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Why does exercise training prevent endothelial dysfunction after acute resistance exercise?

Research Project

Project/Area Number 21K17553
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59020:Sports sciences-related
Research InstitutionChukyo University

Principal Investigator

Morishima Takuma  中京大学, 教養教育研究院, 准教授 (60771706)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2023: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsレジスタンス運動 / 血管内皮機能 / FMD / 一酸化窒素 / エンドセリン-1 / 運動トレーニング / NO / 硝酸塩
Outline of Research at the Start

健康増進のためには、効果的かつ安全にレジスタンス運動を行うことが重要である。この点に関して、非鍛錬者は、一過性のレジスタンス運動後に動脈硬化の予測因子となる血管内皮機能が低下(悪化)する。一方で、運動を長期間継続している鍛錬者は一過性のレジスタンス運動後に血管内皮機能が低下しない。本研究では、この興味深い現象のメカニズムを明らかにすることに挑戦する。本研究から得られる知見は、習慣的な運動トレーニングがもたらす「一過性のレジスタンス運動に対する血管の保護作用」という、まったく新しい観点からの効果を明らかにすることができ、結果的に運動継続の動機付けにも繋がる可能性がある。

Outline of Final Research Achievements

Highly trained individuals with a habit of high-intensity exercise do not experience a decline in endothelial function following acute resistance exercise. This study was conducted to elucidate the physiological mechanisms underlying this phenomenon. The summary of the research findings includes the following points.
(1)Even in sedentary individuals, temporarily enhancing the nitric oxide (a vasodilator) bioavailability by supplementation prevents the endothelial dysfunction following acute resistance exercise. (2)There is no difference in the response of endothelial-derived substances to acute resistance exercise between those with and without an exercise habit. (3)Unlike sedentary individuals, individuals with a habit of exercise experience an improvement in microvascular function after acute resistance exercise.

Academic Significance and Societal Importance of the Research Achievements

本研究は、なぜ運動トレーニングは一過性のレジスタンス運動後における血管内皮機能の低下を予防するのか、その生理学的メカニズムの一端を示した点において学術的価値が高い。また、社会的意義としては、「一過性のレジスタンス運動後における血管内皮機能の低下を予防する」というこれまでとは異なる視点での運動トレーニングの効果を示した点が挙げられる。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (10 results)

All 2024 2023 2022 2021

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Circulating catecholamines, endothelin-1, and nitric oxide releases do not explain the preserved FMD following acute resistance exercise in strength-trained men2024

    • Author(s)
      Takuma Morishima and Nobukazu Kasai
    • Journal Title

      European Journal of Applied Physiology

      Volume: - Issue: 8 Pages: 2417-2425

    • DOI

      10.1007/s00421-024-05468-5

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Slow-Speed Low-Intensity but Not Normal-Speed High-Intensity Resistance Exercise Maintains Endothelial Function2022

    • Author(s)
      Yosuke Tsuchiya, Takuma Morishima, Eisuke Ochi
    • Journal Title

      Research Quarterly for Exercise and Sport

      Volume: 印刷中 Issue: 2 Pages: 1-8

    • DOI

      10.1080/02701367.2021.2022586

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prior beetroot juice ingestion offsets endothelial dysfunction following prolonged sitting2022

    • Author(s)
      Takuma Morishima, Motoyuki Iemitsu, Shumpei Fujie, Eisuke Ochi
    • Journal Title

      Journal of Applied Physiology

      Volume: 133 Issue: 1 Pages: 69-74

    • DOI

      10.1152/japplphysiol.00200.2022

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of combined aerobic and resistance exercise on serum Klotho secretion in healthy young men -a pilot study2022

    • Author(s)
      Takuma Morishima and Eisuke Ochi
    • Journal Title

      Current Research in Physiology

      Volume: 11 Pages: 246-250

    • DOI

      10.1016/j.crphys.2022.06.001

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of a single bout of resistance exercise on serum Klotho in healthy young men2021

    • Author(s)
      Morishima Takuma、Ochi Eisuke
    • Journal Title

      Physiological Reports

      Volume: 9 Issue: 21

    • DOI

      10.14814/phy2.15087

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 前日の高脂肪食摂取が翌日の主観的心理指標および筋パワー発揮に及ぼす影響2024

    • Author(s)
      日田晴登、出口舞、盛田綾香、森嶋琢真
    • Organizer
      第28回日本体力医学会東海地方会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 前日の高脂肪食摂取が翌日の血圧や血管硬化度、エネルギー代謝に与える影響2024

    • Author(s)
      出口舞、日田晴登、盛田綾香、森嶋琢真
    • Organizer
      第28回日本体力医学会東海地方会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Preserved endothelial function in response to acute resistance exercise in strength-trained men is independent of catecholamine and endothelin-1 releases2023

    • Author(s)
      Takuma Morishima and Nobukazu Kasai
    • Organizer
      The 28th Annual Congress of the European College of Sport Science
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ビートルートジュースの摂取は長時間の座位行動後における血管内皮機能の低下を予防する2022

    • Author(s)
      森嶋琢真、家光素行、藤江隼平、越智英輔
    • Organizer
      第77回日本体力医学会大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 長時間の座位行動が血管内皮機能に及ぼす悪影響とその対抗策の提案2022

    • Author(s)
      森嶋琢真
    • Organizer
      第77回日本体力医学会大会
    • Related Report
      2022 Research-status Report
    • Invited

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Published: 2021-04-28   Modified: 2025-01-30  

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