Estimation of dietary melatonin intake and its relationship with menopause, cancer, and cardiovascular disease

• Project/Area Number: 22390132
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Gifu University
• Principal Investigator: NAGATA Chisato 岐阜大学, 大学院・医学系研究科, 教授 (30283295)
• Co-Investigator(Kenkyū-buntansha): HATTORI Atsuhiko 東京医科歯科大学, 教養部, 教授 (70183910) ; WADA Keiko 岐阜大学, 大学院・医学系研究科, 准教授 (00532673)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000); Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2010: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
• Keywords: 疫学 / メラトニン / 食事 / がん / 循環器疾患 / 閉経

Research Abstract

Melatonin concentrations of about 120 foods were measured and used as basic data to estimate melatonin intake from diet through a food frequency questionnaire. Associations of melatonin intake with the risk of menopause and mortality from cancer and cardiovascular disease were assessed in a cohort. A high melatonin intake was associated with a decreased risk of mortality from cardiovascular disease in women. Urinary 6-sulfatoxymelatonin was measured among children and its associations with lifestyle factors and hormone levels were assessed.

Research Products

• [Journal Article] Associations of urinary 6-sulfatoxymelatonin withdemographics, body mass, sex steroids, and lifestyle factors in preschool Japanese children (2013)
  • Author(s): Wada K, Nakamura K, Tamai Y, Tsuji M, Masue T, Watanabe K, Ando K, Nagata C
  • Journal Title: Ann Epidemiol Volume: 23 Pages: 60-5
  • Peer Reviewed
• [Journal Article] Associations of urinary 6-sulfatoxymelatonin with demographics, body mass, sex steroids, and lifestyle factors in preschool Japanese children. (2013)
  • Author(s): Wada K
  • Journal Title: Ann Epidemiol Volume: 23 Pages: 60-65
  • Peer Reviewed
• [Journal Article] Total fat intake is associated with decreased mortality in Japanese men but not inwomen (2012)
  • Author(s): Nagata C, Nakamura K, Wada K, Oba S, Tsuji M, Tamai Y, Kawachi T
  • Journal Title: J Nutr. Volume: 142 Pages: 1713-9
  • Peer Reviewed
• [Journal Article] Associations of urinary 6-sulfatoxymelatonin with biomarkers related to cardiovascular disease in Japanese women. (2012)
  • Author(s): Masue T, Wada K, Hayashi M, Takeda N, Yasuda K, Deguchi T, Nagata C
  • Journal Title: Metabolism. Volume: 61 Pages: 70-5
  • Peer Reviewed
• [Journal Article] Associations of physical activity and diet with the onset of menopause in Japanese women (2012)
  • Author(s): Nagata C, Wada K, Nakamura K, Tamai Y, Tsuji M, Shimizu H.
  • Journal Title: Menopause. Volume: 19 Pages: 75-81
  • Peer Reviewed
• [Journal Article] Total fat intake is associated with decreased mortality in Japanese men but not in women. (2012)
  • Author(s): Nagata C
  • Journal Title: J Nutr Volume: 142 Issue: 9 Pages: 1713-9
  • DOI: 10.3945/jn.112.161661
  • Peer Reviewed
• [Journal Article] Associations of physical activity and diet with the onset of menopause in Japanese women (2012)
  • Author(s): Nagata C., et al
  • Journal Title: Menopause Volume: 19 Pages: 75-81
  • Peer Reviewed
• [Journal Article] Associations of urinary 6-sulfatoxymelatonin with biomarkers related to cardiovascular disease in Japanese women (2012)
  • Author(s): Nasue T, Nagata C, et al
  • Journal Title: Metabolism Volume: 61 Pages: 70-5
  • Peer Reviewed
• [Presentation] 幼児期の行動的問題と睡眠習慣、内因性メラトニンとの関連 (2012)
  • Author(s): 和田恵子、中村こず枝、辻美智子、玉井裕也、渡辺香織、大土早紀子、山本景子、安藤京子、永田知里
  • Organizer: 第22回日本疫学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2012-01-27
• [Presentation] シンポジウム「乳がんなどの助成ホルモン依存性がんのリスク要因に関する疫学的・分子疫学的研究」 高山コホート研究(Takayama Study)の結果から (2010)
  • Author(s): 永田知里
  • Organizer: がん予防学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2010-07-15
• [Remarks]
  • URL: http://www1.gifu-u.ac.jp/~ph/
• [Remarks]
  • URL: http://ww1.gifu-u.ac.jp/~ph/