Synthesis of nioactive natural products having highly functionalizsd torsional structures
| Project/Area Number |
22350045
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Waseda University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TATSUTA Kuniaki 早稲田大学, 名誉教授・栄誉フェロー (40051627)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2010: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | 有機合成化学 / 生理活性 / 天然物 / 創薬 / 全合成 / 多環式骨格 / ねじれ構造 / 天然物合成 / 生理活性物質 / 自己触媒 |
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| Research Abstract |
Synthetic studies on polycyclic and bioactive natural products having torsional and specific structures were performed. The first total syntheses of some natural products have been achieved, and the specific skeletons of other polyciclic natural products have been constructed. Additionally, new methodologies including the cyclization with thiolactones, the construction of a xanthone using chromonecarboxaldehyde and unsaturated malonate, and the short-step synthesis of reduced propionates have been developed.
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Report
(4 results)
Research Products
(51 results)
