Bioengineering of artificial red cells for clinical application
| Project/Area Number |
22300161
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Waseda University |
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Principal Investigator |
SAKAI Hiromi 早稲田大学, 重点領域研究機構, 教授 (70318830)
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| Co-Investigator(Renkei-kenkyūsha) |
KOBAYASHI Koichi 慶應義塾大学, 医学部, 名誉教授 (80051704)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
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| Keywords | 人工臓器工学 / 再生医工学 / 人工血液 / リポソーム / 輸血代替 / 酸素輸液 / 血液代替物 / 臓器灌流 / 再生医療 / 分子集合体 / ヘモレオロジー / 人工赤血球 / ヘモグロビン |
|---|
| Research Abstract |
One of the characteristics of artificial red cells (hemoglobin-vesicles) as a molecular assembly is that their physicochemical properties can be manipulated. New function can also be added to the particles. In this reasech we take the advantages of such artificial red cells to apply for new clinical indications which blood transfusion cannot be attained. We establish “gas bioengineering” using artificial red cells.
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Report
(4 results)
Research Products
(89 results)
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[Journal Article] Physiolgical capacity of the reticuloendothelial system for the degradation of hemoglobin-vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusion for 7 days in Pregnant rats and fetuses.2012
Author(s)
M. Kaga, H. Ohta, Y. Lee, R. Kamii, H. Yamamoto, S. Akiyama, S. Watanabe, T. Matsuda, Y. Kimura, S. Tsuchiya, H. Tei, L. Okamura, H. Sakai, N. Yaegashi
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Journal Title
Life Sci.
Volume: 91
Pages: 420-428
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[Journal Article] Phagocytosis of liposome particles by rat splenic immature monocytes makes them transiently and highly immunosuppressive in ex vivo culture condition.2011
Author(s)
D. Takahashi, H. Azuma, H. Sakai, K. Sou, D. Wakita, H. Abe, M. Fujihara, H. Horinouchi, K. Kobayashi, T. Nishimura, H. Ikeda.
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Journal Title
J. Pharmacol. Exp. Therap
Volume: 337
Pages: 42-49
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[Journal Article] Hepatically-metabolized and .excreted artificial oxygen carrier, hemoglobin-vesicles, can be safely used under conditions of hepatic impairment.2010
Author(s)
K. Taguchi, M. Miyasato, H. Ujihara, H. Watanabe, D. Kadowaki, H. Sakai, E. Tsuchida, H. Horinouchi, K. Kobayashi, T. Maruyama, M. Otagiri
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Journal Title
Toxicol. Appl. Pharmacol.
Volume: 248
Pages: 234-241
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