| Project/Area Number |
22390063
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kansai Medical University |
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Principal Investigator |
ITO Seiji 関西医科大学, 医学部, 教授 (80201325)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMURA Shinji 関西医科大学, 医学部, 講師 (70276393)
KATANO Tayo 関西医科大学, 医学部, 講師 (60469244)
YAO Ikuko 関西医科大学, 医学部, 准教授 (60399681)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | 慢性疼痛 / 疼痛の神経機構 / NMDA 受容体 / リン酸化カスケード / ミクログリア / プロスタグランジン / 術後鎮痛 / アクロメリン酸 / ノシスタチン / 一酸化窒素 / NMDA受容体 / NIPSNAP1 / 術後痛モデル / 帯状疱疹神経痛モデル / 神経再生モデル / ノシセプチン / ハイドロゲル / 消炎鎮痛薬 / 神経因性疼痛 / Ca^<2+>/カルモジュリンキナーゼII / プロスタグランジンE_2 / AMPA受容体 / リン酸化 / プロテオミクス |
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| Research Abstract |
We clarified 1) essential roles of Tyr1472 phosphorylation of the NR2B subunit of NMDA glutamate receptors in maintenance of chronic pain and augmentation of nerve injury, 2) phosphorylation cascade, and 3) blockade of migration of activated microglia by prostaglandin E2 and nitric oxide by using animal models of neuropathic pain, postherpetic neuralgia, and peripheral nerve regeneration. We analyzed neural network in the spinal cord with imaging mass spectrometry and two-photon microscopy. Further, we developed a novel strategy of the control of postoperative pain by biodegradable hydrogel and searched biomarkers of postherpetic pain in the cerebrospinal fluid of the patients.
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