Physiological and pathological analyses of cell adhesion molecules towards the development of diagnostic markers of human cancer
| Project/Area Number |
22300336
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor diagnosis
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITO Akihiko 近畿大学, 医学部, 教授 (80273647)
SAKURAI Mika 東京大学, 医科学研究所, 助教 (80508359)
GOTO Akiteru 秋田大学, 大学院・医学系研究科, 教授 (90317090)
MATSUBARA Daisuke 東京大学, 医科学研究所, 講師 (80415554)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | がんの個性診断 / 細胞接着分子 / CADM1 / 非小細胞肺癌 / 小細胞肺癌 / MET / 分子標的薬 / miRNA / 糖鎖修飾 / 肺がん / 腎細胞がん / 乳がん / ATL / 増殖因子受容体 |
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| Research Abstract |
Physiological and pathological roles of cell adhesion molecules in cancer development and progression were analyzed to establish novel molecular markers of human cancer. We found that a splicing variant of a cell adhesion molecule CADM1 was expressed exclusively in small cell lung cancer (SCLC), providing a candidate diagnostic marker of SCLC. We also found that CADM1 could cross-talk with the MET signaling and may play a role in acquired resistance of lung adenocarcinoma against EGFR-TKItreatment.
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Report
(4 results)
Research Products
(57 results)
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[Journal Article] Expression of a splicing variant of the CADM1 specific to small cell lung cancer2012
Author(s)
Kikuchi S, Iwai M, Sakurai-Yageta M, Tsuboi Y, Ito T, Maruyama T, Tsuda H, Kanai Y, 0nizuka M, Sato Y, Murakami Y
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Journal Title
Cancer Science
Volume: 103
Issue: 6
Pages: 1051-1057
DOI
Related Report
Peer Reviewed
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[Journal Article] Aberrant expression of tumor suppressors, CADM1 and 4. IB, in invasive lesions of primary breast cancer2012
Author(s)
Takahashl Y, Iwai M, Kawai T, Arakawa A, Ito T, Sakurai-Yageta M, Ito A, Goto A, Saito M, Kasumi F, Murakami Y
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Journal Title
Breast Cancer
Volume: (掲載確定)
Issue: 3
Pages: 242-252
DOI
Related Report
Peer Reviewed
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