Developmentaldisorder of fetal GABA system by maternal stress

• Project/Area Number: 22390041
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: FUKUDA Atsuo 浜松医科大学, 医学部, 教授 (50254272)
• Co-Investigator(Renkei-kenkyūsha): INOUE Kouichi 浜松医科大学, 医学部, 准教授 (80345818) ; KUMADA Tatsuro 浜松医科大学, 医学部, 助教 (00402339)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: 生理学 / 神経科学 / ストレス / 脳・神経 / GABA / バルブアルブミン / GAD67 / 発生・分化 / NKCC1 / KCC2 / 塩素イオン / 細胞移動 / タウリン / 母体ストレス / トニックカレント

Research Abstract

The maternal stress perturbed fetal GABAergic system specifically but not principal neuronal system. These results indicate that an abnormality in GABA system could interact with environmental risk factors of psychiatric disorders. Since GABA is important for the development as well as the normal function of the brain, present results show a novel concept that the interaction of stress hormone and GABA system may underlie psychiatric disorders.

Research Products

• [Journal Article] Pre-and post-synaptic switches of GABA actions associated with Cl-homeostatic changes are induced in the spinal nucleus of the trigeminal nerve in a rat model of trigeminal neuropathic pain (2013)
  • Author(s): Wei, B., Kumada, T., Furukawa, T., Inoue, K., Watanabe, M., Sato, K. and Fukuda, A
  • Journal Title: Neuroscience Volume: 228 Pages: 334-348
  • Peer Reviewed
• [Journal Article] Modulation of allopregnanolone on excitatory transmitters release from single glutamatergic terminal. (2013)
  • Author(s): Iwata, S., Wakita, M.,Shin, M., Fukuda, A.and Akaike, N
  • Journal Title: Brain Res. Bull Volume: 93 Pages: 39-46
  • Peer Reviewed
• [Journal Article] アンジェルマン症候群の運動障害と小脳での持続性抑制の低下 (2013)
  • Author(s): 江川潔、福田敦夫
  • Journal Title: 実験医学 Volume: 31 (6) Pages: 914-917
• [Journal Article] Phosphodiesterase 4 inhibition enhances the dopamine D1receptor/PKA/DARPP-32 signaling cascade in frontal cortex (2012)
  • Author(s): Kuroiwa,M., Snyder,G. L., Shuto,T., Fukuda,A., Yanagawa,Y., Benavides,D. R., Nairn,A. C., Bibb,J. A., Greengard,P. andNishi,A
  • Journal Title: Psychopharmacology Volume: 219 Pages: 1065-1079
  • Peer Reviewed
• [Journal Article] Taurine inhibits the K+-Cl-cotransporter KCC2 to regulate embryonic Cl-homeostasis via the with-no-lysine (WNK) protein kinase signaling pathway (2012)
  • Author(s): Inoue, K., Furukawa,T., Kumada,T., Yamada,J., Wang,T., Inoue,R. and Fukuda,A
  • Journal Title: J.Biol.Chem Volume: 287 Pages: 20839-20850
  • Peer Reviewed
• [Journal Article] Guidepost neurons for the lateral olfactory tract: Expression of metabotropic glutamate receptor 1 and innervation by glutamatergic olfactory bulb axons (2012)
  • Author(s): Hirata,T., Kumada,T., Kawasaki,T., Furukawa,T., Aiba,A., Conquet,F., Saga,Y. andFukuda,A
  • Journal Title: Dev.Neurobiol Volume: 72 Pages: 1559-1576
  • Peer Reviewed
• [Journal Article] Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome. (2012)
  • Author(s): Egawa, K., Kitagawa, K., Inoue, K., Takayama, M., Takayama, C., Saitoh, S., Kishino, T., Kitagawa, M. and Fukuda, A
  • Journal Title: Sci. Transl. Med Volume: 4
  • Peer Reviewed
• [Journal Article] GABAのマルチモーダルな作用 (2012)
  • Author(s): 福田敦夫
  • Journal Title: Clinical Neuroscience Volume: 30 (12) Pages: 1355-1359
• [Journal Article] GABAの抑制と興奮の二面性 (2012)
  • Author(s): 福田敦夫
  • Journal Title: Epilepsy Volume: 6 Pages: 85-92
  • NAID: 40019478063
• [Journal Article] Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever! (2012)
  • Author(s): Ben-Ari, Y., Woodin, M.A., Sernagor, E., Cancedda, L., Vinay, L., Rivera, C., Legendre, P., Luhmann, H.J., Bordey, A., Wenner, P.,Fukuda, A., vad den Pol, A.N., Gaiarsa, J.L. and Cherubini, E
  • Journal Title: Front. Cell. Neurosci Volume: 6 Pages: 1-18
  • Peer Reviewed
• [Journal Article] GABA,グリシンの機能-脊髄での機能を中心に (2012)
  • Author(s): 福田敦夫
  • Journal Title: Clinical Neuroscience Volume: 30(7) Pages: 795-798
• [Journal Article] Phosphodiesterase 4 inhibition enhances the dopamine D1receptor/PKA/D ARPP-32 signaling cascade in frontal cortex (2012)
  • Author(s): Kuroiwa, M., et al
  • Journal Title: Psychopharmacology Volume: 219 Issue: 4 Pages: 1065-1079
  • DOI: 10.1007/s00213-011-2436-8
  • Peer Reviewed
• [Journal Article] Taurine inhibits the K+-Cl- cotransporter KCC2 to regulate embryonic Cl- homeostasis via the with-no-lysine (WNK) protein kinase signaling pathway. (2012)
  • Author(s): Inoue, K., Furukawa, T., Kumada, T., Yamada, J., Wang, T., Inoue, R., and Fukuda A.
  • Journal Title: The Journal of Biological Chemistry Volume: 287 Pages: 20839-20850
  • Peer Reviewed
• [Journal Article] Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome. (2012)
  • Author(s): Egawa, K., Kitagawa, K., Inoue, K., Takayama, M., Takayama, C., Saitoh, S., Kishino, T., Kitagawa, M. and Fukuda,A.
  • Journal Title: Science Translational Medicine Volume: 4
  • Peer Reviewed
• [Journal Article] Guidepost Neurons for the Lateral Olfactory Tract: Expression of Metabotropic Glutamate Receptor 1 and Innervation by Glutamatergic Olfactory Bulb Axons. (2012)
  • Author(s): Hirata, T., Kumada, T., Kawasaki, T., Furukawa, T., Aiba, A., Conquet, F., Saga, Y., and Fukuda, A.
  • Journal Title: Developmental Neurobiology Volume: 72 Pages: 1559-1576
  • Peer Reviewed
• [Journal Article] GABAのマルチモーダルな作用. (2012)
  • Author(s): 福田敦夫.
  • Journal Title: Clinical Neuroscience Volume: 30 Pages: 1355-1359
• [Journal Article] GABAの抑制と興奮の二面性. (2012)
  • Author(s): 福田敦夫.
  • Journal Title: Epilepsia Volume: 6 Pages: 85-92
  • NAID: 40019478063
• [Journal Article] GABA，グリシンの機能-脊髄での機能を中心に. (2012)
  • Author(s): 福田敦夫.
  • Journal Title: Clinical Neuroscience Volume: 30 Pages: 795-798
• [Journal Article] Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever! (2012)
  • Author(s): Ben-Ari, Y., Woodin, M.A., Sernagor, E., Cancedda, L., Vinay, L., Rivera, C., Legendre, P., Luhmann, H.J., Bordey, A., Wenner, P., Fukuda, A., et al.
  • Journal Title: Frontiers in Cellular Neuroscience Volume: 6 Pages: 1-18
• [Journal Article] KCC2 was downregulated in small neurons localized in epileptogenic human focal cortical dysplasia (2011)
  • Author(s): Shimizu-Okabe,C., Tanaka,M., Matsuda,K., Mihara,T., Okabe,A., Sato,K., Inoue,Y., Fujiwara,T., Yagi,K. andFukuda,A
  • Journal Title: Epilepsy Res Volume: 93 Pages: 177-184
  • Peer Reviewed
• [Journal Article] A heterozygous deletion in the glutamate decarboxylase 67 gene enhances maternal and fetal stress vulnerability (2011)
  • Author(s): Uchida,T., Oki,Y., Yanagawa,Y.and Fukuda,A
  • Journal Title: Neurosci.Res Volume: 69 Pages: 276-282
  • Peer Reviewed
• [Journal Article] GABA regulates the multidirectional tangential migration of GABAergic interneurons in living neonatal mice (2011)
  • Author(s): Inada, H., Watanabe, M., Uchida, T., Ishibashi, H., Wake, H., Nemoto, T., Yanagawa, Y., Fukuda, A.and Nabekura, J.
  • Journal Title: PLoS ONE Volume: 6
  • Peer Reviewed
• [Journal Article] 幼少時の麻酔暴露による脳障害と脳発達過程の興奮性GABA作用 (2011)
  • Author(s): 福田敦夫
  • Journal Title: 日本臨床麻酔学会誌 Volume: 31巻1号 Pages: 1-11
  • NAID: 10027752867
• [Journal Article] GABA regulates the multidirectional tangential migration of GABAergic interneurons in living neonatal mice (2011)
  • Author(s): Tomomi Nemoto
  • Journal Title: PLoS ONE Volume: Vol.6 Issue: 12 Pages: e27048-e27048
  • DOI: 10.1371/journal.pone.0027048
  • Peer Reviewed
• [Journal Article] 神経回路機能の発達と病態(GABAを中心に) (2011)
  • Author(s): 福田敦夫
  • Journal Title: 小児神経学の進歩 Volume: 40 Pages: 129-142
• [Journal Article] 組織標本(脳スライス)への各種イメージング法適用の実際 (2011)
  • Author(s): 福田敦夫
  • Journal Title: メディカルホトニクスコース講習テキスト Volume: 20 Pages: 57-64
• [Journal Article] Does elevated intracellular chloride cause epilepsy in focal cortical dysplasia? (2011)
  • Author(s): Shimizu-Okabe, C., et al
  • Journal Title: Dysplasia : Causes, Types and Treatment Options, Hauppauge, NY, U.S.A.(eds.Nova Science Publishers) Volume: (In press)
• [Journal Article] Chloride homeodynamics underlying pathogenic modal shifts of GABA actions (2011)
  • Author(s): Fukuda, A.
  • Journal Title: Comprehensive Developmental Neuroscience. Elsevier, Oxford, United Kingdom(eds.Pasko Rakic and John Rubenstein) Volume: 10章(In Press)
• [Journal Article] Multimodal GABA_A receptor functions on cell development (2011)
  • Author(s): Fukuda, A., et al
  • Journal Title: Comprehensive Developmental Neuroscience. Elsevier, Oxford, United Kingdom(eds.Pasko Rakic and John Rubenstein) Volume: 125章(In Press)
• [Journal Article] KCC2 was downregulated in small neurons localized in epileptogenichuman focal cortical dysplasia. (2011)
  • Author(s): Shimizu-Okabe, C., et al.
  • Journal Title: Epilepsy Res. Volume: 93 Pages: 177-184
  • Peer Reviewed
• [Journal Article] A heterozygous deletion in the glutamate decarboxylase 67 gene enhances maternal and fetal stress vulnerability. (2011)
  • Author(s): Uchida, T., et al.
  • Journal Title: Neurosci.Res. Volume: 69 Pages: 276-282
  • Peer Reviewed
• [Journal Article] Difference in binocularity and ocular dominance plasticitybetween GABAergic and excitatory cortical neurons (2010)
  • Author(s): Kameyama,K., Sohya, K., Ebina, T., Fukuda, A., Yanagawa, Y. and Tsumoto,T
  • Journal Title: J. Neurosci Volume: 30 Pages: 1551-1559
  • Peer Reviewed
• [Journal Article] GABA imaging in brain slices using immobilized enzyme-linked photoanalysis (2010)
  • Author(s): Morishima, T.,Uematsu, M., Furukawa, T.,Yanagawa, Y., Fukuda, A.and Yoshida, S
  • Journal Title: Neurosci. Res Volume: 67 Pages: 347-353
  • Peer Reviewed
• [Journal Article] Dominant negative mutations in α-II spectrin cause early onset West syndrome with severe cerebral hypomyelination, spastic quadriplegia, and developmental delay (2010)
  • Author(s): aitsu, H., Tohyama, J., Kumada, T.,Egawa, K., Hamada, K., Okada, I., Mizuguchi, T., Osaka, H., Miyata, R., Furukawa, T.,Haginoya, K., Hoshino, H., Goto, T., Hachiya, Y., Yamagata, T., Saitoh, S., Nagai, T., Nishiyama, K., Nishimura, A., Miyake, N., Komada, M., Hayashi, K., Hirai, S., Ogata, K., Kato, M., Fukuda, A.and Matsumoto,N
  • Journal Title: Am. J. Hum.Genet Volume: 86 Pages: 881-891
  • Peer Reviewed
• [Journal Article] Low-concentration tributyltin perturbs inhibitory synaptogenesis and induces neuronal death in immature but not mature neurons (2010)
  • Author(s): Yamada,J., Inoue, K., Furukawa, T. and Fukuda, A
  • Journal Title: Toxicol.Lett Volume: 198 Pages: 282-288
  • Peer Reviewed
• [Journal Article] The physiological roles of vesicular GABA transporter during embryonic development: a study using knockout mice (2010)
  • Author(s): Saito, K., Kakizaki, T., Hayashi, R., Nishimaru, H., i Furukawa, T., Nakazato, Y., Takamori, S., Ebihara, S., Uematsu, M., Mishina, M., Miyazaki, J., Yokoyama, M., Konishi, S., Inoue, K., Fukuda, A., Fukumoto, M., Nakamura, K., Obata K., and Yanagawa Y
  • Journal Title: Mol. Brain Volume: 3 Pages: 40-40
  • NAID: 120004898442
  • Peer Reviewed
• [Journal Article] 発達期における麻酔薬のGABA受容体に及ぼす影響からの分析.特集「麻酔薬は敵か味方か(神経編)」 (2010)
  • Author(s): 福田敦夫
  • Journal Title: LiSA Volume: 17巻12号 Pages: 1176-1181
• [Journal Article] GABA imaging in brain slices using immobilized enzyme-linked photoanalysis. (2010)
  • Author(s): Morishima, T., et al.
  • Journal Title: Neurosci.Res. Volume: 67 Pages: 347-353
  • Peer Reviewed
• [Journal Article] Dominant negative mutations in α-II spectrin cause early onset West syndrome with severe cerebral hypomyelination, spastic quadriplegia, and developmental delay. (2010)
  • Author(s): Saitsu, H., et al.
  • Journal Title: Am.J.Human Genet. Volume: 86 Pages: 881-891
  • Peer Reviewed
• [Journal Article] Low-concentration tributyltin perturbs inhibitory synaptogenesis and induces neuronal death in immature but not mature neurons. (2010)
  • Author(s): Yamada, J., et al.
  • Journal Title: Toxicol.Lett. Volume: 198 Pages: 282-288
  • Peer Reviewed
• [Journal Article] The physiological roles of vesicular GABA transporter during embryonic development : a study using knockout mice. (2010)
  • Author(s): Saito, K., et al.
  • Journal Title: Mol.Brain Volume: 3 Pages: 40-40
  • Peer Reviewed
• [Journal Article] Accumulation of GABAergic neurons, causing a focal ambient GABA gradient, and downregulation of KCC2are induced during microgyrus formation in a mouse model of polymicrogyria
  • Author(s): Wang, T., Kumada, T., Morishima, T., Iwata, S., Kaneko, T., Yanagawa, Y., Yoshida, S. and Fukuda, A
  • Journal Title: Cereb. Cortex
  • Peer Reviewed
• [Journal Article] A perturbation of multimodal GABA functions underlying the formation of focal cortical malformations: assessments by using animal models
  • Author(s): Fukuda, A.and Wang, T
  • Journal Title: Neuropathology
  • Peer Reviewed
• [Presentation] Developmental Cl-homeodynamics underlying neonatal seizures (2013)
  • Author(s): Fukuda.A
  • Organizer: Current advance in neonatal seizures2013 Pediatric Academic Societies(PAS)Annual Meeting
  • Place of Presentation: Washington, D.C.,USA
• [Presentation] Amibient GABA regulates the multidirectional tangential migration of GABAergic interneurons in living neonatal mice (2013)
  • Author(s): Inada, H., Watanabe, M., Uchida, T., Fukuda, A., Yanagawa, Y., and Nabekura, J
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] 三叉神経痛の動物モデルと病態仮説 (2012)
  • Author(s): 福田敦夫
  • Organizer: 第14回日本脳神経減圧術学会
  • Place of Presentation: 東京
  • Year and Date: 2012-01-19
• [Presentation] 三叉神経痛の動物モデルと病態仮説 (2012)
  • Author(s): 福田敦夫
  • Organizer: 第14回日本脳神経減圧術学会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2012-01-19
• [Presentation] A. Maternal taurine as a modulator of GABAAreceptor and Cl-homeostasis during perinatal period (2012)
  • Author(s): Fukuda, A
  • Organizer: The 15th International Symposium on Neonatal Seizures and Related Disorders (ISNS)
  • Place of Presentation: Tokyo, Japan
• [Presentation] Cl-ホメオダイナミクスによるGABAスイッチと神経オシレーション (2012)
  • Author(s): 福田敦夫
  • Organizer: 神経オシレーション:共振とディスリズミア研究会
  • Place of Presentation: 岡崎
• [Presentation] 動物モデルを用いた皮質形成異常の成因に関するマルチモーダルGABA仮説の検証 (2012)
  • Author(s): 福田敦夫
  • Organizer: 第53回日本神経病理学会総会学術研究会
  • Place of Presentation: 新潟
• [Presentation] 大脳皮質形成における非シナプス性GABA (2012)
  • Author(s): 福田敦夫
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨
• [Presentation] Abnormalchloridetransportation incorticaldysplasia (2012)
  • Author(s): Fukuda,A
  • Organizer: International Symposium on Surgery for Catastrophic Epilepsy inInfants (ISCE)
  • Place of Presentation: Tokyo, Japan
• [Presentation] 動物モデルを用いた皮質形成異常の成因に関するマルチモーダルGABA仮説の検証. (2012)
  • Author(s): 福田敦夫.
  • Organizer: 第53回日本神経病理学会総会学術研究会
  • Place of Presentation: 新潟
  • Invited
• [Presentation] Cl- ホメオダイナミクスによるGABAスイッチと神経オシレーション. (2012)
  • Author(s): 福田敦夫.
  • Organizer: 神経オシレーション：共振とディスリズミア研究会
  • Place of Presentation: 岡崎
  • Invited
• [Presentation] Intracellular taurine inhibits the functioning of KCC2 protein by phosphorylation via with-no-lysine (WNK) protein kinase pathway. (2012)
  • Author(s): Fukuda, A., Inoue, K., Furukawa, T., Yamada, J., Kumada, T., Wang, T., and Inoue, R.
  • Organizer: The 8th FENS Forum of Neuroscience
  • Place of Presentation: Barcelona, Spain.
• [Presentation] アストロサイト回路網によってもたらされる海馬GABAシナプスにおけるホメオスタティックなCl-動態. (2012)
  • Author(s): 福田敦夫, 江川 潔, 山田順子,古川智範, 柳川 右千夫.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] γ-tubulin2の減少は線条体神経細胞のミトコンドリア機能障害を介し非定型パーキンソン病を発症させる. (2012)
  • Author(s): 堤 弘次, 久保亜紀子, 高木博, 赤津裕康, 紺野 在, 宮本裕子, 矢野育子, 山内大輔, 堀尾哲也, 宮 川 剛, 宮嶋裕明, 福田敦夫, 他.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] Allopregnanoloneのグルタミン酸作動性神経終末部に対する効果. (2012)
  • Author(s): 岩田暁美, 福田敦夫, 申 敏哲, 脇田真仁, 赤池 紀生.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] マウス網膜スライス標本を用いたグルタミン酸放出レベルの可視化. (2012)
  • Author(s): 大熊真人, 金田 誠, 吉田祥子, 福田敦夫, 宮地 栄一.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] 過剰量のGABAは小脳発達に影響を及ぼす. (2012)
  • Author(s): 田野崎真, 勝股大樹, 関野祐子, 福田敦夫, 吉田 祥子.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] 発達期小脳皮質のグリアからGABA放出はトランスポーターで制御される. (2012)
  • Author(s): 吉田祥子, 山田ひかり, 栗本侑依, 小林和人, 高山 千利, 山本清二, 福田敦夫,穂積直裕.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] 皮質形成異常の成因に関与する細胞外GABAと細胞内cl-. (2012)
  • Author(s): 福田敦夫, 王 天英, 柳川右千夫.
  • Organizer: 第39回日本脳科学会
  • Place of Presentation: 福岡
• [Presentation] 母体ストレスによるGAD67ヘテロ欠損胎仔でのGABAニューロンの特異的減少. (2012)
  • Author(s): 内田 琢, 柳川右千夫, 福田敦夫.
  • Organizer: 第39回日本脳科学会
  • Place of Presentation: 福岡
• [Presentation] 母性Ube3a 欠失マウス小脳顆粒細胞におけるGABAトランスポーター過剰によるトニック抑制の減弱と 小脳機能障害. (2012)
  • Author(s): 江川 潔, 北川恭子, 井上浩一, 高山理和, 高山 千利, 斉藤伸治, 木住野達也, 北川正敏, 福田敦夫.
  • Organizer: 第59回中部生理学会
  • Place of Presentation: 岡崎
• [Presentation] マウス大脳皮質の移動神経細胞における領域特異的なGABAA受容体応答. (2012)
  • Author(s): 熊田竜郎, 中西康彦, 古川智範, 江川 潔, 福田 敦夫.
  • Organizer: 第59回中部生理学会
  • Place of Presentation: 岡崎
• [Presentation] 活動依存的な内因性タウリンの放出が新生ラット大脳新皮質辺縁体の興奮性シナプス伝達を促進する. (2012)
  • Author(s): 熊田竜郎, 千太哲, 中村直人, 古川智範, Kilb Werner, Luhmann Heiko J., 中原大一郎, 福田敦夫.
  • Organizer: 生理学研究所研究会
  • Place of Presentation: 岡崎
• [Presentation] マウス発生期大脳新皮質においてGABAA受容体を介したシグナルは神経前駆細胞の内在的性質を 制御する. (2012)
  • Author(s): 栃谷史郎, 古川智範, 坂東 遼, 近藤重明, 福田 敦夫, 福井義浩.
  • Organizer: 第35回日本分子生物学会
  • Place of Presentation: 福岡
• [Presentation] Abnormal Chloride Transportation in Cortical Dysplasia (2012)
  • Author(s): Fukuda, A.
  • Organizer: International Symposium on Surgery for Catastrophic Epilepsy in Infants (ISCE)
  • Place of Presentation: Tokyo, Japan(招待講演)
• [Presentation] 大脳皮質形成における非シナプス性GABA (2012)
  • Author(s): 福田敦夫
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨(招待講演)
• [Presentation] Intracellular taurine modulates KCC2 function by phosphorylation (2012)
  • Author(s): Fukuda, A., et al
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 長野
• [Presentation] Ambient taurine controls radial migration in developing cerebral cortex (2012)
  • Author(s): Furukawa, T., et al
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 長野
• [Presentation] Regionally differential calcium oscillation of radially migrating cells in embryonic cortex (2012)
  • Author(s): Kunxada, T., et al
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 長野
• [Presentation] Bidirectional interaction of Maternal stress with fetal and maternal γ-amino butyric acid (GABA) systems (2011)
  • Author(s): Uchida, T., Oki, Y., Yanagawa, Y. and Fukuda, A
  • Organizer: International Symposium "Interaction of nervous and immune systems in health and disease"
  • Place of Presentation: Saint Petersburg, Russia
• [Presentation] Bidirectional interaction of Maternal stress with fetal and maternal γ-amino butyric acid (GABA) systems (2011)
  • Author(s): Fukuda, A., et al
  • Organizer: International Symposium "Interaction of nervous and immune systems in health and disease"
  • Place of Presentation: Saint Petersburg, Russia(招待講演)
• [Presentation] Impairment of tonic inhibition in cerebellum granule cells causes cerebellum dysfunction in Ube3a maternal-deficient mice (2011)
  • Author(s): Egawa, K., et al
  • Organizer: Angelman Syndrome Foundation Scientific Symposium
  • Place of Presentation: Salt Lake City, USA
• [Presentation] Developmental regulation of KCC2 activity by taurine in a phosphorylation-dependent manner (2011)
  • Author(s): Inoue, K., et al
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] GABAergic dysfunction in Ube3a deficient mice, models of angelman syndrome (2011)
  • Author(s): Egawa, K., et al
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] Temporal paracrine GABA and KCC2 downregulation underlie the formation of microgyrus in a model of focal cortical malformation (2011)
  • Author(s): Fukuda, A., et al
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] アンジェルマン症候群における小脳顆粒細胞tonic inhibitionの低下と小脳機能障害 (2011)
  • Author(s): 江川潔, 他
  • Organizer: 第38回日本脳科学会
  • Place of Presentation: 沖縄
• [Presentation] 発達期の大脳皮質の各領域における移動細胞のカルシウム振動 (2011)
  • Author(s): 中西康彦, 他
  • Organizer: 第58回中部生理学会
  • Place of Presentation: 福井
• [Presentation] 生後初期に一過性のバーグマングリア由来の細胞外GABAが小脳顆粒前駆細胞の分裂を促進する (2011)
  • Author(s): 福田敦夫, 他
  • Organizer: 第58回中部生理学会
  • Place of Presentation: 福井
• [Presentation] Ambient GABA released from Bergmann glial cells promotes proliferation of cerebellar granule cell precursors (2011)
  • Author(s): Fukuda, A., et al
  • Organizer: 41st Annual Meeting, Society for Neuroscience
  • Place of Presentation: Washington, D.C., USA
• [Presentation] Impairment of tonic inhibition in cerebellum granule cells causes cerebellum dysfunction in Ube3a maternal-deficient mice (2011)
  • Author(s): Egawa, K., et al
  • Organizer: 41st Annual Meeting, Society for Neuroscience
  • Place of Presentation: Washington, D.C., USA
• [Presentation] Taurine prevents KCC2 from functioning in a phosphorylation-dependent manner to render embryonic Cl homeostasis (2011)
  • Author(s): Inoue, K., et al
  • Organizer: 41st Annual Meeting, Society for Neuroscience
  • Place of Presentation: Washington, D.C., USA
• [Presentation] アンジェルマン症候群における小脳顆粒細胞tonic inhibitionの低下と小脳機能障害 (2011)
  • Author(s): 江川潔, 他
  • Organizer: 平成23年度生理学研究会シナプス2011
  • Place of Presentation: 岡崎
• [Presentation] Roles of paracrine GABA and KCC2 downregulation in a model of focal cortical malformation. (2011)
  • Author(s): Fukuda, A., et al.
  • Organizer: 第88回日本生理学会大会 第116回日本解剖学総会・全国学術集会
  • Place of Presentation: 誌上にて
• [Presentation] GABAergic dysfunctions in Ube3a deficient mice, models of Angelman syndrome. (2011)
  • Author(s): Egawa, K., et al.
  • Organizer: 第88回日本生理学会大会 第116回日本解剖学会総会・全国学術集会
  • Place of Presentation: 誌上にて
• [Presentation] Potential developmental regulation of neuronal KCC2 activity by taurine. (2011)
  • Author(s): Inoue, K., et al.
  • Organizer: 第88回日本生理学会大会 第116回日本解剖学総会・全国学術集会
  • Place of Presentation: 誌上にて
• [Presentation] An origin and a Roles of ambient GABA during cerebellar development (2010)
  • Author(s): Fukuda A., Morishima T., KumadaT.,Takayama, C.and Yoshida, S
  • Organizer: The 9th Korea-Japan Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscles
  • Place of Presentation: Kagoshima, Japan
• [Presentation] 神経生理学から見た未熟な脳の特殊性.シンポジウム「脳低温療法の未来」 (2010)
  • Author(s): 福田敦夫
  • Organizer: 第55回日本未熟児新生児学会学術集会
  • Place of Presentation: 神戸
• [Presentation] A heterozygous deletion in the glutamate decarboxylase 67 gene enhances maternal and fetal stress vulnerability.(Keynote Speaker.) (2010)
  • Author(s): Fukuda A
  • Organizer: The 37th Japan Brain Science Societyand 2010 Tianjin Physiological Society Meeting.
  • Place of Presentation: Tianjin, China
• [Presentation] 神経回路機能の発達と病態(GABAを中心に) (2010)
  • Author(s): 福田敦夫
  • Organizer: 講師,第40回小児神経学セミナー
  • Place of Presentation: 葉山
• [Presentation] Proliferation of cerebellar granule cell precursors is promoted by GABA released from Bergmann glial cells.,シンポジウム" New insights into neuron-glia interrelations" (2010)
  • Author(s): Fukuda, A., Morishima, T., Kumada, T., Takayama, C. and Yoshida,S
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
• [Presentation] Chloride homeo-dynamics causingGABA modalshiftduring developmentand pathogenesis (2010)
  • Author(s): Fukuda,A
  • Organizer: FENS/Hertie WINTER SCHOOL 2010,obergurgl
  • Place of Presentation: Austria
• [Presentation] GABA and taurine releases through volume-sensitive anion channels during early brain development. (2010)
  • Author(s): Fukuda, A.
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 盛岡
• [Presentation] アンジェルマン症候群モデルマウスにおける海馬神経回路網の電気生理学的検 (2010)
  • Author(s): 江川潔, 他
  • Organizer: 第52回日本小児神経学会総会
  • Place of Presentation: 福岡
• [Presentation] 神経細胞の亜鉛毒性におけるTRPM7の役割 (2010)
  • Author(s): 井上浩一, 他
  • Organizer: 平成22年度生理学研究所研究会『TRPチャネルの生理機能と病態生理』
  • Place of Presentation: 岡崎
• [Presentation] Proliferation of cerebellar granule cell precursors is promoted by GABA released from Bergmann glial cells. (2010)
  • Author(s): Fukuda, A., et al.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
• [Presentation] Intracellular taurine inhibits KCC2 transporter activity. (2010)
  • Author(s): Inoue, K., et al.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
• [Presentation] The maternal stress deteriorates GABAergic interneuron proliferation. (2010)
  • Author(s): Uchida, T., et al.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
• [Presentation] Non-synaptic GABA handling system in the rat trigeminal ganglion. (2010)
  • Author(s): Hayasaki, H., et al.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
• [Presentation] Correlated expression of the neuron-specific potassium chloride cotransporter 2 (KCC2) in the neonatal cerebellum and inferior olive. (2010)
  • Author(s): Arata, A., et al.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
• [Presentation] Developmental change of VGAT-Venus expression in organotypic cultured cerebellar cortex and dissociated glial cells. (2010)
  • Author(s): Kurimoto, Y., et al.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
• [Presentation] 神経回路機能の発達と病態(GABAを中心に) (2010)
  • Author(s): 福田敦夫
  • Organizer: 第40回小児神経学セミナー
  • Place of Presentation: 葉山
• [Presentation] Temporal release of GABA from bergmann glia regulates granule cellprecursors proliferation during rat cerebellar cortical development. (2010)
  • Author(s): Morishima, T., et al.
  • Organizer: 第29回内藤コンファレンス
  • Place of Presentation: 葉山
• [Presentation] Astroglial responses to GABA spillover from synaptic clefts and its functional role for regulating extracellular Cl- in CA1 stratum lacunosum-moleculare (SLM). (2010)
  • Author(s): Egawa, K., et al.
  • Organizer: 第29回内藤コンファレンス
  • Place of Presentation: 葉山
• [Presentation] タウリンによる神経特異的イオン輸送体KCC2の活性制御 (2010)
  • Author(s): 井上浩一, 他
  • Organizer: 第57回中部日本生理学会
  • Place of Presentation: 豊明
• [Presentation] 母体ストレスが胎仔の大脳皮質抑制性神経発達に及ぼす影響 (2010)
  • Author(s): 内田琢, 他
  • Organizer: 第57回中部日本生理学会
  • Place of Presentation: 豊明
• [Presentation] A heterozygous deletion in the glutamate decarboxylase 67 gene enhances maternal and fetal stress vulnerability. (2010)
  • Author(s): Fukuda A.
  • Organizer: The 37th Japan Brain Science Society and 2010 Tianjin Physiological Society Meeting
  • Place of Presentation: Tianjin, China
• [Presentation] Temporally-increased GABA underlies the formation of freeze lesion-induced microgyrus and causes GABAA receptor-mediated excitation. (2010)
  • Author(s): Wang, T., et al.
  • Organizer: The 37th Japan Brain Science Society and 2010 Tianjin Physiological Society Meeting
  • Place of Presentation: Tianjin, China
• [Presentation] An origin and a Roles of ambient GABA during cerebellar development. (2010)
  • Author(s): Fukuda, A., et al.
  • Organizer: The 9th Korea-Japan Joint Symposium of BrainSciences, and Cardiac and Smooth Muscles, Kagoshima
  • Place of Presentation: 鹿児島
• [Presentation] Ube3a機能欠失マウス(Angelman症候群モデルマウス)における 神経シナプス回路網病態生理 (2010)
  • Author(s): 江川潔, 他
  • Organizer: 平成22年度生理学研究会シナプス2010
  • Place of Presentation: 岡崎
• [Presentation] Pre- and post-synaptic switches of GABA actions in the spinal nucleus of the trigeminal nerve in a rat model of trigeminal neuropathic pain.
  • Author(s): Kumada, T., Wei, B., Furukawa, T., Inoue, K., Watanabe, M., Sato, K., and Fukuda, A.
  • Organizer: The 12th Kyungpook-Hamamatsu Joint Medical Symposium Hamamatsu Meeting
  • Place of Presentation: Hamamatsu, Japan.
• [Book] A.Does elevated intracellular chloride cause epilepsy in focal cortical dysplasia? (Chspter IV) In:Dysplasia: Causes, Types and Treatment Options. eds. L.M. Sexton and H. J. Leach.Nova Science Publishers (2012)
  • Author(s): Shimizu-Okabe, C., Okabe, A and Fukuda
  • Publisher: Hauppauge, NY, U.S.A.
• [Book] Does elevated intracellular chloride cause epilepsy in focal cortical dysplasia? (Chspter IV) In: Dysplasia: Causes, Types and Treatment Options (2012)
  • Author(s): Shimizu-Okabe, C., Okabe, A., and Fukuda, A.
  • Publisher: L.M. Sexton and H. J. Leach. Nova Science Publishers, Hauppauge.
• [Book] 神経回路機能の発達と病態(GABAを中心に) (2011)
  • Author(s): 福田敦夫
  • Publisher: 診断と治療社
• [Book] 組織標本(脳スライス)への各種イメージング法適用の実際, 第20回メディカルホトニクスコース講習テキスト (2011)
  • Author(s): 福田敦夫
• [Book] 組織標本(脳スライス)への各種イメージング法適用の実際, 第19回メディカルホトニクスコース講習テキスト (2010)
  • Author(s): 福田敦夫
• [Book] 人体の解剖生理学、(分担)7章呼吸の機構 (2010)
  • Author(s): 福田敦夫 遠山正彌、高辻功一, 木山博資編
  • Publisher: 金芳堂
• [Book] 組織標本(脳スライス)への各種イメージング法適用の実際 (2010)
  • Author(s): 福田敦夫
  • Publisher: 第19回メディカルホトニクスコース講習テキスト
• [Book] Multimodal GABAA receptor functions on cell development. Chapter 125. In: Comprehensive Developmental Neuroscience. eds. Pasko Rakic and John Rubenstein
  • Author(s): Fukuda, A., Nakanishi, Y., Kumada, T.and Furukawa, T
  • Publisher: Elsevier, Oxford, United Kingdom.
• [Book] Chloride homeodynamics underlying pathogenic modal shifts of GABA actions. Chapter 10. In: Comprehensive Developmental Neuroscience. eds. Pasko Rakic and John Rubenstein
  • Author(s): Fukuda, A
  • Publisher: Elsevier, Oxford, United Kingdom
• [Remarks]
  • URL: http://www2.hama-med.ac.jp/w1a/phys1/index-j.html
• [Remarks]
  • URL: http://www2.hama-med.ac.jp/w1a/phys1/index-j.html
• [Remarks]
  • URL: http://www2.hama-med.ae.jp/wla/phys1/index-j.html