Development of comprehensive immunotherapy by defuccosylated antibody

• Project/Area Number: 22300333
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor immunology
• Research Institution: Aichi Medical University (2012); Nagoya City University (2010-2011)
• Principal Investigator: UEDA Ryuzo 愛知医科大学, 医学部, 教授 (20142169)
• Co-Investigator(Kenkyū-buntansha): ISHIDA Takashi 名古屋市立大学, 大学院・医学研究科, 准教授 (80405183) ; SUZUKI Susumu 愛知医科大学, 医学部, 助教 (70518422)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
• Keywords: 低フコシル化抗体 / CCR4 / 制御性T細胞(Treg) / CT 抗原 / 細胞傷害性T細胞(CTL) / モガムリズマブ / Treg / CTL / ATL / NOGマウス / HTLV-1 / Tax / 抗CCR4抗体

Research Abstract

Therapeutic experimental model in autologous system by antigen specific cytotoxic T lymphocyte (CTL) using human tumor inoculated NOG mice which mimic pathological features of human tumor including micro environment in the tumor. Significant therapeutic effect was demonstrated in Adult T-cell leukemia (ATL) cells inoculated NOG mice treated with infusion of HTLV-1 Tax specific CTL. The therapeutic mouse model in our study will be more important because the analysis of immune dynamism in tumor site is essential for the immunotherapy development.

Research Products

• [Journal Article] Autologous Tax-Specific CTL Therapy in a Primary Adult T Cell Leukemia/Lymphoma Cell-Bearing NOD/Shi-scid (2013)
  • Author(s): Ishida T, Suzuki S, Ueda R.
  • Journal Title: IL-2Rγnull Mouse Model. J Immunol
  • Peer Reviewed
• [Journal Article] Angioimmunoblastic T-cell lymphoma mice model (2013)
  • Author(s): Ishida T, Suzuki S, Ueda R
  • Journal Title: Leuk Res Volume: 37 Pages: 21-7
  • Peer Reviewed
• [Journal Article] Stevens-Johnson Syndrome associated with mogamulizumab treatment of adult T-cell leukemia / lymphoma (2013)
  • Author(s): Ishida T, Ueda R.
  • Journal Title: Cancer Sci Volume: 104 Pages: 647-50
  • Peer Reviewed
• [Journal Article] Reactivation of hepatitis B virus in a patient with adult T-cell leukemia/lymphoma receiving the anti-CC chemokine receptor 4 antibody mogamulizumab. (2013)
  • Author(s): Ishida T, Ueda R
  • Journal Title: Hepatol Res
  • Peer Reviewed
• [Journal Article] Bath-PUVA Therapy Decreases Infiltrating CCR4-Expressing Tumor Cells and Regulatory T Cells in Patients With Mycosis Fungoides (2013)
  • Author(s): Ueda R.
  • Journal Title: Clin Lymphoma Myeloma Leuk Volume: 13 Pages: 273-80
  • Peer Reviewed
• [Journal Article] Autologous Tax-specific CTL therapy in a primary ATL cell-bearing NOD/Shi-scid, IL-2Rγnull mouse model (2013)
  • Author(s): Masaki A
  • Journal Title: J.Immunol Volume: in press
  • Peer Reviewed
• [Journal Article] Angioimmunoblastic T-cell lymphoma mice model. (2013)
  • Author(s): Sato F
  • Journal Title: Leuk Res. Volume: 37 Issue: 1 Pages: 21-7
  • DOI: 10.1016/j.leukres.2012.09.009
  • Peer Reviewed
• [Journal Article] Bath-PUVA Therapy Decreases Infiltrating CCR4-Expressing Tumor Cells and Regulatory T Cells in Patients With Mycosis Fungoides. (2013)
  • Author(s): Kato H
  • Journal Title: Clin Lymphoma Myeloma Leuk. Volume: Epub ahead Issue: 3 Pages: 273-280
  • DOI: 10.1016/j.clml.2012.12.002
  • Peer Reviewed
• [Journal Article] Reactivation of hepatitis B virus in a patient with adult T-cell leukemia/lymphoma receiving the anti-CC chemokine receptor 4 antibody mogamulizumab. (2013)
  • Author(s): Nakano N
  • Journal Title: Hepatol Res. Volume: Epub ahead Issue: 3 Pages: 354-357
  • DOI: 10.1111/hepr.12117
  • Peer Reviewed
• [Journal Article] Stevens-Johnson Syndrome associated with mogamulizumab treatment of adult T-cell leukemia / lymphoma. (2013)
  • Author(s): Ishida T
  • Journal Title: Cancer Sci. Volume: 104 Issue: 5 Pages: 647-50
  • DOI: 10.1111/cas.12116
  • Peer Reviewed
• [Journal Article] Defucosylated Anti-CCR4 Monoclonal Antibody (KW-0761) for Relapsed Adult T-Cell Leukemia-Lymphoma: A Multicenter Phase II Study. (2012)
  • Author(s): Ishida T, Ueda R.
  • Journal Title: J ClinOncol Volume: 30 Pages: 837-42
  • Peer Reviewed
• [Journal Article] Tax is a potential molecular target for immunotherapy of adult T-cell leukemia/lymphoma (2012)
  • Author(s): Suzuki S, Ishida T, Ueda R.
  • Journal Title: Cancer Sci Volume: 103 Pages: 1764-73
  • Peer Reviewed
• [Journal Article] Potentantitumor effects of bevacizumab in a microenvironment-dependent human lymphoma mouse model (2012)
  • Author(s): Ishida T, Ueda R
  • Journal Title: Blood Cancer J Volume: 2(4)
  • Peer Reviewed
• [Journal Article] Allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia-lymphoma with special emphasis on preconditioning regimen: a nationwide retrospective study. (2012)
  • Author(s): Ishida T
  • Journal Title: Blood Volume: 120 Issue: 8 Pages: 1734-41
  • DOI: 10.1182/blood-2012-03-414490
  • Peer Reviewed
• [Journal Article] Tax is a potential molecular target for immunotherapy of adult T-cell leukemia/lymphoma. (2012)
  • Author(s): Suzuki S
  • Journal Title: Cancer Sci. Volume: 103 Issue: 10 Pages: 1764-73
  • DOI: 10.1111/j.1349-7006.2012.02371.x
  • Peer Reviewed
• [Journal Article] Potent antitumor effects of bevacizumab in a microenvironment-dependent human lymphoma mouse model. (2012)
  • Author(s): Mori F
  • Journal Title: Blood Cancer J. Volume: 2 Issue: 4 Pages: e67-e67
  • DOI: 10.1038/bcj.2012.12
  • Peer Reviewed
• [Journal Article] Cancer/testis antigens are novel targets of immunotherapy for adult T cell leukemia/lymphoma (2012)
  • Author(s): Nishikawa H.
  • Journal Title: Blood Volume: 119(13) Issue: 13 Pages: 3097-104
  • DOI: 10.1182/blood-2011-09-379982
  • Peer Reviewed
• [Journal Article] Defucosylated anti-CCR4 monoclonal antibody (KW-0761) for relapsed adult T-cell leukemia-lymphoma a multicenter phase II study (2012)
  • Author(s): Ishida T.
  • Journal Title: J Clin Oncol Volume: 30(8) Issue: 8 Pages: 837-42
  • DOI: 10.1200/jco.2011.37.3472
  • Peer Reviewed
• [Journal Article] Antibody therapy for adult T-cell leukemia-lymphoma (2011)
  • Author(s): Ishida T, Ueda R
  • Journal Title: Int J Hematol Volume: 94 Pages: 443-4
  • NAID: 10030265658
  • Peer Reviewed
• [Journal Article] Risk of Japanese carriers of hyperphosphorylated paratarg-7, he first autosomal-dominantly inherited risk factor for hematological neoplasms, to develop monoclonal gammopathy of undetermined significance and multiple myeloma (2011)
  • Author(s): Ueda R
  • Journal Title: Cancer Sci Volume: 102(3) Pages: 565-8
• [Journal Article] Clinical significance of hepatitis B virus (HBV)-DNA monitoring to detect HBV reactivation after systemic chemotherapy (2011)
  • Author(s): Ueda R.
  • Journal Title: J Clin Oncol Volume: 1:29(4)
• [Journal Article] Immunopathogenesis of lymphoma: Focus on CCR4. (2011)
  • Author(s): Ishida T and Ueda R
  • Journal Title: Cancer Sci Volume: 102(1) Pages: 44-50
  • NAID: 10029288284
• [Journal Article] Reactivation of hepatitis B virus following rituximab-plus-steroid combination chemotherapy. (2011)
  • Author(s): Ueda R.
  • Journal Title: J Gastroenterol. Volume: 46(1) Pages: 9-16
  • NAID: 10029026408
• [Journal Article] ABO blood group alleles and the risk of pancreatic cancer in Japanese population (2011)
  • Author(s): Nakao M
  • Journal Title: Cancer Sci Volume: 102(5) Issue: 5 Pages: 1076-80
  • DOI: 10.1111/j.1349-7006.2011.01907.x
  • Peer Reviewed
• [Journal Article] Virological and clinical characteristics on reactivation of occult hepatitis B in patients with hematological malignancy (2011)
  • Author(s): Sugauchi F
  • Journal Title: J Med Virol Volume: 83(3) Issue: 3 Pages: 412-8
  • DOI: 10.1002/jmv.21995
  • Peer Reviewed
• [Journal Article] Melphalan-Prednisolone and Vincristine-Doxorubicin-Dexamethasone Chemotherapy followed by Prednisolone/Interferon Maintenance Therapy for Multiple Myeloma (2011)
  • Author(s): Chou T
  • Journal Title: Jpn J Clin Oncol Volume: 41(4) Issue: 4 Pages: 586-9
  • DOI: 10.1093/jjco/hyq245
  • Peer Reviewed
• [Journal Article] Clionical significance of hepatitis B virus (HBV)-DNA monitoring to detect HBV reactivation after systemic chemotherapy (2011)
  • Author(s): Kusumoto S
  • Journal Title: J Clin Oncol Volume: 29(4) Issue: 4 Pages: e100-e100
  • DOI: 10.1200/jco.2010.33.0332
  • Peer Reviewed
• [Journal Article] Serodiagnosis of Mycobacterium avium-complex pulmonary disease with an enzyme immunoassay kit that detects anti-glycopeptidelipid core antigen IgA antibodies in patients with rheumatoid arthritis (2011)
  • Author(s): Watanabe M
  • Journal Title: Mod Rheumatol Volume: 21(2) Issue: 2 Pages: 144-9
  • DOI: 10.1007/s10165-010-0368-5
  • Peer Reviewed
• [Journal Article] Immunopathogenesis of lymphoma : Focus on CCR4 (2011)
  • Author(s): Ishida T
  • Journal Title: Cancer Sci Volume: 102(1) Issue: 1 Pages: 44-50
  • DOI: 10.1111/j.1349-7006.2010.01767.x
  • NAID: 10029288284
  • Peer Reviewed
• [Journal Article] Serodiagnosis of Mycobacterium avium-complex pulmonary disease with an enzyme immunoassay kit that detects anti-glycopeptidelipid core antigen IgA antibodies in patients with rheumatoid arthritis (2010)
  • Author(s): Ueda R
  • Journal Title: Mod Rheumatol Volume: Nov18
• [Journal Article] Anticipatory nausea among ambulatory cancer patients undergoing chemotherapy-prevalence, associated factors, and impact on quality of life. (2010)
  • Author(s): Ueda R.
  • Journal Title: Cancer Sci Volume: 101(12) Pages: 2596-600
  • NAID: 10027834647
• [Journal Article] Acomplement-dependentcytotoxicity-enhancing anti-CD20 antibody mediating potent antitumoractivity in the humanized NOD/Shi-scid, IL-2Rγ(null) mouse lymphoma model. (2010)
  • Author(s): Ishida T, Ueda R.
  • Journal Title: Cancer Immunol Immunother Volume: 59(12) Pages: 1791-1800
• [Journal Article] Significance of thymidylate synthase for resistance to pemetrexed in lung cancer. (2010)
  • Author(s): Ueda R.
  • Journal Title: Cancer Sci Volume: 101(1) Pages: 161-6
  • NAID: 10027199981
• [Journal Article] Defucosylated humanized anti-CCR4 monoclonal antibody KW-0761 as a novel immunotherapeutic agent for adult T-cell leukemia/lymphoma. (2010)
  • Author(s): Ishida T, Ueda R.
  • Journal Title: Clin Cancer Res. Volume: 16(5) Pages: 1520-31
• [Journal Article] Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma. (2010)
  • Author(s): Ishida T, Ueda R.
  • Journal Title: J Clin Oncol. Volume: 28(9) Pages: 1591-8
• [Journal Article] ABCC11/MRP8 confers pemetrexed resistance in lung cancer. (2010)
  • Author(s): Ueda R.
  • Journal Title: Cancer Sci. Volume: 101(11) Pages: 2404-2410
  • NAID: 10027833586
• [Journal Article] A case of compensated liver cirrhosis because of hepatitis C virus of genotype 1b and high viral load in which sustained virological response was achieved by 2-year administration of very low dose recombinant interferonalpha-2b. (2010)
  • Author(s): Ueda R.
  • Journal Title: Eur J Gastroenterol Hepatol Volume: 22(1) Pages: 121-122
• [Journal Article] Efficacy of S-1 monotherapy for non-small cell lung cancer after the failure of two or more prior chemotherapy regimens. (2010)
  • Author(s): Ueda R.
  • Journal Title: Oncology Letters Volume: 1 Pages: 147-150
• [Journal Article] Phase I study of KW-O761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma. (2010)
  • Author(s): Yamamoto K
  • Journal Title: J Clin Oncol. Volume: 28(9) Pages: 1591-8
  • Peer Reviewed
• [Journal Article] Efficacy of S-1 monotherapy for non-small cell lung cancer after the failure of two or more prior chemotherapy regimens (2010)
  • Author(s): Takakuwa O
  • Journal Title: Oncology Letters. Volume: 1 Pages: 147-150
  • Peer Reviewed
• [Journal Article] A retrospective study of the epidemiology of Clostridium difficile infection at a University Hospital in Japan : genotypic features of the isolates and clinical characteristics of the patients. (2010)
  • Author(s): Iwashima Y
  • Journal Title: J Infect Chemother. Volume: 16(5) Pages: 329-339
  • Peer Reviewed
• [Journal Article] Amrubicin monotherapy for elderly patients with previously treated lung cancer. (2010)
  • Author(s): Nakao M
  • Journal Title: Intern Med. Volume: 49(17) Pages: 1857-62
  • Peer Reviewed
• [Journal Article] Bortezomib-resistant myeloma cell lines : a role for mutated PSMB5 in preventing the accumulation of unfolded proteins and fatal ER stress. (2010)
  • Author(s): Ri M
  • Journal Title: Leukemia Volume: 24(8) Pages: 1506-12
  • Peer Reviewed
• [Journal Article] Reactivation of hepatitis B virus in HBsAg-negative patients with multiple myeloma : two case reports. (2010)
  • Author(s): Yoshida T
  • Journal Title: Int J Hematol. Volume: 91(5) Pages: 844-9
  • Peer Reviewed
• [Journal Article] A case of compensated liver cirrhosis with hepatitis C virus of genotype 1b and high viral load in whom sustained virological response was achieved by 2-year administration of very low-dose recombinant interferon alpha-2b. (2010)
  • Author(s): Kato H
  • Journal Title: Eur J Gastroenterol Hepatol. Volume: 22(1) Pages: 121-2
  • Peer Reviewed
• [Journal Article] Significance of thymidylate synthase for resistance to pemetrexed in lung cancer. (2010)
  • Author(s): Ozasa H
  • Journal Title: Cancer Sci. Volume: 101(1) Pages: 161-6
  • Peer Reviewed
• [Presentation] Chemokine receptor 4 (CCR4) is a promising target for development of new tumor immunotherapy. (2013)
  • Author(s): Ueda R
  • Organizer: Inter. Academy for Advanced Oncology (IAAO)
  • Place of Presentation: Tokyo
  • Year and Date: 2013-08-03
• [Presentation] Development of CTL preparation kit for adoptive T cell immunotherapy. (2013)
  • Author(s): Suzuki S, Ueda R.(他3名)
  • Organizer: 20th Annual Cancer Research Institute International Symposium. Cancer Immunotherapy 2012
  • Place of Presentation: New York
• [Presentation] Multicenter phase II study of Mogamulizumab (KW-0761) a defucosylated anti-CCR4 antibody (2012)
  • Author(s): Ishida T, Ueda R.(他17名)
  • Organizer: in patients with relapsed peripheral and cutaneous T-cell lymphoma 54th ASH2012(Abstract #795Oral presentation)
  • Place of Presentation: Atlanta
  • Year and Date: 2012-12-09
• [Presentation] Chemokine receptor 4(CCR4) is a promising new target for tumor immunotherapy. (2012)
  • Author(s): Ueda R
  • Organizer: The Sino-Japan Symposium on Translational Research for Cancer Therapy
  • Place of Presentation: Kobe
  • Year and Date: 2012-11-27
• [Presentation] モガムリズマブはがんワクチン両方の効果増強を目的として併用されるべき有力な新規抗体薬候補である.(シンホ゜12;次世代がん免疫治療の展望) (2012)
  • Author(s): 上田龍三、石田高司
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-21
• [Presentation] バイオテクノロジーが招く、近未来の医学 (2012)
  • Author(s): 上田龍三
  • Organizer: 第21回日本CellDeath学会講演
  • Place of Presentation: 名古屋(名古屋大学医学部)
  • Year and Date: 2012-07-28
• [Presentation] 日本発CCR4抗体開発の歩みーベンチワークからベットサイドまでー (2012)
  • Author(s): 上田龍三
  • Organizer: 第16回日本がん免疫学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-07-26
• [Presentation] Anti-CCR4 Monoclonal antibody, Mogamulizumab, targeting regulatory T cells.Lloyd J. Old Memorial Symposium in Cancer Immunology. (2012)
  • Author(s): Ishida T, Ueda R
  • Organizer: -Challenge for the next generation of Dr. Old's view- Sept.
  • Place of Presentation: Sapporo
• [Presentation] Multicenter Phase II Study of Mogamulizumab (KW-0761), a Defucosylated Anti-CCR4 Antibody, in Patients with Relapsed Peripheral and Cutaneous T-Cell Lymphoma (2012)
  • Author(s): Ishida T
  • Organizer: 54th ASH Annual Meeting and Exposition
  • Place of Presentation: Atlanta, GA
• [Presentation] Reactivation of hepatitis B virus infection in patients with adult T-cell leukemia/lymphoma. (2012)
  • Author(s): Totani H
  • Organizer: The 74th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Kyoto
• [Presentation] Autologous Tax-specific CTL therapy in a primary ATL cell-bearing NOG mouse model. (2012)
  • Author(s): Masaki A
  • Organizer: The 74th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Kyoto
• [Presentation] Potent antitumor effects of bevacizumab in a microenviroment-dependent human ATL mouse model. (2012)
  • Author(s): Mori F
  • Organizer: The 74th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Kyoto
• [Presentation] Development of CTL preparation kit for adoptive T cell immunotherapy. (2012)
  • Author(s): Suzuki S
  • Organizer: 20th Annual Cancer Research Institute International Symposium. Cancer Immunotherapy
  • Place of Presentation: New York
• [Presentation] Anti-CCR4 Monoclonal antibody, Mogamulizumab, targeting regulatory T cells. (2012)
  • Author(s): Ishida T
  • Organizer: Lloyd J. Old Memorial Symposium in Cancer Immunology. –Challenge for the next generation of Dr. Old’s view
  • Place of Presentation: Sapporo
• [Presentation] Mogamulizumab is a promissing new candidate of incorporated modulators for the cancer vaccine therapy (2012)
  • Author(s): Ueda R
  • Organizer: The 71st Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Sapporo
• [Presentation] バイオテクノロジーが招く、近未来の医学 (2012)
  • Author(s): 上田龍三
  • Organizer: 第21回日本Cell Death学会
  • Place of Presentation: Nagoya
• [Presentation] CCR4抗体開発の歩みーベンチワークからベットサイドまで (2012)
  • Author(s): 上田隆三
  • Organizer: 第16回日本がん免疫学会総会
  • Place of Presentation: Sapporo
• [Presentation] Potent Tax-specific CTL response to primary autologous ATL cells (2011)
  • Author(s): 鈴木進
  • Organizer: 第73回日本血液学会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-16
• [Presentation] がんの薬物療法最前線 (2011)
  • Author(s): 上田龍三
  • Organizer: 第18回日本癌学会市民公開講座
  • Place of Presentation: 名古屋国際会議場(愛知県)(招待講演)
  • Year and Date: 2011-10-02
• [Presentation] Establishment of an angioimmunoblastic T-cell lymphoma(AITL) model in the NOG mouse. (2011)
  • Author(s): IshidaT,UedaR.(他6名)
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-09-05
• [Presentation] がん抗体療法の進歩-CCR4抗体を中心に- (2011)
  • Author(s): 上田龍三
  • Organizer: 日本がん分子標的治療学会第15回学術集会
  • Place of Presentation: ホテル日航東京(東京都)(招待講演)
  • Year and Date: 2011-06-22
• [Presentation] Immunology and antibody therapy:Targeting chemokine receptors. (2011)
  • Author(s): Ueda R.
  • Organizer: T-Cell Lymphoma Fourm
  • Place of Presentation: San Francisco, CA
  • Year and Date: 2011-01-28
• [Presentation] がん抗体療法の進歩-抗CCR4抗体を中心にー (2011)
  • Author(s): 上田龍三
  • Organizer: 日本がん分子標的治療学会第15回学術集会基調講演
  • Place of Presentation: 東京(ホテル日航東京)
• [Presentation] AMulticenter phase II study of KW-0761 for relapsed ATL. (2011)
  • Author(s): IshidaT,UedaR.(他18名)
  • Organizer: 第9回日本臨床腫瘍学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Enhancement of HTLV-1 tax protein expression and the response of tax specific CTL by HDAC inhibitor. (2011)
  • Author(s): SuzukiS,IshidaT,UedaR.(他11名)
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] Bevacizumab-induced potent antitumor effect in amicroenvironment-dependent mouse lymphoma model. (2011)
  • Author(s): IshidaT,UedaR(他10名)
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] がんの薬物療法最前線 (2011)
  • Author(s): 上田龍三
  • Organizer: 第18回日本癌学会市民公開講座
  • Place of Presentation: 名古屋
• [Presentation] Bevacizumab-induced potent antitumor effect in a microenvironment-dependentmouse lymphoma model. (2011)
  • Author(s): 石田高司、鈴木進、上田龍三(他8名)
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] がんの薬物療法最前線 (2011)
  • Author(s): 上田龍三
  • Organizer: 第18回日本癌学会市民公開講座
  • Place of Presentation: June Nagoya
• [Presentation] がん抗体療法の進歩-CCR4抗体を中心にー (2011)
  • Author(s): 上田龍三
  • Organizer: 日本がん分子標的治療学会第15回学術集会
  • Place of Presentation: June Nagoya
• [Presentation] Impact of overwegith on outcomes of hematopoietc stem cell transplation: Meta-analysesl.
  • Author(s): Ueda R.(他4名)
  • Organizer: The 74th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 京都
• [Presentation] Potent antitumor effects of bevacizumab in a microenviroment-dependent human ATL
  • Author(s): Ishida T, Suzuki S, Ueda R,(他14名)
  • Organizer: The 74th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 京都
• [Presentation] Autologous Tax-specific CTL therapy in a primary ATL cell-bearing NOG mouse model.
  • Author(s): Ishida T, Suzuki S, Ueda R.(他9名)
  • Organizer: The 74th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 京都
• [Presentation] Reactivation of hepatitis B virus infection in patients with adult T-cell leukemia/lymphoma.
  • Author(s): Ishida T, Ueda R.(他11名)
  • Organizer: The 74th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 京都
• [Presentation] Enhancement of HTLV-1 tax protein expression and the response of tax specific CTL by HDAC inhibitor.
  • Author(s): Suzuki S, Ishida T, Ueda R. (他 9 名)
  • Organizer: The 73th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Nagoya
• [Book] Progress in clinical use of CCR4 antibody for Treg cell suppression.
  • Author(s): Suzuki S, Ishida T, Yoshikawa K and Ueda R.
  • Publisher: Inflammation and Immunity in Cancer