Study of new broad spectrum of anti-parasitic agent and basis of molecular base of it
Project/Area Number |
22390024
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Environmental pharmacy
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Research Institution | Okayama University |
Principal Investigator |
WATAYA Yusuke 岡山大学, 大学院・医歯薬学総合研究科, 名誉教授 (90127598)
|
Co-Investigator(Kenkyū-buntansha) |
SATO Akira 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40530663)
KIM Hye-sook 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70314664)
DOI Hiroyuki 岡山大学, 大学院・医歯薬学総合研究科, 教授 (20452568)
|
Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
|
Keywords | 住血吸虫 / マラリア / 分子生物学 / 抗寄生虫薬 / ゲノミクス / プロテオミクス / マンソン住血吸虫 / マラリア原虫 / 広範囲抗寄生虫薬 / シストソミューラ / N-89 / 標的分子 |
Research Abstract |
The mechanism of action of N-89 for malaria and schistosomiasis; (1) Total 11 of proteins were changed by N-89 in Schistosoma mansoniusing comprehensive proteomics. Among them, paramyosin was reduced to 30% of control after 24hr treatment with N-89. Malaria parasite and S. mansoniwere not similar target molecules in proteomics with N-89 in the study and it will be necessary to validate further the differences in both 2 pathogens. (2) Body length of S. mansoni was shorted by N-89 administration and production of hemozoin also decreased in vivo experiment. (3) Rhodamine-N-89 adducts will may act incorporated into the parasite body clearly.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Applications of triphenylpyrylium salt-sensitized electron transfer photo-oxygenation reactions to the synthesis of benzo-fused 1,4-diaryl-2,3- dioxabicyclo[2.2.2]octanes as new antimalarial cyclic peroxides.2013
Author(s)
Kamata, M., Hagiwara, J., Hokari,T., Suzuki,C., Fujino,R., Kobayashi,S., Kim,H.-S.and Wataya, Y
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Journal Title
Research on Chemical Intermediate
Volume: 39
Pages: 127-137
URL
Related Report
Peer Reviewed
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[Journal Article] Plasmodium falciparumendoplasmic reticulum-resident calcium binding protein is a possible target of synthetic antimalarial endoperoxides, N-89 and N-251.2012
Author(s)
Morita, M., Sanai, H., Hiramoto, A., Sato, A., Hiraoka, O., Sakura, T., Kaneko, O., Masuyama, A., Nojima, M., Wataya, Y. and Kim, H.-S.
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Journal Title
J Proteome Res.
Volume: 11
Pages: 5704-5711
URL
Related Report
Peer Reviewed
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[Journal Article] Andirolides HeP from the flower of andiroba (Carapa guianensis, Meliaceae).2012
Author(s)
Tanaka, Y., Sakamoto, A., Inoue, T., Yamada, T., Kikuchi, T., Kajimoto, T., Muraoka, O., Sato, A., Wataya, Y., Kim, H.-S, and Tanaka, R.
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Journal Title
Tetrahedron
Volume: 68
Pages: 3669-3677
URL
Related Report
Peer Reviewed
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[Journal Article] Plasmodium falciparum endoplasmic reticulum-resident calcium binding protein is a possible target of synthetic antimalarial endoperoxides, N-89 and N-2512012
Author(s)
Morita M., Sanai H., Hiramoto A., Sato A., Hiraoka O., Sakura T., Kaneko O., Masuyama A., Nojima M., Wataya Y., Kim H.-S.
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Journal Title
Journal of Proteome Research
Volume: 11
Issue: 12
Pages: 5704-5711
DOI
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Peer Reviewed
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[Journal Article] Andirolides H-P from the flower of andiroba (Carapa guianensis, Meliaceae)2012
Author(s)
Tanaka Y., Sakamoto A., Inoue T., Yamada T., Kikuchi T., Kajimoto T., Muraoka O., Sato A., Wataya Y., Kim H.-S., Tanaka R.
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Journal Title
Tetrahedron
Volume: 68
Issue: 18
Pages: 3669-3677
DOI
Related Report
Peer Reviewed
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[Journal Article] tetraoxaspiro [7.11]nonadec-4-yl)hexan- 1-ol (N-251) and its carboxylic acid derivatives2011
Author(s)
Sato, A, Kawai, S., Hiramoto, A., Morita, M., Tanigawa, N., Nakase, Y., Komichi, Y., Matsumoto, M., Hiraoka, O., Hiramoto, K., Tokuhara, H., Masuyama, A., Nojima, M., Higaki, K., Hayatsu, H., Wataya,Y., Kim, H.-S.
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Journal Title
Parasitol. Int
Volume: 60 (4)
Pages: 488-492
URL
Related Report
Peer Reviewed
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[Journal Article] Antimalarial Activity of Endoperoxide Compound 6-(1,2,6,7- Tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol.2011
Author(s)
Sato, A., Hiramoto, A., Morita, M., Matsumoto, M., Komich, Y., Nakase, Y., Tanigawa, N., Hiraoka, O., Hiramoto, K., Hayatsu, H., Higaki, K., Kawai, S., Masuyama, A., Nojima, M., Wataya,Y., Kim, H.-S.
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Journal Title
Parasitol. Int.
Volume: 60
Pages: 270-273
URL
Related Report
Peer Reviewed
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[Journal Article] Schistosomicidal and antifecundity effects of oral treatment of synthetic endoperoxide N-89.2011
Author(s)
Taniguchi, T., Kumagai, T., Shimogawara, R., Ichinose, S., Hiramoto, A., Sato, A., Morita, M., Nojima, M., Kim, H.-S., Wataya, Y., Ohta, N.
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Journal Title
arasitology International
Volume: 60
Pages: 231-236
URL
Related Report
Peer Reviewed
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[Journal Article] Antimalarial Activity of 6-(1,2,6,7-Tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) and Its Carboxylic Acid Derivatives2011
Author(s)
Sato A., Kawai S., Hiramoto A., Morita M., Tanigawa N., Nakase Y., Komichi Y., Matsumoto M., Hiraoka O., Hiramoto K., Tokuhara H., Masuyama A., Nojima M., Higaki K., Hayatsu H., Wataya Y., Kim H.-S.
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Journal Title
Parasitology International
Volume: 60
Issue: 4
Pages: 488-492
DOI
Related Report
Peer Reviewed
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[Journal Article] Antimalarial Activity of Endoperoxide Compound 6-(1,2,6,7-Tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol2011
Author(s)
Sato A., Hiramoto A., Morita M., Matsumoto M., Komichi Y., Nakase Y., Tanigawa N., Hiraoka O., Hiramoto K., Hayatsu H., Higaki K., Kawai S., Masuyama A., Nojima M., Wataya Y., Kim H.-S.
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Journal Title
Parasitology International
Volume: 60
Issue: 3
Pages: 270-273
DOI
Related Report
Peer Reviewed
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[Journal Article] Schistosomicidal and anti-fecundity effects of oral treatment of synthetic endoperoxide compound N-892011
Author(s)
Taniguchi T, Kumagai T, Shimogawara R, Ichinose S, Hiramoto A, Sato A, Morita M, Nojima M, Kim HS, Wataya Y, Ohta N
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Journal Title
Parasitology International
Volume: 60
Issue: 3
Pages: 231-236
DOI
Related Report
Peer Reviewed
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[Journal Article] Schistosomicidal and antifecundity effects of oral treatment of synthetic endoperoxide N-89.2011
Author(s)
Taniguchi T, Kumagai T, Shimogawara R, Ichinose S, Hiramoto A, Sato A, Morita M, Nojima M, Kim HS, Wataya Y, Ohta N.
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Journal Title
Parasitol Int.
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Antimalarial activity of endoperoxide compound 6-(1,2,6,7-tetraoxaspiro [7.11]nonadec-4-yl)hexan-1-ol.2011
Author(s)
Sato, A., Hiramoto, A., Morita, M., Matsumoto M., Komichi Y., Nakase, Y., Tanigawa N., Hiraoka, O., Hiramoto, K., Hayatsu, H., Higaki, K., Kawai, A., Masuyama, A., Nojima, M., Wataya, Y., Kim, H.-S.
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Journal Title
Parasitol Int.
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Geranyl derivatices of isoquinoline alkaloids show increased biological activities.2010
Author(s)
Nishiyama, Y., Iwasa, K., Okada, S., Takeuchi, S., Moriyasu, M., Kamigauchi, M., Koyama, J., Takeuchi, A., Tokuda, H., Kim, H.-S., Wataya, Y., Takeda, K., Liu, Y., Wu, P., Bastow, K., Akiyama, T. and Lee, K
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Journal Title
Heterocycles
Volume: 81
Pages: 1193-1229
URL
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Peer Reviewed
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[Journal Article] Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites2010
Author(s)
Morisaki, D., Kim, H.-S., Inoue, H., Terauchi, H., Kuge, S., Naganuma, A., Wataya, Y., Tokuyama, H., Ihara, M. and Takasu, K
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Journal Title
Chemical Science
Volume: 1
Pages: 206-209
URL
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Peer Reviewed
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[Presentation] Drug development research for antimalarial endoperoxide N-2512012
Author(s)
Masayuki Morita, Akiko Hiramoto, Kazuaki Okada, Tatsuya Wakimoto, Akane Katamoto, Hiroki Watanabe, Takuma Takahashi, Chikako Imada, Akira Sato, Kazutaka Higaki, Yusuke Wataya, Hye-Sook Kim
Organizer
Forum Cheju 15; The 15th Japan-Korea Parasitologists’ Seminar
Place of Presentation
Miyazaki, Japan
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