Mechanisms of left-right asymmetry formation and its physiological significance

• Project/Area Number: 22240036
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: National Institute for Physiological Sciences
• Principal Investigator: SHIGEMOTO Ryuichi 生理学研究所, 大脳皮質機能研究系, 教授 (20221294)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥50,440,000 (Direct Cost: ¥38,800,000、Indirect Cost: ¥11,640,000); Fiscal Year 2012: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000); Fiscal Year 2011: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000); Fiscal Year 2010: ¥21,580,000 (Direct Cost: ¥16,600,000、Indirect Cost: ¥4,980,000)
• Keywords: 左右非対称性 / 海馬 / シナプス / グルタミン酸 / 空間学習 / グルタミン酸受容体

Research Abstract

To elucidate the mechanism of left-right asymmetry formation, we identified three lines of mutant mice (CA1-specific NR2B knockout mouse, CA1-specific GluR1 knockout mouse, beta2 microglobulin knockout mouse) that lack the laterality of hippocampal pyramidal cell synapses. To elucidate the physiological significance of the asymmetry, we examined spatial learning ability in mice and discovered right-side dominance. Expression of c-fos in the dentate gyrus was also dominant in the right side of the brain. Using these parameter we are now examining the phenotype of mutant mice lacking asymmetry of the pyramidal cell C-Tn2 CPC

Research Products

• [Journal Article] Neuronal major histocompatibility complex class I molecules are implicated in the generation of asymmetries in hippocampal circuitry (2013)
  • Author(s): Kawahara A, Kurauchi S, Fukata Y, Martinez-Hernandez J, Yagihashi T, Itadani Y, Sho R, Ka j iyama T, Shinzato N, Narusuye K, Fukata M, Lujan R, Shigemoto R, Ito I
  • Journal Title: Journal of Physiology Volume: (in press)
  • NAID: 120005315161
  • Peer Reviewed
• [Journal Article] Right-hemispheric dominance of spatial memory in split-brain mice (2012)
  • Author(s): Shinohara Y, Hosoya A, Yamasaki N, Ahmed H, Hattori S, Eguchi M, Yamaguchi S, Miyakawa T, Hirase H , Shigemoto R
  • Journal Title: Hippocampus Volume: 22巻 Pages: 117-121
  • Peer Reviewed
• [Journal Article] Right-hemispheric dominance of spatial memory in split-brain mice (2012)
  • Author(s): Shigemoto R
  • Journal Title: Hippocampus Volume: 21
  • Peer Reviewed