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Use of long overlapping peptides for cancer vaccine and Treg control for potentiating immune response

Research Project

Project/Area Number 22300332
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Tumor immunology
Research InstitutionKawasaki University of Medical Welfare

Principal Investigator

NAKAYAMA Eiichi  川崎医療福祉大学, 医療福祉学部, 教授 (60180428)

Co-Investigator(Kenkyū-buntansha) KAKIMI Kazuhiro  東京大学, 医学部附属病院, 准教授 (80273358)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywordsがん精巣抗原 / 長鎖ペプチド / がんワクチン / 免疫モニタリング / 抗体反応 / CD4, CD8 T 細胞 / 免疫 / がん抗原 / がん・精巣抗原 / 臨床試験
Research Abstract

We conducted a phase I clinical trials of NY-ESO-1 cancer vaccines using a 20-mer NY-ESO-1f long peptide and 4 different 30-32-mer NY-ESO-1 overlapping peptides with Picibanil OK-432 and Montanide ISA-51. Either vaccine was well tolerated. Immunomonitoring analysis revealed that either vaccine induced antibody, CD4 and CD8T-cell responses in the vaccinated patients. The findings indicated the either long peptide vaccine is promising for immunotherapy.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (69 results)

All 2013 2012 2011 2010 Other

All Journal Article (31 results) (of which Peer Reviewed: 28 results) Presentation (34 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Journal Article] NY-ESO-1 antibody as a novel tumour marker of gastric cancer.2013

    • Author(s)
      Fujiwara S, Wada H, Kawada J, Kawabata R, Takahashi T, Fujita J, Hirao T, Shibata K, Makari Y, Iijima S, Nishikawa H, Jungbluth AA, Nakamura Y, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Nakayama E, Mori M, Doki Y.
    • Journal Title

      Br J Cancer

      Volume: 108(5) Issue: 5 Pages: 1119-1125

    • DOI

      10.1038/bjc.2013.51

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ex vivo characterization of γδ T-cell repertoire in patients after adoptive transfer of Vγ9Vδ2 T cells expressing the interleukin-2 receptor β-chain andthe common γ-chain.2013

    • Author(s)
      Izumi T, Kondo M, Takahashi T, Fujieda N, Kondo A, Tamura N, Murakawa T, Nakajima J, Matsushita H, Kakimi K.
    • Journal Title

      Cytotherapy

      Volume: 15(4) Issue: 4 Pages: 481-491

    • DOI

      10.1016/j.jcyt.2012.12.004

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vaccination with antigen-transfected, NKT cell ligand-loaded, human cells elicits robust in situ immune responses by dendritic cells.2013

    • Author(s)
      Shimizu K, Mizuno T, Shinga J, Asakura M, Kakimi K, Ishii Y, Masuda K, Maeda T, Sugahara H, Sato Y, Matsushita H, Nishida K, Hanada K, Dorrie J, Schaft N, Bickham K, Koike H, Ando T, Nagai R, Fujii S.
    • Journal Title

      Cancer Res.

      Volume: 73(1) Issue: 1 Pages: 62-73

    • DOI

      10.1158/0008-5472.can-12-0759

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of CD8 T-cell responses restricted to multiple HLA class I alleles in a cancer patient by immunization with a 20-mer NY-ESO-1f (NY-ESO-1 91-110) peptide.2013

    • Author(s)
      Eikawa, S., Kakimi, K., Idobe, M., Kuzushima, K., Luescher, I., Ohue, Y., Ikeuchi, K., Uenaka, A., Nishikawa, H., Udono, H., Oka, M., and Nakayama, E.
    • Journal Title

      Int. J. Cancer

      Volume: 132(2) Issue: 2 Pages: 345-54

    • DOI

      10.1002/ijc.27682

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell behavior observation and gene expression analysis of melanoma associated with stromal fibroblasts in a three-dimensional magnetic cell culture array.2013

    • Author(s)
      Okochi, M.
    • Journal Title

      Biotechnology Progress

      Volume: 29(1) Issue: 1 Pages: 135-142

    • DOI

      10.1002/btpr.1642

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Melanoma-targeted chemo-thermotherapy and in situ peptide immunotherapy through HSP production by using melanogenesis substrate, NPrCAP and magnetite nanoparticles.2013

    • Author(s)
      Jimbow, K.
    • Journal Title

      J. Skin Cancer

      Volume: 2013 Pages: 174-180

    • DOI

      10.1155/2013/742925

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 解説「腫瘍による制御T細胞の浸潤誘導」2013

    • Author(s)
      和田 尚
    • Journal Title

      月刊 臨床免疫・アレルギー科

      Volume: 59(2) Pages: 253-258

    • Related Report
      2012 Annual Research Report
  • [Journal Article] がん患者における免疫モニタリング-評価法と国際標準化-2013

    • Author(s)
      和田 尚
    • Journal Title

      週刊 医学のあゆみ がんの免疫制御-研究と臨床の最前線-

      Volume: 244(9) Pages: 871-877

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Serological identification of Tektin5 as a cancer/testis antigen and its immunogenicity2012

    • Author(s)
      Hanafusa T, Mohamed AE, Domae S, Nakayama E, Ono T
    • Journal Title

      BMC Cancer

      Volume: 12 Issue: 1 Pages: 520-520

    • DOI

      10.1186/1471-2407-12-520

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous antibody, and CD4 and CD8T-cell responses against XAGE-1b(GAGED2a) in non-small cell lung cancer patients.2012

    • Author(s)
      Ohue, Y., Eikawa, S., Okazaki, N., Mizote, Y., Isobe, M., Uenaka, A., Fukuda M., Old, L.J., Oka, M., and Nakayama, E.
    • Journal Title

      Int. J. Cancer

      Volume: 131(5) Issue: 5

    • DOI

      10.1002/ijc.27359

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical trial of the intratumoral administration of labeled DC combined with systemic chemotherapy for esophageal cancer.2012

    • Author(s)
      Fujiwara, S., Wada, H., Miyata, H., Kawada, J., Kawabata, R., Nishikawa, H., Gnjatic, S., Sedrak, C., Sato, E., Nakamura, Y., Sakakibara, M., Kanto, T., Shimosegawa, E., Hatazawa, J., Takahashi, T., Kurokawa, Y., Yamasaki, M., Nakajima, K., Takiguchi, S., Nakayama, E., Mori, M.,and Doki, Y.
    • Journal Title

      J. Immunotherapy

      Volume: 35(6) Issue: 6 Pages: 513-521

    • DOI

      10.1097/cji.0b013e3182619cb4

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeting spatiotemporal expression of CD137 on tumor-infiltrating cytotoxic T lymphocytes as a novel strategy for agonistic antibody therapy.2012

    • Author(s)
      Noji S, Hosoi A, Takeda K, Matsushita H, Morishita Y, Seto Y, Kakimi K.
    • Journal Title

      J. Immunother

      Volume: 35(6) Issue: 6 Pages: 460-472

    • DOI

      10.1097/cji.0b013e31826092db

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of putative neo-antigen formation from N-propionyl-4-S-cysteaminylphenol, a tyrosinase substrate, in melanoma models.2012

    • Author(s)
      Ito, S.
    • Journal Title

      Biochemical Pharmacology

      Volume: 84(5) Issue: 5 Pages: 646-653

    • DOI

      10.1016/j.bcp.2012.06.015

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-propionyl-4-S-cysteaminylphenol induces apoptosis in B16F1cells and mediates tumor-specific T-cell immune responses in a mouse melanoma model.2012

    • Author(s)
      Ishii-Osai, Y.
    • Journal Title

      J. Dermatol. Sci.

      Volume: 67 Issue: 1 Pages: 51-60

    • DOI

      10.1016/j.jdermsci.2012.04.009

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conjugation of magnetite nanoparticles with melanogenesis substrate, NPrCAP provides melanoma targeted, in situ peptide vaccine immunotherapy through HSP production by chemo-thermotherapy.2012

    • Author(s)
      Jimbow, K.
    • Journal Title

      Journal of Biomaterials and Nanobiotechnology

      Volume: 3(2) Issue: 02 Pages: 140-153

    • DOI

      10.4236/jbnb.2012.32020

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特論「免疫増強・制御モニタリングとがんワクチン」2012

    • Author(s)
      和田 尚
    • Journal Title

      日本臨床 特集 固形がんの免疫・抗体療法-基礎研究の進歩と臨床応用-

      Volume: 70(12) Pages: 2183-2188

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Conjugation of magnetite nanoparticles with melanogenesis substrate, NPrCAP provides melanoma targeted, in situ peptide vaccine immunotherapy through HSP production by chemo-thermotherapy2012

    • Author(s)
      Jimbow, K., et al
    • Journal Title

      Journal of Biomaterials and Nanobiotechnology

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of animal models to analyze the kinetics and distribution of human tumor antigen-specific CD8^+ T cells2012

    • Author(s)
      Muraoka, D., et al
    • Journal Title

      Cancer Science

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous antibody and CD4 and CD8 T-cell responses against XAGE-1b (GAGED2a) in non-small cell lung cancer patients2012

    • Author(s)
      Ohue, Y., et al
    • Journal Title

      Int.J.Cancer

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heteroclitic serological response in esophageal and prostate cancer patients after NY-ESO-1 protein vaccination2012

    • Author(s)
      Kawada, J., et al
    • Journal Title

      Int.J.Cancer

      Volume: 130(3) Pages: 584-592

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase i study of vaccination with NY-ESO-1f peptide mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen2011

    • Author(s)
      Kakimi K, Isobe M, Uenaka A, Wada H, Sato E, Doki Y, Nakajima J, Seto Y, Yamatsuji T, Naomoto Y, Shiraishi K, Takigawa N, Kiura K, Tsuji K, Iwatsuki K, Oka M, Pan L, Hoffman EW, Old LJ, Nakayama E
    • Journal Title

      International journal of cancer Journal international du cancer

      Volume: 129 Issue: 12 Pages: 2836

    • DOI

      10.1002/ijc.25955

    • URL

      https://pure.teikyo.jp/en/publications/58759438-4771-4be4-89b5-4cf95da8afd3

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration2011

    • Author(s)
      Kurachi Makoto
    • Journal Title

      The Journal of Experimental Medicine

      Volume: 208 Issue: 8 Pages: 1605-1620

    • DOI

      10.1084/jem.20102101

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adoptive immunotherapy for advanced non-small cell lung cancer using zoledronate-expandedγδT cells : a phase I clinical study2011

    • Author(s)
      Sakamoto M, Nakajima J, Murakawa T, Fukami T, Yoshida Y, Murayama T, Takamoto S, Matsushita H, Kakimi K
    • Journal Title

      Journal of immunotherapy

      Volume: 34(2) Issue: 2 Pages: 202-11

    • DOI

      10.1097/cji.0b013e318207ecfb

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and characterization of human lung cancer antigens by serological screening with autologous antibodies.2011

    • Author(s)
      Hanafusa T, Ali Mohamed Ali ElDib, Kitaoka K, Ohue Y, Nakayama E, and Ono T.
    • Journal Title

      Cancer Letter

      Volume: 301(1) Issue: 1 Pages: 57-62

    • DOI

      10.1016/j.canlet.2010.10.024

    • NAID

      120003437013

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase I study of vaccination with NY-ESO-1f peptide mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen2011

    • Author(s)
      Kakimi, K., et al
    • Journal Title

      Int.J.Cancer

      Volume: 129(12) Pages: 2836-2846

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heteroclitic serological response in esophageal and prostate cancer patients after NY-ESO-1 protein vaccination.2011

    • Author(s)
      Kawada, J., et al.
    • Journal Title

      Int.J.Cancer

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase I study of vaccination with NY-ESO-If peptide mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen.2011

    • Author(s)
      Kakimi, K., et al.
    • Journal Title

      Int.J.Cancer

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enrichment of Foxp3+ CD4 Tregs in migrated T-cells to IL-6- and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6.2010

    • Author(s)
      Eikawa, S., Ohue, Y., Kitaoka, K., Aji, T., Uenaka, A., Oka, M., and Nakayama, E.
    • Journal Title

      J. Im」munol.

      Volume: 185(11) Issue: 11 Pages: 6734-6740

    • DOI

      10.4049/jimmunol.1000225

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Three novel NY-ESO-1 epitopes bound to DRB1*0803, DQB1*0401 and DRB1*0901 recognized by CD4 T cells fromCHP-NY-ESO-1-vaccinated patients.2010

    • Author(s)
      Mizote, Y., Taniguchi, T., Tanaka, K., Isobe, M., Wada, H., Saika, T., Kita, S., Koide, Y., Uenaka, A., and Nakayama, E.
    • Journal Title

      Vaccine

      Volume: 28(32) Pages: 5338-5346

    • URL

      http://www.journals.elsevier.com/vaccine/

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enrichment of Foxp3^+ CD4 Tregs in migrated T-cells to IL-6-and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6.2010

    • Author(s)
      Eikawa, S., et al.
    • Journal Title

      J.Immunol.

      Volume: 185(11) Pages: 6734-6743

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three novel NY-ESO-1 epitopes bound to DRB1*0803, DQBl*0401 and DRBl*0901 recognized by CD4 T cells from CHP-NY-ESO-1-vaccinated patients.2010

    • Author(s)
      Mizote, Y., et al.
    • Journal Title

      Vaccine

      Volume: 28(32) Pages: 5338-5346

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] CD8 T cell response in NY-ESO-1 f-peptide vaccinated patient2011

    • Author(s)
      Shingo Eikawa(上中明子), 他
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] "Antigen Spreading" in patients vaccinated with NY-ESO-1 protein2011

    • Author(s)
      Hisashi Wada, 他
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Humoral immune response of cancer patients against newly SEREX-defined antigen, GKAP12011

    • Author(s)
      Shohei Domae, 他
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Detection of CD4 T-cell responses using the HLA class II tetramer in the vaccinated cancer patients2011

    • Author(s)
      Yu Mizote, 他
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Correlation of Antibody and T Cell Responses Against XAGE-1b in NSCLC Patients2011

    • Author(s)
      Yoshihiro Ohue, 他
    • Organizer
      19th Annual International Cancer Immunotherapy Symposium
    • Place of Presentation
      Millennium Conference Center(アメリカ)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Induction of CD8 T Cell Responses Restricted to Multiple HLA Class I Alleles in a Cancer Patient by Immunization with a 20-Mer NY-ESO-1f (NY-ESO-1 91-110) Peptide2011

    • Author(s)
      Shingo Eikawa, 他
    • Organizer
      19th Annual International Cancer Immunotherapy Symposium
    • Place of Presentation
      Millennium Conference Center(アメリカ)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] CD8 T cell response in NY-ESO-1 f-peptide vaccinated patient2011

    • Author(s)
      Shingo Eikawa, 他
    • Organizer
      第15回日本がん免疫学会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府)
    • Year and Date
      2011-06-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] HLAクラスIIテトラマーを用いた免疫モニタリング2011

    • Author(s)
      溝手雄, 他
    • Organizer
      第15回日本がん免疫学会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府)
    • Year and Date
      2011-06-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] NY-ESO-1がんワクチン2011

    • Author(s)
      中山睿一
    • Organizer
      第28回日本医学会総会2011東京
    • Place of Presentation
      丸ビルホール&コンファレンススクエア(東京都)(招待講演)
    • Year and Date
      2011-04-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] NY-ESO-1癌ワクチン2010

    • Author(s)
      和田尚, 他
    • Organizer
      第14回日本がん免疫学会(シンポジウム)
    • Place of Presentation
      KKRホテル熊本(熊本)
    • Related Report
      2010 Annual Research Report
  • [Presentation] NY-ESO-1ワクチン患者におけるCD4T細胞の反応解析2010

    • Author(s)
      溝手雄, 他
    • Organizer
      第14回日本がん免疫学会
    • Place of Presentation
      KKRホテル熊本(熊本)
    • Related Report
      2010 Annual Research Report
  • [Presentation] SEREX法による肺腺癌抗原の同定と発現解析2010

    • Author(s)
      花房直志, 他
    • Organizer
      第14回日本がん免疫学会
    • Place of Presentation
      KKRホテル熊本(熊本)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肺癌患者におけるXAGE-1b特異的T細胞の誘導とその解析2010

    • Author(s)
      大植祥弘, 他
    • Organizer
      第14回 日本がん免疫学会
    • Place of Presentation
      KKRホテル熊本(熊本)
    • Related Report
      2010 Annual Research Report
  • [Presentation] NY-ESO-1fペブチドワクチン投与患者におけるCD8T細胞の免疫応答2010

    • Author(s)
      榮川伸吾, 他
    • Organizer
      第14回 日本がん免疫学会
    • Place of Presentation
      KKRホテル熊本(熊本)
    • Related Report
      2010 Annual Research Report
  • [Presentation] がんワクチンと免疫学的評価2010

    • Author(s)
      中山睿一
    • Organizer
      第69回 日本癌学会総会(モーニングレクチャー)
    • Place of Presentation
      大阪国際会議場(大阪)(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of CD4 T cell responses from NY-ESO-1 vaccinated patients.2010

    • Author(s)
      溝手雄, 他
    • Organizer
      第69回 日本癌学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Isolation and characterizztion of human lung cancer antigens by serological screening with autoloaous antibodies.2010

    • Author(s)
      花房直志, 他
    • Organizer
      第69回 日本癌学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2010 Annual Research Report
  • [Presentation] CD4 and CD8 T cell responses against XAGE-lb antigen in non-small cell lung cancer patients.2010

    • Author(s)
      大植祥弘, 他
    • Organizer
      第69回 日本癌学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2010 Annual Research Report
  • [Presentation] CD8 T cell response in NY-ESO-1 f-peptide vaccinated patient.2010

    • Author(s)
      榮川伸吾, 他
    • Organizer
      第69回 日本癌学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Heteroclitic serological response after NY-ESO-1 protein vaccination.2010

    • Author(s)
      川田純司, 他
    • Organizer
      第69回 日本癌学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Spontaneous XAGE-lb Immunity in Patients with Non-Small-Cell Lung Cancer.2010

    • Author(s)
      YOSHIHIRO OHUE, et al.
    • Organizer
      INTERNATIONAL IMMUNOTHERAPY SYMPOSIA SERIES CANCER IMMUNOTHERAPY 2010
    • Place of Presentation
      Millennium Hotel Conference Center (N.Y)
    • Related Report
      2010 Annual Research Report
  • [Presentation] CD8 T Cell Response in NY-ESO-1 f-Peptide Vaccinated Patients.2010

    • Author(s)
      SHINGO EIKAWA, et al.
    • Organizer
      INTERNATIONAL IMMUNOTHERAPY SYMPOSIA SERIES CANCER IMMUNOTHERAPY 2010
    • Place of Presentation
      Millennium Hotel Conference Center (N.Y.)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肺癌の自然退縮と増悪における免疫学的な病態解析2010

    • Author(s)
      松本博文, 他
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島国際会議場(広島)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肺癌患者におけるXAGE-1b特異的T細胞の誘導とその解析2010

    • Author(s)
      大植祥弘, 他
    • Organizer
      第51回 日本肺癌学会総会
    • Place of Presentation
      広島国際会議場(広島)
    • Related Report
      2010 Annual Research Report
  • [Presentation] NY-ESO-1fペプチドワクチン投与肺がん患者におけるCD8T細胞の免疫応答2010

    • Author(s)
      榮川伸吾, 他
    • Organizer
      第51回 日本肺癌学会総会
    • Place of Presentation
      広島国際会議場(広島)
    • Related Report
      2010 Annual Research Report
  • [Presentation] NY-ESO-1長鎖ペプチドワクチン投与患者におけるCD4-T細胞反応の解析2010

    • Author(s)
      溝手雄, 他
    • Organizer
      第51回 日本肺癌学会総会
    • Place of Presentation
      広島国際会議場(広島)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Correlation of antibody and T-cell responses against XAGE-1n in NSCLC patietns

    • Author(s)
      Yoshihiro OHUE
    • Organizer
      第16回 日本がん免疫学会総会
    • Place of Presentation
      北海道大学 学術交流会館(北海道)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Inhibition of regulatory T-cell migration by ELR motif-binding peptide

    • Author(s)
      Shingo EIKAWA
    • Organizer
      第16回 日本がん免疫学会総会
    • Place of Presentation
      北海道大学 学術交流会館(北海道)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Correlation of antibody and T-cell responses against XAGE-1b in NSCLC patients

    • Author(s)
      Yoshihiro Ohue
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ホテルロイトン札幌(北海道)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Inhibition of regulatory T-cell migration by ELR motif-binding peptide

    • Author(s)
      Shingo Eikawa
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ホテルロイトン札幌(北海道)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Melanoma-targeted chemo-thermo-immunotherapy and in situ peptide vaccine by NPrCAP

    • Author(s)
      Kowichi Jimbow
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ホテルロイトン札幌(北海道)
    • Related Report
      2012 Annual Research Report
  • [Presentation] NY-ESO-1 long peptide vaccine

    • Author(s)
      Hisahi Wada
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ホテルロイトン札幌(北海道)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 非小細胞肺癌患者におけるXAGE-1b(GAGED2a)に対する宿主免疫応答の解析

    • Author(s)
      大植 祥弘
    • Organizer
      第25回日本バイオセラピィ学会学術集会総会
    • Place of Presentation
      倉敷市芸文館(岡山)
    • Related Report
      2012 Annual Research Report
  • [Presentation] CD8 T cell response in NY-ESO-1f peptide vaccinated patients

    • Author(s)
      榮川 伸吾
    • Organizer
      第25回日本バイオセラピィ学会学術集会総会
    • Place of Presentation
      倉敷市芸文館(岡山)
    • Related Report
      2012 Annual Research Report
  • [Book] 癌ワクチン-蛋白とロングペプチド-バイオテクノロジーシリーズ『がん免疫療法-実用化へのチャレンジ-』(監修;珠玖洋)2010

    • Author(s)
      和田尚, 他
    • Publisher
      シーエムシー出版
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.kawasaki-m.ac.jp/resp/

    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] XAGE-1b特異的免疫反応を誘導するペプチドおよびその利用2010

    • Inventor(s)
      中山睿一, 大植祥弘
    • Industrial Property Rights Holder
      国立大学法人岡山大学
    • Filing Date
      2010-05-21
    • Related Report
      2011 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] XAGE-1b特異的免疫反応を誘導するベプチドおよびその利用2010

    • Inventor(s)
      中山睿一, 大植祥弘
    • Industrial Property Rights Holder
      国立大学法人 岡山大学
    • Filing Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
    • Overseas

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Published: 2010-08-23   Modified: 2019-07-29  

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