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Intracellular signal transduction of chronic pain in the spinal cord and tempospatial analysis of intercellular bioactive substances

Research Project

Project/Area Number 22390063
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionKansai Medical University

Principal Investigator

ITO Seiji  関西医科大学, 医学部, 教授 (80201325)

Co-Investigator(Kenkyū-buntansha) MATSUMURA Shinji  関西医科大学, 医学部, 講師 (70276393)
KATANO Tayo  関西医科大学, 医学部, 講師 (60469244)
YAO Ikuko  関西医科大学, 医学部, 准教授 (60399681)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywords慢性疼痛 / 疼痛の神経機構 / NMDA 受容体 / リン酸化カスケード / ミクログリア / プロスタグランジン / 術後鎮痛 / アクロメリン酸 / ノシスタチン / 一酸化窒素 / NMDA受容体 / NIPSNAP1 / 術後痛モデル / 帯状疱疹神経痛モデル / 神経再生モデル / ノシセプチン / ハイドロゲル / 消炎鎮痛薬 / 神経因性疼痛 / Ca^<2+>/カルモジュリンキナーゼII / プロスタグランジンE_2 / AMPA受容体 / リン酸化 / プロテオミクス
Research Abstract

We clarified 1) essential roles of Tyr1472 phosphorylation of the NR2B subunit of NMDA glutamate receptors in maintenance of chronic pain and augmentation of nerve injury, 2) phosphorylation cascade, and 3) blockade of migration of activated microglia by prostaglandin E2 and nitric oxide by using animal models of neuropathic pain, postherpetic neuralgia, and peripheral nerve regeneration. We analyzed neural network in the spinal cord with imaging mass spectrometry and two-photon microscopy. Further, we developed a novel strategy of the control of postoperative pain by biodegradable hydrogel and searched biomarkers of postherpetic pain in the cerebrospinal fluid of the patients.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (73 results)

All 2012 2011 2010 Other

All Journal Article (28 results) (of which Peer Reviewed: 23 results) Presentation (39 results) Remarks (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] The action site of the synthetic kainoid (2S,3R,4R)-3-carboxymethyl-4-(4-methylp henylthio) pyrrolidine-2-carboxylic acid (PSPA-4), an analogue of Japanese mushroom poison acromelic acid, for allodynia (tactile pain)2012

    • Author(s)
      Miyazaki S, Minami T, Mizuma H, Kanazawa, M, Doi H, Matsumura S, Lu J, Onoe H, Furuta K, Suzuki M and Ito S
    • Journal Title

      Eur J Pharmacol

      Volume: (in press) Issue: 1-3 Pages: 120-127

    • DOI

      10.1016/j.ejphar.2012.10.023

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] SCRAPPER regulates the thresholds of long-term potentiation/depression, the bidirectional synaptic plasticity in hippocampal CA3-CAl synapses.2012

    • Author(s)
      Takagi H, Setou M, Ito S, Yao I.
    • Journal Title

      Neural Plast.

      Volume: 2012 Pages: 352829-352829

    • DOI

      10.1155/2012/352829

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic analysis of cerebrospinal fluid before and after intrathecal injection of steroid into patients with postherpetic pain.2012

    • Author(s)
      Lu J, Katano T, Nishimura W, Fujiwara S, Miyazaki S, Okasaki I, Aritake K, Urade Y, Minami T and Ito S
    • Journal Title

      Proteomics

      Volume: 12 Issue: 19-20 Pages: 3105-3112

    • DOI

      10.1002/pmic.201200125

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Tyr1472 phosphorylation of NMDA receptor NR2B subunit in postherpetic neuralgia in model mice2012

    • Author(s)
      Unezaki S, Sasaki A, Yamamoto T. (12名)
    • Journal Title

      Mol Pain

      Volume: Vol.8 Pages: 8-8

    • DOI

      10.1186/1744-8069-8-59

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel strategy for the control of postoperative pain: Long-lasting effect of an implanted analgesic hydrogel in a rat model of postoperative pain.2012

    • Author(s)
      Araki Y, Kaibori M, Matsumura S, Kwon A-Hand Ito S
    • Journal Title

      Anesth Analg

      Volume: 114 Issue: 6 Pages: 1338-1345

    • DOI

      10.1213/ane.0b013e31824b26a2

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of acetylcholine distribution in central nervous system tissue sections by tandem imaging mass spectrometry.2012

    • Author(s)
      Sugiura Y, Zaima N, Setou M, Ito S, Yao I.
    • Journal Title

      Anal Bioanal Chem.

      Volume: 403 Issue: 7 Pages: 1851-1861

    • DOI

      10.1007/s00216-012-5988-5

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of NIPSNAP1 as a nocistatin-interacting protein involving pain transmission.2012

    • Author(s)
      Okuda-Ashitaka E, Minami T, Tsubouchi S, Kiyonari H, Iwamatsu A, Noda T, Handa H and Ito S
    • Journal Title

      J Biol Chem

      Volume: 287 Issue: 13 Pages: 10403-10413

    • DOI

      10.1074/jbc.m111.271866

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ノシセプチンとノシスタチン2012

    • Author(s)
      芦高恵美子, 伊藤誠二
    • Journal Title

      Clinical Neuroscience

      Volume: 30 Pages: 148-151

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Visualization of acetylcholine distribution in central nervous system tissue sections by tandem imaging mass spectrometry2012

    • Author(s)
      Sugiura, Y., ほか4名
    • Journal Title

      Anal.Bioanal.Chem.

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid S-nitrosylation of actin by NO-generating donors and in inflammatory pain model mice.2011

    • Author(s)
      Lu J, Katano T, Uta D, Furue H and ItoS
    • Journal Title

      Mol Pain7

      Volume: 101(1-13) Pages: 101-101

    • DOI

      10.1186/1744-8069-7-101

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of an acromelic acid A analog-based 11C-labeled PET tracer for exploration of the site of action of acromelic acid A in allodynia induction.2011

    • Author(s)
      Kanazawa M, Furuta K, Doi H, Mori T, Minami T and Ito S
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 21 Issue: 7 Pages: 2017-2020

    • DOI

      10.1016/j.bmcl.2011.02.018

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of spinal phosphorylation cascade of Tyr1472-NR2B, Thr286-CaMKII, and Ser831-GluR1 in neuropathic pain2011

    • Author(s)
      Katano, T.; Nakazawa, T.; Nakatsuka, T., et al
    • Journal Title

      Neuropharmacology

      Volume: 60(4) Issue: 4 Pages: 609-616

    • DOI

      10.1016/j.neuropharm.2010.12.005

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of arginase II mRNA by nitric oxide using an in vitro model of gyrate atrophy of choroid and retina.2011

    • Author(s)
      Ohnaka M, Okuda-Ashitaka E, Kaneko S, Ando A, Maeda M, Furuta K, Suzuki M, Takahashi K and Ito S
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Issue: 3 Pages: 1493-1500

    • DOI

      10.1167/iovs.10-5516

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synaptic E3 ligase SCRAPPER in contextual fear conditioning; extensive behavioral phenotyping of Scrapper heterozygote and overexpressing mutant mice.2011

    • Author(s)
      Yao I, Takao K, Miyakawa T, Ito S andSetou M
    • Journal Title

      PLoS ONE

      Volume: 6 Issue: 2 Pages: e17317-e17317

    • DOI

      10.1371/journal.pone.0017317

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 痛みの可塑性と慢性化脊椎2011

    • Author(s)
      伊藤誠二,下條正仁,松村伸治
    • Journal Title

      脊髄ジャーナル

      Volume: 24 Pages: 341-347

    • Related Report
      2012 Final Research Report
  • [Journal Article] 医薬品開発のためのペインクリニックの現状2011

    • Author(s)
      南敏明,伊藤誠二
    • Journal Title

      医薬品医療機器レギュラトリーサイエンス

      Volume: 42 Pages: 474-480

    • NAID

      40018891084

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] 医薬品開発のための慢性疼痛発生・維持機構の考え方2011

    • Author(s)
      伊藤誠二,南敏明
    • Journal Title

      医薬品医療機器レギュラトリーサイエンス

      Volume: 42 Pages: 392-399

    • NAID

      40018846739

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] A novel role of prostaglandin E2 in neuropathic pain : blockade of microglial migration in the spinal cord2011

    • Author(s)
      Kunori S, Matsumura S, Okuda-Ashitaka E, Katano T, Audoly LP, Urade Y, Ito S
    • Journal Title

      Glia

      Volume: 59 Issue: 2 Pages: 208-218

    • DOI

      10.1002/glia.21090

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 痛みの可塑性と慢性化2011

    • Author(s)
      伊藤誠二、下條正仁、松村伸治
    • Journal Title

      脊椎脊髄ジャーナル

      Volume: 24 Pages: 341-347

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Synaptic E3 Ligase SCRAPPER in Contextual Fear Conditioning; Extensive Behavioral Phenotyping of Scrapper Heterozygote and Overexpressing Mutant Mice.2011

    • Author(s)
      Yao, I., 他4名
    • Journal Title

      PloS one

      Volume: 6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of nestin expression in the spinal cord of GFP transgenic mice after peripheral nerve injury.2010

    • Author(s)
      Matsumura S, Takagi K, Okuda-Ashitaka E, Lu J, Naritsuka H, Yamaguchi M and Ito S
    • Journal Title

      Neuroscience

      Volume: 170 Issue: 3 Pages: 942-953

    • DOI

      10.1016/j.neuroscience.2010.07.034

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel cis-active structures in the coding region mediate CRM1-dependent nuclear export of IFN-α1 mRNA.2010

    • Author(s)
      Kimura T, Hashimoto I, Nishizawa M, ItoS and Yamada H
    • Journal Title

      Med Mol Morph

      Volume: 43 Issue: 3 Pages: 145-157

    • DOI

      10.1007/s00795-010-0492-5

    • NAID

      10026727160

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impairment of CaMKII activation and neuropathic pain in mice lacking NR2B phosphorylation at Tyr-14722010

    • Author(s)
      Matsumura S, Kunori S, Mabuchi T, Katano T, Abe T, Nakazawa T, Yamamoto T, Ashitaka-Okuda E, Ito S
    • Journal Title

      Eur J. Neurosci

      Volume: 32 Issue: 5 Pages: 798-810

    • DOI

      10.1111/j.1460-9568.2010.07348.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impairment of CaMKII activation and attenuation of neuropathic pain in mice lacking NR2B phosphorylated at Tyr1472.2010

    • Author(s)
      Matsumura, S., 他9名
    • Journal Title

      Eur.J.Neurosci.

      Volume: 32 Pages: 798-810

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel cis-active structures in the coding region mediate CRMI-dependent nuclear export of IFN-al mRNA.2010

    • Author(s)
      Kimura, T., 他4名
    • Journal Title

      Med.Mol.Morph.

      Volume: 43 Pages: 145-157

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel role of prostaglandin E_2 in neuropathic pain : blockade of microglial migration in the spinal cord.2010

    • Author(s)
      Kunori, S., 他6名
    • Journal Title

      Glia

      Volume: 59 Pages: 208-218

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of arginase II mRNA by nitric oxide using an in vitro model of gyrate atrophy of choroid and retina2010

    • Author(s)
      Ohnaka, M., 他8名
    • Journal Title

      Invest.Ophthalmol. Vis.Sci.

      Volume: 52 Pages: 1493-1500

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of spinal phosphorylation cascade of Tyr1472-NR2B, Thr286-CaMKII, and Ser831-GluR1 in neuropathic pain.2010

    • Author(s)
      Katano, T, 他5名
    • Journal Title

      Neuropharmacol.

      Volume: 60 Pages: 609-616

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Optimization of conditions for acetylcholine detection in the nerve tissue sections by imaging mass spectrometry2012

    • Author(s)
      Yao I, Sugiura Y, Zaima N, Setou M andIto S
    • Organizer
      19th International Mass SpectrometryConference
    • Place of Presentation
      Kyoto
    • Year and Date
      2012-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Functional analysis of neuropathic pain- related protein in vivo. 神経障害性疼痛関連分子の同定と機能解析2012

    • Author(s)
      片野泰代, 山崎真弥, 阿部学, 福田正史, 奥村宣明, 中澤敬信, 高尾敏文, 山本雅, 崎村健二, 伊藤誠二
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡, 福岡国際 会議場・マリンメッセ福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] Imaging of acetylcholine in the nerve tissue sections with mass spectrometry.2012

    • Author(s)
      Yao I, Sugiura Y, Zaima N, Setou M andIto S
    • Organizer
      The 42nd annual meeting of the Society for Neuroscience
    • Place of Presentation
      New Orleans, U.S.A.
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Search of neuropathic pain related proteins in neuropathic pain model mice by iTRAQ proteome analysis.2012

    • Author(s)
      Katano T, Fukuda M, Okumura N, NakazawaT, Yamamoto T, Takao T and Ito S
    • Organizer
      The 42nd annual meeting of the Society forNeuroscience
    • Place of Presentation
      New Orleans, U.S.A.
    • Related Report
      2012 Final Research Report
  • [Presentation] Characterization of postherpetic neuralgia in mice with knock-in mutation of NMDA receptor.2012

    • Author(s)
      Ito S. Sasaki A, Unezaki S, Andoh T, Matsumura S, Katano T, Nishio N, Nakatsuka T, Kuraishi Y and Minami T
    • Organizer
      14th World Congress on Pain, Milano
    • Place of Presentation
      ITALY
    • Related Report
      2012 Final Research Report
  • [Presentation] Visualization of acetylcholine distribution in the brain by imaging mass spectrometry.2012

    • Author(s)
      Yao I, Sugiura Y, Zaima N, Setou M andIto S
    • Organizer
      60th ASMS Conference on Mass Spectrometry and Allied Topics
    • Place of Presentation
      Vancouver, CANADA
    • Related Report
      2012 Final Research Report
  • [Presentation] Visualization of acetylcholine distribution in the brain by imaging mass spectrometry.2012

    • Author(s)
      Yao, I.
    • Organizer
      60th The American Society For Mass Spectrometry Conference
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2012 Annual Research Report
  • [Presentation] Characterization of postherpetic neuralgia in mice with knock-in mutation of NMDA receptor.2012

    • Author(s)
      Ito, S.
    • Organizer
      14th World Congress on Pain
    • Place of Presentation
      Milano, Italy
    • Related Report
      2012 Annual Research Report
  • [Presentation] Optimization of conditions for acetylcholine detection in the nerve tissue sections by imaging mass spectrometry.2012

    • Author(s)
      Yao, I.
    • Organizer
      19th International Mass Spectrometry Conference
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Search of neuropathic pain related proteins in neuropathic pain model mice by iTRAQ proteome analysis.2012

    • Author(s)
      Katano, T.
    • Organizer
      The 42nd annual meeting of the Society for Neuroscience
    • Place of Presentation
      New Orleans, U.S.A.
    • Related Report
      2012 Annual Research Report
  • [Presentation] Functional analysis of neuropathic pain-related protein in vivo. 神経障害性疼痛関連分子の同定と機能解析2012

    • Author(s)
      片野泰代
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡(福岡)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mechanism of maintenance of neuropathic pain in the spinal cord, as a model of neural plasticity.2011

    • Author(s)
      Ito S
    • Organizer
      The 6th International Conference of Neurons and Brain Diseases in Toyama, ANA
    • Place of Presentation
      クラウンプラザホテル, 富山
    • Year and Date
      2011-08-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Mechanism of maintenance of neuropathic pain in the spinal cord, as a model of neural plasticity2011

    • Author(s)
      Ito, S
    • Organizer
      The 6th International Conference of Neurons and Brain Diseases in Toyama
    • Place of Presentation
      ANAクラウンプラザホテル,富山
    • Year and Date
      2011-08-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生体吸収性ゲルの手術創埋込みによる鎮痛薬の徐放効果を用いた新しい術鎮痛法2011

    • Author(s)
      荒木吉朗,海堀昌樹,松村伸治,權雅憲,伊藤誠二
    • Organizer
      第58回日本生化学会近畿支部例会
    • Place of Presentation
      大阪,関西医科大学
    • Year and Date
      2011-05-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 生体吸収性ゲルの手術創埋込みによる鎮痛薬の徐放効果を用いた新しい術鎮痛法2011

    • Author(s)
      荒木吉朗, ほか4名
    • Organizer
      第58回日本生化学会近畿支部例会
    • Place of Presentation
      関西医科大学大阪
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Blockade by prostaglandin E2 of microglial migration in the spinal cord after nerve injury.2011

    • Author(s)
      Ito S
    • Organizer
      The 4th Asian Pain
    • Place of Presentation
      Shanghai, CHINA
    • Year and Date
      2011-05-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Involvement of S-nitrosylation of actin in inhibition of neurotransmitter release by nitric oxide.2011

    • Author(s)
      Lu J, Katano T, Okuda-Ashitaka E, OishiY, Urade Y and Ito S
    • Organizer
      The 4th Asian Pain
    • Place of Presentation
      Shanghai, CHINA
    • Year and Date
      2011-05-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Involvement of S-nitrosylation of actin in inhibition of neurotransmitter release by nitric oxide2011

    • Author(s)
      Lu, J., ほか5名
    • Organizer
      The 4th Asian Pain
    • Place of Presentation
      Shanghai, CHINA
    • Year and Date
      2011-05-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Blockade by prostaglandin E2 of microglial migration in the spinal cord after nerve injury2011

    • Author(s)
      Ito, S
    • Organizer
      The 4th Asian Pain
    • Place of Presentation
      Shanghai, CHINA
    • Year and Date
      2011-05-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] The activation of NR2B-NMDAR by phosphorylation of Tyr1472-NR2B triggers phosphorylation cascade in neuropathicpain.2011

    • Author(s)
      Katano T and Ito S
    • Organizer
      The 41st Annual Meeting of the Society forNeuroscience
    • Place of Presentation
      Washington, U.S.A.
    • Related Report
      2012 Final Research Report
  • [Presentation] Synaptic E3ligase SCRAPPER is crucial for hippocampus-dependent fear memory formation.2011

    • Author(s)
      Yao I, Takao K, Miyakawa T, Ito S andSetou M
    • Organizer
      The 41st Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington, U.S.A.
    • Related Report
      2012 Final Research Report
  • [Presentation] Blockade of microglial migration in the spinal cord by prostaglandin E2 via EP2.2011

    • Author(s)
      Ito S, Kunori S, Matsumura S, Katano T, Urade Y and Okuda-Ashitaka E
    • Organizer
      The 41st Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington, U.S.A.
    • Related Report
      2012 Final Research Report
  • [Presentation] Ascorbic acid and N-acetyl cysteine protects diabetic heart from ischemia/ reperfusion injury by increasing tetrahydrobiopterin and inhibiting iNOS Uncoupling.2011

    • Author(s)
      岡崎徹, 大谷肇, 嶋津孝幸, 吉岡慶, 藤 田昌哲, 片野泰代, 伊藤誠二, 岩坂壽二
    • Organizer
      第75回日本循環器学会学術集会
    • Place of Presentation
      横浜, パ シフィコ横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] 生体吸収性ハイドロゲルの手術創埋込みによる鎮痛薬の徐放効果を用いた革新的な術後鎮痛法の開発2011

    • Author(s)
      荒木吉朗,海堀昌樹,松村伸治,伊藤誠二,權雅憲
    • Organizer
      日本ペインクリニック学会第45回大会
    • Place of Presentation
      松山,愛媛県県民文化会館(ひめぎんホール)
    • Related Report
      2012 Final Research Report
  • [Presentation] Blockade of microglial migration in the spinal cord by prostaglandin E2 via EP22011

    • Author(s)
      Ito, S., ほか5名
    • Organizer
      The 41th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington, U.S.A.
    • Related Report
      2011 Annual Research Report
  • [Presentation] Synaptic E3ligase SCRAPPER is crucial for hippocampus-dependent fear memory formation2011

    • Author(s)
      Yao, I., ほか4名
    • Organizer
      The 41th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington, U.S.A.
    • Related Report
      2011 Annual Research Report
  • [Presentation] The activation of NR2B-NMDAR by phosphorylation of Tyr1472-NR2B triggers phosphorylation cascade in neuropathic pain2011

    • Author(s)
      Katano, T., Ito, S.
    • Organizer
      The 41th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington, U.S.A.
    • Related Report
      2011 Annual Research Report
  • [Presentation] Ascorbic Acid and N-acetyl Cysteine Protects Diabetic Heart from Ischemia/reperfusion Injury by Increasing Tetrahydrobiopterin and Inhibiting iNOS Uncoupling2011

    • Author(s)
      岡崎徹, ほか7名
    • Organizer
      第75回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生体吸収性ハイドロゲルの手術創埋込みによる鎮痛薬の徐放効果を用いた革新的な術後鎮痛法の開発2011

    • Author(s)
      荒木吉朗, ほか4名
    • Organizer
      日本ペインクリニック学会第45回大会
    • Place of Presentation
      愛媛県県民文化会館松山
    • Related Report
      2011 Annual Research Report
  • [Presentation] Direct analysis of histopathological specimen for oligosaccharides by MALDI-MS imaging. 多糖類を主とした質量顕微鏡法に よる組織病理標本の成分解析2010

    • Author(s)
      矢尾育子, 山田正法, 保坂蔵人, 早坂孝 宏, 牛嶋大, 松浦正明, 瀬籐光利, 伊藤誠 二
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      神戸, 神戸ポー トアイランド
    • Year and Date
      2010-12-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Direct analysis of histopathological specimen for oligosaccharides by MALDI-MS.2010

    • Author(s)
      Yao, I., 他7名
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
    • Place of Presentation
      神戸ボートアイランド(兵庫県)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経因性疼痛における脊髄後角でのリン酸化シグナルカスケード2010

    • Author(s)
      片野泰代,中澤敬信,渡辺雅彦,山本雅,伊藤誠二
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      神戸,神戸ポートアイランド
    • Year and Date
      2010-12-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 神経因性疼痛における脊髄後角でのリン酸化シグナルカスケード2010

    • Author(s)
      片野泰代, 他4名
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Behavioral analysis of knockout mice for F-box protein SCRAPPER. F ボックスタンパ ク質 SCRAPPER の遺伝子ノックアウトマウス 行動解析2010

    • Author(s)
      矢尾育子, 高雄啓三, 宮川剛, 伊藤誠二, 瀬藤光利
    • Organizer
      第33回日本神経科学大会,第53 回日本神経 化学会大会,第20 回日本神経回路学会大会 合同大会
    • Place of Presentation
      神戸, 神戸コンベンションセン ター
    • Year and Date
      2010-09-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Behavioral analysis of knockout mice for F-box protein SCRAPPER.2010

    • Author(s)
      Yao, I., 他4名
    • Organizer
      第33回日本神経科学大会,第53回日本神経化学会大会,第20回日本神経回路学会大会合同大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Attenuation of neuropathic pain by impaired Ca2+ signaling in mutant mice lacking the Tyr-1472 phosphorylation site of the NR2B.2010

    • Author(s)
      Matsumura S, Kunori S, Nakazawa T, Abe T, Yamamoto T, Katano T, Watanabe M, Okuda-Ashitaka E and Ito S
    • Organizer
      The 40th Annual Meeting of the Society forNeuroscience
    • Place of Presentation
      San Diego, U.S.A.
    • Related Report
      2012 Final Research Report
  • [Presentation] A search for biomarkers in the cerebrospinal fluid in predicting response to the treatment of postherpetic neuralgia.2010

    • Author(s)
      Ito S, Lu J, Katano T, Fujiwara S, Nishimura W, Urade Y and Minami T
    • Organizer
      The 40th Annual Meeting of the Society forNeuroscience
    • Place of Presentation
      San Diego, U.S.A.
    • Related Report
      2012 Final Research Report
  • [Presentation] A search for biomarkers in the cerebrospinal fluid in predicting response to the treatment of postherpetic neuralgia.2010

    • Author(s)
      Ito, S., 他6名
    • Organizer
      The 40th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, U.S.A.
    • Related Report
      2010 Annual Research Report
  • [Presentation] Attenuation of neuropathic pain by impaired Ca2+ signaling in mutant mice lacking the Tyr-1472 phosphorylation site of the NR2B.2010

    • Author(s)
      Matsumura, S., 他8名
    • Organizer
      The 40th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, U.S.A.
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www3.kmu.ac.jp/medchem/

    • Related Report
      2012 Final Research Report
  • [Remarks] http://www3.kmu.ac.jp/medchem/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www3.kmu.ac.jp/medchem/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www3.kmu.ac.jp/medchem/index.html

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 埋植用鎮痛製剤2010

    • Inventor(s)
      荒木吉朗, 海堀昌樹, 松村伸治, 伊藤誠二, 權雅憲
    • Industrial Property Rights Holder
      学校法人関西医科大学
    • Industrial Property Number
      2010-127252
    • Filing Date
      2010-06-02
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 埋植用鎮痛製剤2010

    • Inventor(s)
      荒木吉朗, 他4名
    • Industrial Property Rights Holder
      関西医科大学
    • Filing Date
      2010-06-02
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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