関する疑問と課題～ (2022)
  • Author(s): 秀 道広
  • Journal Title: 発汗学 Volume: 29 Pages: 15-21
• [Journal Article] 慢性特発性蕁麻疹に対する新規治療法と展望 (2022)
  • Author(s): 秀 道広
  • Journal Title: 臨床免疫・アレルギー科 Volume: 78 Pages: 280-387
• [Journal Article] じんま疹 (2022)
  • Author(s): 秀 道広
  • Journal Title: 治療 シン・アレルギー診療 Volume: 104 Pages: 1183-1187
• [Journal Article] 急性・慢性蕁麻疹 (2022)
  • Author(s): 秀 道広
  • Journal Title: 小児内科 Volume: 54 Pages: 1276-1280
• [Journal Article] 接触蕁麻疹 (2022)
  • Author(s): 秀 道広
  • Journal Title: 小児内科 Volume: 54 Pages: 1281-1284
• [Journal Article] 物理性蕁麻疹 (2022)
  • Author(s): 秀 道広
  • Journal Title: 小児内科 Volume: 54 Pages: 1285-1290
• [Journal Article] コリン性蕁麻疹 (2022)
  • Author(s): 秀 道広
  • Journal Title: 小児内科 Volume: 54 Pages: 1291-1296
• [Journal Article] 血管性浮腫 (2022)
  • Author(s): 秀 道広
  • Journal Title: 小児内科 Volume: 54 Pages: 1297-1300
• [Journal Article] 55年を経て再び光を浴びるIgEとマスト細胞 (2022)
  • Author(s): 秀 道広
  • Journal Title: アレルギーの臨床 Volume: 42 Pages: 825-825
• [Journal Article] 広島市における新型コロナウイルス感染症 －広島市立病院機構4病院の対応の報告－ (2022)
  • Author(s): 高蓋寿朗、伊藤徳明、実綿 慶、北原良洋、沖本真史、加藤雅也、永田信二、菅原文博、小田 登、岡本良一、庄田浩康、西川公一郎、土手慶吾、秀 道広、加世田ゆみ子、三森 倫、影本正之
  • Journal Title: 広島医学 Volume: 75 Pages: 279-289
  • Peer Reviewed
• [Journal Article] アトピー性皮膚炎のけるヤヌスキナーゼ(JAK)阻害内服薬の使用ガイダンス (2022)
  • Author(s): 佐伯秀久、秋山真志、阿部正敏、五十嵐敦之、今福信一、大矢幸弘、加藤則人、亀田秀人、椛島健治、常深祐一郎、秀 道広、大槻マミ太郎
  • Journal Title: 日皮会誌 Volume: 132 Pages: 1797-1812
  • Peer Reviewed
• [Journal Article] Proposal of 0.5?mg of protein/100?g of processed food as threshold for voluntary declaration of food allergen traces in processed food?A first step in an initiative to better inform patients and avoid fatal allergic reactions: A GA?LEN position paper (2021)
  • Author(s): Zuberbier Torsten、Katoh Norito (42番目)、その他合計86名
  • Journal Title: Allergy Volume: － Issue: 6 Pages: 1736-1750
  • DOI: 10.1111/all.15167
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Time course of disease severity from birth to 19 years old in patients with moderate to severe atopic dermatitis in adulthood (2021)
  • Author(s): Tanaka Akio、Morioke Satoshi、Ohya Yukihiro、Shimojo Naoki、Shinichi Ashizawa、Shizukawa Hiroko、Takahagi Shunsuke、Kan Takanobu、Saito Ryo、Hide Michihiro
  • Journal Title: The Journal of Dermatology Volume: 48 Issue: 5
  • DOI: 10.1111/1346-8138.15790
  • Peer Reviewed
• [Journal Article] Comparison of the time course of atopic dermatitis from birth to 19 years old among generations of patients in Japan (2021)
  • Author(s): Tanaka Akio、Morioke Satoshi、Ohya Yukihiro、Shimojo Naoki、Takahashi Masakazu、Tanaka Maiko、Takahagi Shunsuke、Kan Takanobu、Iwamoto Kazumasa、Saito Ryo、Hide Michihiro
  • Journal Title: The Journal of Dermatology Volume: 48 Issue: 10 Pages: 1602-1606
  • DOI: 10.1111/1346-8138.16085
  • Peer Reviewed / Open Access
• [Journal Article] The international EAACI/GA(2)LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria (2021)
  • Author(s): Zuberbier T. Abdul Latiff AH. Abuzakouk M. et al (Hide M 67人中31番目）
  • Journal Title: Allergy Volume: 77 Issue: 3 Pages: 734-766
  • DOI: 10.1111/all.15090
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] アトピー性皮膚炎のかゆみに対するタンニン酸の臨床的有用性 (2021)
  • Author(s): 鈴木 茂、秀 道広
  • Journal Title: FRAGRANCE JOURNAL Volume: 49 Pages: 24-31
• [Journal Article] アトピー性皮膚炎診療ガイドライン2021 (2021)
  • Author(s): 佐伯秀久、大矢幸弘、古田淳一、荒川浩一、市山 進、勝沼俊雄、加藤則人、田中暁生、常深祐一郎、中原剛士、長尾みづほ、成田雅美、秀 道広、藤澤隆夫、二村昌樹、益田浩司、松原知代、室田浩之、山本貴和子
  • Journal Title: 日本皮膚科学会雑誌 Volume: 131 Pages: 2691-2777
  • NAID: 130008131431
  • Peer Reviewed / Open Access
• [Journal Article] アトピー性皮膚炎では汗の減少と感染症はどのように関連しているのか? (2021)
  • Author(s): 沼田智史, 高萩俊輔, 秀 道広
  • Journal Title: 容皮膚医学Beauty Volume: 4 Pages: 33-41
• [Journal Article] 無汗部位と異なる範囲に疼痛を生じた特発性後天性全身性無汗症の1例 (2021)
  • Author(s): 水野隼登, 高萩俊輔, 岡本真由美, 秀 道広
  • Journal Title: 発汗学 Volume: 28 Pages: 31-33
  • Peer Reviewed
• [Journal Article] The relationship between the development of erythroderma in patients with atopic dermatitis and the avoidance of anti-inflammatory topical drugs. (2020)
  • Author(s): Otsuka R, Tanaka A, Takahashi M, Saito R, Iwamoto K, Takahagi S, Kan T, Morioke S, HideM.
  • Journal Title: Allergol Int Volume: - Issue: 3 Pages: 376-378
  • DOI: 10.1016/j.alit.2020.11.009
  • NAID: 130008064049
  • Peer Reviewed / Open Access
• [Presentation] アトピー性皮膚炎における汗の持つ意味 (2023)
  • Author(s): 秀 道広
  • Organizer: 第5回日本アレルギー学会中国・四国地方会
  • Invited
• [Presentation] Burden of disease and health state perceptions in patients with hereditary angioedema in Japan: quantification of patient-reported outcomes (2022)
  • Author(s): Hide M, Kishimoto M, Kotera I, Oh A, Inoue Y, Yamamoto BA, Noto S
  • Organizer: APAAACI2022 (Asia Pacific Association of Allergy, Asthma and Clinical Immunology)
  • Int'l Joint Research
• [Presentation] Insights into urticaria for diagnosis and management (2022)
  • Author(s): Hide M
  • Organizer: 2022 International Congress of 50th anniversary KAAACI (KOREAN ACADEMY OF ASTHMA, ALLERGY AND CLINICAL IMMUNOLOGY)
  • Int'l Joint Research / Invited
• [Presentation] The international WAO/EAAACI Guidelines for the management of Hereditary Angioedema the 2021 revision and update (2022)
  • Author(s): Hide M, Ohsawa I, Nurse C, Yu M
  • Organizer: APAAACI2022 (Asia Pacific Association of Allergy, Asthma and Clinical Immunology)
  • Int'l Joint Research / Invited
• [Presentation] Efficacy and Safety of Lanadelumab in Japanese Patients With Hereditary Angioedema: Results From a Phase 3, Open-Label Study (2022)
  • Author(s): Hide M, Ohsawa I, Nurse C, Yu M
  • Organizer: 第71回日本アレルギー学会総会(English Session)
  • Int'l Joint Research
• [Presentation] Remibrutinib improves CSU in patients with low or high IgE (2022)
  • Author(s): Hide M, Hayama K, Ramsey A, Maurer M, Lheritier K, Zharkov A, Haemmerle S, Nikolaev I
  • Organizer: 6th GA(2)LEN Global Urticaria Forum (GUF) Congress
  • Int'l Joint Research
• [Presentation] 遺伝性血管性浮腫の鑑別と治療目標 (2022)
  • Author(s): 秀 道広
  • Organizer: 第74回日本皮膚科学会西部支部総会
  • Invited
• [Presentation] 小児HAE患者の急性発作に対するイカチバントの安全性、有効性及び薬物動態を評価した第3相非盲検試験 (2022)
  • Author(s): 秀 道広、Wang Y, 土手宣人、宮川 功、杉浦賢吉、石田和之
  • Organizer: 第71回日本アレルギー学会総会
• [Presentation] HAEと付き合う治療からできる治療へ -HAE治療の国際潮流- (2022)
  • Author(s): 秀 道広
  • Organizer: 第71回日本アレルギー学会総会
  • Invited
• [Presentation] 皮膚科の未来像を考える (2022)
  • Author(s): 秀 道広
  • Organizer: 第121回日本皮膚科学会総会
  • Invited
• [Presentation] 蕁麻疹は何のためにおこり、 われわれは何を目指すか (2022)
  • Author(s): 秀 道広
  • Organizer: 第121回日本皮膚科学会総会
  • Invited
• [Presentation] Pathogenesis and treatment of chronic spontaneous urticaria and cholinergic urticaria. (2021)
  • Author(s): Hide M
  • Organizer: The 17th Congress of the Baltic Association of Dermatovenereologists
  • Int'l Joint Research / Invited
• [Presentation] Progress of the treatment of atopic dermatitis and sweat allergy. (2021)
  • Author(s): Hide M
  • Organizer: 17th Congress of the Baltic Association of Dermatovenereologists
  • Int'l Joint Research / Invited
• [Presentation] Cholinergic Urticaria and UCARE meeting in Hiroshima. (2021)
  • Author(s): Hide M
  • Organizer: The 66th Spanish Group of Contact Dermatitis and Cutaneous Allergy
  • Int'l Joint Research / Invited
• [Presentation] Update of Hereditary Angioedema. (2021)
  • Author(s): Hide M
  • Organizer: APAAACI 2021 International Conference
  • Int'l Joint Research / Invited
• [Presentation] Itch of urticaria (2021)
  • Author(s): Hide M
  • Organizer: The 46th Ann Meeting of Japanese Society of Investigative Dermatology
  • Int'l Joint Research / Invited
• [Presentation] Welcome to Hiroshima. Opening remarks (2021)
  • Author(s): Hide M
  • Organizer: UCARE 2021
  • Int'l Joint Research / Invited
• [Presentation] Prevalence and burden of chronic inducible urticaria in Japan (2021)
  • Author(s): Hide M
  • Organizer: UCARE 2021
  • Int'l Joint Research
• [Presentation] 汗は何のために、何が問題か (2021)
  • Author(s): 秀 道広
  • Organizer: 第29回日本発汗学会総会
  • Invited
• [Presentation] 違和感とこだわりから紐解く蕁麻疹とアトピー性皮膚炎のかかわり (2021)
  • Author(s): 秀 道広
  • Organizer: 第150回日本皮膚科学会広島地方会
  • Invited
• [Book] 皮膚科診療Controversy (2022)
  • Author(s): 秀 道広
  • Total Pages: 348
  • Publisher: 中外医学社
• [Book] アレルギー総合ガイドライン2022 (2022)
  • Author(s): 秀 道広
  • Total Pages: 406
  • Publisher: 協和企画