Signaling and functions of CDM family proteins that acts as Rac GEFs
| Project/Area Number |
22247017
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
FUKUI Yoshinori 九州大学, 生体防御医学研究所, 教授 (60243961)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Yoshihiko 九州大学, 生体防御医学研究所, 准教授 (00398083)
NISHIKIMI Nishikimi 九州大学, 生体防御医学研究所, 助教 (70404019)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥43,030,000 (Direct Cost: ¥33,100,000、Indirect Cost: ¥9,930,000)
Fiscal Year 2012: ¥20,930,000 (Direct Cost: ¥16,100,000、Indirect Cost: ¥4,830,000)
Fiscal Year 2011: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2010: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Keywords | 細胞情報伝達機構 / 細胞運動 / Rac / 遺伝子改変マウス / シグナル伝達 / 器官形成 / 血管内皮細胞 |
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| Research Abstract |
In this study, we have analyzed signaling and functions of CDM family proteins that are known to act as Rac GEFs. We obtained several important conclusions as follows:
1) DOCK1 acts downstream of CXCR4 in endothelial cells and plays an important role in cardiovascular development.
2) DOCK2 regulates NK cell-mediated cytotoxicity.
3) DOCK5 plays an important role in osteoclast functions.
4) DOCK1 is required for PDGF-induced dorsal ruffle formation.
5) Unlike DOCK5, DOCK1 and DOCK2 bind to phosphatidic acid.
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Report
(4 results)
Research Products
(90 results)
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[Journal Article] DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migrataon during immune responses2012
Author(s)
Yosuke Harada, Yoshihiko Tanaka, Masao Terasawa, Markus Pieczyk, Katsuyoshi Habiro, Tomoya Katakai, Kyoko Hanawa-Suetsugu, Mutsuko Kukimoto-Niino, Tomoko Nishizaki, Mikako Shirouzu, Xuefeng Duan, Takehito Uruno, Akihiko Nishikimi, Fumiyuki Sanematsu, Shigeyuki Yokoyama, Jens V.Stein, Tatsuo Kinashi, Yoshinori Fukui
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Journal Title
Blood
Volume: (In press)
Issue: 19
Pages: 4451-4461
DOI
Related Report
Peer Reviewed
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[Journal Article] Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activatorDOCK22012
Author(s)
Nishikimi A, Uruno T, Duan X, Cao Q, Okamura Y, Saitoh T, Saitoh N, Sakaoka S, Du Y, Suenaga A, Kukimoto-Niino M, Miyano K, Gotoh K, Okabe T, Sanematsu F, Tanaka Y, Sumimoto H., Honma T, Yokoyama S, Nagano T, Kohda D, Kanai M, and Fukui Y
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Journal Title
Chem. Biol
Volume: 19
Issue: 4
Pages: 488-497
DOI
Related Report
Peer Reviewed
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[Journal Article] Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.2012
Author(s)
Hanawa-Suetsugu K, Kukimoto-Niino M, Mishima-Tsumagari C, Akasaka R, Ohsawa N, Sekine S, Ito T, Tochio N, Koshiba S, Kigawa T, Terada T, Shirouzu M, Nishikimi A, Uruno T, Katakai T, Kinashi T, Kohda D, Fukui Y, Yokoyama S
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 109
Issue: 9
Pages: 3305-3310
DOI
Related Report
Peer Reviewed
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[Journal Article] DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4.2010
Author(s)
Sanematsu F, Hirashima M, Laurin M, Takii R, Nishikimi A, Kitajima K, Ding G, Noda M, Murata Y, Tanaka Y, Masuko S, Suda T, Meno C, Cote JF, Nagasawa T, Fukui Y
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Journal Title
Circ. Res.
Volume: 107
Issue: 9
Pages: 1102-1105
DOI
Related Report
Peer Reviewed
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[Journal Article] Comprehensive analysis of lymph node stroma -expressed Ig superfamily members reveals redundant and non-redundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing.2010
Author(s)
Boscacci RT, Pfeiffer F, Gollmer K, Sevilla AC, Martin AM, Soriano SF, Natale D, Henrickson SE, Andrian UH, Fukui Y, Mellado M, Deutsch U, Engelhardt B, Stein JV
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Journal Title
Blood
Volume: 116
Issue: 6
Pages: 915-925
DOI
Related Report
Peer Reviewed
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