Application of autophagy to forensic diagnosis -evaluation of autophagy as a novel marker
| Project/Area Number |
22390142
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
KIMURA Akihiko 和歌山県立医科大学, 医学部, 准教授 (60136611)
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| Co-Investigator(Kenkyū-buntansha) |
KONO Toshikazu 和歌山県立医科大学, 医学部, 教授 (70251923)
ISHIDA Yuko 和歌山県立医科大学, 医学部, 講師 (10364077)
NOSAKA Mizuho 和歌山県立医科大学, 医学部, 助教 (00244731)
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| Co-Investigator(Renkei-kenkyūsha) |
MUKAIDA Naofumi 金沢大学, がん研究所, 教授 (30182067)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | autophay / 薬物中毒 / 腎障害 / 心不全 / 皮膚創傷 / 法医診断 / autophagy / 大動脈瘤 / 創傷治癒 / 生活反応 / オートファジー / プロテアソーム / 心肥大 / 皮膚損傷 / 体内時計 / 法医病理診断 / 飢餓 |
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| Research Abstract |
The function and pattern of appearance of autophagy in the various tissue injury were analyzed in the mouse models. We showed that autophagy was induced in early stage in the kidney of mice administrated with cisplatin, which was a protective response to cisplatin-induced renal injury. We also found that autophagy was induced in the compensatory stage of cardiac hypertrophy.In analysis of autophagy in the skin wound healing process, we found immediate reduction of autophagy in the wound sites,which might be very useful for forensic practice as a novel marker of vitality of skin wound.
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Report
(5 results)
Research Products
(39 results)
