Use of long overlapping peptides for cancer vaccine and Treg control for potentiating immune response
| Project/Area Number | 22300332 |
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor immunology
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| Research Institution | Kawasaki University of Medical Welfare |
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Principal Investigator |
NAKAYAMA Eiichi 川崎医療福祉大学, 医療福祉学部, 教授 (60180428)
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| Co-Investigator(Kenkyū-buntansha) |
KAKIMI Kazuhiro 東京大学, 医学部附属病院, 准教授 (80273358)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed(Fiscal Year 2012)
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| Budget Amount *help |
¥13,000,000 (Direct Cost : ¥10,000,000、Indirect Cost : ¥3,000,000)
Fiscal Year 2012 : ¥2,470,000 (Direct Cost : ¥1,900,000、Indirect Cost : ¥570,000)
Fiscal Year 2011 : ¥4,940,000 (Direct Cost : ¥3,800,000、Indirect Cost : ¥1,140,000)
Fiscal Year 2010 : ¥5,590,000 (Direct Cost : ¥4,300,000、Indirect Cost : ¥1,290,000)
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| Keywords | がん精巣抗原 / 長鎖ペプチド / がんワクチン / 免疫モニタリング / 抗体反応 / CD4, CD8 T 細胞 / 免疫 / がん抗原 / がん・精巣抗原 / 臨床試験 |
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| Research Abstract |
We conducted a phase I clinical trials of NY-ESO-1 cancer vaccines using a 20-mer NY-ESO-1f long peptide and 4 different 30-32-mer NY-ESO-1 overlapping peptides with Picibanil OK-432 and Montanide ISA-51. Either vaccine was well tolerated. Immunomonitoring analysis revealed that either vaccine induced antibody, CD4 and CD8T-cell responses in the vaccinated patients. The findings indicated the either long peptide vaccine is promising for immunotherapy.
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Report
(4results)
Research Products
(69results)
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[Journal Article] NY-ESO-1 antibody as a novel tumour marker of gastric cancer.2013
Author(s)
Fujiwara S, Wada H, Kawada J, Kawabata R, Takahashi T, Fujita J, Hirao T, Shibata K, Makari Y, Iijima S, Nishikawa H, Jungbluth AA, Nakamura Y, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Nakayama E, Mori M, Doki Y.
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Journal Title
Br J Cancer
Volume : 108(5)
Pages : 1119-1125
DOI
Related Report
Peer Reviewed
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[Journal Article] Vaccination with antigen-transfected, NKT cell ligand-loaded, human cells elicits robust in situ immune responses by dendritic cells.2013
Author(s)
Shimizu K, Mizuno T, Shinga J, Asakura M, Kakimi K, Ishii Y, Masuda K, Maeda T, Sugahara H, Sato Y, Matsushita H, Nishida K, Hanada K, Dorrie J, Schaft N, Bickham K, Koike H, Ando T, Nagai R, Fujii S.
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Journal Title
Cancer Res.
Volume : 73(1)
Pages : 62-73
DOI
Related Report
Peer Reviewed
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[Journal Article] Induction of CD8 T-cell responses restricted to multiple HLA class I alleles in a cancer patient by immunization with a 20-mer NY-ESO-1f (NY-ESO-1 91-110) peptide.2013
Author(s)
Eikawa, S., Kakimi, K., Idobe, M., Kuzushima, K., Luescher, I., Ohue, Y., Ikeuchi, K., Uenaka, A., Nishikawa, H., Udono, H., Oka, M., and Nakayama, E.
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Journal Title
Int. J. Cancer
Volume : 132(2)
Pages : 345-54
DOI
Related Report
Peer Reviewed
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[Journal Article] Spontaneous antibody, and CD4 and CD8T-cell responses against XAGE-1b(GAGED2a) in non-small cell lung cancer patients.2012
Author(s)
Ohue, Y., Eikawa, S., Okazaki, N., Mizote, Y., Isobe, M., Uenaka, A., Fukuda M., Old, L.J., Oka, M., and Nakayama, E.
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Journal Title
Int. J. Cancer
Volume : 131(5)
DOI
Related Report
Peer Reviewed
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[Journal Article] A phase I study of vaccination with NY-ESO-1f peptide mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen2011
Author(s)
Kakimi K, Isobe M, Uenaka A, Wada H, Sato E, Doki Y, Nakajima J, Seto Y, Yamatsuji T, Naomoto Y, Shiraishi K, Takigawa N, Kiura K, Tsuji K, Iwatsuki K, Oka M, Pan L, Hoffman EW, Old LJ, Nakayama E
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Journal Title
International journal of cancer Journal international du cancer
Volume : 129(12)
Pages : 2836-46
DOI
Related Report
Peer Reviewed
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[Journal Article] Enrichment of Foxp3+ CD4 Tregs in migrated T-cells to IL-6- and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6.2010
Author(s)
Eikawa, S., Ohue, Y., Kitaoka, K., Aji, T., Uenaka, A., Oka, M., and Nakayama, E.
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Journal Title
J. Im」munol.
Volume : 185(11)
Pages : 6734-6740
DOI
Related Report
Peer Reviewed
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[Journal Article] Three novel NY-ESO-1 epitopes bound to DRB1*0803, DQB1*0401 and DRB1*0901 recognized by CD4 T cells fromCHP-NY-ESO-1-vaccinated patients.2010
Author(s)
Mizote, Y., Taniguchi, T., Tanaka, K., Isobe, M., Wada, H., Saika, T., Kita, S., Koide, Y., Uenaka, A., and Nakayama, E.
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Journal Title
Vaccine
Volume : 28(32)
Pages : 5338-5346
URL
Related Report
Peer Reviewed
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