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The development of surgical adhesive material with high pressure resistance and conformability

Research Project

Project/Area Number 21K08879
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55040:Respiratory surgery-related
Research InstitutionUniversity of Tsukuba

Principal Investigator

Sato Yukio  筑波大学, 医学医療系, 教授 (10312844)

Co-Investigator(Kenkyū-buntansha) 小林 尚寛  筑波大学, 医学医療系, 講師 (10746564)
田口 哲志  国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, グループリーダー (70354264)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords外科用接着剤 / 肺瘻 / 気漏 / ゼラチン
Outline of Research at the Start

1.混合噴霧デバイスの作製
共同研究を行っているニプロ株式会社と協力し、2成分混合システムを設計・作成し、外科用シーラントの機能を十分に発揮するシステムを開発する。予備実験では接着剤が最適な状態で混合した際には80cmH2O以上の耐圧強度が確認できている。
2.動物実験による耐圧力・組織適合性評価
1)全身麻酔下豚モデルを用いた急性期耐圧試験により、フィブリンシーラントと疎水化タラゼラチンシーラントとの接着力・組織追従性を評価。
2)ラット慢性実験により、慢性期の組織適合性・炎症反応・癒着等の組織反応・肝腎機能等への影響を評価する。

Outline of Final Research Achievements

The adhesive quality of novel surgical sealant (Gelatin sealant: GS) was evaluated compared with conventional surgical sealant (Fibrin glue: FG). GS showed high adhesive quality and conformability in excised porcine lungs. GS showed high adhesive quality in anesthetized pig lungs. In chronic rat experiment, GS and FG caused no adverse events. While FG was absorbed in 2 weeks with some inflammatory response, GS was absorbed in 8 weeks with less inflammatory response.

Academic Significance and Societal Importance of the Research Achievements

新規組織接着剤 (Gelatin sealant: GS)はex vivo、in vivo実験にて高い接着力・追従性を示し、慢性実験でも有害事象を認めず惹起する炎症反応も軽度であった。呼吸器外科手術に於ける最も頻度の高い合併症である気漏閉鎖への臨床応用が期待できる。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (4 results)

All 2022 2021

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (2 results)

  • [Journal Article] Alaska pollock gelatin sealant shows long-term efficacy and safety in a pulmonary air leakage rat model.2022

    • Author(s)
      Yanagihara T, Maki N, Kawamura T, Kobayashi N, Kikuchi S, Goto Y, Ichimura H, Watanabe S, Taguchi T, Sato Y
    • Journal Title

      European Journal of Cardio-Thoracic Surgery

      Volume: 62 Issue: 5

    • DOI

      10.1093/ejcts/ezac497

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of Alaska Pollock Gelatin Sealant for Pulmonary Air Leakage in Porcine Models2022

    • Author(s)
      Yanagihara Takahiro、Maki Naoki、Wijesinghe A.I.、Sato Shoko、Saeki Yusuke、Kitazawa Shinsuke、Yamaoka Masatoshi、Kobayashi Naohiro、Kikuchi Shinji、Goto Yukinobu、Ichimura Hideo、Watanabe Shiharu、Taguchi Tetsushi、Sato Yukio
    • Journal Title

      The Annals of Thoracic Surgery

      Volume: 113 Issue: 5 Pages: 1641-1647

    • DOI

      10.1016/j.athoracsur.2021.05.023

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] タラゼラチンを用いた呼吸器外科用接着剤の開発2021

    • Author(s)
      佐藤幸夫
    • Organizer
      第72回日本気管食道科学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 疎水化タラゼラチンとポリエチレングリコール系架橋剤からなる新規組織接着剤の開発2021

    • Author(s)
      柳原 隆宏
    • Organizer
      第38回日本呼吸器外科学会総会
    • Related Report
      2021 Research-status Report

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Published: 2021-04-28   Modified: 2025-01-30  

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