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Study on the hydration structural changes in coupling with the internal motions of proteins using time-resolved fluorscence measurement

Research Project

Project/Area Number 22244054
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biophysics/Chemical physics
Research InstitutionKeio University

Principal Investigator

NAKASAKO Masayoshi  慶應義塾大学, 理工学部, 教授 (30227764)

Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥48,100,000 (Direct Cost: ¥37,000,000、Indirect Cost: ¥11,100,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥36,140,000 (Direct Cost: ¥27,800,000、Indirect Cost: ¥8,340,000)
Keywordsタンパク質水和 / 水和構造 / 分子動力学シミュレーション / 蛍光分光 / 和周波測定 / 非線形光学 / X線結晶構造解析 / 主成分分析 / 蛋白質水和構造 / 水和構造解析 / ドメイン運動 / 溶媒応答 / トリプトファン蛍光 / 分子動力学計算 / 水素結合 / 時間分解蛍光測定 / 和周波 / X線小角度散乱 / タンパク質 / 和周波分光 / X線小角散乱 / 溶媒応答関数 / 低温X線結晶構造解析 / 蛍光発光 / 蛋白質水和 / 悲線形光学現象 / 結晶構造解析 / 遺伝子組み換え / 溶媒応咎関数 / 溶媒和 / フェムト秒レーザー
Research Abstract

Proteins are engaged in the elementary processes of life in cells and fold and function only in aqueous environment. To understand why water is indispensable for proteins it is necessary to visualize the hydration structures of proteins at spatial resolution of atomic level and ps temporal resolution. In this research project, through developing time-resolved fluorescence measurement system dedicated for proteins, we analyzed the dynamics of protein hydration from the experimental point of view using the fluorescence measurement and structure analyses as well as molecular dynamics simulation.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (76 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (22 results) (of which Peer Reviewed: 22 results) Presentation (48 results) (of which Invited: 12 results) Book (3 results) Remarks (3 results)

  • [Journal Article] Light-induced conformational changes of LOV (Light Oxygen Voltage-sensing domain) 1 and LOV2 relative to the kinase domain and regulation of kinase activity in Chlamydomonas phototropin.2014

    • Author(s)
      Okajima, K., Y. Aihara, Y. Takayama, M. Nakajima, S. Kashojiya, T. Hikima, T. Oroguchi, A. Kobayashi, Y. Sekiguchi, M. Yamamoto, T. Suzuki, A. Nagatani, M. Nakasako and S. Tokutomi
    • Journal Title

      J. Biol. Chem

      Volume: 289 Issue: 1 Pages: 413-422

    • DOI

      10.1074/jbc.m113.515403

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of empirical hydration distribution functions around polar atoms for assessing hydration structures of proteins2013

    • Author(s)
      D. Matsuoka and M. Nakasako
    • Journal Title

      Chemical Physics

      Volume: 419 Pages: 59-64

    • DOI

      10.1016/j.chemphys.2012.12.040

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional structure determination protocol for non-crystalline biomolecules using x-ray free-electron laser diffraction imaging2013

    • Author(s)
      T. Oroguchi and M. Nakasako
    • Journal Title

      Physical Review E

      Volume: 87

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 先端的X線光源による細胞の空間階層イメージング2013

    • Author(s)
      中迫雅由, 山本雅貴
    • Journal Title

      パリティ

      Volume: 28, No. 7 Pages: 16-19

    • URL

      http://pub.maruzen.co.jp/book_magazine/magazine/parity-back/parity2013/2013_07/1307_cont.html

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 蛋白質水和構造の実験研究2013

    • Author(s)
      中迫雅由, 苙口友隆, 高山裕貴, 中島真, 松井夕花
    • Journal Title

      アンサンブル

      Volume: 15 Pages: 7-18

    • NAID

      130004566739

    • URL

      http://mol-sim.c.ooco.jp/

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 蛋白質極性原子周辺の水分子分布 -データベース解析と水和構造予測―2013

    • Author(s)
      松岳大輔、中迫雅由
    • Journal Title

      アンサンブル

      Volume: 15 Pages: 19-27

    • NAID

      130004566740

    • URL

      http://mol-sim.c.ooco.jp/

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 経験的水和分布関数の構築と蛋白質水和構造予測への応用2013

    • Author(s)
      松岳大輔、中迫雅由
    • Journal Title

      タンパク質結晶の最前線(シーエムシー出版)

      Volume: なし Pages: 221-229

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional structure determination protocol for noncrystalline biomolecules using x-ray free-electron laser diffraction imaging2013

    • Author(s)
      T. Oroguchi and M. Nakasako
    • Journal Title

      Physical Review E

      Volume: 87

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BCR/抗体による認識 (第二部 構成的メカニズム:認識のメカニズム)2013

    • Author(s)
      中迫雅由
    • Journal Title

      標準免疫学

      Volume: 第三版 Pages: 107-114

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 蛋白質極性原子周辺の水分子分布 -データベース解析と水和構造予測―2013

    • Author(s)
      松岳大輔、中迫雅由
    • Journal Title

      アンサンブル

      Volume: 15 Pages: 19-27

    • NAID

      130004566740

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Humidity-controlled preparation of frozen-hydrated biological samples for cryogenic coherent X-ray diffraction microscopy2012

    • Author(s)
      Y. Takayama and M. Nakasako
    • Journal Title

      Review of Scientific Instruments

      Volume: 83 Issue: 5

    • DOI

      10.1063/1.4718359

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A few low-frequency normal modes predominantly contribute to conformational responses of hen egg white lysozyme in the tetragonal crystal to variations of molecular packing controlled by environmental humidity2011

    • Author(s)
      Y.Takayama, M.Nakasako
    • Journal Title

      Biophysical Chemistry

      Volume: 159 Issue: 2-3 Pages: 237-246

    • DOI

      10.1016/j.bpc.2011.07.001

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New monoclinic form of bovine pancreatic ribonuclease A from a high-salt solution and intermolecular interactions2011

    • Author(s)
      H.Takusagawa, S. Yamamura, S. Endo, Y. Sugawara, T. Inagaki, and M. Nakasako
    • Journal Title

      Journal of Crystal Growth

      Volume: 319 Issue: 1 Pages: 49-56

    • DOI

      10.1016/j.jcrysgro.2011.01.037

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Light-induced movement of the LOV2 domain in an Asp720Asn-mutated LOV2-kinase fragment of Arabidopsis phototropin 22011

    • Author(s)
      Y.Takayama, M.Nakasako, K.Okajima, A.Iwata, S.Kashojiya, Y.Matsui, S.Tokutomi
    • Journal Title

      Biochemistry

      Volume: 50 Issue: 7 Pages: 1174-1183

    • DOI

      10.1021/bi101689b

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 生命にはなぜ水が必要なのか-たんぱく質の機能と水和構造の相関2011

    • Author(s)
      中迫雅由、松岳大輔
    • Journal Title

      応用物理

      Volume: 80 Pages: 903-907

    • NAID

      10029623197

    • URL

      http://www.jsap.or.jp/ap/2011/10/ob800903.xml

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of a real-space three-dimensional image reconstruction method in the structural analysis of non-crystalline biological macromolecules enveloped by water in coherent X-ray diffraction microscopy2011

    • Author(s)
      W.Kodama, M.Nakasako
    • Journal Title

      Physical Review E

      Volume: 84 Issue: 2

    • DOI

      10.1103/physreve.84.021902

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生命には何故水が必要なのか-蛋白質の機能と水和構造の相関2011

    • Author(s)
      中迫雅由、松岳大輔
    • Journal Title

      日本応用物理学会誌

      Volume: 80 Pages: 903-907

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] X線自由電子レーザー(XFEL)の生命科学での利用2011

    • Author(s)
      中迫雅由、山本雅貴
    • Journal Title

      日本生物物理学会誌

      Volume: 51 Pages: 278-281

    • NAID

      10030038033

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Light-induced movement of the LOV2 domain in an Asp720Asn-mutated LOV2-kinase fragment of Arabidopsis phototropin 22011

    • Author(s)
      Y.Takayama, M.Nakasako, K.Okajima, A.Iwata, S.Kashojiya, Y.Matsui, S.Tokutomi
    • Journal Title

      Biochemistry

      Volume: 50 Pages: 1174-1183

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New monoclinic form of bovine pancreatic ribonuclease A from a salt solution and comparison of intermolecular interactions in ribonucleases A2011

    • Author(s)
      H.Takusagawa, S.Yamamura, S.Endo, Sugawara, T.Inagaki, M.Nakasako
    • Journal Title

      Journal of Crystal Growth

      Volume: 319 Pages: 49-56

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of a real-space three-dimensional image reconstruction method in the structural analysis of non-crystalline biological macromolecules enveloped by water in coherent X-ray diffraction microscopy2011

    • Author(s)
      W.Kodama, M.Nakasako
    • Journal Title

      Physical Review E

      Volume: (掲載決定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Redox-dependent domain rearrangement of protein disulfide isomerase from a thermophilic fungus2010

    • Author(s)
      M.Nakasako, A.Maeno, E.Kurimoto, T.Harada, Y.Yamaguchi, T.Oka, Y.Takayama, A.Iwata, K.Kato
    • Journal Title

      Biochemistry

      Volume: 49 Pages: 6953-6962

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Empirical hydration distribution functions around polar atoms for studying hydration structures of proteins2013

    • Author(s)
      D. Matsuoka and M. Nakasako
    • Organizer
      The 13-th Korea Institute of Advanced Study (KIAS) Conference
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2013-09-26
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 分子動力学計算によるグルタミン酸脱水素酵素ドメイン運動に協奏した水和構造変化の観察2013

    • Author(s)
      苙口友隆, 中島 真, 中迫雅由
    • Organizer
      第13回日本蛋白質科学会年会
    • Place of Presentation
      鳥取
    • Year and Date
      2013-06-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Cryogenic X-ray diffraction for illustrating hierarchical structures in cells2013

    • Author(s)
      M. Nakasako
    • Organizer
      International Symposium on Protein Folding and its Biological Significance
    • Place of Presentation
      Okazaki, Japan
    • Year and Date
      2013-03-05
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 経験的水和分布関数の構築と水和構造予測への応用2013

    • Author(s)
      中迫雅由, 松岳大輔
    • Organizer
      情報計算化学生物学会
    • Place of Presentation
      東京
    • Year and Date
      2013-02-15
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Invited
  • [Presentation] Cryogenic X-ray diffraction for illustrating hierarchical structures in cell2013

    • Author(s)
      M. Nakasako
    • Organizer
      International Symposium on Protein Folding and its Biological Significance
    • Place of Presentation
      Okazaki, Japan
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] タンパク質疎水性表面に関する水和構造予測アルゴリズムの開発2013

    • Author(s)
      中迫雅由、松岳大輔
    • Organizer
      特定領域 高次分子系 成果公開シンポジウム
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] A protocol for structure analysis of non-crystalline particles with X-ray free electron laser2012

    • Author(s)
      T. Oroguchi, M. Nakasako
    • Organizer
      生物物理学会第50回年会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-23
    • Related Report
      2013 Final Research Report
  • [Presentation] タンパク質疎水性表面に関する水和構造予測アルゴリズムの開発2012

    • Author(s)
      中迫雅由, 松岳大輔
    • Organizer
      特定領域高次分子系成果公開シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2012-05-26
    • Related Report
      2013 Final Research Report
  • [Presentation] Static and Dynamical Pictures of Protein Hydration - to understadn why water is indispensable for structures and functions of proteins2012

    • Author(s)
      M. Nakasako
    • Organizer
      JST International Symposium on Multi-scale Simulation of Condensed-phase Reacting Systems
    • Place of Presentation
      Nagoya
    • Year and Date
      2012-05-11
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] XFELで超分子複合体の構造解析は可能か?2012

    • Author(s)
      中迫雅由、笠口友隆、高山裕貴、山本雅貴
    • Organizer
      新学術領域"天然変性"第二回公開シンポジウム
    • Place of Presentation
      大阪(招待講演)
    • Year and Date
      2012-01-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] コヒーレントX線回折顕微鏡実験における位相限定相関を用いたデータ解析手法の開発2012

    • Author(s)
      関口優希、高山裕貴、中迫雅由
    • Organizer
      第25回日本放射光学会年会・放射光科学合同シンポジウム
    • Place of Presentation
      鳥栖
    • Year and Date
      2012-01-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] コヒーレントX線回折顕微鏡法回折パターンにおけるCCD検出器の電荷転送に由来するバックグラウンドの評価2012

    • Author(s)
      高山裕貴、中迫雅由
    • Organizer
      第25回日本放射光学会年会・放射光科学合同シンポジウム
    • Place of Presentation
      鳥栖
    • Year and Date
      2012-01-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] クライオ試料照射装置の整備・高度化と低温回折実験2012

    • Author(s)
      中迫雅由、高山裕貴、笠口友隆、関口優希、児玉渉、山本雅貴、香村芳樹、引間孝明、米倉功治、高橋幸生、鈴木明大
    • Organizer
      第25回日本放射光学会年会・放射光科学合同シンポジウム
    • Place of Presentation
      鳥栖
    • Year and Date
      2012-01-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] X線自由電子レーザーによる生体超分子の新規構造解析法の提案及びシミュレーション2012

    • Author(s)
      苙口友隆, 中迫雅由
    • Organizer
      第25回日本放射光学会年会・放射光科学合同シンポジウム
    • Place of Presentation
      鳥栖
    • Year and Date
      2012-01-08
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] Static and Dynamical Pictures of Protein Hydration - to understadn why water is2012

    • Author(s)
      M. Nakasako
    • Organizer
      JST International Symposium on Multi-scale Simulation of Condensed-phase
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] X線波の干渉で分子の姿・かたちを調べる2012

    • Author(s)
      中迫雅由
    • Organizer
      理研/JASRI サイエンスサマーキャンプ
    • Place of Presentation
      播磨
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] X線自由電子レーザー(SACLA)を用いたバイオサイエンスの展開2012

    • Author(s)
      中迫雅由
    • Organizer
      味の素株式会社 イノベーション研究所 セミナー
    • Place of Presentation
      川崎
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] X線自由電子レーザーを用いるサブミクロン粒子のナノメートル分解能構造解析2011

    • Author(s)
      中迫雅由
    • Organizer
      蛋白質構造解析コンソーシアム
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 低温コヒーレントX線回折顕微鏡法の為の湿度制御下凍結水和生体試料作製装置の開発2011

    • Author(s)
      高山裕貴, 中迫雅由
    • Organizer
      日本結晶学会年会2011
    • Place of Presentation
      札幌
    • Year and Date
      2011-11-25
    • Related Report
      2013 Final Research Report
  • [Presentation] X線自由電子レーザーの生命科学での利用2011

    • Author(s)
      中迫雅由、山本雅貴
    • Organizer
      日本結晶学会年会2011
    • Place of Presentation
      札幌(招待講演)
    • Year and Date
      2011-11-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 低温コヒ-レントX線回折顕微鏡法の為の湿度制御下凍結水和生体試料作製装置の開発2011

    • Author(s)
      高山裕貴、中迫雅由
    • Organizer
      日本結晶学会年会2011
    • Place of Presentation
      札幌
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Preparation method of frozen-hydrated biological samples under controlled humidity for coherent X-ray diffraction microscopy2011

    • Author(s)
      Y. Takayama and M. Nakasako
    • Organizer
      生物物理学会第49回年会
    • Place of Presentation
      姫路
    • Year and Date
      2011-09-17
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] Coherent X-ray diffraction microscopy of non-crystalline biological particles at cryogenic temperature2011

    • Author(s)
      M.Nakasako, M.Yamamoto
    • Organizer
      生物物理学会第49回年会
    • Place of Presentation
      姫路(招待講演)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] タンパク質の結晶化:結晶化条件スクリーニングの基礎-フォトトロピンLOV1ドメインの結晶化を例に-2011

    • Author(s)
      中迫雅由
    • Organizer
      新学術領域「植物環境感覚」タンパク質構造解析ワークショップ
    • Place of Presentation
      堺(招待講演)
    • Year and Date
      2011-09-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] X線小角散乱:どのような分子構造情報が得られるか?-フォトトロピンフラグメントを例に-2011

    • Author(s)
      中迫雅由
    • Organizer
      新学術領域「植物環境感覚」タンパク質構造解析ワークショップ
    • Place of Presentation
      堺(招待講演)
    • Year and Date
      2011-09-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] データベース解析による蛋白質水和構造の特徴抽出とその応用2011

    • Author(s)
      松岳大輔, 中迫雅由
    • Organizer
      放射光学会第3回若手研究会
    • Place of Presentation
      姫路
    • Year and Date
      2011-08-18
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] バイオサイエンスで想定されるXFEL利用実験2011

    • Author(s)
      中迫雅由
    • Organizer
      シンポジウム「X線自由電子レーザー」
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2011-04-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] XFEL生体非結晶粒子構造解析用低温回折装置2011

    • Author(s)
      中迫雅由
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡(招待講演 中止となったが、発表は成立)
    • Year and Date
      2011-03-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] Coherent X-ray diffraction microscopy for structural studies of biological particles2011

    • Author(s)
      M.Nakasako
    • Organizer
      第52回日本植物生理学会
    • Place of Presentation
      仙台(invited 中止となったが、発表は成立)
    • Year and Date
      2011-03-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 植物青色光受容体フォトトロピン2 の立体構造研究2011

    • Author(s)
      中迫雅由, 高山裕貴, 岩田彩, 松井夕花, 岡島公司, 嘉祥寺谷幸子, 徳富哲
    • Organizer
      第24回日本放射光学会年会放射光科学合同シンポジウム
    • Place of Presentation
      つくば
    • Year and Date
      2011-01-09
    • Related Report
      2013 Final Research Report
  • [Presentation] コヒーレントX線回折顕微鏡法による生体単粒子構造解析に向けた三次元像回復シミュレーション2011

    • Author(s)
      児玉渉、中迫雅由
    • Organizer
      第24回日本放射光学会年会放射光科学合同シンポジウム
    • Place of Presentation
      つくば
    • Year and Date
      2011-01-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] コヒーレントX線回折顕微鏡実験に向けた湿度制御下生体粒子凍結試料作製装置の開発2011

    • Author(s)
      高山裕貴、中迫雅由
    • Organizer
      第24回日本放射光学会年会放射光科学合同シンポジウム
    • Place of Presentation
      つくば
    • Year and Date
      2011-01-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] コヒーレントX線回折実験のためのコンパクトなクライオ生体試料照射装置の開発2011

    • Author(s)
      鈴木茂之、山本雅貴、中迫雅由
    • Organizer
      第24回日本放射光学会年会放射光科学合同シンポジウム
    • Place of Presentation
      つくば
    • Year and Date
      2011-01-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] XFEL用クライオ試料照射装置を用いたX線回折実験2011

    • Author(s)
      中追雅由、山本雅貴、西野吉則、高山裕貴、坂本啓太、児玉渉、鈴木茂之、松井夕花、米倉功治、眞木さおり、引間孝明、高橋幸生、久保英人、堤良輔、榊茂之
    • Organizer
      第24回日本放射光学会年会放射光科学合同シンポジウム
    • Place of Presentation
      つくば
    • Year and Date
      2011-01-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 植物青色光受容体フォトトロピン2の立体構造研究2011

    • Author(s)
      中迫雅由、高山裕貴、岩田彩、松井夕花、岡島公司、嘉祥寺谷幸子、徳富哲
    • Organizer
      第24回日本放射光学会年会放射光科学合同シンポジウム
    • Place of Presentation
      つくば
    • Year and Date
      2011-01-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] RNaseA 新規三斜晶の構造と分子間相互作用の解析2010

    • Author(s)
      田草川英昇, 山村滋典, 猿渡茂, 菅原洋子, 稲垣敏幸, 中迫雅由
    • Organizer
      平成22年度日本結晶学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-03
    • Related Report
      2013 Final Research Report
  • [Presentation] RNaseA新規三斜晶の構造と分子間相互作用の解析2010

    • Author(s)
      田草川英昇、山村滋典、猿渡茂、菅原洋子、稲垣敏幸、中迫雅由
    • Organizer
      平成22年度日本結晶学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] タンパク質疎水性表面に関する水和構造予測アルゴリズムの開発2010

    • Author(s)
      松岳大輔, 中迫雅由
    • Organizer
      特定領域「高次系分子科学」第四回公開シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2010-11-25
    • Related Report
      2013 Final Research Report 2010 Annual Research Report
  • [Presentation] Coherent X-ray diffraction microscopy of non-crystalline biological particles at cryogenic temperatures2010

    • Author(s)
      M.Nakasako, M.Yamamoto, Y Takayama, W.Kodama, K.Sakamoto, Y Nishino, K.Yonekura, K.Maeshima, K.Shirahama, K.Namba
    • Organizer
      The 3rd Workshop on FEL Science : Emerging X-ray Applications in Biological Systems-II
    • Place of Presentation
      北湯沢、北海道(invited)
    • Year and Date
      2010-10-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 経験的水和分布関数を用いた水和水分子位置の評価2010

    • Author(s)
      松岳大輔, 高山裕貴, 中迫雅由
    • Organizer
      第48回日本生物物理学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-22
    • Related Report
      2013 Final Research Report 2010 Annual Research Report
  • [Presentation] X線自由電子レーザーは生物の研究に役立つの?2010

    • Author(s)
      中迫雅由
    • Organizer
      第6回X線自由電子レーザーシンポジウム
    • Place of Presentation
      大阪(招待講演)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] XFEL非結晶ナノ粒子構造研究の準備状況と将来展望2010

    • Author(s)
      中迫雅由
    • Organizer
      第5回XFEL利用ワークショップ
    • Place of Presentation
      播磨(招待講演)
    • Year and Date
      2010-07-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 経験的水和水分布関数を用いた蛋白質水和構造予測2010

    • Author(s)
      松岳大輔, 中迫雅由
    • Organizer
      第10回日本蛋白質科学会
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-17
    • Related Report
      2013 Final Research Report 2010 Annual Research Report
  • [Presentation] 蛋白質結晶湿度制御装置の開発と蛋白質運動性制御への応用2010

    • Author(s)
      高山裕貴, 中迫雅由
    • Organizer
      第10回日本蛋白質科学会
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-17
    • Related Report
      2013 Final Research Report 2010 Annual Research Report
  • [Presentation] Coherent X-ray diffraction imaging of non-crystalline particles with sub-micrometer dimensions

    • Author(s)
      M. Nakasako, Y. Takayama, T. Oroguchi, Y. Sekiguchi, A. Kobayashi, K. Shirahama, M. Yamamoto, T. Hikima, K. Yonekura, S. Maki-Yonekura, Y. Kohmura, Y. Inubushi, Y. Takahashi, A. Suzuki, S. Matsunaga, Y. Inui, Y. Ichikawa, H. Kurumizaka, K. Tono, T. Kameshima, Y. Joti, T. Hoshi
    • Organizer
      Modeling biomolecular systems in cellular environment
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Empirical hydration distribution functions around polar atoms for studying

    • Author(s)
      D. Matsuoka and M. Nakasako
    • Organizer
      The 13-th Korea Institute of Advanced Study (KIAS) Conference
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 低温X線構造解析の展開 蛋白質水和構造解析からコヒーレントX線回折イメージングまで

    • Author(s)
      中迫雅由
    • Organizer
      超高速光エレクトロニクス研究会・光波シンセシス研究グループ研究会・理研シンポジウム
    • Place of Presentation
      和光、埼玉
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 分子動力学計算によるグルタミン酸脱水素酵素ドメイン運動に協奏した水和構造変化の観察

    • Author(s)
      苙口友隆、中島 真、中迫雅由
    • Organizer
      第13回日本蛋白質科学会年会
    • Place of Presentation
      鳥取
    • Related Report
      2013 Annual Research Report
  • [Book] 『タンパク質結晶の最前線』経験的水和分布関数の構築と蛋白質水和構造予測への応用2013

    • Author(s)
      松岳大輔, 中迫雅由
    • Publisher
      シーエムシー出版
    • Related Report
      2013 Final Research Report
  • [Book] 『標準免疫学第三版』第二部, 構成的メカニズム:認識のメカニズム, F.BCR/抗体による認識2013

    • Author(s)
      中迫雅由
    • Publisher
      医学書院
    • Related Report
      2013 Final Research Report
  • [Book] 標準免疫学第三版第二部構成的メカニズム:認識のメカニズムF.BCR/抗体による認識2012

    • Author(s)
      中迫雅由
    • Publisher
      医学書院(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.phys.keio.ac.jp/guidance/labs/nakasako/nakasako-lab.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 中迫研究室

    • URL

      http://www.phys.keio.ac.jp/guidance/labs/nakasako/nakasako-lab.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.phys.keio.ac.jp/guidance/labs/nakasako/nakasako-lab.html

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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