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Application of autophagy to forensic diagnosis -evaluation of autophagy as a novel marker

Research Project

Project/Area Number 22390142
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Legal medicine
Research InstitutionWakayama Medical University

Principal Investigator

KIMURA Akihiko  和歌山県立医科大学, 医学部, 准教授 (60136611)

Co-Investigator(Kenkyū-buntansha) KONO Toshikazu  和歌山県立医科大学, 医学部, 教授 (70251923)
ISHIDA Yuko  和歌山県立医科大学, 医学部, 講師 (10364077)
NOSAKA Mizuho  和歌山県立医科大学, 医学部, 助教 (00244731)
Co-Investigator(Renkei-kenkyūsha) MUKAIDA Naofumi  金沢大学, がん研究所, 教授 (30182067)
Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Keywordsautophay / 薬物中毒 / 腎障害 / 心不全 / 皮膚創傷 / 法医診断 / autophagy / 大動脈瘤 / 創傷治癒 / 生活反応 / オートファジー / プロテアソーム / 心肥大 / 皮膚損傷 / 体内時計 / 法医病理診断 / 飢餓
Research Abstract

The function and pattern of appearance of autophagy in the various tissue injury were analyzed in the mouse models. We showed that autophagy was induced in early stage in the kidney of mice administrated with cisplatin, which was a protective response to cisplatin-induced renal injury. We also found that autophagy was induced in the compensatory stage of cardiac hypertrophy.In analysis of autophagy in the skin wound healing process, we found immediate reduction of autophagy in the wound sites,which might be very useful for forensic practice as a novel marker of vitality of skin wound.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (39 results)

All 2014 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (32 results)

  • [Journal Article] Immunohistochemical detection of intrathrombotic macrophage-derived cytokines and its application to thrombus age estimation in murine deep vein thrombosis model2013

    • Author(s)
      Nosaka M, Ishida Y, Kimura A, Kondo T
    • Journal Title

      Int J Legal Med

      Volume: 127(5) Pages: 937-42

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interferon-γ is protective in cisplatin-induced renal injury by enhancing autophagic flux2012

    • Author(s)
      Kimura A, Ishida Y, Inagaki M, Nakamura Y, Sanke T, Mukaida N, Kondo T
    • Journal Title

      Kidney Int

      Volume: 82(10) Pages: 1093-104

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing2012

    • Author(s)
      Ishida Y, Kimura A, Kuninaka Y, Inui M, Matsushima K, Mukaida N, Kondo T
    • Journal Title

      J Clin Invest

      Volume: 122(2) Pages: 711-21

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interferon- γ is protective in cisplatin-induced renal injury by enhancing autophagic flux.2012

    • Author(s)
      Kimura A, Ishida Y, Inagaki M, Nakamura Y, Sanke T, Mukaida N, Kondo T
    • Journal Title

      Kidney Int

      Volume: 82 Issue: 10 Pages: 1093-1104

    • DOI

      10.1038/ki.2012.240

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Absence of IFN-・ accelerates thrombus resolution through enhanced MMP-9 and VEGF expression in mice2011

    • Author(s)
      Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Inui M, Mukaida N, Kondo T
    • Journal Title

      J Clin Invest

      Volume: 121(7) Pages: 2911-20

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estimating time of death based on the biological clock2011

    • Author(s)
      Kimura A, Ishida Y, Hayashi T, Nosaka M, Kondo T
    • Journal Title

      Int J Legal Med

      Volume: 125(3) Pages: 385-91

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Absence of IFN-γ accelerates thrombus resolution through enhanced MMP-9 and VEGF expression in mice2011

    • Author(s)
      Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Inui M, Mukaida N, Kondo T
    • Journal Title

      J Clin Invest

      Volume: 121 Issue: 7 Pages: 2911-2920

    • DOI

      10.1172/jci40782

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] マウス急性砒素腎障害モデルにおけるIL-6およびエストロゲンの役割解析2014

    • Author(s)
      木村章彦, 石田裕子, 野坂みずほ, 國中由美, 向田直史, 近藤稔和
    • Organizer
      第13回分子予防環境医学研究会
    • Place of Presentation
      和歌山
    • Related Report
      2013 Final Research Report
  • [Presentation] Lack of IFN-gamma exergarates ANG II-induced aortic aneurysm through reduction of autophagy2013

    • Author(s)
      Kimura A, Ishida Y, Nosaka M, Kuninaka Y, Mukaida N, Kondo T
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2013 Final Research Report
  • [Presentation] 皮膚組織におけるautophagyのcircadian rhythmと創傷治癒2013

    • Author(s)
      近藤稔和, 木村章彦, 石田裕子, 野坂みずほ, 國中由美, 川口真理子
    • Organizer
      第43回日本創傷治癒学会
    • Place of Presentation
      大分
    • Related Report
      2013 Final Research Report
  • [Presentation] Pivotal involvement of IFN-gamma/Stat5 axis in compensatory cardiac hypertrophy induced by pressure overload2013

    • Author(s)
      Kimura A, Ishida Y, Furuta M, Nosaka M, Kuninaka Y, Kawaguchi M, Mukaida N, Kondo T
    • Organizer
      ESC Congress 2013
    • Place of Presentation
      Amsterdam (The Netherlands)
    • Related Report
      2013 Final Research Report
  • [Presentation] 圧負荷による代償性心肥大の分子メカニズム-IFN-γの役割について2013

    • Author(s)
      木村章彦, 野坂みずほ, 向田直史, 近藤稔和
    • Organizer
      第34回日本炎症・再生医学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 損傷が体内時計に及ぼす影響-皮膚損傷について-2013

    • Author(s)
      木村章彦, 石田裕子, 野坂みずほ ,國中由美, 川口真理子, 近藤稔和
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] IFN-γ/Stat5 axis is essential in compensatory cardiac hypertrophy induced by pressure overload2013

    • Author(s)
      Kimura A, Ishida Y, Nosaka M, Kuninaka Y, Kawaguchi M, Mukaida N, Kondo T
    • Organizer
      JSICR-MMCB2013
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
  • [Presentation] 損傷が体内時計に及ぼす影響 -皮膚損傷について-2013

    • Author(s)
      木村章彦、石田裕子、野阪みずほ、國中由美、川口真理子、近藤稔和
    • Organizer
      第97次本法医学会学術全国集会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] Pivotal involvement of IFN-gamma/Stat5 axis in compensatory cardiac hypertrophy induced by pressure overload2013

    • Author(s)
      木村章彦、石田裕子、古田眞智、野阪みずほ、國中由美、川口真理子、向田直史、近藤稔和
    • Organizer
      ESC Congress 2013
    • Place of Presentation
      オランダ (アムステルダム)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 皮膚組織におけるautophagyのcircadian rhythmと創傷治癒2013

    • Author(s)
      近藤稔和、木村章彦、石田裕子、野坂みずほ、國中由美、川口真理子
    • Organizer
      第43回日本創傷治癒学会
    • Place of Presentation
      大分
    • Related Report
      2013 Annual Research Report
  • [Presentation] Lack of IFN-g exaggerates ANG II-induced aortic aneurysm through reduction of autophagy2013

    • Author(s)
      木村章彦、石田裕子、野阪みずほ、國中由美、向田直史、近藤稔和
    • Organizer
      第42 回日本 免疫学会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2013 Annual Research Report
  • [Presentation] IFN-gamma plays a protective role in pressure overload-induced cardiac hypertrophy through PI3K/Akt signaling activation2012

    • Author(s)
      Kimura A, Ishida Y, Nosaka M, Mukaida N, Kondo T
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] A role of IFN-gamma in pressure overload-induced compensatory cardiac hypertrophy2012

    • Author(s)
      Kimura A, Ishida Y, Nosaka M, Kuninaka Y, Kawaguchi M, Mukaida N, Kondo T
    • Organizer
      10th Joint Meeting of International Cytokine Society and International Society for Interferon and Cytokine Research
    • Place of Presentation
      Geneva
    • Related Report
      2013 Final Research Report
  • [Presentation] 圧負荷による代償性心肥大におけるIFN-γの役割2012

    • Author(s)
      木村章彦, 石田裕子, 野坂みずほ, 向田直史, 近藤稔和
    • Organizer
      第33回日本炎症・再生医学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of wound on circadian rhythm of skin tissue2012

    • Author(s)
      Kimura A, Nosaka M, Ishida Y, Kuninaka Y, Kondo T
    • Organizer
      22nd Congress of the International Academy of Legal Medicine (IALM2012)
    • Place of Presentation
      Istanbul
    • Related Report
      2013 Final Research Report
  • [Presentation] A role of IFN-γ in the pathogenesis of pressure overload-induced heart failure2012

    • Author(s)
      木村章彦, 石田裕子, 野坂みずほ, 川口真理子, 國中由美, 近藤稔和
    • Organizer
      第96次日本法医学会学術全国集会
    • Place of Presentation
      静岡
    • Related Report
      2013 Final Research Report
  • [Presentation] A role of IFN-gamma in the pathogenesis of pressure overload-induced heart failure.2012

    • Author(s)
      木村章彦
    • Organizer
      第96次日本法医学会学術全国集会
    • Place of Presentation
      浜松
    • Related Report
      2012 Annual Research Report
  • [Presentation] A role of IFN-gamma in pressure overload-induced compensatory cardiac hypertrophy2012

    • Author(s)
      Kimura Akihiko
    • Organizer
      10th Joint Meeting of International Cytokine Society and International Society for Interferon and Cytokine Research
    • Place of Presentation
      スイス (Geneva)
    • Related Report
      2012 Annual Research Report
  • [Presentation] IFN- gamma plays a protective role in pressure overload-induced cardiac hypertrophy through PI3K/Akt signaling activation2012

    • Author(s)
      Kimura Akihiko
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] Pressure overload-induced cardiac hypertrophy affects oscillation amplitude of clock genes expression but not their circadian rhythm2011

    • Author(s)
      Kimura A
    • Organizer
      19th IAFS world meeting
    • Place of Presentation
      Portugal
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] IFN-γ plays a protective role in pressure overload-induced cardiac hyper trophy2011

    • Author(s)
      Kimura A
    • Organizer
      The 10th World Congress on Inflammation
    • Place of Presentation
      Paris
    • Year and Date
      2011-06-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] IFN-gamma plays a protective role in pressure overload-induced cardiac hypertrophy through immunoproteasome activation

    • Author(s)
      Kimura A, Ishida Y, Nosaka M, Mukaida N, Kondo T
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2013 Final Research Report
  • [Presentation] Application of the biological clock-based method for estimating the time of death to forensic practices

    • Author(s)
      Kimura A, Ishida Y, Nosaka M, Kuninaka Y, Kawaguchi M, Kondo T
    • Organizer
      8th International Symposium Advances in Legal Medicine (ISALM)
    • Place of Presentation
      Frankfurt
    • Related Report
      2013 Final Research Report
  • [Presentation] Pressure overload-induced cardiac hypertrophy affects oscillation amplitude of clock genes expression but not their circadian rhythm

    • Author(s)
      Kimura A, Ishida Y, Nosaka M, Kawaguchi M, Wagatsuma S, Ohata S, Kondo T
    • Organizer
      19th IAFS world meeting
    • Place of Presentation
      Portugal
    • Related Report
      2013 Final Research Report
  • [Presentation] IFN-γ plays a protective role in pressure overload-induced cardiac hypertrophy

    • Author(s)
      Kimura A, Ishida Y, Nosaka M, Mukaida N, Kondo T
    • Organizer
      The 10th World Congress on Inflammation
    • Place of Presentation
      Paris
    • Related Report
      2013 Final Research Report
  • [Presentation] Essential roles of CCL3-CCR1 axis in the pathogenesis of antigen-induced arthritis

    • Author(s)
      Kondo T, Ishida Y, Inui M, Kimura A, Nosaka M, Kuninaka Y, Mukaida N
    • Organizer
      第32回日本炎症・再生医学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] Essential role of chemokine receptor CX3CR1 in bleomycin-induced pulmonary fibrosis through regulation of bone marrow-derived fibrocyte infiltration

    • Author(s)
      Ishida Y, Kimura A, Kuninaka Y, Mukaida N, Kondo T
    • Organizer
      JSICR-MMCB2011
    • Place of Presentation
      Osaka
    • Related Report
      2013 Final Research Report
  • [Presentation] Eisenmenger W. Detection of fibrocytes in human skin wounds and its application for wound age determination

    • Author(s)
      Kondo T, Ishida Y, Kimura A, Kawaguchi M, Murata S, Takatsu A
    • Organizer
      20th Spring meeting of German Society of Legal Medicine in South
    • Place of Presentation
      Munich
    • Related Report
      2013 Final Research Report
  • [Presentation] Essential role of chemokine receptor CX3CR1 in bleomycin-induced pulmonary fibrosis through regulation of bone marrow-derived fibrocyte infiltration

    • Author(s)
      Ishida Y, Kimura A, Kuninaka Y, Mukaida N, Kondo T
    • Organizer
      Experimental Biology2011
    • Place of Presentation
      Washington D.C.
    • Related Report
      2013 Final Research Report
  • [Presentation] Absence of IFN-γ accelerates thrombus resolution through enhanced MMP-9 and VEGF expression

    • Author(s)
      Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Mukaida N, Kondo T
    • Organizer
      Experimental Biology 2011
    • Place of Presentation
      Washington D.C.
    • Related Report
      2013 Final Research Report
  • [Presentation] Crosstalk between estrogen/estrogen receptor and IL-6/Jak/Stat3 signal in pathogenesis of sodium arsenite -induced renal injury

    • Author(s)
      Kimura A, Ishida Y, Nosaka M, Mukaida N, Kondo T
    • Organizer
      2010 Joint meeting between the Society for Leukocyte Biology & the International Endotoxin and Innate Immunity Society
    • Place of Presentation
      Voncouver
    • Related Report
      2013 Final Research Report
  • [Presentation] Estrogen はIL-6/Jak/Stat3 signalを抑制してヒ素による腎障害を増悪する

    • Author(s)
      木村章彦, 石田裕子, 向田直史, 近藤稔和
    • Organizer
      第31回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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