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Social and health sciences fusion research for the elucidation process leading to cardiovascular disease from psychosocial factors

Research Project

Project/Area Number 22249022
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionOsaka University

Principal Investigator

ISO Hiroyasu  大阪大学, 医学(系)研究科(研究院), 教授 (50223053)

Co-Investigator(Kenkyū-buntansha) OOHIRA Tetsuya  大阪大学, 医学系研究科, 招へい教授 (50448031)
HONJYO Kaori  大阪大学, 医学系研究科, 准教授 (60448032)
TAMAKOSHI Akiko  北海道大学, 医学系研究科, 教授 (90236737)
INOUE Manami  東京大学, 医学系研究科, 教授 (70250248)
KITAMURA Akihiko  (財)大阪府保健医療財団大阪がん循環器病予防センター, 予防推進部 循環器病予防 健康開発部, 部長 (80450922)
TANIGAWA Takeshi  愛媛大学, 医学系研究科, 教授 (80227214)
YAMAGISHI Kazumasa  筑波大学, 医学系研究科, 講師 (20375504)
SHIRAI Kokoro  琉球大学, 法文学部, 准教授 (80530211)
Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥47,710,000 (Direct Cost: ¥36,700,000、Indirect Cost: ¥11,010,000)
Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2012: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2011: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2010: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Keywords循環器疾患 / 社会疫学 / 社会心理 / 生活習慣 / バイオマーカー
Research Abstract

We found that newly identified cardiovascular risk factors such as adiponectin levels and C-reactive protein levels were associated with risk of cardiovascular disease in addition to conventional risk factors.We also identified the possible mechanism of the association between psychological factors and cardiovascular diseases;our results suggested that the association between psychological factors and risk of cardiovascular diseases could be mediated through diabetes mellitus and home high blood pressure.Areal deprivation level was associated with higher cardiovascular mortality and morbidity after adjustment for individual socioeconomic conditions.Unequal distribution of cardiovascular risk factors,in particular biological risk factors,by areal deprivation level be a mechanism of the identified association.Our results suggest that areal environment could be a crucial public health target in addition to the existing individual public health approach.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (49 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (33 results) (of which Peer Reviewed: 25 results) Presentation (14 results) (of which Invited: 2 results) Remarks (2 results)

  • [Journal Article] Influence of municipal- and individual-level socioeconomic conditions on mortality in Japan2014

    • Author(s)
      Honjo K, Iso H, Fukuda Y, Nishi N, Nakaya T, Fujino Y, Tanabe N, Suzuki S, Subramanian SV, Tamakoshi A, and for the JACC Study Group.
    • Journal Title

      Int J Behav Med

      Volume: in press

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Association of subjective and objective socioeconomic status with subjective mental health and mental disorders among Japanese men and women2014

    • Author(s)
      Honjo K, Kawakami N, Tsuchiya M, Sakurai K, WMHJ 2002-2006 Survey Group
    • Journal Title

      Int J Behav Med

      Volume: in press

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 循環器疾患の社会格差2014

    • Author(s)
      本庄かおり
    • Journal Title

      日本循環器予防学会誌

      Volume: 49

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Association between Chlamydophila pneumoniae infection and risk of coronary heart disease for Japanese: The JPHC study2014

    • Author(s)
      Sakurai-Komada N, Iso H, Koike KA, Ikeda A, Umesawa M, Ikehara S, Inoue M, Tsugane S
    • Journal Title

      Atherosclerosis

      Volume: 233 Pages: 338-342

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heavy Alcohol Consumption and Risk of Atrial Fibrillation: The Circulatory Risk in Communities Study(CIRCS)2014

    • Author(s)
      Sano F, Ohira T, Kitamura A, Imano H, Cui R, Kiyama M, Okada T, Yamagishi K, Sankai T, Tanigawa T, Kario K, Iso H
    • Journal Title

      Circ J

      Volume: in press

    • NAID

      130003391047

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Is the association between healthy lifestyle behaviors and cardiovascular mortality modified by overweight status? The Japan Collaborative Cohort Study2014

    • Author(s)
      Eguchi E, Iso H, Tanabe N, Yatsuya H, Tamakoshi A; on behalf of the Japan Collaborative Cohort Study Group
    • Journal Title

      Prev Med

      Volume: 62 Pages: 142-147

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Associations of all-cause mortality with census-based neighbourhood deprivation and population density in Japan: A multilevel survival analysis2014

    • Author(s)
      Nakaya T, Honjo K, Hanibuchi T, Ikeda A, Iso H, Inoue M , Sawada N, Tsugane S, and the Japan Public Health Center-based Prospective Study Group
    • Journal Title

      PLOS ONE

      Volume: in press

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Total and high molecular weight adiponectin levels and risk of cardiovascular disease in individuals with high blood glucose levels2013

    • Author(s)
      Saito I, Tanigawa T,et al
    • Journal Title

      Atherosclerosis

      Volume: 229 Pages: 222-7

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Associations of Childhood Socioeconomic Status and Adulthood Height With Functional Limitations Among Japanese Older People: Results From the JAGES 2010 Project2013

    • Author(s)
      Fujiwara T, Kondo K, Shirai K, Suzuki K, Kawachi I.
    • Journal Title

      J Gerontol A Biol Sci Med Sci

      Volume: in press

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Do obesity and sleep problems cluster in the workplace? A multivariate, multilevel study2013

    • Author(s)
      Oksanen T, Kawachi I, Subramanian S, Kim D, Shirai K, Kouvonen A, Pentti J, Salo P, Virtanen M, Vahtera J, Kivimäki M.
    • Journal Title

      Scand J Work Environ Health.

      Volume: 1;39 Pages: 276-83

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between dietary behavior and risk of hypertension among Japanese male workers2013

    • Author(s)
      Umesawa M, Kitamura A, Kiyama M, Okada T, Shimizu Y, Imano H, Ohira T, Nakamura M, Maruyama K, Iso H
    • Journal Title

      Hypertens Res

      Volume: 36 Pages: 374-80

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cohort profile of the Japan Collaborative Cohort Study at final follow-up2013

    • Author(s)
      Tamakoshi A, Ozasa K, Fujino Y, Suzuki K, Sakata K, Mori M, Kikuchi S, Iso H; JACC Study Group, Sakauchi F, Motohashi Y, Tsuji I, Nakamura Y, Mikami H, Kurosawa M, Hoshiyama Y, Tanabe N, Tamakoshi K, Wakai K, Tokudome S, Hashimoto S, Wada Y, et al.
    • Journal Title

      J Epidemiol.

      Volume: 23 Pages: 227-32

    • NAID

      10031167782

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary intake of saturated fatty acids and incident stroke and coronary heart disease in Japanese communities: the JPHC Study.2013

    • Author(s)
      Yamagishi K, Iso H, Kokubo Y, Saito I, Yatsuya H, Ishihara J, Inoue M, Tsugane S; JPHC Study Group.
    • Journal Title

      Eur Heart J.

      Volume: 34 Pages: 1225-32

    • NAID

      120007136192

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soft drink, 100% fruit juice, and vegetable juice intakes and risk of diabetes mellitus2013

    • Author(s)
      Eshak ES, Iso H, Mizoue T, Inoue M, Noda M, Tsugane S.
    • Journal Title

      Clin Nutr.

      Volume: 32 Pages: 300-8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The impact of green tea and coffee consumption on the reduced risk of stroke incidence in Japanese population: the Japan public health center-based study cohort2013

    • Author(s)
      Kokubo Y, Iso H, Saito I, Yamagishi K, Yatsuya H, Ishihara J, Inoue M, Tsugane S.
    • Journal Title

      Stroke

      Volume: 44 Pages: 1369-74

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary patterns and risk of cardiovascular deaths among middle-aged Japanese: JACC Study2013

    • Author(s)
      Maruyama K, Iso H, Date C, Kikuchi S, Watanabe Y, Wada Y, Inaba Y, Tamakoshi A; JACC Study Group.
    • Journal Title

      Nutr Metab Cardiovasc Dis

      Volume: 23 Pages: 519-27

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Living alone and risk of cardiovascular events following discharge after acute myocardial infarction in Japan2013

    • Author(s)
      Kitamura T, Sakata Y, Nakatani D, Suna S, Usami M, Matsumoto S, Hara M, Hamasaki T, Nanto S, Sato H, Hori M, Iso H, Komuro I
    • Journal Title

      J Cardiol

      Volume: 62 Pages: 257-262

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adult Height and Body Mass Index in Relation to Risk of Total Stroke and its Subtypes: The Circulatory Risk in Communities Study2013

    • Author(s)
      Shimizu Y, Imano H, Ohira T, Kitamura A, Kiyama M, Okada T, Ishikawa Y, Shimamoto T, Yamagishi K, Tanigawa T, Iso H
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: S1052-3057 Pages: 230-9

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alcohol consumption and risk of stroke and coronary heart disease among Japanese women: The Japan Public Health Center-based prospective study2013

    • Author(s)
      Ikehara S, Iso H, Yamagishi K, Kokubo Y, Saito I, Yatsuya H, Inoue M, Tsugane S; for the JPHC Study Group
    • Journal Title

      Prev Med

      Volume: 57 Pages: 505-510

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The combination of Helicobacter pylori- and cytotoxin-associated gene-A seropositivity in relation to the risk of myocardial infarction in middle-aged Japanese: The Japan Public Health Center-based study2013

    • Author(s)
      Ikeda A, Iso H, Sasazuki S, Inoue M, Tsugane S; for the JPHC Study Group
    • Journal Title

      Atherosclerosis

      Volume: 230 Pages: 67-72

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association Between Weight Change Since 20 Years of Age With Mortality From Myocardial Infarction and Chronic Heart Failure in the Japan Collaborative Cohort (JACC) Study2013

    • Author(s)
      R Cui, H Iso, N Tanabe, Y Watanabe, A Tamakoshi and JACC Study Group
    • Journal Title

      Circ J

      Volume: in print

    • NAID

      130003382248

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Effectiveness of the combined approach for assessing social gradients in stroke risk among married women in Japan2012

    • Author(s)
      Honjo K
    • Journal Title

      Journal of Epidemiology

      Volume: 22 Pages: 324-330

    • NAID

      10030784194

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Social epidemiology and Eastern Wisdom2012

    • Author(s)
      Burnner E
    • Journal Title

      Journal of Epidemiology

      Volume: 22 Pages: 291-294

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The impact of C-reactive protein on risk of stroke, stroke subtypes, and ischemic heart disease in middle-aged Japanese: the Japan public health center-based study.2012

    • Author(s)
      Iso H
    • Journal Title

      J Atheroscler Thromb

      Volume: 19 Pages: 756-766

    • NAID

      130004444626

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellular growth factors in relation to mortality from cardiovascular disease in middle-aged Japanese: the JACC study.2012

    • Author(s)
      Iso H
    • Journal Title

      Atherosclerosis

      Volume: 224 Issue: 1 Pages: 154-160

    • DOI

      10.1016/j.atherosclerosis.2012.05.026

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soft drink intake in relation to incident ischemic heart disease, stroke, and stroke subtypes in Japanese men and women: the Japan Public Health Centre-based study cohort I.2012

    • Author(s)
      Eshak ES
    • Journal Title

      Am J Clin Nutr

      Volume: 96 Issue: 6 Pages: 1390-1397

    • DOI

      10.3945/ajcn.112.037903

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effectiveness of combined approach for assessing social gradients in stroke risk among married women in Japan2012

    • Author(s)
      Honjo K, Iso H, Iwata M, Cable N, et al
    • Journal Title

      J Epidemiol

      Volume: (in press)

    • NAID

      10030784194

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Healthy lifestyle behaviours and cardiovascular mortality among Japanese men and women : the Japan collaborative cohort study2012

    • Author(s)
      Tamakoshi A, Ikeda A, Fujino Y, Tamakoshi K, Iso H
    • Journal Title

      Eur Heart J

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Healthy lifestyle behaviours and cardiovascular mortality among Japanese men and women : the Japan collaborative cohort study2012

    • Author(s)
      Eguchi E, Iso H, Tanabe N, Wada Y, Yatsuya H, Kikuchi S, Inaba Y, Tamakoshi A
    • Journal Title

      Eur Heart J

      Volume: 33 Pages: 467-477

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A prospective cohort study of neighborhood stress and ischemic heart disease in Japan : a multilevel analysis using the JACC study data2011

    • Author(s)
      Fujino Y, Tanabe N, Honjo K, Suzuki S, Shirai K, Iso H, Tamakoshi A
    • Journal Title

      BMC Public Health

      Volume: 11 Pages: 398-398

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adult height and the risk of cardiovascular disease among middle aged men and women in Japan.2011

    • Author(s)
      Honjo K, Iso H, Inoue M, Tsugane S.
    • Journal Title

      Eur J Epidemiol

      Volume: 26 Pages: 13-21

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interest in health screening as a predictor of long-term overall mortality : multilevel analysis of a Japanese national cohort study.2011

    • Author(s)
      Fujino Y, Tanabe N, Honjo K, Suzuki S, Iso H, Tamakoshi A ; JACC Study Group.
    • Journal Title

      Prev Med

      Volume: 52 Pages: 78-83

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 健康の社会的決定要因:認知症2010

    • Author(s)
      白井こころ、磯博康、近藤克則
    • Journal Title

      公衆衛生学雑誌

      Volume: 57 Pages: 1015-1022

    • Related Report
      2010 Annual Research Report
  • [Presentation] 精神疾患の社会階層間格差:日米比較2013

    • Author(s)
      本庄かおり
    • Organizer
      第23回日本疫学会総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] 失業と循環器疾患死亡・総死亡の関係:JACC Study2012

    • Author(s)
      白井こころ・磯博康・藤野善久・野田博之・本庄かおり・玉腰暁子, 他
    • Organizer
      日本疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-01-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] A comparison study of 12 month prevalence of psychiatric disorders according to subjective and objective social position in Japan and US2012

    • Author(s)
      Honjo K
    • Organizer
      12th International Society of Behavior Medicine
    • Place of Presentation
      Budapest, Hungary
    • Related Report
      2012 Annual Research Report
  • [Presentation] 健康リスクへの先駆的対応と公衆衛生の課題2012

    • Author(s)
      磯博康
    • Organizer
      第71回日本公衆衛生学会総会
    • Place of Presentation
      山口
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 既婚女性の社会階層指標:既婚女性における脳卒中発症リスクの社会階層間格差の把握2012

    • Author(s)
      本庄かおり
    • Organizer
      第71回日本公衆衛生学会総会
    • Place of Presentation
      山口
    • Related Report
      2012 Annual Research Report
  • [Presentation] 「人から頼りにされている」意識と循環器疾患死亡の関係 JACC Study2011

    • Author(s)
      白井こころ、磯博康、内藤真理子、坂田清美、丹野高三、玉腰暁子
    • Organizer
      日本疫学会総会
    • Place of Presentation
      かでる2.7・札幌
    • Year and Date
      2011-01-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 地域のストレスと虚血性心疾患に関するマルチレベル分析2011

    • Author(s)
      藤野善久、田邊直仁、本庄かおり、鈴木貞夫、白井こころ、磯博康、玉腰暁子
    • Organizer
      日本疫学会総会
    • Place of Presentation
      かでる2.7・札幌
    • Year and Date
      2011-01-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 地域の教育水準と循環器疾患死亡リスク:JACC Study2011

    • Author(s)
      本庄かおり、磯博康、藤野善久、田邊直仁、鈴木貞夫、玉腰暁子
    • Organizer
      日本疫学会総会
    • Place of Presentation
      かでる2.7・札幌
    • Year and Date
      2011-01-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 地域の社会経済的指標と死亡リスク:JACC Study2010

    • Author(s)
      本庄かおり、磯博康、藤野善久、田邊直仁、鈴木貞夫、玉腰暁子
    • Organizer
      日本公衆衛生学会総会
    • Place of Presentation
      東京国際フォーラム・東京
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Municipal socioeconomic status in relation to cause-specific mortality among Japanese middle aged men and women : a multilevel study in Japan2010

    • Author(s)
      Honjo K, Iso H, Fukuda Y, Nishi N, Tamakoshi A
    • Organizer
      International Society of Behavior Medicine
    • Place of Presentation
      Washington DC USA
    • Year and Date
      2010-08-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 教育歴と精神健康の関連:日米比較

    • Author(s)
      本庄かおり、川上憲人、土屋政雄、 桜井桂子 、World Mental Health Japan Survey 研究グループ
    • Organizer
      日本疫学会
    • Place of Presentation
      徳島
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 日米比較からみた社会階層と精神健康

    • Author(s)
      本庄かおり
    • Organizer
      日本ストレス学会
    • Place of Presentation
      徳島
    • Related Report
      2013 Annual Research Report
  • [Presentation] Gender and Health. Health inequalities and gender in Japan

    • Author(s)
      本庄かおり
    • Organizer
      The International Conference on Social Stratification and Health 2013- Social stratification and health: Interdisciplinary Research and Action for Equity
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 循環器病疾患の社会格差:日本における大規模コホート研究の結果から

    • Author(s)
      本庄かおり
    • Organizer
      日本循環器病予防学会
    • Place of Presentation
      金沢
    • Related Report
      2013 Annual Research Report
  • [Remarks] 大阪大学大学院医学系研究科公衆衛生学教室業績

    • URL

      http://www.pbhel.med.osaka-u.ac.jp/result/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.pbhel.med.osaka-u.ac.jp/

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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