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A non-invasive method to detect sinoatrial node function in human

Research Project

Project/Area Number 21K08847
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55030:Cardiovascular surgery-related
Research InstitutionSaitama Medical University

Principal Investigator

Tsutsui Kenta  埼玉医科大学, 医学部, 客員准教授 (30534284)

Co-Investigator(Kenkyū-buntansha) 住友 直方  埼玉医科大学, 医学部, 教授 (50231379)
千本松 孝明  埼玉医科大学, 医学部, 教授 (70216563)
森 仁  埼玉医科大学, 医学部, 講師 (50900148)
池田 礼史  埼玉医科大学, 医学部, 准教授 (80789529)
加藤 律史  埼玉医科大学, 医学部, 教授 (10286049)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2023: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2021: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords心臓老化 / 心拍揺らぎ / 老化性心不全 / 心拍ゆらぎ / フラクタル解析
Outline of Research at the Start

近年急増している心不全など心疾患の予後を改善するため、根本的原因である「心臓老化」を診断する手法が求められる。これまで、安静時の心拍数ゆらぎ(Heart Rate Variability, HRV)データを心臓成分と自律神経成分へと非侵襲的に分離し、HRV心臓成分が老化や心疾患と関連して変化することを見出した。本研究では、こうした動物実験によって得られた成果をヒト用発展させ、臨床応用を目指す。

Outline of Final Research Achievements

The present study examines the effects of aging on sinoatrial node (SAN) function, analyzing the interplay between the autonomic nervous system (ANS) and intrinsic mechanisms. We recorded electrocardiograms from young (n=16) and adult (n=23) patients under anesthesia and after ANS blockade. We identified distinct "signatures" of ANS and intrinsic mechanisms on beat interval variability (BIV), finding age-related changes in their contributions. In young patients, intrinsic mechanisms largely influence long-term BIV, whereas in adults, both ANS and intrinsic mechanisms affect both short- and long-term BIV. Anesthesia impacts ANS function differently across age groups.

Academic Significance and Societal Importance of the Research Achievements

この研究で得られたデータをもとに、薬剤の投与なしで、10分前後の心拍の揺らぎから心臓の加齢状態に関する洞察が得られる可能性が見出された。「心臓老化の非侵襲的診断」開発手法の確立へ向けて着実に前進することができた。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (4 results)

All 2023 2022 Other

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Int'l Joint Research] Technion(イスラエル)

    • Related Report
      2021 Research-status Report
  • [Journal Article] Age-dependent contribution of intrinsic mechanisms to sinoatrial node function in humans2023

    • Author(s)
      Weiser-Bitoun Ido、Mori Hitoshi、Nabeshima Taisuke、Tanaka Naomichi、Kudo Daisuke、Sasaki Wataru、Narita Masataka、Matsumoto Kazuhisa、Ikeda Yoshifumi、Arai Takahide、Nakano Shintaro、Sumitomo Naokata、Senbonmatsu Taka-aki、Matsumoto Kazuo、Kato Ritsushi、Morrell Christopher H.、Tsutsui Kenta、Yaniv Yael
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 1-11

    • DOI

      10.1038/s41598-023-45101-7

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] A non-invasive method to detect sinoatrial node function in human2023

    • Author(s)
      Kenta Tsutsui, et al.
    • Organizer
      日本循環器学会
    • Related Report
      2022 Research-status Report
  • [Presentation] A non-invasive method to detect sinoatrial node function in human2022

    • Author(s)
      Kenta Tsutsui, et al.
    • Organizer
      APHRS2022@Singapore
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research

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Published: 2021-04-28   Modified: 2025-01-30  

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