| Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
|
|---|
| Research Abstract |
Heterosis was found more than 100 years ago. Since then, it has become a genetic phenomenon essential for animal and plant breeding. However, no causative gene for heterosis has been cloned. I previously discovered a new QTL (quantitative trait locus) for heterosis of body weight from a gene pool of wild mice and I fine-mapped it to a limited chromosomal region by QTL analysis using a congenic mouse strain. In this study, I performed exome analysis, phenotypic analysis and gene-expression analysis using congenic and subcongenic mouse strains developed in previous and present studies. I fine-mapped the body weight QTL to an about 6-Mb genomic region, although its heterotic effect was unfortunately not confirmed in this study. I also revealed that four genes are putative candidate genes for the body weight QTL.
|
