Genome wide association study of intermediate phenotypes of schizophrenia

• Project/Area Number: 22390225
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Osaka University
• Principal Investigator: HASHIMOTO Ryota 大阪大学, 大学院・連合小児発達学研究科, 准教授 (10370983)
• Co-Investigator(Kenkyū-buntansha): YASUDA Yuka 大阪大学, 大学院・連合小児発達学研究科, 特任研究員 (20448062) ; YAMAMORI Hidenaga 大阪大学, 大学院・医学系研究科, 寄附講座助教 (90570250) ; IWASE Masao 大阪大学, 大学院・医学系研究科, 助教 (60362711) ; KAZUI Hiroaki 大阪大学, 大学院・医学系研究科, 講師 (30346217) ; TAKEDA Masatoshi 大阪大学, 大学院・医学系研究科, 教授 (00179649)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2010: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
• Keywords: 統合失調症 / 中間表現型 / ゲノム / 認知機能 / 脳画像 / 神経生理機能

Research Abstract

Many patients with schizophrenia experience a decline in intellectual functioning. We conducted a genome-wide association study (GWAS) of cognitive decline in 166 patients with schizophrenia. Cognitive decline (subtraction of JART score from full-scale IQ) was -16.1.The strongest association was observed at rs7157599 on chromosome 14, a missense polymorphism (Asn8Ser) in the DEGS2 gene (p=5.4×10-7). Replication analysis using the National Institute of Mental Health Clinical Brain Disorders Branch sample revealed a directionally consistent trend association of genotype for a proxy of the top SNP. Although the study should be replicated with a larger sample size, our results indicate that the measurement of cognitive decline in schizophrenia as a quantitative phenotype (in conjunction with GWAS) could be a gene discovery tool.

Research Products

• [Journal Article] An integrated eye movement score as a neurophysiological marker of schizophrenia. (2014)
  • Author(s): Umeda-Yano S, et al
  • Journal Title: Schizophr Res. Volume: e-pub Pages: 228-9
  • Peer Reviewed
• [Journal Article] The KCNH2 gene is associated with neurocognition and the risk of schizophrenia (2013)
  • Author(s): Hashimoto R, Ohi K, Yasuda Y, Fukumnoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Takeda M.
  • Journal Title: World J Biol Psychiatry Volume: 14(2) Pages: 114-20
  • Peer Reviewed
• [Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia (2013)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M
  • Journal Title: World J Biol Psychiatry Volume: 14(2) Pages: 100-13
  • Peer Reviewed
• [Journal Article] The regulation of gene expression involved in TGF-β signaling by ZNF804A, a risk gene for schizophrenia (2013)
  • Author(s): Umeda-Yano S, Hashimoto R, Yamamori H, Okada T, Yasuda Y, Ohi K, Fukumoto M, Ito A, Takeda M
  • Journal Title: Schizophr Res Volume: (e-pub)
  • Peer Reviewed
• [Journal Article] An association analysis of the cardiomyopathy-associated 5(CMYA5) gene with schizophrenia in a Japanese population. (2013)
  • Author(s): Furukawa M, et al
  • Journal Title: Psychiatr Genet Volume: e-pub
  • Peer Reviewed
• [Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia. (2013)
  • Author(s): Ohi K, Hashimoto R, et al
  • Journal Title: World J Biol Psychiatry. Volume: e-pub Pages: 100-113
  • DOI: 10.3109/15622975.2011.591826
  • Peer Reviewed
• [Journal Article] The KCNH2 gene is associated with neurocognition and the risk of schizophrenia (2013)
  • Author(s): Hashimoto R, et al,
  • Journal Title: World J Biol Psychiatry Volume: 14(2): Pages: 114-20
  • DOI: 10.3109/15622975.2011.604350
  • Peer Reviewed
• [Journal Article] Analysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel based morphometry and mutation screening. (2012)
  • Author(s): Aleksic B., Kushima I, Hashimoto R, Ohi K, Ikeda M, Yoshimi A, Nakamura Y, Ito Y, Okochi T, Fukuo Y, Yasuda Y, Fukumoto M, Yamamori H, Ujike H, Suzuki M, Inada T, Takeda M, Kaibuchi K, Iwata N, Ozaki N
  • Journal Title: Schizophrenia Bulletin Volume: (e-pub)
  • Peer Reviewed
• [Journal Article] Expression analysis of a novel mRNA variant of the schizophrenia risk gene ZNF804A (2012)
  • Author(s): Okada T, Hashimoto R, Yamamori H, Umeda-Yano S, Yasuda Y, Ohi K, Fukumoto M, Ikemoto K, KUnii Y, Tomita H, Ito A, Takeda M
  • Journal Title: Schizophr Res Volume: 141(2-3) Pages: 277-8
  • Peer Reviewed
• [Journal Article] Personality traits and schizophrenia: evidence from a case-control study and meta-analysis. (2012)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Iwase M, Kazui H, Takeda M
  • Journal Title: Psychiatry Research Volume: 198(1) Pages: 7-11
  • Peer Reviewed
• [Journal Article] Functional genetic variation at the NRGN gene and schizophrenia: evidence from a gene-based case-control study and gene expression analysis. (2012)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ohmura T, Iwata N, Ueno S, Ozaki N, Ohmori T, Arai H, Takeda M
  • Journal Title: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Volume: 159B(4) Pages: 405-13
  • Peer Reviewed
• [Journal Article] Resequencing and Association Analysis of the KALRN and EPHB1 Genes And Their Contribution to Schizophrenia Susceptibility (2012)
  • Author(s): Kushima I, Nakamura Y, Aleksic B, Ikeda M, Ito Y, Shiino T, Okochi T, Fukuo Y, Ujike H, Suzuki M, Inada T, Hashimoto R, Takeda M, Kaibuchi K, Iwata N, Ozaki N
  • Journal Title: Schizophr Bull Volume: 38(3) Pages: 552-560
  • Peer Reviewed
• [Journal Article] The p250GAP Gene is Associated with Risk for Schizophrenia and Schizotypal Personality Traits (2012)
  • Author(s): Ohi K, Hashimoto R, Nakazawa T, Okada T, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Iwase M, Kazui H, Yamamoto T, Kano M, Takeda M
  • Journal Title: PLoS One Volume: 7(4)
  • Peer Reviewed
• [Journal Article] A promoter variant in the Chitinase 3-Like 1 gene is associated with serum YKL-40 level and personality trait (2012)
  • Author(s): Yamamori H, Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Kasahara E, Sekiyama A, Umeda-Yano S, Okada T, Iwase M, Kazui H, Ito A, Takeda M
  • Journal Title: Neurosci Lett Volume: 513(3) Pages: 204-208
  • Peer Reviewed
• [Journal Article] Relationship of Prepulse Inhibition to Temperament and Character in Healthy Japanese subjects. (2012)
  • Author(s): Takahashi H, Iwase M, Yasuda Y, Ohi Y, Fukumoto M, Iike N, Yamamori H, Nakahachi T, Ikezawa K, Azechi M, Canuet L, Ishii R, Kazui H, Hashimoto R, Takeda M
  • Journal Title: Neuroscience Research Volume: 72(2) Pages: 187-193
  • Peer Reviewed
• [Journal Article] Impact of the Genome Wide Supported NRGN Gene on Anterior Cingulate Morphology in Schizophrenia (2012)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Nemoto K, Ohnishi T, Fukumoto M, Yamamori H, Umeda-Yano S. Okada T, Iwase M, Kazui H, Takeda M
  • Journal Title: PLoS One Volume: 7(1)
  • Peer Reviewed
• [Journal Article] Analysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel based morphometry and mutation screening. (2012)
  • Author(s): Aleksic B., et al
  • Journal Title: Schizophrenia Bulletin. Volume: e-pub
  • Peer Reviewed
• [Journal Article] Discrimination of female schizophrenia patients from healthy women using multiple structural brain measures obtained with voxel-based morphometry (2012)
  • Author(s): Ota M, et al,
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 66(7): Pages: 611-617
  • DOI: 10.1111/j.1440-1819.2012.02397.x
  • Peer Reviewed
• [Journal Article] Meta-analysis of association studies between DISC1 missense variants and schizophrenia in the Japanese population. (2012)
  • Author(s): Kinoshita M, et al
  • Journal Title: Schizophr Res. Volume: 141(2-3): Pages: 271-273
  • DOI: 10.1016/j.schres.2012.07.020
  • Peer Reviewed
• [Journal Article] Expression analysis of anovel mRNA variant of the schizophrenia risk gene ZNF804A (2012)
  • Author(s): Okada T, et al,
  • Journal Title: Schizophr Res. Volume: 141(2-3): Pages: 277-278
  • DOI: 10.1016/j.schres.2012.08.015
  • Peer Reviewed
• [Journal Article] No Associations Found between the Genes Situated at 6p22.1, HIST1H2BJ, PRSS16 and PGBD1 in Japanese Patients Diagnosed With Schizophrenia. (2012)
  • Author(s): Kitazawa M, Ohnuma T, Takebayashi Y, Shibata N, Baba H, Ohi K, Yasuda Y, Nakamura Y, Aleksic B, Yoshimi A, Okochi T, Ikeda M, Naitoh H, Hashimoto R, Iwata N, Ozaki N, Takeda M, Arai H
  • Journal Title: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume: 159B(4) Pages: 456-464
  • DOI: 10.1002/ajmg.b.32049
  • Peer Reviewed
• [Journal Article] Personality traits and schizophrenia: evidence from a case-control study and meta-analysis (2012)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Iwase M, Kazui H, Takeda M
  • Journal Title: Psychiatry Research Volume: (Epub ahead of print) Pages: 7-11
  • DOI: 10.1016/j.psychres.2011.12.018
  • Peer Reviewed
• [Journal Article] Functional genetic variation at the NRGN gene and schizophrenia: Evidence from a gene-based case-control study and gene expression analysis. (2012)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ohnuma T, Iwata N, Ueno S, Ozaki N, Ohmori T, Arai H, Takeda M
  • Journal Title: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Volume: 159B(4) Pages: 405-13
  • DOI: 10.1002/ajmg.b.32043
  • Peer Reviewed
• [Journal Article] Searching for a consensus five-factor model of the Positive and Negative Syndrome Scale for schizophrenia. (2012)
  • Author(s): Wallwork RS, et al
  • Journal Title: Schizophr Res, Volume: 137(1-3): Pages: 246-50
  • DOI: 10.1016/j.schres.2012.01.031
  • Peer Reviewed
• [Journal Article] A two-stage case-control association study between tryptophan hydroxylase 2 (TPH2) gene and schizophrenia in a Japanese population (2012)
  • Author(s): Watanabe Y, Egawa J, Iijima Y, Nunokawa A, Kaneko N, Shibuya M, Arinami T, Ujike H, Inada T, Iwata N, Tochigi M, Kunugi H, Itokawa M, Ozaki N, Hashimoto R, Someya T
  • Journal Title: Schizophrenia Research, Volume: 137(1-3) Pages: 264-266
  • DOI: 10.1016/j.schres.2012.01.034
  • Peer Reviewed
• [Journal Article] Common Variants in MAGI2 Gene Are Associated with Increased Risk for Cognitive Impairment in Schizophrenic Patients. (2012)
  • Author(s): Koide T, Banno M, Aleksic B, Yamashita S, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Kushima I, Nakamura Y, Okada T, Ikeda M, Ohi K, Yasuda Y, Hashimoto R, Inada T, Ujike H, Iidaka T, Suzuki M, Takeda M, Iwata N, Ozaki N
  • Journal Title: PLos One Volume: 7(5)
  • DOI: 10.1371/journal.pone.0036836
  • Peer Reviewed
• [Journal Article] Resequencing and Association Analysis of the KALRN and EPHB1 Genes And Their Contribution to Schizophrenia Susceptibility. (2012)
  • Author(s): Kushima I, Nakamura Y, Aleksic B, Ikeda M, Ito Y, Shiino T, Okochi T, Fukuo Y, Ujike H, Suzuki M, Inada T, Hashimoto R, Takeda M, Kaibuchi K, Iwata N, Ozaki N
  • Journal Title: Schizophr Bull, Volume: 38(3) Pages: 552-560
  • DOI: 10.1093/schbul/sbq118
  • Peer Reviewed
• [Journal Article] The p250GAP gene is associated with risk for schizophrenia and schizotypal personality trait. (2012)
  • Author(s): Hashimoto R
  • Journal Title: PLoS One Volume: 7
  • DOI: 10.1371/journal.pone.0035696
  • Peer Reviewed
• [Journal Article] Discrimination of schizophrenic females from healthy women using multiple structural brain measures obtained with voxel-based morphometry (2012)
  • Author(s): Ota M, Hashimoto R, et al
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: (掲載確定)
  • Peer Reviewed
• [Journal Article] Functional genetic variation at the NEGN gene and schizophrenia : evidence from a gene-based case-control study and gene expression analysis (2012)
  • Author(s): Ohi K, Hashimoto R, et al
  • Journal Title: American Journal of Medical Genetics Part B : Neuropsychiatric Genetics Volume: (掲載確定)
  • Peer Reviewed
• [Journal Article] Analysis of the VAV3 as candidate gene for schizophrenia : evidences from voxel based morphometry and mutation screening (2012)
  • Author(s): Aleksic B., Hashimoto R, et al
  • Journal Title: Schizophrenia Bulletin Volume: (掲載確定)
  • Peer Reviewed
• [Journal Article] A promoter variant in the Chitinase 3-Like 1 gene is associated with serum YKL-40 level and personality trait (2012)
  • Author(s): Yamamori H, Hashimoto R, et al
  • Journal Title: Neuroscience Letters Volume: (掲載確定)
  • Peer Reviewed
• [Journal Article] A two-stage case-control association study between the tryptophan hydroxylase 2(TPH2) gene and schizophrenia in a Japanese population (2012)
  • Author(s): Watanabe Y, Hashimoto R, et al
  • Journal Title: Schizophrenia Research Volume: (掲載確定)
  • Peer Reviewed
• [Journal Article] Personality traits and schizophrenia : evidence from a case-control study and meta-analysis (2012)
  • Author(s): Ohi K, Hashimoto R, et al
  • Journal Title: Psychiatry Research Volume: (掲載確定)
  • Peer Reviewed
• [Journal Article] Relationship of Prepulse Inhibition to Temperament and Character in Healthy Japanese subjects. (2012)
  • Author(s): Takahashi H, Iwase M, Yasuda Y, Ohi K, Fukumoto M, Iike N, Yamamori H, Nakahachi T, Ikezawa K, Azechi M, Canuet L, Ishii R, Kazui H, Hashimoto R, Takeda M
  • Journal Title: Neuroscience Research Volume: 72(2) Pages: 187-193
  • DOI: 10.1016/j.neures.2011.10.009
  • Peer Reviewed
• [Journal Article] Impact of the genome wide supported NRGN gene on anterior cingulate morphology in schizophrenia. (2012)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Nemoto K, Ohnishi T, Fukumoto M, Yamaniori H, Umeda-Yano S, Okada T, Iwase M, Kazui H, Takeda M
  • Journal Title: PLoS One. Volume: 7(1)
  • DOI: 10.1371/journal.pone.0029780
  • Peer Reviewed
• [Journal Article] Variants of the RELA gene are associated with schizophrenia and their startle responses (2011)
  • Author(s): Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Takahashi H, Iwase M, Okochi T, Kazui H, Saitoh O, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Kunugi H, Takeda M
  • Journal Title: Neuropsychopharmacology Volume: 36(9) Pages: 1921-1931
  • Peer Reviewed
• [Journal Article] Dysbindin-1 and NRG-1 gene expression in immortalized lymphocytes from patients with schizophrenia (2011)
  • Author(s): Yamamori H, Hashimoto R, Verrall L, Yasuda Y, Ohi K, Fukumoto M, Umeda-Yano S, Ito A, Takeda M
  • Journal Title: J Hum Genet Volume: 56(7) Pages: 478-83
  • NAID: 10030659941
  • Peer Reviewed
• [Journal Article] Gene expression analysis in lymphoblasts derived from patients with autism spectrum disorder (2011)
  • Author(s): Yasuda Y, Hashimoto R, Yamamori H, Ohi K, Fukumoto M, Umeda-Yano S, Mohri I, Ito A, Taniike M, Takeda M
  • Journal Title: Molecular Autism Volume: 2(1) Pages: 9-9
  • NAID: 40019049794
  • Peer Reviewed
• [Journal Article] No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis. (2011)
  • Author(s): Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ueno S, Ohmori T, Iwata N, Ozaki N, Takeda M
  • Journal Title: Schizophrenia Res Volume: 129 Pages: 80-84
  • Peer Reviewed
• [Journal Article] Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene (2011)
  • Author(s): Yasuda Y, Hashimoto R, Ohi K , Fukumoto M, Umeda-Yano S, Yamamori H, Okochi T, Iwase M, Kazui H, Iwata N, Takeda M
  • Journal Title: Neurosci let Volume: 495 Pages: 216-220
  • Peer Reviewed
• [Journal Article] PACAP is Implicated in the Stress Axes (2011)
  • Author(s): Hashimoto H, Shintani N, Tanida M, Hayata A, Hashimoto R, Baba A
  • Journal Title: Curr Pharm Des, review Volume: 17(10) Pages: 985-9
  • Peer Reviewed
• [Journal Article] The SIGMAR1 gene is associated with a risk of schizophrenia and activation of the prefrontal cortex (2011)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Kamino K, Ikezawa K, Azechi M, Iwase M, Kazui H, Kasai K, Takeda M
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 35 Pages: 1309-1315
  • Peer Reviewed
• [Journal Article] Genome-Wide Association Study of Schizophrenia in a Japanese Population. (2011)
  • Author(s): Ikeda M, Aleksic B, Kinoshita Y, Okochi T, Kawashima K, Kushima I, Ito Y, Nakamura Y, Kishi T, Okumura T, Fukuo Y, Williams HJ, Hamshere ML, Ivanov D, Inada T, Suzuki M, Hashimoto R, Ujike H, Takeda M, Craddock N, Kaibuchi K, Owen MJ, Ozaki N, O'Donovan M
  • Journal Title: Biol Psychiatry Volume: 69(5) Pages: 472-478
  • Peer Reviewed
• [Journal Article] Different Characteristics of Cognitive Impairment in Elderly Schizophrenia and Alzheimer's Disease in the Mild Cognitive Impairment Stage (2011)
  • Author(s): Kazui H, Yoshida T, Takaya M, Sugiyama H, Yamamoto D, Kito Y, Wada T, Nomura K, Yasuda Y, Yamamori H, Ohi K, Fukumoto M, Iike N, Iwase M, Morihara T, Tagami S, Shimosegawa E, Hatazawa J, Ikeda Y, Uchida E, Tanaka T, Kudo T, Hashimoto R, Takeda M
  • Journal Title: Dement Geriatr CognDisord Volume: 1 Pages: 20-30
  • Peer Reviewed
• [Journal Article] A polymorphism of the ABCA1 gene confers susceptibility to schizophrenia and related gray matter reduction. (2011)
  • Author(s): Ota M, Fujii T, Nemoto K, Tatsumi M, Moriguchi Y, Hashimoto R, et al
  • Journal Title: Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume: 35(8) Pages: 1877-1883
  • DOI: 10.1016/j.pnpbp.2011.07.012
  • Peer Reviewed
• [Journal Article] Decreased alpha event-related synchronization in the left posterior temporal cortex in schizophrenia : A magnetoencephalography-beamformer study (2011)
  • Author(s): Ikezawa K, et al
  • Journal Title: Neurosci Res Volume: 71(3) Pages: 235-243
  • DOI: 10.1016/j.neures.2011.07.1819
  • Peer Reviewed
• [Journal Article] Gene expression analysis in lymphoblasts derived from patients with autism spectrum disorder. (2011)
  • Author(s): Yasuda Y, Hashimoto R, et al
  • Journal Title: Molecular Autism Volume: 2(1) Pages: 9-9
  • DOI: 10.1186/2040-2392-2-9
  • NAID: 40019049794
  • Peer Reviewed
• [Journal Article] No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis. (2011)
  • Author(s): Hashimoto R, et al
  • Journal Title: Schizophr Res. Volume: 129 Pages: 80-84
  • DOI: 10.1016/j.schres.2011.03.024
  • Peer Reviewed
• [Journal Article] Genome-Wide Association Study of Schizophrenia in a Japanese Population (2011)
  • Author(s): Ikeda M, Hashimoto R, et al.
  • Journal Title: Biol Psychiatry Volume: 69(5) Pages: 472-478
  • Peer Reviewed
• [Journal Article] Reduced rate of neurogenesis in the hippocampus of adult dysbindin null (sandy) mouse (2011)
  • Author(s): Nihonmatsu-Kikuchi N, Hashimoto R, et al.
  • Journal Title: PLoS One Volume: 18;6(1)
  • Peer Reviewed
• [Journal Article] Apolipoprotein E and central nervous system disorders: reviews of clinical findings (2010)
  • Author(s): Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R
  • Journal Title: Psychiatry Clin Neurosci Volume: 64(6) Pages: 592-607
  • Peer Reviewed
• [Journal Article] The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia. (2010)
  • Author(s): Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M
  • Journal Title: Am J Med Genet B Neuropsychiatry Genet Volume: 153B(8) Pages: 1459-1464
  • Peer Reviewed
• [Journal Article] NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala. (2010)
  • Author(s): Delawary M, Tezuka T, Kiyama Y, Yokoyama K, Inoue T, Hattori S, Hashimoto R, Umemori H, Manabe T, Yamamoto T, Nakazawa T
  • Journal Title: Mol Brain Volume: 3(1) Pages: 37-37
• [Journal Article] Association study of KIBRA gene with memory performance in a Japanese population (2010)
  • Author(s): Yasuda Y, Hashimoto R, Ohi K, Fukumoto M, Takamura H, Iike N, Kiribayashi M, Yoshida T, Hayashi N, Takahashi H, Yamamori H, Morihara T, Tagami S, Okochi M, Tanaka T, Kudo T, Kamino K, Ishii R, Iwase M, Kazui H, Takeda M
  • Journal Title: World J Biol Psychiatry Volume: 11(7) Pages: 852-857
  • Peer Reviewed
• [Journal Article] Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy Japanese subjects. (2010)
  • Author(s): Takahashi H, Iwase M, Canuet L, Yasuda Y, Ohi K, Fukumoto M, Iike N, Nakahachi T, Ikezawa K, Azechi M, Kurimoto R, Ishii R, Yoshida T, Kazui H, Hashimoto R, Takeda M
  • Journal Title: Psychophysiology Volume: 47(5) Pages: 831-837
  • Peer Reviewed
• [Journal Article] Laughter and humor as complementary and alternative medicines to dementia patients (2010)
  • Author(s): Takeda M, Hashimoto R, Kudo T, Okochi M, Tagami S, Morihara T, Sadick G, Tanaka T
  • Journal Title: BMC Complement Altern Med Volume: 10(1) Pages: 28-28
  • Peer Reviewed
• [Journal Article] A functional polymorphism in the disrupted-in schizophrenia 1 gene is associated with chronic fatigue syndrome (2010)
  • Author(s): Fukuda S, Hashimoto R, Ohi K, Yamaguti K, Nakatomi Y, Yasuda Y, Kamino K, Takeda M, Tajima S, Kuratsune H, Nishizawa Y, Watanabe Y
  • Journal Title: Life Sci Volume: 86(19-20) Pages: 722-725
  • Peer Reviewed
• [Journal Article] Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population (2010)
  • Author(s): Aleksic B, Kushima I, Ito Y, Nakamura Y, Ujike H, Suzuki M, Inada T, Hashimoto R, Takeda M, Iwata N, Ozaki N
  • Journal Title: Schizophr Res Volume: 118(1-3) Pages: 113-117
  • Peer Reviewed
• [Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort (2010)
  • Author(s): Hayashi N, Hashimoto R, at al.
  • Journal Title: Dement Geriatr Cogn Disord Volume: 30(4) Pages: 302-308
  • Peer Reviewed
• [Journal Article] NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala (2010)
  • Author(s): Delawary M, Hashimoto R, at al.
  • Journal Title: Mol Brain Volume: 3(1) Pages: 37-37
  • Peer Reviewed
• [Journal Article] Apolipoprotein E and central nervous system disorders : reviews of clinical findings (2010)
  • Author(s): Takeda M, Hashimoto R, at al.
  • Journal Title: Psychiatry Clin Neurosci Volume: 64(6) Pages: 592-607
  • Peer Reviewed
• [Journal Article] The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia (2010)
  • Author(s): Hashimoto R, et al.
  • Journal Title: Am J Med Genet B Neuropsychiatry Genet Volume: 153B Pages: 1459-1464
  • Peer Reviewed
• [Journal Article] Association study of KIBRA gene with memory performance in a Japanese population (2010)
  • Author(s): Yasuda Y, Hashimoto R, et al.
  • Journal Title: The World Journal of Biological Psychiatry Volume: 11 Pages: 852-857
  • Peer Reviewed
• [Journal Article] Plasma levels of vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF-2) in patients with major depressive disorders (2010)
  • Author(s): Takebayashi M, Hashimoto R, at al.
  • Journal Title: J Neural Transm Volume: 117(9) Pages: 1119-1122
  • Peer Reviewed
• [Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel (2010)
  • Author(s): Mori K, Hashimoto R, at al.
  • Journal Title: Psychogeriatrics Volume: 10(3) Pages: 117-123
  • NAID: 10029771051
  • Peer Reviewed
• [Journal Article] Association study between the pericentrin (PCNT) gene and schizophrenia (2010)
  • Author(s): Numata S, Hashimoto R, et al.
  • Journal Title: NeuroMolecular Medicine Volume: 12(3) Pages: 243-247
  • Peer Reviewed
• [Journal Article] Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy Japanese subjects (2010)
  • Author(s): Takahashi H, Hashimoto R, at al.
  • Journal Title: Psychophysiology Volume: 47(5) Pages: 831-837
  • Peer Reviewed
• [Journal Article] A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects (2010)
  • Author(s): Koide T, Hashimoto R, et al.
  • Journal Title: J Hum Genet Volume: 55(7) Pages: 469-472
  • NAID: 10030735981
  • Peer Reviewed
• [Journal Article] Laughter and humor as complementary and alternative medicines to dementia patients (2010)
  • Author(s): Takeda M, Hashimoto R, at al.
  • Journal Title: BMC Complement Altern Med Volume: 10(1) Pages: 28-28
  • Peer Reviewed
• [Journal Article] The International Consortium on Lithium Genetics (ConLiGen) : An Initiative by the NIMH and IGSLI to Study the Genetic Basis of Response to Lithium Treatment (2010)
  • Author(s): Schulze T, Hashimoto R, at al.
  • Journal Title: Neuropsychobiology Volume: 62(1) Pages: 72-78
  • Peer Reviewed
• [Journal Article] Two genetic variants of CD38 in subjects with autism spectrum disorder and controls (2010)
  • Author(s): Munesue T, Hashimoto R, et al.
  • Journal Title: Neurosci Res Volume: 67 Pages: 181-191
  • Peer Reviewed
• [Journal Article] Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia: a three-stage case-control association study (2010)
  • Author(s): Amagane H, Hashimoto R, et al.
  • Journal Title: Schizophr Res Volume: 118(1-3) Pages: 106-112
  • Peer Reviewed
• [Journal Article] No association between DAO and schizophrenia in a Japanese patient population : A multicenter replication study (2010)
  • Author(s): Ohnuma T, Hashimoto R, et al.
  • Journal Title: Schizophr Res Volume: 118(1-3) Pages: 300-302
  • Peer Reviewed
• [Journal Article] Genetic association study of KREMEN1 and DKK1 and schizophrenia in Japanese population (2010)
  • Author(s): Aleksic B, Hashimoto R, et al.
  • Journal Title: Schizophr Res Volume: 118(1-3) Pages: 113-117
  • Peer Reviewed
• [Presentation] Genome-wide association study of cognitive decline in schizophrenia (2013)
  • Author(s): Hashimoto R, Ikeda M, Kazutaka O, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Dickinson D, Aleksic B, Iwase M, Kazui H, Ozaki N, Weinberger DR, Iwata N, Takeda M
  • Organizer: The 3rd Asian Congress on Schizophrenia Research
  • Place of Presentation: Bali, Indonesia
• [Presentation] Genome-wide association study of cognitive decline in schizophrenia (2013)
  • Author(s): Hashimoto R,
  • Organizer: The 3rd Asian Congress on Schizophrenia Research
  • Place of Presentation: Indonesia
  • Invited
• [Presentation] The p250GAP Gene is Associated with Risk for Schizophrenia and Schizotypal Personality Trait (2012)
  • Author(s): Hashimoto R, Ohi K, Nakazawa T, Yasuda Y, Yamamori H, Fukumoto M, Iwase M, Kazui H, Yamamoto T, Kano M, Takeda M
  • Organizer: CNIP 28th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Stockholm, Sweden
• [Presentation] 統合失調症入院プログラムにおける治療抵抗性統合失調症に対するclozapineの有用性 (2012)
  • Author(s): 橋本亮太、山森英長、安田由華、福本素由己、大井一高、井上頌子、竹上学、武田雅俊
  • Organizer: 第22回日本臨床精神神経薬理学会第42回日本神経精神薬理学会合同年会
  • Place of Presentation: 栃木
• [Presentation] Variants of the RELA gene are associated with schizophrenia and their startleresponses (2012)
  • Author(s): Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Takahashi H, Iwase M, Okochi T, Kazui H, Saitoh O, Tatsumi M, Iwata N, OzakiN, Kamijima K, Kunugi H, Takeda M
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸
• [Presentation] 広汎性発達障害の原因遺伝子とその探索ストラテジーResearch strategy for identifying ASDgenes- (2012)
  • Author(s): 橋本亮太、安田由華、山森英長、梅田知美、深井綾子、大井一高、福本素由己、毛利育子、谷池雅子、松本直通、武田雅俊
  • Organizer: 第34回日本生物学的精神医学会、第11回アジア太平洋神経化学会大会・第55回日本神経化学会大会合同シンポジウム
  • Place of Presentation: 神戸
• [Presentation] 「ゲノム研究による精神疾患診断は可能か?」、シンポジウム:バイオロジカルマーカー研究からDSM-Vに向けて (2012)
  • Author(s): 橋本亮太、大井一高、安田由華、山森英長、梅田知美、福本素由己、武田雅俊
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸
• [Presentation] 統合失調症の分子メカニズム研究の新しい潮流:中間表現型を用いた統合失調症の病態解明 (2012)
  • Author(s): 橋本亮太、大井一高、安田由華、山森英長、梅田知美、岩瀬真生、数井裕光、武田雅俊
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 愛知
• [Presentation] ヒトにおける脳表現型の分子機構の解明:ヒト脳表現型コンソーシアムについて (2012)
  • Author(s): 橋本亮太、大井一高、安田由華、梅田知美、山森英長、武田雅俊
  • Organizer: 2012年度包括脳ネットワーク夏のワークショップ
  • Place of Presentation: 仙台
• [Presentation] 阪大病院における 20症例の治療抵抗性統合失調症患者へのクロザピンの使用経験 (2012)
  • Author(s): 橋本亮太、山森英長、安田由華、福本 素由己、大井 一高、梅田 知美、岡田 武也、武田雅俊
  • Organizer: 第108回日本精神神経学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 統合失調症専門外来・入院プログラムによる地域医療と臨床研究の融合システムの構築 (2012)
  • Author(s): 橋本亮太、大井 一高、安田由華、山森英長、福本素由己、梅田 知美、岡田 武也、武田雅俊
  • Organizer: 第108回日本精神神経学会学術総会
  • Place of Presentation: 札幌
• [Presentation] The p250GAP Gene is Associated with Risk for Schizophrenia and Schizotypal Personality Trait. (2012)
  • Author(s): Hashimoto R,
  • Organizer: 28th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Sweden
• [Presentation] 統合失調症入院プログラムにおける治療抵抗性統合失調症に対するclozapineの有用性、 (2012)
  • Author(s): 橋本亮太
  • Organizer: 第22回日本臨床精神神経薬理学会第42回日本神経精神薬理学会合同年会
  • Place of Presentation: 栃木
• [Presentation] Variants of the RELA gene are associated with schizophrenia and their startle responses. (2012)
  • Author(s): Hashimoto R,橋本亮太
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸
• [Presentation] 広汎性発達障害の原因遺伝子とその探索ストラテジー- Research strategy for identifying ASD genes- (2012)
  • Author(s): 橋本亮太
  • Organizer: 第34回日本生物学的精神医学会、第11回アジア太平洋神経化学会大会・第55回日本神経化学会大会
  • Place of Presentation: 神戸
• [Presentation] ゲノム研究による精神疾患診断は可能か？ (2012)
  • Author(s): 橋本亮太
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸
  • Invited
• [Presentation] 統合失調症の分子メカニズム研究の新しい潮流：中間表現型を用いた統合失調症の病態解明 (2012)
  • Author(s): 橋本亮太
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 愛知
  • Invited
• [Presentation] ヒトにおける脳表現型の分子機構の解明：ヒト脳表現型コンソーシアムについて (2012)
  • Author(s): 橋本亮太
  • Organizer: 2012年度包括脳ネットワーク夏のワークショップ
  • Place of Presentation: 仙台
• [Presentation] 阪大病院における20症例の治療抵抗性統合失調症患者へのクロザピンの使用経験 (2012)
  • Author(s): 橋本亮太
  • Organizer: 第108回日本精神神経学会学術総会
  • Place of Presentation: 札幌
• [Presentation] The KCNH2 gene is associated with neurocognition and the risk of schizophrenia (2011)
  • Author(s): Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Takeda M
  • Organizer: 2nd Congress of AsCNP
  • Place of Presentation: Seoul, Korea
• [Presentation] Variants of the RELA gene are associated with schizophrenia and their startle responses (2011)
  • Author(s): Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Takahashi H, Iwase M, Okochi T, Kazui H, Saitoh O, Tatsumi M, Iwata N, OzakiN, Kamijima K, Kunugi H, Takeda M
  • Organizer: 19th World Congress of Psychiatric Genetics
  • Place of Presentation: Washington D.C., U.S.A.
• [Presentation] Dysbindin: Possible target molecule for antipsychotic development (2011)
  • Author(s): Hashimoto R, Yasuda Y, Ohi K, Fukumoto M, Yamamori H, Takeda M
  • Organizer: 10th World Congress of Biological Psychiatry
  • Place of Presentation: Prague, Czech Republic
• [Presentation] 統合失調症の候補遺伝子の精神生物学 (2011)
  • Author(s): 橋本亮太、安田由華、大井一高、福本素由己、山森英長、梅田知美、岡田武也、高雄啓三、小林克典、楯林義孝、宮川剛、貝淵弘三、岩田仲生、尾崎紀夫、武田雅俊
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 石川
• [Presentation] ヒト脳表現型と分子を結ぶ新しいアプローチ:ヒト脳表現型コンソーシアム (2011)
  • Author(s): 橋本亮太、大井一高、安田由華、福本素由己、山森英長、梅田知美、岡田武也、岩瀬真生、数井裕光、武田雅俊
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 石川
• [Presentation] 統合失調症の中間表現型研究の最前線-The front line of intermediate phenotype study in schizophrenia- (2011)
  • Author(s): 橋本亮太、大井一高、安田由華、福本素由己、山森英長、梅田知美、岩瀬真生、数井裕光、武田雅俊
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京
• [Presentation] Dysbindin and Pathophysiology of Schizophrenia (2011)
  • Author(s): Hashimoto R, Yasuda Y, Ohi K, Fukumoto M, Yamamori H, and Takeda M
  • Organizer: 2nd Asian Congress on Schizophrenia Research
  • Place of Presentation: Seoul, Korea
• [Presentation] KCNH2 Gene is associated with Neurocognition and Risk for Schizophrenia (2011)
  • Author(s): Hashimoto R, Ohi K, Yasuda Y, Fukumoto M,Yamamori H,Kamino K, Morihara T, Iwase M, Kazui K, Takeda M
  • Organizer: 第6回日本統合失調症学会
  • Place of Presentation: 札幌
• [Presentation] Dysbindin : Possible target molecule for antipsychotic development (2011)
  • Author(s): Hashimoto R
  • Organizer: 10th World Congress of Biological Psychiatry
  • Place of Presentation: Prague, Czech Republic(invited speaker)
• [Presentation] 統合失調症の候補遺伝子の精神生物学 (2011)
  • Author(s): Hashimoto R
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 石川(招待講演)
• [Presentation] 統合失調症の中間表現型研究の最前線-The front line of intermediate pheno type study in schizophrenia- (2011)
  • Author(s): Hashimoto R
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京(招待講演)
• [Presentation] Dysbindin and Pathophysiology of Schizophrenia (2011)
  • Author(s): Hashimoto R
  • Organizer: The 2^<nd> Asian Congress on Schizophrenia Research
  • Place of Presentation: Seoul, Korea(invited speaker)
• [Presentation] KCNH2 Gene is associated with Neurocognition and Risk for Schizophrenia (2011)
  • Author(s): Hashimoto R
  • Organizer: 第6回日本統合失調症学会
  • Place of Presentation: 福島
• [Presentation] Schizophrenia and Dysbindin, a Susceptibility Gene (2010)
  • Author(s): Hashimoto R, Takeda M
  • Organizer: The 25th Anniversary Conference, Korean Society of Biological Psychiatry
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-10-01
• [Presentation] Schizophrenia and Dysbindin, a Susceptibility Gene (2010)
  • Author(s): Hashimoto R
  • Organizer: The 25^<th> Anniversary Conference, Korean Society of Biological Psychiatry
  • Place of Presentation: Seoul, Korea(invited speaker)
  • Year and Date: 2010-10-01
• [Presentation] The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia (2010)
  • Author(s): Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M,Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H,Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M
  • Organizer: The 49th ACNP (American College of Neuropsychopharmacology) Annual Meeting
  • Place of Presentation: Miami Beach, Florida, USA
• [Presentation] Translational Research For Schizophrenia: Genes, Intermediate Phenotypes, and Function. (2010)
  • Author(s): Hashimoto R, Yasuda Y, Ohi K, Fukumoto M, Yamamori H, Takeda M
  • Organizer: 11th Australasian Schizophrenia Conference
  • Place of Presentation: Sydney, Australia
• [Presentation] 統合失調症の中間表現型解析-その現状と展望 (2010)
  • Author(s): 橋本亮太、安田由華、大井一高、福本素由己、山森英長、岩瀬真生、数井裕光、武田雅俊
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 福岡
• [Presentation] 統合失調症の新しい理解に向けて (2010)
  • Author(s): 橋本亮太
  • Organizer: 日本心理学会第74回大会
  • Place of Presentation: 大阪
• [Presentation] 発達障害治療薬の現状と展望 (2010)
  • Author(s): 橋本亮太
  • Organizer: 第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会合同年会
  • Place of Presentation: 仙台
• [Presentation] 統合失調症の認知機能障害に対する遺伝子研究はどこまで到達したか? (2010)
  • Author(s): 橋本亮太
  • Organizer: 統合失調症の認知機能障害のメカニズム-その到達点と将来の展望
  • Place of Presentation: 神戸
• [Presentation] ヒトにおける脳表現型の分子機構の解明:ヒト脳表現型コンソーシアムについて (2010)
  • Author(s): 橋本亮太、安田由華、大井一高、福本素由己、山森英長、岩瀬真生、数井裕光、高雄啓三、宮川剛、武田雅俊
  • Organizer: 包括脳ネットワーク 夏のワークショップ
  • Place of Presentation: 札幌
• [Presentation] 統合失調症、精神医学研修コース「ここまでわかった精神疾患の脳内メカニズム」 (2010)
  • Author(s): 橋本亮太
  • Organizer: 第106回日本精神神経学会
  • Place of Presentation: 広島
• [Presentation] The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia (2010)
  • Author(s): Hashimoto R
  • Organizer: The 49th ACNP (American College of Neuropsych opharmacology) Annual Meeting
  • Place of Presentation: Florida, USA
• [Presentation] Translational Research For Schizophrenia : Genes, Intermediate Phenotypes, and Function (2010)
  • Author(s): Hashimoto R
  • Organizer: 11^<th> Australasian Schizophrenia Conference
  • Place of Presentation: Sydney, Australia(invited speaker)
• [Presentation] 統合失調症の中間表現型解析-その現状と展望 (2010)
  • Author(s): 橋本亮太
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 福岡(招待)
• [Presentation] 統合失調症の認知機能障害に対する遺伝子研究はどこまで到達したか?「統合失調症の認知機能障害のメカニズム-その到達点と将来の展望」 (2010)
  • Author(s): 橋本亮太
  • Organizer: Neuro2010
  • Place of Presentation: 神戸(招待)
• [Presentation] ここまでわかった精神疾患の脳内メカニズム (2010)
  • Author(s): 橋本亮太
  • Organizer: 第106回日本精神神経学会
  • Place of Presentation: 広島(招待)
• [Book] 臨床精神薬理 15 (2012)
  • Author(s): 橋本亮太、山森英長、安田由華、福本素由己、大井一高、井上頌子、竹上学、武田雅俊
  • Publisher: 星和書店
• [Book] 統合失調症入院プログラムにおける治療抵抗性統合失調症に対するclozapineの有用性、 (2012)
  • Author(s): 橋本亮太
  • Publisher: 臨床精神薬理、星和書店
• [Book] 中間表現型、精神医学キーワード事典 (2011)
  • Author(s): 橋本亮太、武田雅俊
  • Publisher: 中山書
• [Book] 中間表現型、精神医学キーワード事典 (2011)
  • Author(s): 橋本亮太、武田雅俊
  • Publisher: 中山書店
• [Book] 疾病と治療III (2010)
  • Author(s): 橋本亮太、安田由華
  • Publisher: 南江堂
• [Book] 疾病と治療III (2010)
  • Author(s): 橋本亮太、大井一高
  • Publisher: 南江堂
• [Book] 疾病と治療III(看護学テキスト) (2010)
  • Author(s): 橋本亮太(共著)
  • Publisher: 南江堂
• [Remarks]
• [Remarks]
  • URL: http://www.sp-web.sakura.ne.jp/lab/index.html