| Budget Amount *help |
¥43,030,000 (Direct Cost: ¥33,100,000、Indirect Cost: ¥9,930,000)
Fiscal Year 2012: ¥20,930,000 (Direct Cost: ¥16,100,000、Indirect Cost: ¥4,830,000)
Fiscal Year 2011: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2010: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Research Abstract |
In this study, we have analyzed signaling and functions of CDM family proteins that are known to act as Rac GEFs. We obtained several important conclusions as follows:
1) DOCK1 acts downstream of CXCR4 in endothelial cells and plays an important role in cardiovascular development.
2) DOCK2 regulates NK cell-mediated cytotoxicity.
3) DOCK5 plays an important role in osteoclast functions.
4) DOCK1 is required for PDGF-induced dorsal ruffle formation.
5) Unlike DOCK5, DOCK1 and DOCK2 bind to phosphatidic acid.
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