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Development of clinical marker to predict longitudinal prognosis of early psychosis

Research Project

Project/Area Number 22390219
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionTohoku University

Principal Investigator

MATSUMOTO Kazunori  東北大学, 大学院・医学系研究科, 准教授 (40301056)

Co-Investigator(Kenkyū-buntansha) MATSUOKA Hiroo  東北大学, 大学院・医学系研究科, 教授 (00173815)
MUGIKURA Syunji  東北大学, 大学院・医学系研究科, 講師 (20375017)
富田 博秋  東北大学, 大学院・医学系研究科, 准教授 (90295064)
Research Collaborator TOMITA Hiroaki  東北大学, 災害科学国際研究所, 教授 (90295064)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords早期精神病 / 早期介入 / ARMS / 統合失調症 / 診断 / At Risk Mental State / 予防精神医学 / 前駆期 / 脳構造 / 認知機能
Research Abstract

To develop useful and reliable clinical markers to predict the longitudinal prognosis of early psychosis, we investigated clinical variables of at risk mental state (ARMS) and first episode psychosis (FEP) at intake and follow-up. In our sample of 116 patients with ARMS, 14% transited to psychosis. Cognitive performance improved to a greater extent in patients with ARMS than in those with FEP. The present findings indicate the importance of using multiple clinical variables in combination to assess and predict the functionalprognosis of early psychosis.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (54 results)

All 2013 2012 2011 2010 Other

All Journal Article (13 results) (of which Peer Reviewed: 7 results) Presentation (31 results) Book (10 results)

  • [Journal Article] 精神病アットリスク状態(ARMS)に対する早期介入2012

    • Author(s)
      桂雅宏,小原千佳,松本和紀
    • Journal Title

      臨床精神医学

      Volume: 41 Pages: 1413-1419

    • URL

      http://ci.nii.ac.jp/naid/40019450720

    • Related Report
      2012 Final Research Report
  • [Journal Article] The Japanese version of the Brief Core Schema Scale for schemata concerning the self and others: Identification of schema patterns and relationship with depression2012

    • Author(s)
      内田知宏,川村知慧子,三船奈緒子,濱家由美子,松本和紀,安保英勇,上埜高志
    • Journal Title

      The Japanese Journal of Personality

      Volume: 20 Issue: 3 Pages: 143-154

    • DOI

      10.2132/personality.20.143

    • NAID

      130001905637

    • ISSN
      1348-8406, 1349-6174
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prefrontal and Striatal Volumes in Monozygotic Twins Concordant and Discordant forSchizophrenia2012

    • Author(s)
      Ettinger U, Schmechtig A, Toulopoulou T, Borg C, Orrells C, Owens S, Matsumoto K, van Haren NE, Hall MH, Kumari V, McGuire PK, Murray RM, Picchioni M.
    • Journal Title

      Schizophrenia Bulletin

      Volume: 38 Issue: 1 Pages: 192-203

    • DOI

      10.1093/schbul/sbq060

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 日本版Brief Core Schema Scale を用いた自己,他者スキーマの検討―クラスターパターンの類型化および抑うつとの関連2012

    • Author(s)
      内田知宏
    • Journal Title

      パーソナリティ研究

      Volume: 20 Pages: 143-154

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 精神病アットリスク状態(ARMS)に対する早期介入2012

    • Author(s)
      桂雅宏
    • Journal Title

      臨床精神医学

      Volume: 41(10) Pages: 1413-1419

    • Related Report
      2012 Annual Research Report
  • [Journal Article] It's not what you say but the way that you say it: an fMRI study of differential lexical and non-lexical prosodic pitch processing2011

    • Author(s)
      Tracy DK, Ho DK, O'Daly O, Michalopoulou P, Lloyd LC, Dimond E, Matsumoto K, Shergill SS.
    • Journal Title

      BMC Neuroscience

      Volume: 12 Issue: 1 Pages: 128-128

    • DOI

      10.1186/1471-2202-12-128

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ketamine-induced disruption of verbal self-monitoring linked to superior temporal activation2011

    • Author(s)
      Stone JM, Abel KM, Allin MP, van Haren N, Matsumoto K, McGuire PK, Fu CH.
    • Journal Title

      Pharmacopsychiatry

      Volume: 44 Pages: 33-48

    • DOI

      10.1055/s-0030-1267942

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ARMS の治療:早期精 神病の診断と治療2010

    • Author(s)
      松本和紀,大室則幸
    • Journal Title

      医学書院

      Pages: 103-119

    • Related Report
      2012 Final Research Report
  • [Journal Article] 東北大学病院精神科 SAFE クリニックでの早期介入:発症リスク状態への認知行動的アプローチを用いた支 援2010

    • Author(s)
      濱家由美子,森本幸子,大室則幸,桂雅宏, 松岡洋夫,松本和紀
    • Journal Title

      思春期学

      Volume: 28 Pages: 391-396

    • NAID

      10027849800

    • Related Report
      2012 Final Research Report
  • [Journal Article] Psychosis 早期段階における心理学的要因2010

    • Author(s)
      井藤佳恵,内田知宏,大室則幸,宮腰哲生, 井藤文晃,桂雅宏,佐藤博俊,濱家由美子,松 岡洋夫,松本和紀
    • Journal Title

      精神神経学雑誌

      Pages: 112353-359

    • NAID

      10026310362

    • URL

      https://www.jspn.or.jp/journal/journal/pdf/2010/04/journal112_04_p353.pdf

    • Related Report
      2012 Final Research Report
  • [Journal Article] ARMSの治療と経過2010

    • Author(s)
      大室則行,桂雅宏,松本和紀,松岡洋夫
    • Journal Title

      精神科

      Volume: 17 Pages: 261-266

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 東北大学病院精神科SAFEクリニック8での早期介入2010

    • Author(s)
      濱家由美子、松本和紀, 他
    • Journal Title

      思春期学

      Volume: 28 Pages: 391-396

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Prefrontal and Striatal Volumes in Monozygotic Twins Concordant and Discordant for Schizophrenia2010

    • Author(s)
      Ettinger U, Matsumoto K, et al
    • Journal Title

      Schizophrenia Bulletin

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ARMS(At-Risk Mental State)における抗精神病薬・抗うつ薬の処方状況とその 特徴2012

    • Author(s)
      小原千佳,大室則幸,桂雅宏,菊池達郎,濱 家由美子,内田知宏,砂川恵美,松本和紀,松岡洋夫
    • Organizer
      第16回日本精神保健・予防学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] At-Risk Mental State にお ける認知機能障害と認知的洞察との関連2012

    • Author(s)
      内田知宏,松本和紀,大室則幸,桂雅宏,濱家由美子,砂川恵美,前澤裕子,石井優,高杢 高志,松岡洋夫
    • Organizer
      第16回日本精神保健・予防学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] ARMSにおけるQOLの検討関連要因の検討2012

    • Author(s)
      石井優,内田知宏,桂雅宏,大室則幸,小原千佳,菊池達郎,高杢高志,松本和紀,松岡洋夫
    • Organizer
      第16回日本精神保健・予防学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Negative schemata and positive symptoms in ARMS:Comparison with FEP using the brief Core Shema Scales2012

    • Author(s)
      Masahiro Katsura, Kazunori Matsumoto, Tomohiro Uchida, Noriyuki Ohmuro, Tatsuo Kikuchi, Chika Obara, Yumiko Hamaie, Emi Sunakawa, Hiroo Matsuoka
    • Organizer
      8th International Conference on Early Psychosis
    • Place of Presentation
      From Neurobiology to Public Policy San Francisco,USA
    • Year and Date
      2012-10-12
    • Related Report
      2012 Final Research Report
  • [Presentation] Association of deficits in theory of mind and functioning in at-risk mental states and first-episode psychosis2012

    • Author(s)
      Noriyuki Ohmuro, Kazunori Matsumoto, Masahiro Katsura, Atsushi Sakuma, Kunio Iizuka, Tatsuo Kikuchi, Chika Obara, Yumiko Hamaie, Tomohiro Uchida, Emi Sunakawa, Fumiaki Ito, Hiroo Matsuoka.
    • Organizer
      8th International Conference on Early Psychosis
    • Place of Presentation
      From Neurobiology to Public Policy San Francisco,USA
    • Year and Date
      2012-10-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 名取EIプロジェクト:宮城県立精神医療センターを中心とした早期介入プロジェクト2012

    • Author(s)
      大野高志,船越俊一,角藤芳久,谷口宏,三塚杏子,野村綾,横川信弘,齋藤和子,香山明美,石黒奈々子,大室則幸,桂雅宏,濱家由美子,小高晃,松本和紀,松岡洋夫
    • Organizer
      第108回日本精神神経学会学術総会
    • Place of Presentation
      北海道
    • Year and Date
      2012-05-26
    • Related Report
      2012 Final Research Report
  • [Presentation] サイコーシス早期段階におけるCBTの活用2012

    • Author(s)
      松本和紀,濱家由美子,光永憲香,内田知宏,砂川恵美,大室則幸,桂雅宏,松岡洋夫
    • Organizer
      第108回日本精神神経学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-05-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Cognitive insight and attenuated positive symptoms in At-Risk Mental State2012

    • Author(s)
      Tomohiro Uchida, Noriyuki Omuro, Masahiro Katsura, Yumiko Hamaie, Emi Sunakawa, Kazunori Matsumoto, Hiroo Matsuoka
    • Organizer
      3rd Biennial Schizophrenia International Research Conference Florence
    • Place of Presentation
      Italy
    • Year and Date
      2012-04-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 早期精神病診療における就学支援の重要性:専門外来での通学状況調査より2011

    • Author(s)
      本庄谷奈央,桂雅宏,大室則幸,濱家由美子,内田知宏,砂川恵美,松本和紀,松岡洋夫
    • Organizer
      第15回日本精神保健・予防学会
    • Place of Presentation
      東京
    • Year and Date
      2011-12-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 初回エピソード精神病患者と精神病発症リスク状態(ARMS)における心の理論課題成績と機能との関連2011

    • Author(s)
      大室則幸,桂雅宏,伊藤文晃,内田知宏,濱家由美子,砂川恵美,松本和紀,松岡洋夫
    • Organizer
      第11回精神疾患と認知機能研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-05
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] ARMS専門外来における患者特性:SAFEクリニックにおけるインテイク時臨床データより2011

    • Author(s)
      桂雅宏,大室則幸,内田知宏,濱家由美子,宮腰哲生,伊藤文晃,松本和紀,松岡洋夫
    • Organizer
      第6回日本統合失調症学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-07-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 初回精神病に対する個別心理プログラムの位置づけ-臨床指標の推移を通して-2011

    • Author(s)
      濱家由美子,内田知宏,光永憲香,大室則幸,桂雅宏,高橋綾,松本和紀,松岡洋夫
    • Organizer
      第6回日本統合失調症学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-07-19
    • Related Report
      2012 Final Research Report
  • [Presentation] ARMS(at-risk mental state)の認知機能障害と臨床症状および全般的機能との関連について2011

    • Author(s)
      大室則幸,伊藤文晃,桂雅宏,濱家由美子,内田知宏,高橋綾,松本和紀,松岡洋夫
    • Organizer
      第6回日本統合失調症学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-07-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 実践研究からのARMSへの早期介入:終結に向けての留意点2011

    • Author(s)
      松本和紀
    • Organizer
      第6回日本統合失調症学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-07-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 実践研究からのARMSへの早期介入:集結に向けての留意点2011

    • Author(s)
      松本和紀
    • Organizer
      第6回日本統合失調症学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-07-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] ARMSおよび初回エピソード精神病におけるQOLの検討2010

    • Author(s)
      内田知宏,大室則幸,桂雅宏,濱家由美子,高橋綾,松本和紀,松岡洋夫
    • Organizer
      第14回日本精神保健・予防学会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 初回精神病エピソード患者家族に対する家族療法の試み2010

    • Author(s)
      桂雅宏,大室則幸,濱家由美子,内田知宏,本庄谷奈央,高橋綾,松本和紀,松岡洋夫
    • Organizer
      第14回日本精神保健・予防学会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 初回エピソード精神病およびARMS患者家族のインテイク時における心の心理的特徴2010

    • Author(s)
      高橋綾,桂雅宏,大室則幸,濱家由美子,内田知宏,松本和紀,松岡洋夫
    • Organizer
      第14回日本精神保健・予防学会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Implementation of a psychological program during the recovery phase of first-episode psychosis in Japanese clinical setting2010

    • Author(s)
      Yumiko Hamaie, Norika Mitsunaga, Tomohiro Uchida, Noriyuki Ohmuro, Masahiro Katsura, Hiroo Matsuoka, Kazunori Matsumoto.
    • Organizer
      7th International Conference on Early Psychosis Amsterdam Nederland
    • Year and Date
      2010-11-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Cognitive insight and positive symptoms in ARMS: A follow-up study using the Beck Cognitive Insight Scale2010

    • Author(s)
      Masahiro Katsura, Tomohiro Uchida, Noriyuki Ohmuro, Fumiaki Ito, YumikoHamaie, Takashi Ueno, Kazunori Matsumoto, Hiroo Matsuoka
    • Organizer
      7th International Conference on Early Psychosis Amsterdam Nederland
    • Year and Date
      2010-11-29
    • Related Report
      2012 Final Research Report
  • [Presentation] A 1-year follow-up study of antipsychotics-medicated patients with at-risk mental state2010

    • Author(s)
      Noriyuki Ohmuro,Masahiro Katsura, Fumiaki Ito,Yumiko Hamaie, Tomohiro Uchida, Kazunori Matsumoto, Hiroo Matsuoka
    • Organizer
      7th International Conference on Early Psychosis Amsterdam Nederland
    • Year and Date
      2010-11-28
    • Related Report
      2012 Final Research Report
  • [Presentation] At-Risk Mental State の診断 限界と可能性2010

    • Author(s)
      松本和紀
    • Organizer
      第30回日本精神科診断学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-11-12
    • Related Report
      2012 Final Research Report
  • [Presentation] At-Risk Mental Stateの診断:限界と可能性2010

    • Author(s)
      松本和紀
    • Organizer
      第30回日本精神科診断学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 精神病発症リスク状態 (At-Risk Mental State:ARMS)における心理的因子の検討2010

    • Author(s)
      内田知宏,大室則幸,桂雅宏,伊藤文晃, 濱家由美子,松本和紀,上埜高志,松岡洋夫
    • Organizer
      第10回日本認知療法学会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Cognitive insight and attenuated positive symptoms in At-Risk Mental State

    • Author(s)
      Tomohiro Uchida
    • Organizer
      3rd Biennial Schizophrenia International Research Conference
    • Place of Presentation
      Florence,Italy
    • Related Report
      2012 Annual Research Report
  • [Presentation] Association of deficits in theory of mind and functioning in at-risk mental states and first-episode psychosis

    • Author(s)
      Noriyuki Ohmuro
    • Organizer
      8th International Conference on Early Psychosis:From Neurobiology to Public Policy
    • Place of Presentation
      San Francisco,USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Negative schemata and positive symptoms in ARMS:Comparison with FEP using the brief Core Shema Scales

    • Author(s)
      Masahiro Katsura
    • Organizer
      8th International Conference on Early Psychosis:From Neurobiology to Public Policy
    • Place of Presentation
      San Francisco,USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Family Attitude Scale: Relatives'expressed emotion to the patients with early psychosis

    • Author(s)
      Yumiko Hamaie
    • Organizer
      8th International Conference on Early Psychosis:From Neurobiology to Public Policy
    • Place of Presentation
      San Francisco,USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] ARMSにおけるQOLの検討:関連要因の検討

    • Author(s)
      石井優
    • Organizer
      第16回日本精神保健・予防学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] At-Risk Mental Stateにおける認知機能障害と認知的洞察との関連

    • Author(s)
      内田知宏
    • Organizer
      第16回日本精神保健・予防学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] ARMS(At-Risk Mental State)における抗精神病薬・抗うつ薬の処方状況とその特徴

    • Author(s)
      小原千佳
    • Organizer
      第16回日本精神保健・予防学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Book] 精神保健福祉白書2013年版2013

    • Author(s)
      松本和紀,大室則幸:精神疾患に対する早期介入
    • Publisher
      中央法規
    • Related Report
      2012 Final Research Report
  • [Book] 精神疾患に対する早期介入,精神保健福祉白書2013

    • Author(s)
      松本和紀
    • Publisher
      中央法規
    • Related Report
      2012 Annual Research Report
  • [Book] 統合失調症への早期介入:精神保健福祉白書2012年版2012

    • Author(s)
      大室則幸,松本和紀
    • Publisher
      中央法規
    • Related Report
      2012 Final Research Report
  • [Book] 統合失調症の幻覚妄想:脳とこころのプライマリ.ケア62011

    • Author(s)
      松岡洋夫,松本和紀
    • Publisher
      シナジー
    • Related Report
      2012 Final Research Report
  • [Book] 精神障害の早期介入:精神医学キーワード事典2011

    • Author(s)
      松本和紀
    • Publisher
      中山書店
    • Related Report
      2012 Final Research Report
  • [Book] 発症リスク状態:精神医学キーワード事典2011

    • Author(s)
      松本和紀,大室則幸
    • Publisher
      中山書店
    • Related Report
      2012 Final Research Report
  • [Book] 精神医学キーワード事典2011

    • Author(s)
      松本和紀
    • Total Pages
      7
    • Publisher
      中山書店
    • Related Report
      2011 Annual Research Report
  • [Book] ARMSの治療:早期精神病の診断と治2010

    • Author(s)
      松本和紀,大室則幸
    • Publisher
      医学書院
    • Related Report
      2012 Final Research Report
  • [Book] ARMSの治療と経過精神科172010

    • Author(s)
      大室則幸,桂雅宏,松本和紀,松岡洋夫
    • Publisher
      科学評論社
    • Related Report
      2012 Final Research Report
  • [Book] 早期精神病の診断と治療2010

    • Author(s)
      大室則行、松本和紀
    • Publisher
      医学書院
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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