Genome wide association study of intermediate phenotypes of schizophrenia
Project/Area Number |
22390225
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Osaka University |
Principal Investigator |
HASHIMOTO Ryota 大阪大学, 大学院・連合小児発達学研究科, 准教授 (10370983)
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Co-Investigator(Kenkyū-buntansha) |
YASUDA Yuka 大阪大学, 大学院・連合小児発達学研究科, 特任研究員 (20448062)
YAMAMORI Hidenaga 大阪大学, 大学院・医学系研究科, 寄附講座助教 (90570250)
IWASE Masao 大阪大学, 大学院・医学系研究科, 助教 (60362711)
KAZUI Hiroaki 大阪大学, 大学院・医学系研究科, 講師 (30346217)
TAKEDA Masatoshi 大阪大学, 大学院・医学系研究科, 教授 (00179649)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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Keywords | 統合失調症 / 中間表現型 / ゲノム / 認知機能 / 脳画像 / 神経生理機能 |
Research Abstract |
Many patients with schizophrenia experience a decline in intellectual functioning. We conducted a genome-wide association study (GWAS) of cognitive decline in 166 patients with schizophrenia. Cognitive decline (subtraction of JART score from full-scale IQ) was -16.1.The strongest association was observed at rs7157599 on chromosome 14, a missense polymorphism (Asn8Ser) in the DEGS2 gene (p=5.4×10-7). Replication analysis using the National Institute of Mental Health Clinical Brain Disorders Branch sample revealed a directionally consistent trend association of genotype for a proxy of the top SNP. Although the study should be replicated with a larger sample size, our results indicate that the measurement of cognitive decline in schizophrenia as a quantitative phenotype (in conjunction with GWAS) could be a gene discovery tool.
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Report
(4 results)
Research Products
(136 results)
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[Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia2013
Author(s)
Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M
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Journal Title
World J Biol Psychiatry
Volume: 14(2)
Pages: 100-13
Related Report
Peer Reviewed
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[Journal Article] Analysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel based morphometry and mutation screening.2012
Author(s)
Aleksic B., Kushima I, Hashimoto R, Ohi K, Ikeda M, Yoshimi A, Nakamura Y, Ito Y, Okochi T, Fukuo Y, Yasuda Y, Fukumoto M, Yamamori H, Ujike H, Suzuki M, Inada T, Takeda M, Kaibuchi K, Iwata N, Ozaki N
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Journal Title
Schizophrenia Bulletin
Volume: (e-pub)
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Peer Reviewed
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[Journal Article] Expression analysis of a novel mRNA variant of the schizophrenia risk gene ZNF804A2012
Author(s)
Okada T, Hashimoto R, Yamamori H, Umeda-Yano S, Yasuda Y, Ohi K, Fukumoto M, Ikemoto K, KUnii Y, Tomita H, Ito A, Takeda M
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Journal Title
Schizophr Res
Volume: 141(2-3)
Pages: 277-8
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Peer Reviewed
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[Journal Article] Functional genetic variation at the NRGN gene and schizophrenia: evidence from a gene-based case-control study and gene expression analysis.2012
Author(s)
Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ohmura T, Iwata N, Ueno S, Ozaki N, Ohmori T, Arai H, Takeda M
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Journal Title
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume: 159B(4)
Pages: 405-13
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Peer Reviewed
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[Journal Article] Resequencing and Association Analysis of the KALRN and EPHB1 Genes And Their Contribution to Schizophrenia Susceptibility2012
Author(s)
Kushima I, Nakamura Y, Aleksic B, Ikeda M, Ito Y, Shiino T, Okochi T, Fukuo Y, Ujike H, Suzuki M, Inada T, Hashimoto R, Takeda M, Kaibuchi K, Iwata N, Ozaki N
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Journal Title
Schizophr Bull
Volume: 38(3)
Pages: 552-560
Related Report
Peer Reviewed
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[Journal Article] The p250GAP Gene is Associated with Risk for Schizophrenia and Schizotypal Personality Traits2012
Author(s)
Ohi K, Hashimoto R, Nakazawa T, Okada T, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Iwase M, Kazui H, Yamamoto T, Kano M, Takeda M
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Journal Title
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Peer Reviewed
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[Journal Article] A promoter variant in the Chitinase 3-Like 1 gene is associated with serum YKL-40 level and personality trait2012
Author(s)
Yamamori H, Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Kasahara E, Sekiyama A, Umeda-Yano S, Okada T, Iwase M, Kazui H, Ito A, Takeda M
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Journal Title
Neurosci Lett
Volume: 513(3)
Pages: 204-208
Related Report
Peer Reviewed
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[Journal Article] Relationship of Prepulse Inhibition to Temperament and Character in Healthy Japanese subjects.2012
Author(s)
Takahashi H, Iwase M, Yasuda Y, Ohi Y, Fukumoto M, Iike N, Yamamori H, Nakahachi T, Ikezawa K, Azechi M, Canuet L, Ishii R, Kazui H, Hashimoto R, Takeda M
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Journal Title
Neuroscience Research
Volume: 72(2)
Pages: 187-193
Related Report
Peer Reviewed
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[Journal Article] Impact of the Genome Wide Supported NRGN Gene on Anterior Cingulate Morphology in Schizophrenia2012
Author(s)
Ohi K, Hashimoto R, Yasuda Y, Nemoto K, Ohnishi T, Fukumoto M, Yamamori H, Umeda-Yano S. Okada T, Iwase M, Kazui H, Takeda M
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[Journal Article] No associations found between the genes situated at 6p22.1, HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with schizophrenia2012
Author(s)
Kitazawa M, Ohnuma T, Takebayashi Y, Shibata N, Baba H, Ohi K, Yasuda Y, Nakamura Y, Aleksic B, Yoshimi A, Okochi T, Ikeda M, Naitoh H, Hashimoto R, Iwata N, Ozaki N, Takeda M, Arai H
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Journal Title
Am J Med Genet B Neuropsychiatr Genet
Volume: 159B(4)
Issue: 4
Pages: 456-464
DOI
Related Report
Peer Reviewed
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[Journal Article] Functional genetic variation at the NRGN gene and schizophrenia: Evidence from a gene-based case-control study and gene expression analysis2012
Author(s)
Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ohnuma T, Iwata N, Ueno S, Ozaki N, Ohmori T, Arai H, Takeda M
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Journal Title
Am J Med Genet B Neuropsychiatr Genet
Volume: 159B(4)
Issue: 4
Pages: 405-413
DOI
Related Report
Peer Reviewed
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[Journal Article] A two-stage case-control association study between the tryptophan hydroxylase 2 (TPH2) gene and schizophrenia in a Japanese population2012
Author(s)
Watanabe Y, Egawa J, Iijima Y, Nunokawa A, Kaneko N, Shibuya M, Arinami T, Ujike H, Inada T, Iwata N, Tochigi M, Kunugi H, Itokawa M, Ozaki N, Hashimoto R, Someya T
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Journal Title
Schizophr Res
Volume: 137(1-3)
Issue: 1-3
Pages: 264-266
DOI
Related Report
Peer Reviewed
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[Journal Article] Common Variants in MAGI2 Gene Are Associated with Increased Risk for Cognitive Impairment in Schizophrenic Patients2012
Author(s)
Koide T, Banno M, Aleksic B, Yamashita S, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Kushima I, Nakamura Y, Okada T, Ikeda M, Ohi K, Yasuda Y, Hashimoto R, Inada T, Ujike H, Iidaka T, Suzuki M, Takeda M, Iwata N, Ozaki N
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Journal Title
PLoS One
Volume: 7(5)
Issue: 5
Pages: e36836-e36836
DOI
Related Report
Peer Reviewed
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[Journal Article] Resequencing and Association Analysis of the KALRN and EPHB1 Genes And Their Contribution to Schizophrenia Susceptibility2012
Author(s)
Kushima I, Nakamura Y, Aleksic B, Ikeda M, Ito Y, Shiino T, Okochi T, Fukuo Y, Ujike H, Suzuki M, Inada T, Hashimoto R, Takeda M, Kaibuchi K, Iwata N, Ozaki N
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Journal Title
Schizophr Bull
Volume: 38(3)
Issue: 3
Pages: 552-560
DOI
Related Report
Peer Reviewed
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[Journal Article] Relationship of prepulse inhibition to temperament and character in healthy Japanese subjects2012
Author(s)
Takahashi H, Iwase M, Yasuda Y, Ohi K, Fukumoto M, Iike N, Yamamori H, Nakahachi T, Ikezawa K, Azechi M, Canuet L, Ishii R, Kazui H, Hashimoto R, Takeda M
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Journal Title
Neurosci Res
Volume: 72(2)
Issue: 2
Pages: 187-193
DOI
Related Report
Peer Reviewed
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[Journal Article] Impact of the genome wide supported NRGN gene on anterior cingulate morphology in schizophrenia2012
Author(s)
Ohi K, Hashimoto R, Yasuda Y, Nemoto K, Ohnishi T, Fukumoto M, Yamaniori H, Umeda-Yano S, Okada T, Iwase M, Kazui H, Takeda M
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Journal Title
PLoS One
Volume: 7(1)
Issue: 1
Pages: e29780-e29780
DOI
Related Report
Peer Reviewed
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[Journal Article] Variants of the RELA gene are associated with schizophrenia and their startle responses2011
Author(s)
Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Takahashi H, Iwase M, Okochi T, Kazui H, Saitoh O, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Kunugi H, Takeda M
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Journal Title
Neuropsychopharmacology
Volume: 36(9)
Pages: 1921-1931
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[Journal Article] No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis.2011
Author(s)
Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ueno S, Ohmori T, Iwata N, Ozaki N, Takeda M
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Journal Title
Schizophrenia Res
Volume: 129
Pages: 80-84
Related Report
Peer Reviewed
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[Journal Article] Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene2011
Author(s)
Yasuda Y, Hashimoto R, Ohi K , Fukumoto M, Umeda-Yano S, Yamamori H, Okochi T, Iwase M, Kazui H, Iwata N, Takeda M
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Journal Title
Neurosci let
Volume: 495
Pages: 216-220
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Peer Reviewed
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[Journal Article] The SIGMAR1 gene is associated with a risk of schizophrenia and activation of the prefrontal cortex2011
Author(s)
Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Kamino K, Ikezawa K, Azechi M, Iwase M, Kazui H, Kasai K, Takeda M
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry
Volume: 35
Pages: 1309-1315
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Peer Reviewed
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[Journal Article] Genome-Wide Association Study of Schizophrenia in a Japanese Population.2011
Author(s)
Ikeda M, Aleksic B, Kinoshita Y, Okochi T, Kawashima K, Kushima I, Ito Y, Nakamura Y, Kishi T, Okumura T, Fukuo Y, Williams HJ, Hamshere ML, Ivanov D, Inada T, Suzuki M, Hashimoto R, Ujike H, Takeda M, Craddock N, Kaibuchi K, Owen MJ, Ozaki N, O'Donovan M
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Journal Title
Biol Psychiatry
Volume: 69(5)
Pages: 472-478
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[Journal Article] Different Characteristics of Cognitive Impairment in Elderly Schizophrenia and Alzheimer's Disease in the Mild Cognitive Impairment Stage2011
Author(s)
Kazui H, Yoshida T, Takaya M, Sugiyama H, Yamamoto D, Kito Y, Wada T, Nomura K, Yasuda Y, Yamamori H, Ohi K, Fukumoto M, Iike N, Iwase M, Morihara T, Tagami S, Shimosegawa E, Hatazawa J, Ikeda Y, Uchida E, Tanaka T, Kudo T, Hashimoto R, Takeda M
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Journal Title
Dement Geriatr CognDisord
Volume: 1
Pages: 20-30
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[Journal Article] The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia.2010
Author(s)
Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M
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Journal Title
Am J Med Genet B Neuropsychiatry Genet
Volume: 153B(8)
Pages: 1459-1464
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[Journal Article] NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala.2010
Author(s)
Delawary M, Tezuka T, Kiyama Y, Yokoyama K, Inoue T, Hattori S, Hashimoto R, Umemori H, Manabe T, Yamamoto T, Nakazawa T
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Journal Title
Mol Brain
Volume: 3(1)
Pages: 37-37
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[Journal Article] Association study of KIBRA gene with memory performance in a Japanese population2010
Author(s)
Yasuda Y, Hashimoto R, Ohi K, Fukumoto M, Takamura H, Iike N, Kiribayashi M, Yoshida T, Hayashi N, Takahashi H, Yamamori H, Morihara T, Tagami S, Okochi M, Tanaka T, Kudo T, Kamino K, Ishii R, Iwase M, Kazui H, Takeda M
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Journal Title
World J Biol Psychiatry
Volume: 11(7)
Pages: 852-857
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Peer Reviewed
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[Journal Article] Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy Japanese subjects.2010
Author(s)
Takahashi H, Iwase M, Canuet L, Yasuda Y, Ohi K, Fukumoto M, Iike N, Nakahachi T, Ikezawa K, Azechi M, Kurimoto R, Ishii R, Yoshida T, Kazui H, Hashimoto R, Takeda M
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Journal Title
Psychophysiology
Volume: 47(5)
Pages: 831-837
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[Journal Article] A functional polymorphism in the disrupted-in schizophrenia 1 gene is associated with chronic fatigue syndrome2010
Author(s)
Fukuda S, Hashimoto R, Ohi K, Yamaguti K, Nakatomi Y, Yasuda Y, Kamino K, Takeda M, Tajima S, Kuratsune H, Nishizawa Y, Watanabe Y
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Journal Title
Life Sci
Volume: 86(19-20)
Pages: 722-725
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Peer Reviewed
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[Journal Article] Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population2010
Author(s)
Aleksic B, Kushima I, Ito Y, Nakamura Y, Ujike H, Suzuki M, Inada T, Hashimoto R, Takeda M, Iwata N, Ozaki N
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Journal Title
Schizophr Res
Volume: 118(1-3)
Pages: 113-117
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Peer Reviewed
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[Presentation] Genome-wide association study of cognitive decline in schizophrenia2013
Author(s)
Hashimoto R, Ikeda M, Kazutaka O, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Dickinson D, Aleksic B, Iwase M, Kazui H, Ozaki N, Weinberger DR, Iwata N, Takeda M
Organizer
The 3rd Asian Congress on Schizophrenia Research
Place of Presentation
Bali, Indonesia
Related Report
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[Presentation] The p250GAP Gene is Associated with Risk for Schizophrenia and Schizotypal Personality Trait2012
Author(s)
Hashimoto R, Ohi K, Nakazawa T, Yasuda Y, Yamamori H, Fukumoto M, Iwase M, Kazui H, Yamamoto T, Kano M, Takeda M
Organizer
CNIP 28th CINP World Congress of Neuropsychopharmacology
Place of Presentation
Stockholm, Sweden
Related Report
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[Presentation] Variants of the RELA gene are associated with schizophrenia and their startleresponses2012
Author(s)
Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Takahashi H, Iwase M, Okochi T, Kazui H, Saitoh O, Tatsumi M, Iwata N, OzakiN, Kamijima K, Kunugi H, Takeda M
Organizer
第34回日本生物学的精神医学会
Place of Presentation
神戸
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[Presentation] The KCNH2 gene is associated with neurocognition and the risk of schizophrenia2011
Author(s)
Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Takeda M
Organizer
2nd Congress of AsCNP
Place of Presentation
Seoul, Korea
Related Report
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[Presentation] Variants of the RELA gene are associated with schizophrenia and their startle responses2011
Author(s)
Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Takahashi H, Iwase M, Okochi T, Kazui H, Saitoh O, Tatsumi M, Iwata N, OzakiN, Kamijima K, Kunugi H, Takeda M
Organizer
19th World Congress of Psychiatric Genetics
Place of Presentation
Washington D.C., U.S.A.
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[Presentation] The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia2010
Author(s)
Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M,Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H,Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M
Organizer
The 49th ACNP (American College of Neuropsychopharmacology) Annual Meeting
Place of Presentation
Miami Beach, Florida, USA
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