| Co-Investigator(Kenkyū-buntansha) |
YASUDA Yuka 大阪大学, 大学院・連合小児発達学研究科, 特任研究員 (20448062)
YAMAMORI Hidenaga 大阪大学, 大学院・医学系研究科, 寄附講座助教 (90570250)
IWASE Masao 大阪大学, 大学院・医学系研究科, 助教 (60362711)
KAZUI Hiroaki 大阪大学, 大学院・医学系研究科, 講師 (30346217)
TAKEDA Masatoshi 大阪大学, 大学院・医学系研究科, 教授 (00179649)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Research Abstract |
Many patients with schizophrenia experience a decline in intellectual functioning. We conducted a genome-wide association study (GWAS) of cognitive decline in 166 patients with schizophrenia. Cognitive decline (subtraction of JART score from full-scale IQ) was -16.1.The strongest association was observed at rs7157599 on chromosome 14, a missense polymorphism (Asn8Ser) in the DEGS2 gene (p=5.4×10-7). Replication analysis using the National Institute of Mental Health Clinical Brain Disorders Branch sample revealed a directionally consistent trend association of genotype for a proxy of the top SNP. Although the study should be replicated with a larger sample size, our results indicate that the measurement of cognitive decline in schizophrenia as a quantitative phenotype (in conjunction with GWAS) could be a gene discovery tool.
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