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The effects of androgens on female metabolic functions and their mechanisms

Research Project

Project/Area Number 21K09518
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56040:Obstetrics and gynecology-related
Research InstitutionThe University of Tokushima

Principal Investigator

IWASA Takeshi  徳島大学, 大学院医歯薬学研究部(医学域), 教授 (00707903)

Co-Investigator(Kenkyū-buntansha) 河北 貴子  徳島大学, 大学院医歯薬学研究部(医学域), 徳島大学専門研究員 (00724121)
山本 由理  徳島大学, 病院, 講師 (90622879)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2023: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsアンドロゲン / 肥満 / PCOS / エストロゲン / オキシトシン
Outline of Research at the Start

女性においてエストロゲンは栄養代謝機能に良好な作用を及ぼす。一方、アンドロゲンが栄養代謝機能に及ぼす影響については明らかにされていない。本研究では実験動物を用いて、アンドロゲンが栄養代謝機能および食事の好みに及ぼす影響とその機序について検討する。また、アンドロゲンが悪影響を及ぼすことが明らかとなれば、それを予防する方法について検討する。本研究の結果は女性の健康増進を図る上で有用な情報になり得ると考えられる。

Outline of Final Research Achievements

This study showed that androgens give some adverse effects on female metabolic functions and appetite. In addition, their underlying mechanisms, i.e. some central and peripheral appetite and metabolic regulatory factors, were also clarified. Furthermore, it was clarified that temporal restriction of feeding may induce reduction of subcutaneous and peripheral fats in hyper-androgenic obese animals.

Academic Significance and Societal Importance of the Research Achievements

肥満はさまざまな疾患の原因となるだけでなく、生殖世代の女性において不妊症の原因となるなど、健康リスクを著しく増加させる。一方、単純性の肥満に比べ、高アンドロゲンなどホルモンの不調によって引き起こされる肥満では、減量が困難であることが知られている。本研究によって高アンドロゲンによる肥満のメカニズムならびに効果的な食事摂取の方法についての知見が得られた。これらは肥満に対する効果的な介入方法を確立する上で、重要な情報になると考えられる。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (10 results)

All 2024 2023 2022 2021

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Progesterone treatment reduces food intake and body weight in ovariectomized female rats2024

    • Author(s)
      Uchishiba Maimi、Yamamoto Shota、Takeda Asuka、Arakaki Ryosuke、Arata Moeka、Noguchi Hiroki、Aoki Hidenori、Tamura Kou、Maeda Takaaki、Minato Saki、Nii Mari、Inui Hiroaki、Kamada Shuhei、Kinouchi Riyo、Yamamoto Yuri、Yoshida Kanako、Yagi Shigetaka、Kato Takeshi、Kaji Takashi、Iwasa Takeshi
    • Journal Title

      Steroids

      Volume: 203 Pages: 109367-109367

    • DOI

      10.1016/j.steroids.2024.109367

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New discoveries on the interaction between testosterone and oxytocin in male rats ― Testosterone-mediated effects of oxytocin in the prevention of obesity2023

    • Author(s)
      Yamamoto Shota、Arakaki Ryosuke、Noguchi Hiroki、Takeda Asuka、Uchishiba Maimi、Kamada Shuhei、Mineda Ayuka、Kon Masafumi、Kawakita Takako、Kinouchi Riyo、Yamamoto Yuri、Yoshida Kanako、Shinohara Nobuo、Iwasa Takeshi
    • Journal Title

      Physiology & Behavior

      Volume: 266 Pages: 114199-114199

    • DOI

      10.1016/j.physbeh.2023.114199

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Developmental Changes in Hypothalamic and Serum Oxytocin Levels in Prenatally Normally Nourished and Undernourished Rats2023

    • Author(s)
      Imaizumi Junki、Kamada Shuhei、Taniguchi Miyu、Sugimoto Tatsuro、Maeda Takaaki、Arakaki Ryosuke、Yamamoto Shota、Shirakawa Aya、Mineda Ayuka、Yoshida Atsuko、Iwasa Takeshi、Kaji Takashi
    • Journal Title

      Nutrients

      Volume: 15 Issue: 12 Pages: 2768-2768

    • DOI

      10.3390/nu15122768

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in Serum Oxytocin Levels under Physiological and Supraphysiological Gonadal Steroid Hormone Conditions in Women of Reproductive Age: A Preliminary Study2022

    • Author(s)
      Tachibana Ayaka、Yamamoto Yuri、Noguchi Hiroki、Takeda Asuka、Tamura Kou、Aoki Hidenori、Minato Saki、Uchishiba Maimi、Yamamoto Shota、Kamada Shuhei、Yoshida Atsuko、Kinouchi Riyo、Yoshida Kanako、Iwasa Takeshi
    • Journal Title

      Nutrients

      Volume: 14 Issue: 24 Pages: 5350-5350

    • DOI

      10.3390/nu14245350

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Changes in Endogenous Oxytocin Levels and the Effects of Exogenous Oxytocin Administration on Body Weight Changes and Food Intake in Polycystic Ovary Syndrome Model Rats2022

    • Author(s)
      Yamamoto Shota、Noguchi Hiroki、Takeda Asuka、Arakaki Ryosuke、Uchishiba Maimi、Imaizumi Junki、Minato Saki、Kamada Shuhei、Kagawa Tomohiro、Yoshida Atsuko、Kawakita Takako、Yamamoto Yuri、Yoshida Kanako、Kon Masafumi、Shinohara Nobuo、Iwasa Takeshi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 15 Pages: 8207-8207

    • DOI

      10.3390/ijms23158207

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effects of androgens on metabolic functions in females2021

    • Author(s)
      Iwasa Takeshi、Yamamoto Yuri、Shinya Akari、Minato Saki、Yanagihara Rie、Kamada Shuhei、Imaizumi Junki、Kagawa Tomohiro、Shirakawa Aya、Noguchi Hiroki、Nakagawa Tomotaka、Taniguchi Miyu、Kadota Yuri、Kawakita Takako、Yoshida Kanako、Kato Takeshi、Yasui Toshiyuki、Irahara Minoru
    • Journal Title

      The Journal of Medical Investigation

      Volume: 68 Issue: 3.4 Pages: 228-231

    • DOI

      10.2152/jmi.68.228

    • NAID

      130008115652

    • ISSN
      1343-1420, 1349-6867
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of gonadal status and the estrogen milieu on hypothalamic oxytocin gene expression and serum oxytocin levels in female rats2021

    • Author(s)
      Tokui Takako、Kawakita Takako、Yanagihara Rie、Kamada Shuhei、Minato Saki、Takeda Asuka、Imaizumi Junki、Yamamoto Yuri、Yoshida Kanako、Kato Takeshi、Irahara Minoru、Iwasa Takeshi
    • Journal Title

      Hormones and Behavior

      Volume: 133 Pages: 105005-105005

    • DOI

      10.1016/j.yhbeh.2021.105005

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel PCOS rat model and an evaluation of its reproductive, metabolic, and behavioral phenotypes2021

    • Author(s)
      Kamada Shuhei、Yamamoto Yuri、Aoki Hidenori、Tamura Kou、Takeda Asuka、Minato Saki、Masaki Rie、Yanagihara Rie、Hayashi Noriko、Yano Yuya、Imaizumi Junki、Kagawa Tomohiro、Yoshida Atsuko、Kawakita Takako、Irahara Minoru、Iwasa Takeshi
    • Journal Title

      Reproductive Medicine and Biology

      Volume: 21 Issue: 1

    • DOI

      10.1002/rmb2.12416

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] 生殖世代のホルモン研究から考える女性医学2023

    • Author(s)
      岩佐 武
    • Organizer
      第38回日本女性医学学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] PGT-A, past, present, and future in Japan.2023

    • Author(s)
      岩佐 武
    • Organizer
      The 1st Asian Congress for Reproductive Immunology
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research

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Published: 2021-04-28   Modified: 2025-01-30  

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