Neuroactive marine metabolites that modulate synaptic functions
Project/Area Number |
22380114
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Fisheries chemistry
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Research Institution | Hokkaido University |
Principal Investigator |
RYUICHI Sakai 北海道大学, 大学院水産科学研究院, 教授 (20265721)
|
Project Period (FY) |
2010-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
|
Keywords | 海洋天然物 / 中枢神経 / 生理活性物質 / グルタミン酸受容体 / GPCR / レクチン / プリン / Gタンパク質共役型受容体 / ペプチド / ポリアミン / 海洋生理活性天然物 / ガレクチン / シナプス受容体 / 海綿 / 脱感作 / GABA受容体 / イソグアニン |
Research Abstract |
Marine natural products are a rich source of neuroactive compounds that selectively acts to ion channels and receptors that function or modulate synaptic neurotransmission. Here, we have isolated biologically active metabolites that modulate neuronal functions, including new polyamine-modified peptide toxin aculeines, a sponge galectin CchGs that modulate actions of AMPA/KA-type glutamate receptors, a new alkaloids from sponges that target neuronal receptors selectively. We determined chemical structure, target receptors, and modes of activity of those molecules.
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Report
(6 results)
Research Products
(39 results)
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[Journal Article] Studies on an (S)-2-amino-3-(3-hydroxy- 5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159 : asymmetric synthesis, neuroactivity, and structural characterization2013
Author(s)
Juknaite, L.; Sugamata, Y.; Tokiwa, K.; Ishikawa, Y.; Takamizawa, S.; Eng, A.; Sakai, R.; Pickering, D. S.; Frydenvang, K.; Swanson, G. T.; Kastrup, J. S.; Oikawa, M.
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Journal Title
J. Med. Chem
Volume: 56
Issue: 6
Pages: 2283-93
DOI
Related Report
Peer Reviewed
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[Journal Article] Isolation, amino acid sequence and biological activities of novel long-chain polyamine-associated peptide toxins from the sponge Axinyssa aculeata2011
Author(s)
Matsunaga, S., Jimbo, M., Gill, M.B., Wyhe, L.L., Murata, M., Nonomura, K., Swanson, G.T., Sakai, R.
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Journal Title
Chembiochem
Volume: 14
Issue: 14
Pages: 2191-2200
DOI
Related Report
Peer Reviewed
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[Presentation] Aculeineおよびその類縁体の構造解析2011
Author(s)
松永智子、酒井隆一、Gill, M.B., Lash, Van-Wyhe, L.L., Swanson G.T.
Organizer
第53回天然有機化合物討論会
Place of Presentation
大阪国際センター(大阪)
Year and Date
2011-09-28
Related Report
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