Use of long overlapping peptides for cancer vaccine and Treg control for potentiating immune response

• Project/Area Number: 22300332
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor immunology
• Research Institution: Kawasaki University of Medical Welfare
• Principal Investigator: NAKAYAMA Eiichi 川崎医療福祉大学, 医療福祉学部, 教授 (60180428)
• Co-Investigator(Kenkyū-buntansha): KAKIMI Kazuhiro 東京大学, 医学部附属病院, 准教授 (80273358)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
• Keywords: がん精巣抗原 / 長鎖ペプチド / がんワクチン / 免疫モニタリング / 抗体反応 / CD4, CD8 T 細胞 / 免疫 / がん抗原 / がん・精巣抗原 / 臨床試験

Research Abstract

We conducted a phase I clinical trials of NY-ESO-1 cancer vaccines using a 20-mer NY-ESO-1f long peptide and 4 different 30-32-mer NY-ESO-1 overlapping peptides with Picibanil OK-432 and Montanide ISA-51. Either vaccine was well tolerated. Immunomonitoring analysis revealed that either vaccine induced antibody, CD4 and CD8T-cell responses in the vaccinated patients. The findings indicated the either long peptide vaccine is promising for immunotherapy.

Research Products

• [Journal Article] Ex vivo characterization of γδ T-cell repertoire in patients after adoptive transfer of Vγ9Vδ2 T cells expressing the interleukin-2 receptor β-chain and the common γ-chain (2014)
  • Author(s): Izumi T, Kondo M, Takahashi T, Fujieda N, Kondo A, Tamura N, Murakawa T, Nakajima J, Matsushita H, Kakimi K.
  • Journal Title: Cytotherapy. Volume: 15(4) Pages: 481-491
  • DOI: 10.1016/j.jcyt.2012.12.004
  • Peer Reviewed
• [Journal Article] NY-ESO-1 antibody as a novel tumour marker of gastric cancer (2013)
  • Author(s): Fujiwara S, Wada H, Kawada J, Kawabata R, Takahashi T, Fujita J, Hirao T, Shibata K, Makari Y, Iijima S, Nishikawa H, Jungbluth AA, Nakamura Y, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Nakayama E, Mori M, Doki Y.
  • Journal Title: British Journal of Cancer Volume: 108(5) Pages: 1119-1125
  • DOI: 10.1038/bjc.2013.51
  • Peer Reviewed
• [Journal Article] Vaccination with antigen mRNA-transfected, NKT cell ligand-loaded, human vector cells elicits robust in situ immune responses by dendritic cells (2013)
  • Author(s): Shimizu K, Mizuno T, Shinga J, Asakura M, Kakimi K, Ishii Y, Masuda K, Maeda T, Sugahara H, Sato Y, Matsushita H, Nishida K, Hanada K, Dorrie J, Schaft N, Bickham K, Koike H, Ando T, Nagai R, Fujii S.
  • Journal Title: Cancer Res Volume: 73(1) Pages: 62-73
  • DOI: 10.1158/0008-5472.can-12-0759
  • Peer Reviewed
• [Journal Article] Induction of CD8 T-cell responses restricted to multiple HLA class I alleles in a cancer patient by immunization with a 20-mer NY-ESO-1f (NY-ESO-191-110) peptide (2013)
  • Author(s): Eikawa, S., Kakimi, K., Idobe, M., Kuzushima, K., Luescher, I., Ohue, Y., Ikeuchi, K., Uenaka, A., Nishikawa, H., Udono, H., Oka, M., and Nakayama, E.
  • Journal Title: International Journal of Cancer Volume: 132(2) Pages: 345-354
  • DOI: 10.1002/ijc.27682
  • Peer Reviewed
• [Journal Article] "Clinical Trial of the Intratumoral Administration of Labeled DC Combined With Systemic Chemotherapy for Esophageal Cancer (2013)
  • Author(s): Fujiwara, S., Wada, H., Miyata, H., Kawada, J., Kawabata, R., Nishikawa, H., Gnjatic, S., Sedrak, C., Sato, E., Nakamura, Y., Sakakibara, M., Kanto, T., Shimosegawa, E., Hatazawa, J., Takahashi, T., Kurokawa, Y., Yamasaki, M., Nakajima, K., Takiguchi, S., Nakayama, E., Mori, M.,and Doki, Y.
  • Journal Title: J Immunother Volume: 35(6) Pages: 345-354
  • DOI: 10.1097/cji.0b013e3182619cb4
  • Peer Reviewed
• [Journal Article] Cell behavior observation and gene expression analysis of melanoma associated with stromal fibroblasts in a three-dimensional magnetic cell culture array. (2013)
  • Author(s): Okochi, M.
  • Journal Title: Biotechnology Progress Volume: 29(1) Pages: 135-142
  • DOI: 10.1002/btpr.1642
  • Peer Reviewed
• [Journal Article] Melanoma-targeted chemothermotherapy and in situ peptide immunotherapy through HSP production by using melanogenesis substrate, NPrCAP, and magnetite nanoparticles (2013)
  • Author(s): Jimbow, K.
  • Journal Title: J Skin Cancer Volume: 2013 Pages: 174-180
  • DOI: 10.1155/2013/742925
  • Peer Reviewed
• [Journal Article] 解説「腫瘍による制御T細胞の浸潤誘導」 (2013)
  • Author(s): 和田 尚
  • Journal Title: 月刊 臨床免疫・アレルギー科 Volume: 59（2） Pages: 253-258
• [Journal Article] がん患者における免疫モニタリング－評価法と国際標準化－ (2013)
  • Author(s): 和田 尚
  • Journal Title: 週刊 医学のあゆみ がんの免疫制御－研究と臨床の最前線－ Volume: 244（9） Pages: 871-877
• [Journal Article] Serological identification of Tektin5 as a cancer/testis antigen and its immunogenicity (2012)
  • Author(s): Hanafusa T, Mohamed AE, Domae S, Nakayama E, Ono T
  • Journal Title: BMC Cancer Volume: 12 Pages: 520-520
  • DOI: 10.1186/1471-2407-12-520
  • Peer Reviewed
• [Journal Article] Spontaneous antibody, and CD4 and CD8 T-cell responses against XAGE-1b (GAGED2a) in non-small cell lung cancer patients (2012)
  • Author(s): Ohue, Y., Eikawa, S., Okazaki, N., Mizote, Y., Isobe, M., Uenaka, A., Fukuda M., Old, L.J., Oka, M., and Nakayama, E.
  • Journal Title: International Journal of Cancer Volume: 131(5)
  • DOI: 10.1002/ijc.27359
  • Peer Reviewed
• [Journal Article] Targeting spatiotermporal expression of CD137 on tumor-infiltrating cytotoxic T lymphocytes as a novel strategy for agonistic antibody therapy. (2012)
  • Author(s): Noji S, Hosoi A, Takeda K, Matsushita H, Morishita Y, Seto Y, Kakimi K.
  • Journal Title: J Immunother Volume: 35(6) Pages: 460-472
  • DOI: 10.1097/cji.0b013e31826092db
  • Peer Reviewed
• [Journal Article] Mechanism of putative neo-antigen formation from N-propionyl-4-S-cysteaminylphenol, a tyrosinase substrate, in melanoma models. (2012)
  • Author(s): Ito, S.
  • Journal Title: Biochemical Pharmacology Volume: 84(5) Pages: 646-653
  • DOI: 10.1016/j.bcp.2012.06.015
  • Peer Reviewed
• [Journal Article] N-propionyl-4-S-cysteaminylphenol induces apoptosis in B16F1 cells and mediates tumor-specific T-cell immune responses in a mouse melanoma model. (2012)
  • Author(s): Ishii-Osai, Y.
  • Journal Title: J Dermatol Sci. Volume: 67 Pages: 51-60
  • DOI: 10.1016/j.jdermsci.2012.04.009
  • Peer Reviewed
• [Journal Article] Conjugation of magnetite nanoparticles with melanogenesis substrate, NPrCAP provides melanoma targeted, in situ peptide vaccine immunotherapy through HSP production by chemo-thermotherapy. (2012)
  • Author(s): Jimbow, K.
  • Journal Title: Journal of Biomaterials and Nanobiotechnology Volume: 3(2) Pages: 140-153
  • DOI: 10.4236/jbnb.2012.32020
  • Peer Reviewed
• [Journal Article] 特論「免疫増強・制御モニタリングとがんワクチン」 (2012)
  • Author(s): 和田 尚
  • Journal Title: 日本臨床 特集 固形がんの免疫・抗体療法－基礎研究の進歩と臨床応用－ Volume: 70（12） Pages: 2183-2188
• [Journal Article] Conjugation of magnetite nanoparticles with melanogenesis substrate, NPrCAP provides melanoma targeted, in situ peptide vaccine immunotherapy through HSP production by chemo-thermotherapy (2012)
  • Author(s): Jimbow, K., et al
  • Journal Title: Journal of Biomaterials and Nanobiotechnology Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Establishment of animal models to analyze the kinetics and distribution of human tumor antigen-specific CD8^+ T cells (2012)
  • Author(s): Muraoka, D., et al
  • Journal Title: Cancer Science Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Spontaneous antibody and CD4 and CD8 T-cell responses against XAGE-1b (GAGED2a) in non-small cell lung cancer patients (2012)
  • Author(s): Ohue, Y., et al
  • Journal Title: Int.J.Cancer Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Heteroclitic serological response in esophageal and prostate cancer patients after NY-ESO-1 protein vaccination (2012)
  • Author(s): Kawada, J., et al
  • Journal Title: Int.J.Cancer Volume: 130(3) Pages: 584-592
  • Peer Reviewed
• [Journal Article] A phase I study of vaccination with NY-ESO-1f peptide mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen. (2011)
  • Author(s): Kakimi K, Isobe M, Uenaka A, Wada H, Sato E, Doki Y, Nakajima J, Seto Y, Yamatsuji T, Naomoto Y, Shiraishi K, Takigawa N, Kiura K, Tsuji K, Iwatsuki K, Oka M, Pan L, Hoffman EW, Old LJ, Nakayama E
  • Journal Title: Int J Cancer Volume: 129(12) Pages: 2836-2846
  • DOI: 10.1002/ijc.25955
  • Peer Reviewed
• [Journal Article] Chemokine receptor CXCR3 facilitates CD8^+T cell differentiation into short-lived effector cells leading to memory degeneration (2011)
  • Author(s): Kurachi Makoto
  • Journal Title: J. Exp. Med Volume: 208 Pages: 1605-1620
  • DOI: 10.1084/jem.20102101
  • Peer Reviewed
• [Journal Article] Adoptive immunotherapy for advanced non-small cell lung cancer using zoledronate-expanded γδTcells: a phase I clinical study. (2011)
  • Author(s): Sakamoto M, Nakajima J, Murakawa T, Fukami T, Yoshida Y, Murayama T, Takamoto S, Matsushita H, Kakimi K
  • Journal Title: J. Immunother Volume: 34(2) Pages: 202-11
  • DOI: 10.1097/cji.0b013e318207ecfb
  • Peer Reviewed
• [Journal Article] Isolation and characterization of human lung cancer antigens by serological screening with autologous antibodies. (2011)
  • Author(s): Hanafusa T, Ali Mohamed Ali ElDib, Kitaoka K, Ohue Y, Nakayama E, and Ono T.
  • Journal Title: Cancer Letter Volume: 301(1) Pages: 57-62
  • DOI: 10.1016/j.canlet.2010.10.024
  • NAID: 120003437013
  • Peer Reviewed
• [Journal Article] A phase I study of vaccination with NY-ESO-1f peptide mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen (2011)
  • Author(s): Kakimi, K., et al
  • Journal Title: Int.J.Cancer Volume: 129(12) Pages: 2836-2846
  • Peer Reviewed
• [Journal Article] Heteroclitic serological response in esophageal and prostate cancer patients after NY-ESO-1 protein vaccination. (2011)
  • Author(s): Kawada, J., et al.
  • Journal Title: Int.J.Cancer Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] A phase I study of vaccination with NY-ESO-If peptide mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen. (2011)
  • Author(s): Kakimi, K., et al.
  • Journal Title: Int.J.Cancer Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Enrichment of Foxp3+ CD4 Tregs in migrated T-cells to IL-6- and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6. (2010)
  • Author(s): Eikawa, S., Ohue, Y., Kitaoka, K., Aji, T., Uenaka, A., Oka, M., and Nakayama, E.
  • Journal Title: J. Im」munol. Volume: 185(11) Pages: 6734-6740
  • DOI: 10.4049/jimmunol.1000225
  • Peer Reviewed
• [Journal Article] Three novel NY-ESO-1 epitopes bound to DRB1*0803, DQB1*0401 and DRB1*0901 recognized by CD4 T cells fromCHP-NY-ESO-1-vaccinated patients. (2010)
  • Author(s): Mizote, Y., Taniguchi, T., Tanaka, K., Isobe, M., Wada, H., Saika, T., Kita, S., Koide, Y., Uenaka, A., and Nakayama, E.
  • Journal Title: Vaccine Volume: 28(32) Pages: 5338-5346
  • URL: http://www.journals.elsevier.com/vaccine/
  • Peer Reviewed
• [Journal Article] Enrichment of Foxp3^+ CD4 Tregs in migrated T-cells to IL-6-and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6. (2010)
  • Author(s): Eikawa, S., et al.
  • Journal Title: J.Immunol. Volume: 185(11) Pages: 6734-6743
  • Peer Reviewed
• [Journal Article] Three novel NY-ESO-1 epitopes bound to DRB1*0803, DQBl*0401 and DRBl*0901 recognized by CD4 T cells from CHP-NY-ESO-1-vaccinated patients. (2010)
  • Author(s): Mizote, Y., et al.
  • Journal Title: Vaccine Volume: 28(32) Pages: 5338-5346
  • Peer Reviewed
• [Presentation] CD8 T cell response in NY-ESO-1 f-peptide vaccinated patient (2011)
  • Author(s): Shingo Eikawa(上中明子), 他
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-05
• [Presentation] "Antigen Spreading" in patients vaccinated with NY-ESO-1 protein (2011)
  • Author(s): Hisashi Wada, 他
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-05
• [Presentation] Humoral immune response of cancer patients against newly SEREX-defined antigen, GKAP1 (2011)
  • Author(s): Shohei Domae, 他
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-05
• [Presentation] Detection of CD4 T-cell responses using the HLA class II tetramer in the vaccinated cancer patients (2011)
  • Author(s): Yu Mizote, 他
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-04
• [Presentation] Correlation of Antibody and T Cell Responses Against XAGE-1b in NSCLC Patients (2011)
  • Author(s): Yoshihiro Ohue, 他
  • Organizer: 19th Annual International Cancer Immunotherapy Symposium
  • Place of Presentation: Millennium Conference Center(アメリカ)
  • Year and Date: 2011-10-03
• [Presentation] Induction of CD8 T Cell Responses Restricted to Multiple HLA Class I Alleles in a Cancer Patient by Immunization with a 20-Mer NY-ESO-1f (NY-ESO-1 91-110) Peptide (2011)
  • Author(s): Shingo Eikawa, 他
  • Organizer: 19th Annual International Cancer Immunotherapy Symposium
  • Place of Presentation: Millennium Conference Center(アメリカ)
  • Year and Date: 2011-10-03
• [Presentation] CD8 T cell response in NY-ESO-1 f-peptide vaccinated patient (2011)
  • Author(s): Shingo Eikawa, 他
  • Organizer: 第15回日本がん免疫学会
  • Place of Presentation: 千里ライフサイエンスセンター(大阪府)
  • Year and Date: 2011-06-30
• [Presentation] HLAクラスIIテトラマーを用いた免疫モニタリング (2011)
  • Author(s): 溝手雄, 他
  • Organizer: 第15回日本がん免疫学会
  • Place of Presentation: 千里ライフサイエンスセンター(大阪府)
  • Year and Date: 2011-06-30
• [Presentation] NY-ESO-1がんワクチン (2011)
  • Author(s): 中山睿一
  • Organizer: 第28回日本医学会総会2011東京
  • Place of Presentation: 丸ビルホール&コンファレンススクエア(東京都)(招待講演)
  • Year and Date: 2011-04-08
• [Presentation] NY-ESO-1癌ワクチン (2010)
  • Author(s): 和田尚, 他
  • Organizer: 第14回日本がん免疫学会(シンポジウム)
  • Place of Presentation: KKRホテル熊本(熊本)
• [Presentation] NY-ESO-1ワクチン患者におけるCD4T細胞の反応解析 (2010)
  • Author(s): 溝手雄, 他
  • Organizer: 第14回日本がん免疫学会
  • Place of Presentation: KKRホテル熊本(熊本)
• [Presentation] SEREX法による肺腺癌抗原の同定と発現解析 (2010)
  • Author(s): 花房直志, 他
  • Organizer: 第14回日本がん免疫学会
  • Place of Presentation: KKRホテル熊本(熊本)
• [Presentation] 肺癌患者におけるXAGE-1b特異的T細胞の誘導とその解析 (2010)
  • Author(s): 大植祥弘, 他
  • Organizer: 第14回 日本がん免疫学会
  • Place of Presentation: KKRホテル熊本(熊本)
• [Presentation] NY-ESO-1fペブチドワクチン投与患者におけるCD8T細胞の免疫応答 (2010)
  • Author(s): 榮川伸吾, 他
  • Organizer: 第14回 日本がん免疫学会
  • Place of Presentation: KKRホテル熊本(熊本)
• [Presentation] がんワクチンと免疫学的評価 (2010)
  • Author(s): 中山睿一
  • Organizer: 第69回 日本癌学会総会(モーニングレクチャー)
  • Place of Presentation: 大阪国際会議場(大阪)(招待講演)
• [Presentation] Analysis of CD4 T cell responses from NY-ESO-1 vaccinated patients. (2010)
  • Author(s): 溝手雄, 他
  • Organizer: 第69回 日本癌学会総会
  • Place of Presentation: 大阪国際会議場(大阪)
• [Presentation] Isolation and characterizztion of human lung cancer antigens by serological screening with autoloaous antibodies. (2010)
  • Author(s): 花房直志, 他
  • Organizer: 第69回 日本癌学会総会
  • Place of Presentation: 大阪国際会議場(大阪)
• [Presentation] CD4 and CD8 T cell responses against XAGE-lb antigen in non-small cell lung cancer patients. (2010)
  • Author(s): 大植祥弘, 他
  • Organizer: 第69回 日本癌学会総会
  • Place of Presentation: 大阪国際会議場(大阪)
• [Presentation] CD8 T cell response in NY-ESO-1 f-peptide vaccinated patient. (2010)
  • Author(s): 榮川伸吾, 他
  • Organizer: 第69回 日本癌学会総会
  • Place of Presentation: 大阪国際会議場(大阪)
• [Presentation] Heteroclitic serological response after NY-ESO-1 protein vaccination. (2010)
  • Author(s): 川田純司, 他
  • Organizer: 第69回 日本癌学会総会
  • Place of Presentation: 大阪国際会議場(大阪)
• [Presentation] Spontaneous XAGE-lb Immunity in Patients with Non-Small-Cell Lung Cancer. (2010)
  • Author(s): YOSHIHIRO OHUE, et al.
  • Organizer: INTERNATIONAL IMMUNOTHERAPY SYMPOSIA SERIES CANCER IMMUNOTHERAPY 2010
  • Place of Presentation: Millennium Hotel Conference Center (N.Y)
• [Presentation] CD8 T Cell Response in NY-ESO-1 f-Peptide Vaccinated Patients. (2010)
  • Author(s): SHINGO EIKAWA, et al.
  • Organizer: INTERNATIONAL IMMUNOTHERAPY SYMPOSIA SERIES CANCER IMMUNOTHERAPY 2010
  • Place of Presentation: Millennium Hotel Conference Center (N.Y.)
• [Presentation] 肺癌の自然退縮と増悪における免疫学的な病態解析 (2010)
  • Author(s): 松本博文, 他
  • Organizer: 第51回日本肺癌学会総会
  • Place of Presentation: 広島国際会議場(広島)
• [Presentation] 肺癌患者におけるXAGE-1b特異的T細胞の誘導とその解析 (2010)
  • Author(s): 大植祥弘, 他
  • Organizer: 第51回 日本肺癌学会総会
  • Place of Presentation: 広島国際会議場(広島)
• [Presentation] NY-ESO-1fペプチドワクチン投与肺がん患者におけるCD8T細胞の免疫応答 (2010)
  • Author(s): 榮川伸吾, 他
  • Organizer: 第51回 日本肺癌学会総会
  • Place of Presentation: 広島国際会議場(広島)
• [Presentation] NY-ESO-1長鎖ペプチドワクチン投与患者におけるCD4-T細胞反応の解析 (2010)
  • Author(s): 溝手雄, 他
  • Organizer: 第51回 日本肺癌学会総会
  • Place of Presentation: 広島国際会議場(広島)
• [Presentation] Correlation of antibody and T-cell responses against XAGE-1n in NSCLC patietns
  • Author(s): Yoshihiro OHUE
  • Organizer: 第16回 日本がん免疫学会総会
  • Place of Presentation: 北海道大学 学術交流会館（北海道）
• [Presentation] Inhibition of regulatory T-cell migration by ELR motif-binding peptide
  • Author(s): Shingo EIKAWA
  • Organizer: 第16回 日本がん免疫学会総会
  • Place of Presentation: 北海道大学 学術交流会館（北海道）
• [Presentation] Correlation of antibody and T-cell responses against XAGE-1b in NSCLC patients
  • Author(s): Yoshihiro Ohue
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ホテルロイトン札幌（北海道）
• [Presentation] Inhibition of regulatory T-cell migration by ELR motif-binding peptide
  • Author(s): Shingo Eikawa
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ホテルロイトン札幌（北海道）
• [Presentation] Melanoma-targeted chemo-thermo-immunotherapy and in situ peptide vaccine by NPrCAP
  • Author(s): Kowichi Jimbow
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ホテルロイトン札幌（北海道）
• [Presentation] NY-ESO-1 long peptide vaccine
  • Author(s): Hisahi Wada
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ホテルロイトン札幌（北海道）
• [Presentation] 非小細胞肺癌患者におけるXAGE-1b（GAGED2a）に対する宿主免疫応答の解析
  • Author(s): 大植 祥弘
  • Organizer: 第25回日本バイオセラピィ学会学術集会総会
  • Place of Presentation: 倉敷市芸文館（岡山）
• [Presentation] CD8 T cell response in NY-ESO-1f peptide vaccinated patients
  • Author(s): 榮川 伸吾
  • Organizer: 第25回日本バイオセラピィ学会学術集会総会
  • Place of Presentation: 倉敷市芸文館（岡山）
• [Book] 癌ワクチン-蛋白とロングペプチド-バイオテクノロジーシリーズ『がん免疫療法-実用化へのチャレンジ-』(監修;珠玖洋) (2010)
  • Author(s): 和田尚, 他
  • Publisher: シーエムシー出版
• [Remarks]
  • URL: http://www.kawasaki-m.ac.jp/resp/
• [Patent(Industrial Property Rights)] XAGE-1b特異的免疫反応を誘導するペプチドおよびその利用 (2010)
  • Inventor(s): 中山睿一, 大植祥弘
  • Industrial Property Rights Holder: 国立大学法人岡山大学
  • Filing Date: 2010-05-21
  • Application Year: 2010
  • Overseas
• [Patent(Industrial Property Rights)] XAGE-1b特異的免疫反応を誘導するベプチドおよびその利用 (2010)
  • Inventor(s): 中山睿一, 大植祥弘
  • Industrial Property Rights Holder: 国立大学法人 岡山大学
  • Filing Date: 2010-05-21
  • Application Year: 2010
  • Overseas