Strategies to prevent progression from premalignant lesion to cancer in the pancreas

• Project/Area Number: 21K19480
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 53:Organ-based internal medicine and related fields
• Research Institution: Kyoto University
• Principal Investigator: Seno Hiroshi 京都大学, 医学研究科, 教授 (90335266)
• Project Period (FY): 2021-07-09 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2023: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2022: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 膵がん

Outline of Research at the Start

膵発がんの超初期段階を解析し、がんへの進行を食い止める方策の樹立は重要である。膵発がんの超初期段階では腺房導管異形成（ADM）とKras変異の併存が必要とされる。本研究では、（１）ADMを中心とするマウス生体内外3次元細胞系譜を解析し、（２）ADMの脱分化・再分化に関わるシグナルをプロファイリングし、（３）ADMから腫瘍化するpoint of no returnを決定するシグナルに対する介入実験を行う。これらの検討を通じて、超初期段階から「引き返す」膵がん予防戦略を探求する。

Outline of Final Research Achievements

To improve preventive and therapeutic efficacy against pancreatic cancer, it would be important to analyze the early steps of pancreatic cancer development. In this project, we analyzed the early steps of pancreatic carcinogenesis; ADM (acinar-to-ductal metaplasia) formation and Kras activation. By using lineage tracing technique and RNA expression analyses, we performed following experiments. 1) In vivo lineage tracing in ADM, 2) Extraction of key signaling cascades during de-differentiation and re-differentiation of ADM, 3) Determinants to promote the transition from ADM to pancreatic tumor. Through these experiments, we could approach the core mechanisms of the early steps of pancreatic carcinogenesis, and at the same time obtain several hints to prevent the progression from ADM to pancreatic cancer progenitors.

Academic Significance and Societal Importance of the Research Achievements

本研究はADMという膵臓のユニークな病変を手がかりに実験を展開するもので、他臓器のがん研究には見られない独自性を有するとともに、生体が持つ可塑性にチャレンジする試みであった。また、CreERにより任意のタイミングでADMにKras変異を挿入して膵腫瘍を形成させる実験系、過去困難であったADMの動態を生体内で経時的に可視化する実験系など、申請者らが構築してきたシステムが有用であった。そこに先端的な遺伝子解析技術を併用して、膵発がんの超初期病変の本質に挑む解析は、他では実施困難な挑戦的内容と思われた。さらにそこから得た知見を、中長期的に新規膵がん予防、治療法へ発展させる萌芽とすることができた。

Research Products

• [Int'l Joint Research] ミュンヘン工科大(ドイツ)
• [Journal Article] Sporadic gastric juvenile polyposis with a novel SMAD4 nonsense mutation in a mosaic pattern. (2024)
  • Author(s): Matsuyama S, Fukuda A, Matsumoto A, Eguchi H, Ueo T, Ohana M, Seno H.
  • Journal Title: Clin J Gastroenterol Volume: 17 Issue: 1 Pages: 23-28
  • DOI: 10.1007/s12328-023-01884-w
  • Peer Reviewed
• [Journal Article] THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer (2023)
  • Author(s): Omatsu Mayuki、Nakanishi Yuki、Kasashima Hiroaki、et al.
  • Journal Title: Nature Communications Volume: 14 Issue: 1 Pages: 5534-5534
  • DOI: 10.1038/s41467-023-41095-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pancreatic RECK inactivation promotes cancer formation, epithelial-mesenchymal transition, and metastasis. (2023)
  • Author(s): Masuda T, Fukuda A, Yamakawa G, Omatsu M, Namikawa M, Sono M, Fukunaga Y, Nagao M, Araki O, Yoshikawa T, Ogawa S, Masuo K, Goto N, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Masui T, Hatano E, Matsuzaki T, Noda M, Seno H.
  • Journal Title: J Clin Invest Volume: 133 Issue: 18
  • DOI: 10.1172/jci161847
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comprehensive analyses of the clinicopathological features and genomic mutations of combined hepatocellular‐cholangiocarcinoma (2023)
  • Author(s): Ito Takashi、Ishii Takamichi、Takeda Haruhiko、Sumiyoshi Shinji、Tomofuji Katsuhiro、Wakama Satoshi、Makino Kenta、Horie Hiroshi、Kumagai Ken、Takai Atsushi、Uebayashi Elena Yukie、Ogiso Satoshi、Fukumitsu Ken、Haga Hironori、Seno Hiroshi、Hatano Etsuro
  • Journal Title: Hepatology Research Volume: 54 Issue: 1 Pages: 103-115
  • DOI: 10.1111/hepr.13965
  • Peer Reviewed
• [Journal Article] ELF3 suppresses gallbladder cancer development through downregulation of the EREG/EGFR/mTOR complex 1 signalling pathway. (2023)
  • Author(s): Nakamura T, Nishikawa Y, Shiokawa M, Takeda H, Yokode M, Matsumoto S, Muramoto Y, Ota S, Yoshida H, Okada H, Kuwada T, Marui S, Matsumori T, Maruno T, Uza N, Kodama Y, Hatano E, Seno H.
  • Journal Title: J Pathol Volume: 261 Issue: 1 Pages: 28-42
  • DOI: 10.1002/path.6144
  • Peer Reviewed / Open Access
• [Journal Article] Simultaneous activation of Kras?Akt and Notch pathways induces extrahepatic biliary cancer via the <scp>mTORC1</scp> pathway (2023)
  • Author(s): Namikawa Mio、Fukuda Akihisa、Omatsu Mayuki、Sono Makoto、Masuda Tomonori、Araki Osamu、Nagao Munemasa、Yoshikawa Takaaki、Ogawa Satoshi、Hiramatsu Yukiko、Muta Yu、Tsuda Motoyuki、Maruno Takahisa、Nakanishi Yuki、Tsuruyama Tatsuaki、Taura Kojiro、Hatano Etsuro、Seno Hiroshi
  • Journal Title: The Journal of Pathology Volume: 260 Issue: 4 Pages: 478-492
  • DOI: 10.1002/path.6139
  • Peer Reviewed / Open Access
• [Journal Article] Concomitant occurrence of pancreatic cancer during long-term follow-up for serous neoplasms. (2023)
  • Author(s): Matsumori T, Uza N, Shiokawa M, Maruno T, Seno H.
  • Journal Title: J Med Ultrason Volume: 50 Issue: 3 Pages: 451-452
  • DOI: 10.1007/s10396-023-01327-6
  • Peer Reviewed / Open Access
• [Journal Article] Brg1 controls stemness and metastasis of pancreatic cancer through regulating hypoxia pathway (2023)
  • Author(s): Araki Osamu、Tsuda Motoyuki、Omatsu Mayuki、Namikawa Mio、Sono Makoto、Fukunaga Yuichi、Masuda Tomonori、Yoshikawa Takaaki、Nagao Munemasa、Ogawa Satoshi、Masuo Kenji、Goto Norihiro、Muta Yu、Hiramatsu Yukiko、Maruno Takahisa、Nakanishi Yuki、Koyasu Sho、et al.
  • Journal Title: Oncogene Volume: 42 Issue: 26 Pages: 2139-2152
  • DOI: 10.1038/s41388-023-02716-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Innovative method for the diagnosis of bile duct lesions using a novel tapered-tip sheath system to facilitate biliary biopsies. (2023)
  • Author(s): Matsumori T, Uza N, Okada H, Shiokawa M, Maruno T, Kuwada T, Yoshida H, Yasuda M, Yamazaki H, Taura K, Hatano E, Kodama Y, Seno H.
  • Journal Title: Gastrointest Endosc Volume: 98 Issue: 1 Pages: 43-50
  • DOI: 10.1016/j.gie.2023.02.005
  • Peer Reviewed
• [Journal Article] On the origin of gastric tumours: analysis of a case with intramucosal gastric carcinoma and oxyntic gland adenoma (2023)
  • Author(s): Ken Kumagai, Takahiro Shimizu, Mitsuhiro Nikaido, Tomonori Hirano, Nobuyuki Kakiuchi, Yasuhide Takeuchi, Sachiko Minamiguchi, Takaki Sakurai, Mari Teramura, Takahiro Utsumi, Yukiko Hiramatsu, Yuki Nakanishi, Atsushi Takai, Shin'ichi Miyamoto, Seishi Ogawa, Hiroshi Seno
  • Journal Title: Journal of Pathology Volume: 259 Issue: 4 Pages: 362-368
  • DOI: 10.1002/path.6050
  • Peer Reviewed
• [Journal Article] Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells. (2023)
  • Author(s): Ueda T, Shiina S, Iriguchi S, Terakura S, Kawai Y, Kabai R, Sakamoto S, Watanabe A, Ohara K, Wang B, Xu H, Minagawa A, Hotta A, Woltjen K, Uemura Y, Kodama Y, Seno H, Nakatsura T, Tamada K, Kaneko S.
  • Journal Title: Nat Biomed Eng. Volume: 7(1) Pages: 24-37
  • DOI: 10.1038/s41551-022-00969-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Context-Dependent Roles of Hes1 in the Adult Pancreas and Pancreatic Tumor Formation. (2022)
  • Author(s): Marui S, Nishikawa Y, Shiokawa M, Yokode M, Matsumoto S, Muramoto Y, Ota S, Nakamura T, Yoshida H, Okada H, Kuwada T, Matsumori T, Kuriyama K, Fukuda A, Saur D, Aoi T, Uza N, Kodama Y, Chiba T, Seno H.
  • Journal Title: Gastroenterology. Volume: 163 Issue: 6 Pages: 1613-1629
  • DOI: 10.1053/j.gastro.2022.08.048
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Loss of Arid1a and Pten in Pancreatic Ductal Cells Induces Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway. (2022)
  • Author(s): Fukunaga Y, Fukuda A, Omatsu M, Namikawa M, Sono M, Masuda T, Araki O, Nagao M, Yoshikawa T, Ogawa S, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Ferrer J, Tsuruyama T, Masui T, Hatano E, Seno H.
  • Journal Title: Gastroenterology. Volume: 163 Issue: 2 Pages: 466-480
  • DOI: 10.1053/j.gastro.2022.04.020
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expansion of gastric intestinal metaplasia with copy number aberrations contributes to field cancerization (2022)
  • Author(s): Kumagai Ken、Shimizu Takahiro、Takai Atsushi、Kakiuchi Nobuyuki、Takeuchi Yasuhide、Hirano Tomonori、Takeda Haruhiko、Mizuguchi Aya、Teramura Mari、Ito Takahiko、Iguchi Eriko、Nikaido Mitsuhiro、Eso Yuji、Takahashi Ken、Ueda Yoshihide、Miyamoto Shin-ichi、Obama Kazutaka、Ogawa Seishi、Marusawa Hiroyuki、Seno Hiroshi
  • Journal Title: Cancer Research Volume: - Issue: 9 Pages: 1712-1723
  • DOI: 10.1158/0008-5472.can-21-1523
  • Peer Reviewed
• [Journal Article] Concurrent activation of Kras and canonical Wnt signaling induces premalignant lesions that progress to extrahepatic biliary cancer in mice (2022)
  • Author(s): Nagao M, Fukuda A, Omatsu M, Namikawa M, Sono M, Fukunaga Y, Masuda T, Araki O, Yoshikawa T, Ogawa S, Masuo K, Goto N, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Taketo MM, Ferrer J, Tsuruyama T, Nakanuma Y, Taura K, Uemoto S, Seno H.
  • Journal Title: Cancer Res. Volume: - Issue: 9 Pages: 1803-1817
  • DOI: 10.1158/0008-5472.can-21-2176
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Multiple pancreatic neuroendocrine tumors in OFCD syndrome caused by somatic BCOR mosaicism (2022)
  • Author(s): Yamauchi Y, Kodama Y, Kakiuchi N, Seno H
  • Journal Title: Pancreatology. Volume: 22 Issue: 2 Pages: 335-337
  • DOI: 10.1016/j.pan.2021.12.014
  • Peer Reviewed
• [Journal Article] A novel technique for mapping biopsy of bile duct cancer. (2021)
  • Author(s): Okada H, Uza N, Matsumori T, Matsumoto S, Muramoto Y, Ota S, Nakamura T, Yoshida H, Hirano T, Kuwada T, Marui S, Sogabe Y, Morita T, Kakiuchi N, Mima A, Ueda T, Nishikawa Y, Tsuda M, Maruno T, Shiokawa M, Takahashi K, Taura K, Minamiguchi S, Kodama Y, Seno H.
  • Journal Title: Endoscopy. Volume: 53 Issue: 06 Pages: 647-651
  • DOI: 10.1055/a-1248-2138
  • Peer Reviewed
• [Journal Article] Identification of an Anti?Integrin αvβ6 Autoantibody in Patients With Ulcerative Colitis (2021)
  • Author(s): Kuwada T, Shiokawa M, Kodama Y, Ota S, Kakiuchi N, Nannya Y, Yamazaki H, Yoshida H, Nakamura T, Matsumoto S, Muramoto Y, Yamamoto S, Honzawa Y, Kuriyama K, Okamoto K, Hirano T, Okada H, Marui S, Sogabe Y, Morita T, Matsumori T, Mima A, Nishikawa Y, Ueda T, Matsumura K, Uza N, Chiba T, Seno H
  • Journal Title: Gastroenterology Volume: - Issue: 7 Pages: 2383-2394
  • DOI: 10.1053/j.gastro.2021.02.019
  • NAID: 120006976020
  • Peer Reviewed / Open Access
• [Journal Article] Essential role of Notch/Hes1 signaling in postnatal pancreatic exocrine development (2021)
  • Author(s): Kuriyama K, Kodama Y, Shiokawa M, Nishikawa Y, Marui S, Kuwada T, Sogabe Y, Kakiuchi N, Tomono T, Matsumori T, Mima A, Morita T, Ueda T, Tsuda M, Yamauchi Y, Sakuma Y, Ota Y, Maruno T, Uza N, Kageyama R, Chiba T, Seno H.
  • Journal Title: Journal of Gastroenterology Volume: 56(7) Issue: 7 Pages: 673-687
  • DOI: 10.1007/s00535-021-01779-y
  • Peer Reviewed / Open Access
• [Journal Article] SNAIL2 contributes to tumorigenicity and chemotherapy resistance in pancreatic cancer by regulating IGFBP2 (2021)
  • Author(s): Masuo K, Chen R, Yogo A, Sugiyama A, Fukuda A, Masui T, Uemoto S, Seno H, Takaishi S.
  • Journal Title: Cancer Sci. Volume: 112 Issue: 12 Pages: 4987-4999
  • DOI: 10.1111/cas.15162
  • Peer Reviewed / Open Access
• [Presentation] THBS1による高悪性度大腸癌の微小環境制御機構の解明とその治療応用について (2023)
  • Author(s): 尾松万悠紀、中西祐貴、妹尾浩
  • Organizer: 第109回日本消化器病学会総会
• [Presentation] 小児炎症性腸疾患における抗インテグリンαVβ6抗体の意義 (2023)
  • Author(s): 村本雄哉、塩川雅広、妹尾浩
  • Organizer: 第109回日本消化器病学会総会
• [Presentation] MSH2は細胞周期を抑制することで肝癌の進行に抑制的に働くほか、脂質代謝にも影響を及ぼす (2023)
  • Author(s): 中野重治、髙井淳、上野真行、藤井洋佑、網野遥、伊藤卓彦、寺村茉利、三嶋眞紗子、井口恵里子、犬塚義、竹田治彦、清水孝洋、妹尾浩
  • Organizer: 第82回日本癌学会学術総会
• [Presentation] Regnase-1 は Nfkbiz mRNA を分解し IL-17 signaling を制御することで大腸腫瘍の発育を抑制する (2023)
  • Author(s): 井口恵里子、髙井淳、妹尾浩
  • Organizer: 第82回日本癌学会学術総会
• [Presentation] 肝細胞癌は多段階発がんの各段階でどのような変異シグネチャーを有するか？ (2023)
  • Author(s): 上野真行、竹田治彦、髙井淳、中野重治、波多野悦朗、妹尾浩
  • Organizer: 第82回日本癌学会学術総会
• [Presentation] TERTの発現上昇はｐ21のユビキチン化を介して細胞増殖を促進し肝発癌に寄与する (2023)
  • Author(s): 三嶋眞紗子、竹田治彦、上野真行、中野重治、井口恵里子、清水孝洋、髙井淳、妹尾浩
  • Organizer: 第82回日本癌学会学術総会
• [Presentation] 腸上皮化生におけるDNAメチル化異常が胃発癌に与える影響 (2023)
  • Author(s): 寺村茉利、清水孝洋、熊谷健、伊藤卓彦、網野遥、髙井淳、妹尾浩
  • Organizer: 第82回日本癌学会学術総会
• [Presentation] In situ vaccine combining TLR9 nanoligand K3-SPG and nearinfrared photoimmunotherapy evokes potent antitumor immunity (2023)
  • Author(s): Hiroaki Yaku, Ken Takahashi, Hirokazu Okada, Kouji Kobiyama, Keiko Iwaisako, Masataka Asagiri, Masahiro Shiokawa, Yuzo Kodama, Norimitsu Uza, Ken J. Ishii, Hiroshi Seno
  • Organizer: 第82回日本癌学会学術総会
• [Presentation] 膵癌オルガノイドにおけるERK MAPKシグナルの不均一性のライブイメージング (2023)
  • Author(s): 平塚 徹、塚本 祥子、アルコウサ ホウサム、待永 明仁、垣内 伸之、小川 誠司、妹尾 浩、東山 繁樹、松田 道行
  • Organizer: 第82回日本癌学会学術総会
• [Presentation] 同時性・異時性多発膵癌のクローン起源について (2023)
  • Author(s): 平野 智紀、垣内 伸之、竹内 康英、増井 俊彦、白石 友一、宮野 悟、宇座 徳光、児玉 裕三、増田 充弘、田中 雄志、妹尾 浩、小川 誠司
  • Organizer: 第82回日本癌学会学術総会
• [Presentation] THBS1 contributes to the creatoin of immunosuppressive microenvironment and promotes metastasis in colorectal cancer. (2023)
  • Author(s): Mayuki Omatsu, Yuki Nakanishi, Kenta Mizukoshi, Kosuke Iwane, Munenori Kawai, Go Yamakawa, Mio Namikawa, Makoto Sono, Tomonori Masuda, Munemasa Nagao, Takahisa Maruno, Hiroaki Kasashima, Masakazu Yashiro, Akihisa Fukuda, Hiroshi Seno.
  • Organizer: 第82回日本癌学会学術総会
• [Presentation] ARID1A has opposite functions in the conventional and serrated pathways in colon tumorigenesis. (2023)
  • Author(s): Go Yamakawa, Akihisa Fukuda, Kosuke Iwane, Munenori Kawai, Mayuki Omatsu, Mio Namikawa, Makoto Sono, Tomonori Masuda, Osamu Araki, Munemasa Nagao, Takaaki Yoshikawa, Takahisa Maruno, Yuki Nakanishi, Yukiko Hiramatsu, Hiroshi Seno.
  • Organizer: 第82回日本癌学会学術総会
• [Presentation] PBRM1/VIMENTIN axis is a critical determinant for tumor grade and metastasis in Pancreatic cancer. (2023)
  • Author(s): Munenori Kawai, Akihisa Fukuda, Yuki Nakanishi, Yukiko Hiramatsu, Makoto Sono, Tomonori Masuda, Mayuki Omatsu, Mio Namikawa, Go Yamakawa, Kosuke Iwane, Kenta Mizukoshi, Kei, Iimori, Shinnosuke Nakayama, Naoki Aoyama, Takahisa Maruno, Hiroshi Seno.
  • Organizer: 第82回日本癌学会学術総会
• [Presentation] The functional role of Kras, p53, canonical Wnt and Notch pathways in the tumorigenesis of extrahepatic biliary system. (2023)
  • Author(s): Munemasa Nagao, Akihisa Fukuada, Mio Namikawa, Kenta Mizukoshi, Shinnosuke Nakayama, Yukiko Hiramatsu, Takahisa Maruno, Yuki Nakanishi, Hiroshi Seno.
  • Organizer: 第82回日本癌学会学術総会
• [Presentation] 臨床検体を用いた網羅的遺伝子解析による肝発癌初期のゲノム異常の解析 (2023)
  • Author(s): 竹田治彦、髙井淳、妹尾浩
  • Organizer: JDDW2023
• [Presentation] THBS1による高悪性度大腸癌の微小環境制御機構の解明とその治療応用について (2023)
  • Author(s): 尾松万悠紀、中西祐貴、妹尾浩
  • Organizer: JDDW2023
• [Presentation] Simultaneous activation of Notch and Kras pathways leads to biliary cancer via premalignant lesions through mTOR pathway (2022)
  • Author(s): 並川実桜、福田晃久、薗誠、益田朋典、長尾宗政、平松由紀子、丸野貴久、中西祐貴、妹尾浩
  • Organizer: 第81回 日本癌学会学術総会
• [Presentation] Kras および WNT signaling の活性化により肝外胆管・胆嚢に前癌 病変が形成され、胆道癌に進展する (2022)
  • Author(s): 長尾 宗政、福田 晃久、水越 健太、岩根 康祐、河相 宗矩、山川 剛、尾松 万悠紀、並川 実桜、薗 誠、益田 朋典、平松 由紀子、 丸野 貴久、中西 祐貴、妹尾 浩
  • Organizer: 第81回 日本癌学会学術総会
• [Presentation] Reck suppresses pancreatic cancer formation, epithelial-mesenchymal transition and metastasis. (2022)
  • Author(s): Tomonori Masuda, Fukuda Akihisa, Sono Makoto, Fukunaga Yuichi, Yoshikawa Takaaki, Araki Osamu, Munemasa Nagao, Hiramatsu Yukiko, Ogawa Satoshi,Tsuda Motoyuki, Maruno Takahisa, Nakanishi Yuki, Matsuzaki Tomoko, Noda Makoto, Seno Hiroshi
  • Organizer: 第81回 日本癌学会学術総会
• [Presentation] Dual Loss of Arid1a and Pten in pancreatic ductal cells induces PDAC through activation of YAP/TAZ pathway. (2022)
  • Author(s): Fukunaga Yuichi, Fukuda Akihisa, Tomonori Masuda, Sono Makoto, Yoshikawa Takaaki, Araki Osamu, Munemasa Nagao, Hiramatsu Yukiko, Ogawa Satoshi, Tsuda Motoyuki, Maruno Takahisa, Nakanishi Yuki, Seno Hiroshi.
  • Organizer: The 7th JCA-AACR Special Joint Conference
  • Int'l Joint Research
• [Presentation] Insights into initiation and progression of PDAC. (2022)
  • Author(s): Akihisa Fukuda, Takahisa Maruno, Kyoichi Takaori, Hiroshi Seno
  • Organizer: American Pancreatic Association Annual meeting 2022
  • Int'l Joint Research
• [Presentation] 多段階発癌におけるミスマッチ修復異常関連体細胞変異シグネチャーの抽出 (2021)
  • Author(s): 竹田治彦、高井淳、恵荘裕嗣、高橋健、田浦康二朗、波多野悦朗、喜多竜一、丸澤宏之、藤本明洋、妹尾浩
  • Organizer: 第24回日本肝がん分子標的 治療研究会
• [Presentation] The mechanism of pancreatic cancer development. (2021)
  • Author(s): Akihisa Fukuda
  • Organizer: The 5th Annual conference of Al-Azhar Hepatogastroenterology club
  • Int'l Joint Research / Invited
• [Presentation] SETDB1 IS REQUIRED FOR FORMATION OF PANCREATIC DUCTAL ADENOCARCINOMA BY INHIBITING APOPTOSIS THROUGH REGULATION OF P53 EXPRESSION (2021)
  • Author(s): 小川智、福田晃久、妹尾浩
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] Bmi1 is required for pancreatic ductal adenocarcinoma formation through regulating PI3K/AKT pathway and acinar genes (2021)
  • Author(s): Makoto Sono, Akihisa Fukuda, Tomonori Masuda, Yuichi Fukunaga, Takaaki Yoshikawa, Osamu Araki, Munemasa Nagao, Satoshi Ogawa, Yukiko Hiramatsu, Takahisa Maruno, Yuki Nakanishi, Hiroshi Seno
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] 福永裕一、福田晃久、薗誠、益田朋典、吉川貴章、荒木理、長尾宗政、平松由紀子、小川智、丸野貴久、中西佑貴、鶴山竜昭、妹尾浩 (2021)
  • Author(s): Simultaneous loss of Arid1a and Pten in pancreatic ductal cells induces ITPN and PDAC through activation of YAP/TAZ
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] Reck suppresses pancreatic cancer formation, epithelial-mesenchymal transition and metastasis in mice. (2021)
  • Author(s): Tomonori Masuda, Fukuda Akihisa, Sono Makoto, Fukunaga Yuichi, Yoshikawa Takaaki, Araki Osamu, Munemasa Nagao, Hiramatsu Yukiko, Ogawa Satoshi,Tsuda Motoyuki, Maruno Takahisa, Nakanishi Yuki, Matsuzaki Tomoko, Noda Makoto, Seno Hiroshi.
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] Analysis of pancreato-biliary cancer development using mice and organoids (2021)
  • Author(s): Hiroshi Seno, Munemasa Nagao, Yuichi Fukunaga, Satoshi Ogawa, Takahisa Maruno, Akihisa Fukuda
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] クロマチン制御因子Brg1は膵癌の増大・転移に重要である (2021)
  • Author(s): 荒木理、福田晃久、妹尾浩
  • Organizer: 第107回日本消化器病学会総会
• [Remarks] 京都大学消化器内科ウェブサイト
  • URL: https://gastro.kuhp.kyoto-u.ac.jp/