8歳児における握力及び四肢筋量と動脈硬化危険因子との関連

• Project/Area Number: 21K10472
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Kochi University
• Principal Investigator: 幸 篤武 高知大学, 教育研究部人文社会科学系教育学部門, 准教授 (00623224)
• Co-Investigator(Kenkyū-buntansha): 滿田 直美 高知大学, 医学部, 特任助教 (30611389) ; 栄徳 勝光 高知大学, 教育研究部医療学系連携医学部門, 講師 (50552733)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2023: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 小児 / 代謝性疾患 / 四肢筋量 / 握力 / 横断解析 / 子どもの健康と環境に関する全国調査 / 筋力 / 骨格筋量 / メタボリックシンドローム

Outline of Research at the Start

本研究では高知県で実施されている環境省「子どもの健康と環境に関する全国調査（エコチル調査）」の学童期検査に参加する8歳児約2,000名を対象に、握力及び骨格筋量と血圧及び血中のHbA1c、コレステロールとの関連性について検討する。また、筋力及び筋量と動脈硬化の危険因子との関連に肥満が及ぼす影響についても検討を行い、8歳児における握力及び四肢筋量と動脈硬化危険因子との関連についてより詳細に明らかにすることを目指す。

Outline of Annual Research Achievements

本研究は高知県で実施されている環境省「子どもの健康と環境に関する全国調査（エコチル調査）」における研究対象者6,464名のうち、学童期検査に参加する8歳児約2,000名を対象として、握力及び骨格筋量と血圧及び血中のHbA1c、コレステロールとの関連を解析し、筋力及び筋量と血中の動脈硬化の危険因子並びにその異常と関連するか明らかにする。また筋力及び筋量の多寡と動脈硬化の危険因子との関連に対する肥満の交絡について明らかにすることを目的としている。これにより、学童期における生活習慣改善の機会を新たに提供することや、動脈硬化予防・改善を目的とした運動処方プログラムの選択肢を増やすことを目指すも
のである。
2023年度は8歳時学童期検査参加者2,192名のうち、選択除外基準に照らし合わせた665名分のデータを用い、握力及び生体インピーダンス法による骨格筋量と血中の動脈硬化の危険因子（収縮期血圧、拡張期血圧、HbA1c、中性脂肪、Low Density Lipoprotein、High Density Lipoprotein）並びにその異常との関連について、相関分析、一般線形モデルおよび一般化線形モデルを用い、検討を行った。また筋力及び筋量の多寡と動脈硬化の危険因子との関連に対する肥満の交絡についても検討に着手し、BMI、全身体脂肪率、内臓脂肪量指標である腹囲などの交絡の影響について、従属変数を連続変数とする一般線形モデルにて検討を行った。

Research Products

• [Journal Article] Association of a low chest-to-head circumference ratio with breech or transverse lie: the Japan Environment and Children’s Study (2024)
  • Author(s): J-P Naw Awn、Watanabe Takafumi、Eitoku Masamitsu、Yamasaki Keiko、Mitsuda Naomi、Maeda Nagamasa、Fujieda Mikiya、Suganuma Narufumi、the Japan Environment and Children’s Study (JECS) Group
  • Journal Title: The Journal of Maternal-Fetal & Neonatal Medicine Volume: 37 Issue: 1 Pages: 2305678-2305678
  • DOI: 10.1080/14767058.2024.2305678
  • Peer Reviewed / Open Access
• [Journal Article] Vitamin D deficiency associated with neurodevelopmental problems in 2‐year‐old Japanese boys (2023)
  • Author(s): Yasumitsu‐Lovell Kahoko、Thompson Lucy、Fernell Elisabeth、Eitoku Masamitsu、Suganuma Narufurmi、Gillberg Christopher、the Japan Environment and Children's Study Group
  • Journal Title: Acta Paediatrica Volume: 113 Issue: 1 Pages: 119-126
  • DOI: 10.1111/apa.16998
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between eating habits during adolescence and gestational diabetes: data from the Japan environment and children’s study (2023)
  • Author(s): Minami Marina、Watanabe Takafumi、Eitoku Masamitsu、Maeda Nagamasa、Fujieda Mikiya、Suganuma Narufumi、the Japan Environment and Children’s Study (JECS) Group
  • Journal Title: Journal of Diabetes & Metabolic Disorders Volume: 22 Issue: 2 Pages: 1625-1633
  • DOI: 10.1007/s40200-023-01294-2
  • Peer Reviewed
• [Journal Article] Influence of chest/head circumference ratio at birth on obstetric and neonatal outcomes: The Japan environment and children's study (2023)
  • Author(s): J-P NA, Mitsuda N, Eitoku M, Yamasaki K, Maeda N, Fujieda M, Suganuma N; Japan Environment and Children's Study (JECS) Group
  • Journal Title: American Journal of Human Biology Volume: Online ahead of print Issue: 6
  • DOI: 10.1002/ajhb.23875
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between the ratio of placental weight to birthweight and the risk of neurodevelopmental delay in 3-year-Olds: The Japan environment and Children's study (2022)
  • Author(s): Mitsuda N、Eitoku M、Yamasaki K、J-P Naw Awn、Fujieda M、Suganuma N、Japan Environment and Children's Study (JECS) Group
  • Journal Title: Placenta Volume: 128 Pages: 49-56
  • DOI: 10.1016/j.placenta.2022.08.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gestational weight gain mediates the effects of energy intake on birth weight among singleton pregnancies in the Japan Environment and Children’s Study (2022)
  • Author(s): Minami M, J-P NA, Noguchi S, Eitoku M, Muchanga SMJ, Mitsuda N, Komori K, Yasumitsu-Lovell K, Maeda N, Fujieda M, Suganuma N; Japan Environment and Children’s Study (JECS) Group
  • Journal Title: BMC Pregnancy and Childbirth Volume: 22 Issue: 1 Pages: 568-568
  • DOI: 10.1186/s12884-022-04898-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dose-response relationships between maternal urinary cotinine and placental weight and ratio of placental weight to birth weight: The Japan Environment and Children's Study (2022)
  • Author(s): Yamasaki K, Mitsuda N, J-P NA, Eitoku M, Maeda N, Fujieda M, Suganuma N; Japan Environment and Children's Study Group (JECS Group)
  • Journal Title: Environmental Research Volume: 205 Pages: 112470-112470
  • DOI: 10.1016/j.envres.2021.112470
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Exogenous oxytocin used to induce labor has no long-term adverse effect on maternal-infant bonding: Findings from the Japan Environment and Children's Study (2022)
  • Author(s): Kunimi Yusuke、Minami Marina、Muchanga Sifa Marie Joelle、Eitoku Masamitsu、Hayashi Kazutoshi、Fujieda Mikiya、Suganuma Narufumi、Maeda Nagamasa
  • Journal Title: Journal of Affective Disorders Volume: 299 Pages: 37-44
  • DOI: 10.1016/j.jad.2021.11.058
  • Peer Reviewed
• [Journal Article] Breastfeeding and risk of febrile seizures in the first 3 years of life: The Japan Environment and Children’s Study (2022)
  • Author(s): Mitsuda Naomi、J-P Naw Awn、Hosokawa Takatoshi、Eitoku Masamitsu、Fujieda Mikiya、Suganuma Narufumi
  • Journal Title: Brain and Development Volume: 44 Issue: 3 Pages: 203-209
  • DOI: 10.1016/j.braindev.2021.10.008
  • Peer Reviewed
• [Journal Article] Development of a parent-reported screening tool for avoidant/restrictive food intake disorder (ARFID): Initial validation and prevalence in 4-7-year-old Japanese children (2022)
  • Author(s): Dinkler Lisa、Yasumitsu-Lovell Kahoko、Eitoku Masamitsu、Fujieda Mikiya、Suganuma Narufumi、Hatakenaka Yuhei、Hadjikhani Nouchine、Bryant-Waugh Rachel、R?stam Maria、Gillberg Christopher
  • Journal Title: Appetite Volume: 168 Pages: 105735-105735
  • DOI: 10.1016/j.appet.2021.105735
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lack of concern about body image and health during pregnancy linked to excessive gestational weight gain and small-for-gestational-age deliveries: the Japan Environment and Children’s Study (2021)
  • Author(s): J-P Naw Awn、the Japan Environment and Children’s Study (JECS) Group、Minami Marina、Eitoku Masamitsu、Maeda Nagamasa、Fujieda Mikiya、Suganuma Narufumi
  • Journal Title: BMC Pregnancy and Childbirth Volume: 21 Issue: 1 Pages: 396-396
  • DOI: 10.1186/s12884-021-03827-0
  • Peer Reviewed
• [Journal Article] Birth month and infant gross motor development: Results from the Japan Environment and Children’s Study (JECS) (2021)
  • Author(s): Yasumitsu-Lovell Kahoko、Thompson Lucy、Fernell Elisabeth、Eitoku Masamitsu、Suganuma Narufumi、Gillberg Christopher、the Japan Environment and Children’s Study Group
  • Journal Title: PLOS ONE Volume: 16 Issue: 5 Pages: e0251581-e0251581
  • DOI: 10.1371/journal.pone.0251581
  • Peer Reviewed
• [Presentation] 子どもの出生月と粗大運動発達の関連について (2022)
  • Author(s): 安光 ラヴェル香保子、Lucy Thompson、Elisabeth Fernell、 栄徳 勝光、菅沼 成文、Christopher Gillberg、and the Japan Environment and Children’s Study Group
  • Organizer: 第92回日本衛生学会学術総会
• [Remarks] こうちエコチル調査
  • URL: https://kochi-ecochil.jp/