| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
|
|---|
| Research Abstract |
By utilizing small-molecule immobilization methods and thus obtained small molecule-immobilized solid supports, we have developed the following technologies: i.e., (1) a technology to identify cellular binding protein(s) for bioactive small molecules, and (2) a technology platform to identify substrate(s) for P450 enzymes of interest. Among them, the latter was realized by developing a fluorescent turn-on probe that react with NAD(P)+ produced during P450 substrate oxidation.
|
