Evaluation system for regenerative medicine of genetic disorders by using cloned pigs established from endoderm somatic stem cells
| Project/Area Number |
22390209
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kumamoto University |
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Principal Investigator |
ENDO Fumio 熊本大学, 大学院・生命科学研究部, 教授 (00176801)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Kimitoshi 熊本大学, 医学部附属病院, 講師 (30336234)
MATSUMOTO Shiro 熊本大学, 医学部附属病院, 助教 (70467992)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Keywords | 再生医学 / 移植・再生医療 / 糖尿病 / 発生・分化 / バイオテクノロジー / 幹分離法 / 内胚葉幹細胞 / 唾液腺 / 膵臓 / 肝臓 |
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| Research Abstract |
We first isolated tissue stem cells originated from porcinesalivary gland. This clone was used for the generation of cloned pigs. Using this clonedpigs, we established a model system of cell-transplantation for the treatment of liverand pancreatic disorders. We also established a new culture system using variousconcentrations of amino acids in the medium.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Calreticulin induces dilatedcardiomyopathy2013
Author(s)
Lee D, Oka T, Hunter B, Robinson A, PappS, Nakamura K, Srisakuldee W, Nickel BE,Light PE, Dyck JRB, Lopaschuk GD,Kardami E, Opas M, and Michalak M
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Journal Title
Plos One
Volume: (inpress)
Related Report
Peer Reviewed
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[Journal Article] p.E66Q Mutation in the GLAGene is Associated with a High Risk ofCerebral Small-Vessel Occlusion inElderly Japanese Males2013
Author(s)
Nakamura K, Sekijima Y, NakamuraK,Hattori K, Nagamatsu K, Shimizu Y,Yazaki M, Sakurai A, Endo F, FukushimaY, Ikeda S
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Journal Title
Eur J Neurol
Volume: (inpress)
Related Report
Peer Reviewed
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[Journal Article] Re-evaluation of the indications forliver transplantation in Wilson'sdisease based on the outcomes ofpatients referred to a transplantcenter2013
Author(s)
Ohya Y, Okajima H, Honda M, HayashidaS, Suda H, Matsumoto S, Lee KJ,Yamamoto H, Takeichi T, Mitsubuchi H,Asonuma K, Endo F, Inomata Y
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Journal Title
Pediatr Transplant
Volume: 17(4)
Pages: 369-737
Related Report
Peer Reviewed
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[Journal Article] Current status of hepaticglycogen storage disease in Japan:clinical manifestations, treatmentsand long-term outcomes2013
Author(s)
Kido J, Nakamura K, Matsumoto S,Mitsubuchi H, Ohura T, Shigematsu Y,Yorifuji T, Kasahara M, Horikawa R,Endo F
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Journal Title
J Hum Genet
Volume: 58(5)
Pages: 285-92
Related Report
Peer Reviewed
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[Journal Article] Long-term outcome and intervention of urea cycle disorders in Japan2011
Author(s)
Kido J, Nakamura K, Mitsubuchi H, Ohura T, Takayanagi M, Matsuo M, Yoshino M, Shigematsu Y, Yorifuji T, Kasahara M, Horikawa R, Endo F
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Journal Title
J Inherit Metab Dis
Volume: (Epub ahead of print)
Related Report
Peer Reviewed
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