New strategy for lissencephaly therapeutic medicine development.
| Project/Area Number |
22390056
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Osaka City University |
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Principal Investigator |
YAMADA Masami 大阪市立大学, 大学院・医学研究科, 准教授 (10322851)
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| Co-Investigator(Kenkyū-buntansha) |
KATAOKA Yosuke 独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター・細胞機能評価研究チーム, チームリーダー (40291033)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
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| Keywords | LIS1 / カルパイン阻害剤 / 滑脳症 / 神経遊走 / 細胞内物質輸送 / 細胞質ダイニン / カルパイン 阻害薬 / 神経細胞遊走 / 微小管モータータンパク質 / タンパク質分解酵素 / カルパイン阻害薬 / 低分子量GTPase Rab6 |
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| Research Abstract |
Toward a therapeutic intervention of lissencephaly, we applied a novel calpain inhibitor, SNJ1945. Peri-natal or post-natal treatment with SNJ1945 rescued defective neuronal migration in Lis1^+/^- mice, impaired behavioral performance. Thus, SNJ1945 is a
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Post-natal therapeutic intervention for lissencephaly using a blood-brain-barrier permeable calpain inhibitor2013
Author(s)
Shiori Toba, Yasuhisa Tamura, Kanako Kumamoto, Masami Yamada, Keizo Takao, Satoko Hattori, Tsuyoshi Miyakawa, Yosky Kataoka, Mitsuyoshi Azuma, Kiyoshi Hayasaka, Masano Amamoto, Keiko Tominaga, Anthony Wynshaw-Boris, Mitsuhiro Kato and Shinji Hirotsune
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Journal Title
SNJ1945 Scientific Reports
Volume: 3
Issue: 1
Pages: 1224-1224
DOI
Related Report
Peer Reviewed
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[Journal Article] Rab6a releases LIS1 from a dynein idling complex and activates dynein for retrograde movement.
Author(s)
Masami Yamada, Kanako Kumamoto, Shintaro Mikuni, Yoshiyuki Arai, Masataka Kinjo, Takeharu Nagai, Yoshikazu Tsukasaki, Tomonobu M. Watanabe, Mitsuru Fukui, Mingyue Jin, Shiori Toba and Shinji Hirotsune
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Journal Title
Nature Communications
Volume: (in press)
Related Report
Peer Reviewed
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