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Development of advanced bioimaging technology based on integration of optics and ultrasound by spatio-temporal modulation

Research Project

Project/Area Number 22240063
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionKyoto University

Principal Investigator

SHIINA Tsuyoshi  京都大学, 医学研究科, 教授 (40192603)

Co-Investigator(Kenkyū-buntansha) YAMAKAWA Makoto  京都大学, 学際融合教育研究推進センター, 特定准教授 (60344876)
TOI Masakazu  京都大学, 医学研究科, 教授 (10207516)
NITTA Naotaka  産業技術総合研究所, 人間福祉医工学研究部門, 研究員 (60392643)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥40,170,000 (Direct Cost: ¥30,900,000、Indirect Cost: ¥9,270,000)
Fiscal Year 2012: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2011: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2010: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Keywords超音波医科学 / 可視化 / 計測工学 / 生物・生体工学 / 医療・福祉 / 非侵襲可視化技術 / 光計測 / 超音波計測 / 光音響イメージング / 医用画像計測 / 癌
Research Abstract

We investigated development of the advanced bioimaging method by integration of optics and ultrasound technologies which have common merits such as non-invasive, easy-to-use and real-time. Based onthe interaction between optics and ultrasound, i.e., the modulation of ultrasound by coded excitation of optical pulse, and the control of optical scattering by ultrasound-modulated optics, we developed fundamental technologies for the advanced photo-acoustic imaging with high SNR, temporal resolution and large measurable depth. The performance of proposed methods was validated by simulation and phantom experiments.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (27 results)

All 2013 2012 2011 2010

All Journal Article (11 results) (of which Peer Reviewed: 10 results) Presentation (14 results) Book (2 results)

  • [Journal Article] Simultaneous Multispectral Coded Excitation Using Gold Codes for Photoacoustic Imaging2012

    • Author(s)
      Haichong Zhang, Kengo Kondo, Makoto Yamakawa, Tsuyoshi Shiina
    • Journal Title

      Jpn. J. Appl. Phys

      Volume: Vol. 51 Issue: 7S Pages: 07GF03-07GF03

    • DOI

      10.1143/jjap.51.07gf03

    • NAID

      210000140975

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 光と超音波の融合による医用イメージング技術の新たな展開2012

    • Author(s)
      椎名 毅
    • Journal Title

      日本レーザー医学会誌

      Volume: Vol. 33, No.4 Pages: 367-373

    • NAID

      10031161992

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanical Model Analysis for Quantitative Evaluation of Liver Fibrosis Based on Ultrasound Tissue Elasticity Imaging2012

    • Author(s)
      T.Shiina
    • Journal Title

      Jpn. J. Appl. Physics.

      Volume: 51 Issue: 7S Pages: 07GF11-07GF11

    • DOI

      10.1143/jjap.51.07gf11

    • NAID

      210000140983

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 超音波で硬さを測る:超音波エラストグラフィの理論と実際2012

    • Author(s)
      椎名 毅
    • Journal Title

      成人病と生活習慣病

      Volume: 42 Pages: 769-778

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Model-Based Reconstruction IntegratedWith Fluence Compensation for Photoacoustic Tomography2012

    • Author(s)
      S.Bu
    • Journal Title

      IEEE Trans. on Biomedical Engineering

      Volume: 59 Pages: 1354-1363

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High Range Resolution Ultrasonographic Vascular Imaging Using Frequency Domain Interferometry with the Capon Method2012

    • Author(s)
      H.Taki, K.Taki, T.Sakamoto, M.Yamakawa, T.Shi ina, M.Kudo, T.Sato
    • Journal Title

      IEEE Trans.Med.Imaging

      Volume: 31 Issue: 2 Pages: 417-429

    • DOI

      10.1109/tmi.2011.2170847

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adaptive and quantitative reconstruction algorithm for photoacoustic tomography2011

    • Author(s)
      Shuhui Bu
    • Journal Title

      Proc.of SPIE

      Volume: 7,899 Pages: 78992G-78992G

    • DOI

      10.1117/12.871436

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Combinational Method of Laser and Hydrophone Measurements in A Combinational Method of Laser and Hydrophone Measurements in Ultrasound Propagation for Evaluating Elasticity of Regenerating Cartilage Sample2010

    • Author(s)
      Naotaka. Nitta, Kazuhiko Homma, Masaki Misawa, K. Hoshi, Shuhui. Bu, and Tsuyoshi. Shiina
    • Journal Title

      Proc. of 2010 IEEE Int. Ultrasonics Symp

      Pages: 1400-1403

    • DOI

      10.1109/ultsym.2010.5935566

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adaptive Depth Compensation Algorithm for Photoacoustic Tomography2010

    • Author(s)
      Shuhui Bu
    • Journal Title

      Proc.of 2010 IEEE Ultrasonics Symposium

      Volume: 1巻(印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual illumination mode photoacoustic tomography for quantitative imaging2010

    • Author(s)
      Kazuhiko Fukutani
    • Journal Title

      Proc.of 2010 IEEE Ultrasonics Symposium

      Volume: 1巻

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myocardial strain imaging with high-performance adaptive dynamic grid interpolation method2010

    • Author(s)
      Shuhui Bu
    • Journal Title

      Jpn.J.Appl.Phys

      Volume: 49巻

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Simultaneous Multispectral Coded Excitation Using Periodic and Unipolar M-sequences for Photoacoustic Imaging2013

    • Author(s)
      Haichong Zhang, Kengo Kondo, Makoto Yamakawa, Tsuyoshi Shiina
    • Organizer
      SPIE Photonics West 2013-BiOS
    • Place of Presentation
      San Francisco
    • Year and Date
      2013-02-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Simultaneous Multispectral Coded Excitation Using Periodic and Unipolar M-sequence for Photoacoustic Imaging2013

    • Author(s)
      H. Zhang
    • Organizer
      SPIE Photonics West BiOS 2013
    • Place of Presentation
      San Francisco
    • Related Report
      2012 Annual Research Report
  • [Presentation] 光超音波イメージングにおける符号化多波長同時励起法の実験的検討2012

    • Author(s)
      張海崇、近藤健悟、山川 誠、椎名 毅
    • Organizer
      日本超音波医学会第85回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-05-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Simultaneous Multispectral Coded Excitation for Photoacoustic Imaging2012

    • Author(s)
      H. Zhang
    • Organizer
      2012 IEEE International Ultrasonics Symposium
    • Place of Presentation
      Dresden
    • Related Report
      2012 Annual Research Report
  • [Presentation] Experimental Evaluation of Simultaneous Multispectral Coded excitation for Photoacoustic Imaging2012

    • Author(s)
      H. Zhang
    • Organizer
      The 11th International Tissue Elasticity Conferences
    • Place of Presentation
      Deauville
    • Related Report
      2012 Annual Research Report
  • [Presentation] Experimental Evaluation of Simultaneous Multispectral Photoacoustic Imaging by Coded Excitation2012

    • Author(s)
      H. Zhang
    • Organizer
      The 85th Annual Scientific Meeting of the Japan Society of Ultrasonics in Medicine
    • Place of Presentation
      Tokyo
    • Related Report
      2012 Annual Research Report
  • [Presentation] A Fast Acoustic Field Mapping Approach Based on Fabry–Perot Sensor with High–Speed CMOS Camera2012

    • Author(s)
      B Cong
    • Organizer
      The 11th International Tissue Elasticity Conferences
    • Place of Presentation
      Deauville
    • Related Report
      2012 Annual Research Report
  • [Presentation] 光超音波イメージングのためのGold Code符号化による多波長同時励起法2011

    • Author(s)
      張海崇
    • Organizer
      第32回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Place of Presentation
      京都大学百周年時計台記念館(京都)
    • Year and Date
      2011-11-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 仮想双曲線走査による2次元変調を用いた変位ベクトル計測の実験的検討2011

    • Author(s)
      近藤健悟
    • Organizer
      第32回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Place of Presentation
      京都大学百周年時計台記念館(京都)
    • Year and Date
      2011-11-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 3-D平面走査光超音波トモグラフィーのための定量的な再構成方法2011

    • Author(s)
      Shuhui Bu
    • Organizer
      日本超音波医学会第84回学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 光超音波マンモグラフィを用いた乳癌診断法の開発2011

    • Author(s)
      鍛利幸
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京電機大学(東京)
    • Year and Date
      2011-04-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Adaptive and Quantitative Reconstruction Algorithm for Photoacoustic Tomography2011

    • Author(s)
      Shuhui Bu
    • Organizer
      SPIE Photonics West 2010-BiOS
    • Place of Presentation
      サンフランシスコU.S.A
    • Year and Date
      2011-01-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] "Interpolation Method for Model-based 3-D Planar Photoacoustic Tomography Reconstruction2010

    • Author(s)
      Shuhui Bu, Makoto Yamakawa, and Tsuyoshi Shiina
    • Organizer
      The Biomedical Engineering International Conference
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-08-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Interpolation method for mode-based 3-D planar photoacoustic tomography reconstruction2010

    • Author(s)
      Shuhui Bu
    • Organizer
      The Biomedical Engineering International Conference 2010
    • Place of Presentation
      京都大学
    • Year and Date
      2010-07-23
    • Related Report
      2010 Annual Research Report
  • [Book] 医用画像解析ハンドブック2012

    • Author(s)
      椎名毅
    • Total Pages
      835
    • Publisher
      オーム社
    • Related Report
      2012 Annual Research Report
  • [Book] 医用画像ハンドブック(第6編超音波画像)2010

    • Author(s)
      椎名毅
    • Publisher
      オーム社
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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