Creation of judging method for livestock egg quality based on the molecular mechanism of follicular selection
| Project/Area Number |
22380148
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied animal science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MANABE Noboru 東京大学, 農学生命科学研究科, 教授 (80243070)
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| Co-Investigator(Kenkyū-buntansha) |
MIYANO Takashi 神戸大学, 大学院・農学研究科, 教授 (80200195)
OKUDA Kiyoshi 岡山大学, 大学院・自然科学研究科, 教授 (40177168)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | 卵子品質 / 卵胞閉鎖 / 細胞死阻害因子 / 顆粒層細胞 / アポトーシス / 家畜卵巣 / 発現制御 / 家畜 / 卵巣 / 哺乳類 |
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| Research Abstract |
Less than 1% of several hundreds of thousand primordial follicles in livestock ovary leads to ovulation, and the rest to selectively disappear by atresia. Many studies in endocrine have been performed but follicle selection mechanism is unknown. We have shown that intracellular signaling pathway of cell death ligand-receptor system that regulates follicle granulosa cell apoptosis is the key to control the follicle selection. In the present project, the factors in this signaling pathway were precisely examined. We indicated that the signal inhibitors are involved in dominant factor to control the follicle selection, and that they are useful as an indicator of oocyte quality determination.
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Report
(5 results)
Research Products
(189 results)
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[Journal Article] The molecular mechanism of apoptosis upon caspase-8 activation: Quantitative experimental validation of a mathematical model.2012
Author(s)
Katsuya Kominami, Jun Nakabayashi, Takeharu Nagai, Yuki Tsujimura, Kumiko Chiba, Haruna Kimura, Atsushi Miyawaki, Tatsuya Sawasaki, Hideo Yokota, Noboru Manabe, Kazuhiro Sakamaki
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Journal Title
Biochimica et Biophysica Acta (Molecular Cell Research)
Volume: 1832
Pages: 1825-1840
Related Report
Peer Reviewed
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[Journal Article] 福島第一原子力発電所事故後の茨城県産牧草を給与した牛の乳における放射性核種物質濃度2012
Author(s)
橋本健, 田野井慶太朗, 桜井健太, 飯本武志, 野川憲夫, 桧垣正吾, 小坂尚樹, 高橋友継, 榎本百合子, 小野山一郎, 李俊佑, 眞鍋昇, 中西友子
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Journal Title
Radioisotopes
Volume: 60
Pages: 335-338
Related Report
Peer Reviewed
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