Ligand-free hepatocyte-targeting of nanomedicines by selective stealth coating of liver reticuloendothelial system scavenger cells
| Project/Area Number |
21K18062
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 90110:Biomedical engineering-related
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| Research Institution | Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine |
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Principal Investigator |
ディリサラ アンジャネユル 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 主任研究員 (70794353)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2022: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2021: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | Liver sinusoidal coating / Liver stealth coating / Hepatocyte targeting / Gene delivery / Hepatocytes / Genome editing / CRISPR/Cas9 / Gene drugs |
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| Outline of Research at the Start |
Hepatocyte-selective delivery of nanomedicines is a potential strategy for treating liver diseases. However, liver scavenger cells eliminate most of the injected dose before reaching hepatocytes. Research will be focused on minimizing this nonspecific uptake to maximize hepatocyte-directed delivery.
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| Outline of Annual Research Achievements |
Our transient liver sinusoidal stealth coating strategy successfully increased the protein expression efficiency in the liver from mRNA-adsorbed liposomes than the level observed without two-arm-PEG-OligoLys preinjection. Intriguingly, the same sinusoidal stealth coating strategy decreased the liver expression of mRNA-loaded lipid nanoparticles and relocated them from liver to spleen. This discrepancy in the gene expression efficiency may be attributed to size and charge of nanoparticles.
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Report
(2 results)
Research Products
(16 results)
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[Journal Article] Enzymatically Transformable Polymersome-Based Nanotherapeutics to Eliminate Minimal Relapsable Cancer2021
Author(s)
J. Li, Z. Ge, K. Toh, X. Liu, A. Dirisala, W. Ke, P. Wen, H. Zhou, Z. Wang, S. Xiao, J.F.R. Van Guyse, T.A. Tockary, J. Xie, D. Gonzalez-Carter, H. Kinoh, S. Uchida, Y. Anraku, K. Kataoka
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Journal Title
Adv. Mater.
Volume: 33
Issue: 49
Pages: 2105254-2105254
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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