Effects of stress on neuronal activities relating the function of the amygdala.
| Project/Area Number |
22390012
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MATSUKI Norio 東京大学, 大学院・薬学系研究科, 教授 (70126168)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 記憶・学習 / 海馬 / 扁桃体 / ストレス / シナプス伝達 / スパイン / 恐怖記憶 / 内的興奮性 / 慢性ストレス / コルチコステロン / Arc / 学習 / 恐怖条件付け / シナプス可塑性 / 消失記憶 / 活動依存的変化 / シナプス後電流 |
|---|
| Research Abstract |
The purpose of the present study was to investigate effects of stress on brain function, especially amygdale-dependent learning, in relation to depression. Synaptic transmission in the amygdale was shown to increase after fear-conditioning. Chronic stress affected neuronal morphology in the amygdale. Effects of peripheral stress on learning and memory was also shown.
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Report
(4 results)
Research Products
(117 results)
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[Journal Article] Locally synchronized synaptic inputs2012
Author(s)
Takahashi, N., Kitamura, K., Matsuo, N., Mayford, M., Kano, M., Matsuki, N. and Ikegaya, Y
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Journal Title
Science
Volume: 335
Pages: 353-356
Related Report
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[Journal Article] Activity-dependent Proteolytic Cleavage ofNeuroligin2012
Author(s)
Suzuki, K., Y. Hayashi, S. Nakahara, H.Kumazaki, J. Prox, K. Horiuchi, M. Zeng, S. Tanimura, Y. Nishiyama, S. Osawa, A.Sehara-Fujisawa, P. Saftig, S. Yokoshima, T. Fukuyama, N. Matsuki, R. Koyama, T. Tomita and T. Iwatsubo
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Journal Title
Neuron
Volume: 76
Pages: 410-422
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[Journal Article] Activity-dependent proteolytic cleavage of neuroligin-12012
Author(s)
Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zeng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Fukuyama T, Matsuki N, Koyama R, Tomita T, Iwatsubo T.
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Journal Title
Neuron
Volume: 76(2)
Issue: 2
Pages: 410-422
DOI
Related Report
Peer Reviewed
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[Journal Article] p38 MAP kinase regulates the expression of genes in the dopaminesynthesis pathway through phosphorylation of NR4A nuclear receptors2011
Author(s)
Sekine, Y., S. Takagahara, R. Hatanaka, T.Watanabe, H. Oguchi, T. Noguchi, I. Naguro, K. Kobayashi, M. Tsunoda, T. Funatsu, H. Nomura, T. Toyoda, N. Matsuki, E. Kuranaga, M. Miura, K. Takeda and H. Ichijo
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Journal Title
J. Cell Sci
Volume: 124
Pages: 3006-3016
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[Journal Article] Development of a Far-Red to Near-Infrared Fluorescence Probe for Calcium Ion and its Application to Multicolor Neuronal Imaging2011
Author(s)
Egawa, T., K. Hanaoka, Y. Koide, S. Ujita, N. Takahashi, Y. Ikegaya, N. Matsuki, T. Terai, T. Ueno, T. Komatsu, and T. Nagano
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Journal Title
J. Am. Chem. Soc
Volume: 133
Pages: 14157-14159
Related Report
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[Journal Article] Hippocampal polysynaptic computation2011
Author(s)
Kimura, R., Kang, S., Takahashi, N., Usami, A., Matsuki, N., Fukai, T., Ikegaya, Y.
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Journal Title
The Journal of Neuroscience
Volume: 31
Issue: 37
Pages: 13168-13179
DOI
Related Report
Peer Reviewed
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[Journal Article] Fluorescent pipettes for optically targeted patch-clamp recordings2010
Author(s)
Ishikawa, D., Takahashi, N., Sasaki, T., Usami, A., Matsuki, N. and Ikegaya, Y
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Journal Title
Neural Networks
Volume: 23
Pages: 669-672
Related Report
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[Journal Article] Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1 (ASK1)-deficient mice2010
Author(s)
Kumakura, K., H. Nomura, T. Toyoda, K.Hashikawa, T. Noguchi, K. Takeda, H. Ichijo, M. Tsunoda, T. Funatsu, D. Ikegami, M. Narita, T. Suzuki and N. Matsuki
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Journal Title
Neurosci. Res
Volume: 66
Pages: 313-320
NAID
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