| Project/Area Number |
22390019
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOGURE Noriyuki 千葉大学, 大学院・薬学研究院, 助教 (80396689)
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| Co-Investigator(Renkei-kenkyūsha) |
HORIE Shunji 城西国際大学, 薬学部, 教授 (50209285)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Keywords | 鎮痛薬 / 脳機能改善薬 / 天然活性物質 / 生物活性物質の探索 / 全合成 / アルカロイト / 構造活性相関 / アルカロイド / 天然物化学 / 生物活性天然物 / オピオイド / 不斉全合成 / リコポジウム |
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| Research Abstract |
To develop new analgesics for cancer pain, structure of the lead-compound having Corynanthe-type skeleton was modified, resulting in the creation of new derivatives with potent analgesic activity as well as with stability against microsomal metabolism. Iboga-type indole alkaloids were found to be a new class of antagonist of CB1 receptors. Voacangalactonine, a new alkaloid possessing Iboga structure, was synthesized in an asymmetric manner. To investigate the seeds molecules for development of medicines for dementia, isolation, structure elucidation, and total syntheses of Lycopodium alkaloids were performed.
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