| Project/Area Number |
21K09219
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56020:Orthopedics-related
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| Research Institution | Yamagata University |
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Principal Investigator |
Honma Ryusuke 山形大学, 医学部, 非常勤講師 (70716688)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2023: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ポドプラニン / 滑膜炎 |
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| Outline of Research at the Start |
腎臓や肺などの正常組織の細胞にはポドプラニンという蛋白質が存在しています。近年、関節リウマチの炎症部位や腫瘍にもこの蛋白質が存在していることが報告されています。ウサギの膝関節に細菌の成分を注射して炎症を起こしたところ、ポドプラニンの増加を認めました。今回の実験では、炎症を起こした膝関節にポドプラニンに対する抗体を投与することで、関節炎を沈静化させることが可能かを調べます。関節リウマチの治療につながる大変重要な研究になると思われます。
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| Outline of Final Research Achievements |
Podoplanin is a type I transmembrane protein and is expressed in normal tissues such as renal glomerular epithelial cells, lung type I alveolar epithelial cells, osteocytes, and chondrocytes, as well as in pathological tissues such as malignant tumors and synovial tissue of rheumatoid arthritis. We induced synovitis by injecting lipopolysaccharide into the knee joints of rabbits and found that podoplanin is expressed in synovial tissues. We hypothesized that injecting anti-podoplanin antibody after induction of synovitis could suppress synovitis, but since podoplanin expression was decreased even after spontaneous remission by autoimmunity, it was difficult to determine the suppressive effect of anti-podoplanin antibody on synovitis.
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| Academic Significance and Societal Importance of the Research Achievements |
滑膜炎に発現するポドプラニンを抑制することができれば、関節リウマチなどの関節炎治療に応用可能と考えられる。
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