| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Research Abstract |
We revised the established theory of the structure of human chromosomes by X-ray scattering experiments conducted using SPring-8. Experimental data indicate irregularly folded nucleosome fibers without a 30-nm chromatin structure or regularly folding of chromatin fibers. We also proposed a new coherent imaging method using a confined illumination, which can be applicable also to frozen-hydrated biological samples with extended ice layer, to overcome the limitation of conventional data analysis algorithm in X-ray diffraction microscopy.
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