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Genome wide association study of intermediate phenotypes of schizophrenia

Research Project

Project/Area Number 22390225
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionOsaka University

Principal Investigator

HASHIMOTO Ryota  大阪大学, 大学院・連合小児発達学研究科, 准教授 (10370983)

Co-Investigator(Kenkyū-buntansha) YASUDA Yuka  大阪大学, 大学院・連合小児発達学研究科, 特任研究員 (20448062)
YAMAMORI Hidenaga  大阪大学, 大学院・医学系研究科, 寄附講座助教 (90570250)
IWASE Masao  大阪大学, 大学院・医学系研究科, 助教 (60362711)
KAZUI Hiroaki  大阪大学, 大学院・医学系研究科, 講師 (30346217)
TAKEDA Masatoshi  大阪大学, 大学院・医学系研究科, 教授 (00179649)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Keywords統合失調症 / 中間表現型 / ゲノム / 認知機能 / 脳画像 / 神経生理機能
Research Abstract

Many patients with schizophrenia experience a decline in intellectual functioning. We conducted a genome-wide association study (GWAS) of cognitive decline in 166 patients with schizophrenia. Cognitive decline (subtraction of JART score from full-scale IQ) was -16.1.The strongest association was observed at rs7157599 on chromosome 14, a missense polymorphism (Asn8Ser) in the DEGS2 gene (p=5.4×10-7). Replication analysis using the National Institute of Mental Health Clinical Brain Disorders Branch sample revealed a directionally consistent trend association of genotype for a proxy of the top SNP. Although the study should be replicated with a larger sample size, our results indicate that the measurement of cognitive decline in schizophrenia as a quantitative phenotype (in conjunction with GWAS) could be a gene discovery tool.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (136 results)

All 2013 2012 2011 2010 Other

All Journal Article (75 results) (of which Peer Reviewed: 74 results) Presentation (52 results) (of which Invited: 3 results) Book (7 results) Remarks (2 results)

  • [Journal Article] The KCNH2 gene is associated with neurocognition and the risk of schizophrenia2013

    • Author(s)
      Hashimoto R, Ohi K, Yasuda Y, Fukumnoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Takeda M.
    • Journal Title

      World J Biol Psychiatry

      Volume: 14(2) Pages: 114-20

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia2013

    • Author(s)
      Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M
    • Journal Title

      World J Biol Psychiatry

      Volume: 14(2) Pages: 100-13

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The regulation of gene expression involved in TGF-β signaling by ZNF804A, a risk gene for schizophrenia2013

    • Author(s)
      Umeda-Yano S, Hashimoto R, Yamamori H, Okada T, Yasuda Y, Ohi K, Fukumoto M, Ito A, Takeda M
    • Journal Title

      Schizophr Res

      Volume: (e-pub)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The regulation of gene expression involved in TGF-β signaling by ZNF804A, a risk gene for schizophrenia2013

    • Author(s)
      Umeda-Yano S, et al
    • Journal Title

      Schizophr Res

      Volume: e-pub

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An association analysis of the cardiomyopathy-associated 5(CMYA5) gene with schizophrenia in a Japanese population.2013

    • Author(s)
      Furukawa M, et al
    • Journal Title

      Psychiatr Genet

      Volume: e-pub

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel based morphometry and mutation screening.2012

    • Author(s)
      Aleksic B., Kushima I, Hashimoto R, Ohi K, Ikeda M, Yoshimi A, Nakamura Y, Ito Y, Okochi T, Fukuo Y, Yasuda Y, Fukumoto M, Yamamori H, Ujike H, Suzuki M, Inada T, Takeda M, Kaibuchi K, Iwata N, Ozaki N
    • Journal Title

      Schizophrenia Bulletin

      Volume: (e-pub)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression analysis of a novel mRNA variant of the schizophrenia risk gene ZNF804A2012

    • Author(s)
      Okada T, Hashimoto R, Yamamori H, Umeda-Yano S, Yasuda Y, Ohi K, Fukumoto M, Ikemoto K, KUnii Y, Tomita H, Ito A, Takeda M
    • Journal Title

      Schizophr Res

      Volume: 141(2-3) Pages: 277-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Personality traits and schizophrenia: evidence from a case-control study and meta-analysis.2012

    • Author(s)
      Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Iwase M, Kazui H, Takeda M
    • Journal Title

      Psychiatry Research

      Volume: 198(1) Pages: 7-11

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional genetic variation at the NRGN gene and schizophrenia: evidence from a gene-based case-control study and gene expression analysis.2012

    • Author(s)
      Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ohmura T, Iwata N, Ueno S, Ozaki N, Ohmori T, Arai H, Takeda M
    • Journal Title

      American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

      Volume: 159B(4) Pages: 405-13

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Resequencing and Association Analysis of the KALRN and EPHB1 Genes And Their Contribution to Schizophrenia Susceptibility2012

    • Author(s)
      Kushima I, Nakamura Y, Aleksic B, Ikeda M, Ito Y, Shiino T, Okochi T, Fukuo Y, Ujike H, Suzuki M, Inada T, Hashimoto R, Takeda M, Kaibuchi K, Iwata N, Ozaki N
    • Journal Title

      Schizophr Bull

      Volume: 38(3) Pages: 552-560

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The p250GAP Gene is Associated with Risk for Schizophrenia and Schizotypal Personality Traits2012

    • Author(s)
      Ohi K, Hashimoto R, Nakazawa T, Okada T, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Iwase M, Kazui H, Yamamoto T, Kano M, Takeda M
    • Journal Title

      PLoS One

      Volume: 7(4)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A promoter variant in the Chitinase 3-Like 1 gene is associated with serum YKL-40 level and personality trait2012

    • Author(s)
      Yamamori H, Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Kasahara E, Sekiyama A, Umeda-Yano S, Okada T, Iwase M, Kazui H, Ito A, Takeda M
    • Journal Title

      Neurosci Lett

      Volume: 513(3) Pages: 204-208

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of Prepulse Inhibition to Temperament and Character in Healthy Japanese subjects.2012

    • Author(s)
      Takahashi H, Iwase M, Yasuda Y, Ohi Y, Fukumoto M, Iike N, Yamamori H, Nakahachi T, Ikezawa K, Azechi M, Canuet L, Ishii R, Kazui H, Hashimoto R, Takeda M
    • Journal Title

      Neuroscience Research

      Volume: 72(2) Pages: 187-193

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of the Genome Wide Supported NRGN Gene on Anterior Cingulate Morphology in Schizophrenia2012

    • Author(s)
      Ohi K, Hashimoto R, Yasuda Y, Nemoto K, Ohnishi T, Fukumoto M, Yamamori H, Umeda-Yano S. Okada T, Iwase M, Kazui H, Takeda M
    • Journal Title

      PLoS One

      Volume: 7(1)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel based morphometry and mutation screening.2012

    • Author(s)
      Aleksic B., et al
    • Journal Title

      Schizophrenia Bulletin.

      Volume: e-pub

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discrimination of female schizophrenia patients from healthy women using multiple structural brain measures obtained with voxel-based morphometry2012

    • Author(s)
      Ota M, et al,
    • Journal Title

      Psychiatry and Clinical Neurosciences,

      Volume: 66 Issue: 7 Pages: 611

    • DOI

      10.1111/j.1440-1819.2012.02397.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis of association studies between DISC1 missense variants and schizophrenia in Japanese population.2012

    • Author(s)
      Kinoshita M, et al
    • Journal Title

      Schizophr Res,

      Volume: 141(2-3): Issue: 2-3 Pages: 271-273

    • DOI

      10.1016/j.schres.2012.07.020

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression analysis of a novel mRNA variant of the schizophrenia risk gene ZNF804A.2012

    • Author(s)
      Okada T, et al,
    • Journal Title

      Schizophr Res,

      Volume: 141(2-3): Issue: 2-3 Pages: 277-278

    • DOI

      10.1016/j.schres.2012.08.015

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] No associations found between the genes situated at 6p22.1, HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with schizophrenia2012

    • Author(s)
      Kitazawa M, Ohnuma T, Takebayashi Y, Shibata N, Baba H, Ohi K, Yasuda Y, Nakamura Y, Aleksic B, Yoshimi A, Okochi T, Ikeda M, Naitoh H, Hashimoto R, Iwata N, Ozaki N, Takeda M, Arai H
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet

      Volume: 159B(4) Issue: 4 Pages: 456-464

    • DOI

      10.1002/ajmg.b.32049

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Personality traits and schizophrenia : evidence from a case-control study and meta-analysis2012

    • Author(s)
      Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Iwase M, Kazui H, Takeda M
    • Journal Title

      Psychiatry Res

      Volume: (Epub ahead of print) Issue: 1 Pages: 7-11

    • DOI

      10.1016/j.psychres.2011.12.018

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional genetic variation at the NRGN gene and schizophrenia: Evidence from a gene-based case-control study and gene expression analysis2012

    • Author(s)
      Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ohnuma T, Iwata N, Ueno S, Ozaki N, Ohmori T, Arai H, Takeda M
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet

      Volume: 159B(4) Issue: 4 Pages: 405-413

    • DOI

      10.1002/ajmg.b.32043

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Searching for a consensus five-factor model of the Positive and Negative Syndrome Scale for schizophrenia.2012

    • Author(s)
      Wallwork RS, et al
    • Journal Title

      Schizophr Res,

      Volume: 137(1-3): Issue: 1-3 Pages: 246-50

    • DOI

      10.1016/j.schres.2012.01.031

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A two-stage case-control association study between the tryptophan hydroxylase 2 (TPH2) gene and schizophrenia in a Japanese population2012

    • Author(s)
      Watanabe Y, Egawa J, Iijima Y, Nunokawa A, Kaneko N, Shibuya M, Arinami T, Ujike H, Inada T, Iwata N, Tochigi M, Kunugi H, Itokawa M, Ozaki N, Hashimoto R, Someya T
    • Journal Title

      Schizophr Res

      Volume: 137 Issue: 1-3 Pages: 264

    • DOI

      10.1016/j.schres.2012.01.034

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common Variants in MAGI2 Gene Are Associated with Increased Risk for Cognitive Impairment in Schizophrenic Patients2012

    • Author(s)
      Koide T, Banno M, Aleksic B, Yamashita S, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Kushima I, Nakamura Y, Okada T, Ikeda M, Ohi K, Yasuda Y, Hashimoto R, Inada T, Ujike H, Iidaka T, Suzuki M, Takeda M, Iwata N, Ozaki N
    • Journal Title

      PLoS One

      Volume: 7(5) Issue: 5 Pages: e36836-e36836

    • DOI

      10.1371/journal.pone.0036836

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resequencing and Association Analysis of the KALRN and EPHB1 Genes And Their Contribution to Schizophrenia Susceptibility2012

    • Author(s)
      Kushima I, Nakamura Y, Aleksic B, Ikeda M, Ito Y, Shiino T, Okochi T, Fukuo Y, Ujike H, Suzuki M, Inada T, Hashimoto R, Takeda M, Kaibuchi K, Iwata N, Ozaki N
    • Journal Title

      Schizophr Bull

      Volume: 38(3) Issue: 3 Pages: 552-560

    • DOI

      10.1093/schbul/sbq118

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits2012

    • Author(s)
      Hashimoto R
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 4 Pages: e35696-e35696

    • DOI

      10.1371/journal.pone.0035696

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discrimination of schizophrenic females from healthy women using multiple structural brain measures obtained with voxel-based morphometry2012

    • Author(s)
      Ota M, Hashimoto R, et al
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: (掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional genetic variation at the NEGN gene and schizophrenia : evidence from a gene-based case-control study and gene expression analysis2012

    • Author(s)
      Ohi K, Hashimoto R, et al
    • Journal Title

      American Journal of Medical Genetics Part B : Neuropsychiatric Genetics

      Volume: (掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of the VAV3 as candidate gene for schizophrenia : evidences from voxel based morphometry and mutation screening2012

    • Author(s)
      Aleksic B., Hashimoto R, et al
    • Journal Title

      Schizophrenia Bulletin

      Volume: (掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A promoter variant in the Chitinase 3-Like 1 gene is associated with serum YKL-40 level and personality trait2012

    • Author(s)
      Yamamori H, Hashimoto R, et al
    • Journal Title

      Neuroscience Letters

      Volume: (掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A two-stage case-control association study between the tryptophan hydroxylase 2(TPH2) gene and schizophrenia in a Japanese population2012

    • Author(s)
      Watanabe Y, Hashimoto R, et al
    • Journal Title

      Schizophrenia Research

      Volume: (掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Personality traits and schizophrenia : evidence from a case-control study and meta-analysis2012

    • Author(s)
      Ohi K, Hashimoto R, et al
    • Journal Title

      Psychiatry Research

      Volume: (掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of prepulse inhibition to temperament and character in healthy Japanese subjects2012

    • Author(s)
      Takahashi H, Iwase M, Yasuda Y, Ohi K, Fukumoto M, Iike N, Yamamori H, Nakahachi T, Ikezawa K, Azechi M, Canuet L, Ishii R, Kazui H, Hashimoto R, Takeda M
    • Journal Title

      Neurosci Res

      Volume: 72(2) Issue: 2 Pages: 187-193

    • DOI

      10.1016/j.neures.2011.10.009

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of the genome wide supported NRGN gene on anterior cingulate morphology in schizophrenia2012

    • Author(s)
      Ohi K, Hashimoto R, Yasuda Y, Nemoto K, Ohnishi T, Fukumoto M, Yamaniori H, Umeda-Yano S, Okada T, Iwase M, Kazui H, Takeda M
    • Journal Title

      PLoS One

      Volume: 7(1) Issue: 1 Pages: e29780-e29780

    • DOI

      10.1371/journal.pone.0029780

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variants of the RELA gene are associated with schizophrenia and their startle responses2011

    • Author(s)
      Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Takahashi H, Iwase M, Okochi T, Kazui H, Saitoh O, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Kunugi H, Takeda M
    • Journal Title

      Neuropsychopharmacology

      Volume: 36(9) Pages: 1921-1931

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dysbindin-1 and NRG-1 gene expression in immortalized lymphocytes from patients with schizophrenia2011

    • Author(s)
      Yamamori H, Hashimoto R, Verrall L, Yasuda Y, Ohi K, Fukumoto M, Umeda-Yano S, Ito A, Takeda M
    • Journal Title

      J Hum Genet

      Volume: 56(7) Pages: 478-83

    • NAID

      10030659941

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression analysis in lymphoblasts derived from patients with autism spectrum disorder2011

    • Author(s)
      Yasuda Y, Hashimoto R, Yamamori H, Ohi K, Fukumoto M, Umeda-Yano S, Mohri I, Ito A, Taniike M, Takeda M
    • Journal Title

      Molecular Autism

      Volume: 2(1) Pages: 9-9

    • NAID

      40019049794

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis.2011

    • Author(s)
      Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ueno S, Ohmori T, Iwata N, Ozaki N, Takeda M
    • Journal Title

      Schizophrenia Res

      Volume: 129 Pages: 80-84

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene2011

    • Author(s)
      Yasuda Y, Hashimoto R, Ohi K , Fukumoto M, Umeda-Yano S, Yamamori H, Okochi T, Iwase M, Kazui H, Iwata N, Takeda M
    • Journal Title

      Neurosci let

      Volume: 495 Pages: 216-220

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PACAP is Implicated in the Stress Axes2011

    • Author(s)
      Hashimoto H, Shintani N, Tanida M, Hayata A, Hashimoto R, Baba A
    • Journal Title

      Curr Pharm Des, review

      Volume: 17(10) Pages: 985-9

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The SIGMAR1 gene is associated with a risk of schizophrenia and activation of the prefrontal cortex2011

    • Author(s)
      Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Kamino K, Ikezawa K, Azechi M, Iwase M, Kazui H, Kasai K, Takeda M
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 35 Pages: 1309-1315

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-Wide Association Study of Schizophrenia in a Japanese Population.2011

    • Author(s)
      Ikeda M, Aleksic B, Kinoshita Y, Okochi T, Kawashima K, Kushima I, Ito Y, Nakamura Y, Kishi T, Okumura T, Fukuo Y, Williams HJ, Hamshere ML, Ivanov D, Inada T, Suzuki M, Hashimoto R, Ujike H, Takeda M, Craddock N, Kaibuchi K, Owen MJ, Ozaki N, O'Donovan M
    • Journal Title

      Biol Psychiatry

      Volume: 69(5) Pages: 472-478

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Different Characteristics of Cognitive Impairment in Elderly Schizophrenia and Alzheimer's Disease in the Mild Cognitive Impairment Stage2011

    • Author(s)
      Kazui H, Yoshida T, Takaya M, Sugiyama H, Yamamoto D, Kito Y, Wada T, Nomura K, Yasuda Y, Yamamori H, Ohi K, Fukumoto M, Iike N, Iwase M, Morihara T, Tagami S, Shimosegawa E, Hatazawa J, Ikeda Y, Uchida E, Tanaka T, Kudo T, Hashimoto R, Takeda M
    • Journal Title

      Dement Geriatr CognDisord

      Volume: 1 Pages: 20-30

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia2011

    • Author(s)
      Ohi K, Hashimoto R, et al
    • Journal Title

      World J Biol Psychiatry

      Volume: e-pub Issue: 2 Pages: 100-13

    • DOI

      10.3109/15622975.2011.591826

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The KCNH2 gene is associated with neurocognition and the risk of schizophrenia2011

    • Author(s)
      Hashimoto R, et al
    • Journal Title

      World J Biol Psychiatry.

      Volume: e-pub Issue: 2 Pages: 114-20

    • DOI

      10.3109/15622975.2011.604350

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A polymorphism of the ABCA1 gene confers susceptibility to schizophrenia and related brain changes2011

    • Author(s)
      Ota M, Fujii T, Nemoto K, Tatsumi M, Moriguchi Y, Hashimoto R, et al
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 35 Issue: 8 Pages: 1877

    • DOI

      10.1016/j.pnpbp.2011.07.012

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased alpha event-related synchronization in the left posterior temioral cortex in schizophrenia : a magnetoencephalography-beamformer study2011

    • Author(s)
      Ikezawa K, et al
    • Journal Title

      Neurosci Res

      Volume: 71(3) Issue: 3 Pages: 235-243

    • DOI

      10.1016/j.neures.2011.07.1819

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression analysis in lymphoblasts derived from patients with autism spectrum disorder2011

    • Author(s)
      Yasuda Y, Hashimoto R, et al
    • Journal Title

      Molecular Autism

      Volume: 2(1) Issue: 1 Pages: 9-9

    • DOI

      10.1186/2040-2392-2-9

    • NAID

      40019049794

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] No association between the PCM1 gene and schizophrenia : a multi-center case-control study and a meta-analysis2011

    • Author(s)
      Hashimoto R, et al
    • Journal Title

      Schizophrenia Research

      Volume: 129 Issue: 1 Pages: 80-84

    • DOI

      10.1016/j.schres.2011.03.024

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-Wide Association Study of Schizophrenia in a Japanese Population2011

    • Author(s)
      Ikeda M, Hashimoto R, et al.
    • Journal Title

      Biol Psychiatry

      Volume: 69(5) Pages: 472-478

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced rate of neurogenesis in the hippocampus of adult dysbindin null (sandy) mouse2011

    • Author(s)
      Nihonmatsu-Kikuchi N, Hashimoto R, et al.
    • Journal Title

      PLoS One

      Volume: 18;6(1)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apolipoprotein E and central nervous system disorders: reviews of clinical findings2010

    • Author(s)
      Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 64(6) Pages: 592-607

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia.2010

    • Author(s)
      Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M
    • Journal Title

      Am J Med Genet B Neuropsychiatry Genet

      Volume: 153B(8) Pages: 1459-1464

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala.2010

    • Author(s)
      Delawary M, Tezuka T, Kiyama Y, Yokoyama K, Inoue T, Hattori S, Hashimoto R, Umemori H, Manabe T, Yamamoto T, Nakazawa T
    • Journal Title

      Mol Brain

      Volume: 3(1) Pages: 37-37

    • Related Report
      2012 Final Research Report
  • [Journal Article] Association study of KIBRA gene with memory performance in a Japanese population2010

    • Author(s)
      Yasuda Y, Hashimoto R, Ohi K, Fukumoto M, Takamura H, Iike N, Kiribayashi M, Yoshida T, Hayashi N, Takahashi H, Yamamori H, Morihara T, Tagami S, Okochi M, Tanaka T, Kudo T, Kamino K, Ishii R, Iwase M, Kazui H, Takeda M
    • Journal Title

      World J Biol Psychiatry

      Volume: 11(7) Pages: 852-857

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy Japanese subjects.2010

    • Author(s)
      Takahashi H, Iwase M, Canuet L, Yasuda Y, Ohi K, Fukumoto M, Iike N, Nakahachi T, Ikezawa K, Azechi M, Kurimoto R, Ishii R, Yoshida T, Kazui H, Hashimoto R, Takeda M
    • Journal Title

      Psychophysiology

      Volume: 47(5) Pages: 831-837

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Laughter and humor as complementary and alternative medicines to dementia patients2010

    • Author(s)
      Takeda M, Hashimoto R, Kudo T, Okochi M, Tagami S, Morihara T, Sadick G, Tanaka T
    • Journal Title

      BMC Complement Altern Med

      Volume: 10(1) Pages: 28-28

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A functional polymorphism in the disrupted-in schizophrenia 1 gene is associated with chronic fatigue syndrome2010

    • Author(s)
      Fukuda S, Hashimoto R, Ohi K, Yamaguti K, Nakatomi Y, Yasuda Y, Kamino K, Takeda M, Tajima S, Kuratsune H, Nishizawa Y, Watanabe Y
    • Journal Title

      Life Sci

      Volume: 86(19-20) Pages: 722-725

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population2010

    • Author(s)
      Aleksic B, Kushima I, Ito Y, Nakamura Y, Ujike H, Suzuki M, Inada T, Hashimoto R, Takeda M, Iwata N, Ozaki N
    • Journal Title

      Schizophr Res

      Volume: 118(1-3) Pages: 113-117

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort2010

    • Author(s)
      Hayashi N, Hashimoto R, at al.
    • Journal Title

      Dement Geriatr Cogn Disord

      Volume: 30(4) Pages: 302-308

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala2010

    • Author(s)
      Delawary M, Hashimoto R, at al.
    • Journal Title

      Mol Brain

      Volume: 3(1) Pages: 37-37

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apolipoprotein E and central nervous system disorders : reviews of clinical findings2010

    • Author(s)
      Takeda M, Hashimoto R, at al.
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 64(6) Pages: 592-607

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia2010

    • Author(s)
      Hashimoto R, et al.
    • Journal Title

      Am J Med Genet B Neuropsychiatry Genet

      Volume: 153B Pages: 1459-1464

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association study of KIBRA gene with memory performance in a Japanese population2010

    • Author(s)
      Yasuda Y, Hashimoto R, et al.
    • Journal Title

      The World Journal of Biological Psychiatry

      Volume: 11 Pages: 852-857

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma levels of vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF-2) in patients with major depressive disorders2010

    • Author(s)
      Takebayashi M, Hashimoto R, at al.
    • Journal Title

      J Neural Transm

      Volume: 117(9) Pages: 1119-1122

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel2010

    • Author(s)
      Mori K, Hashimoto R, at al.
    • Journal Title

      Psychogeriatrics

      Volume: 10(3) Pages: 117-123

    • NAID

      10029771051

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association study between the pericentrin (PCNT) gene and schizophrenia2010

    • Author(s)
      Numata S, Hashimoto R, et al.
    • Journal Title

      NeuroMolecular Medicine

      Volume: 12(3) Pages: 243-247

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy Japanese subjects2010

    • Author(s)
      Takahashi H, Hashimoto R, at al.
    • Journal Title

      Psychophysiology

      Volume: 47(5) Pages: 831-837

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects2010

    • Author(s)
      Koide T, Hashimoto R, et al.
    • Journal Title

      J Hum Genet

      Volume: 55(7) Pages: 469-472

    • NAID

      10030735981

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laughter and humor as complementary and alternative medicines to dementia patients2010

    • Author(s)
      Takeda M, Hashimoto R, at al.
    • Journal Title

      BMC Complement Altern Med

      Volume: 10(1) Pages: 28-28

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The International Consortium on Lithium Genetics (ConLiGen) : An Initiative by the NIMH and IGSLI to Study the Genetic Basis of Response to Lithium Treatment2010

    • Author(s)
      Schulze T, Hashimoto R, at al.
    • Journal Title

      Neuropsychobiology

      Volume: 62(1) Pages: 72-78

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two genetic variants of CD38 in subjects with autism spectrum disorder and controls2010

    • Author(s)
      Munesue T, Hashimoto R, et al.
    • Journal Title

      Neurosci Res

      Volume: 67 Pages: 181-191

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia: a three-stage case-control association study2010

    • Author(s)
      Amagane H, Hashimoto R, et al.
    • Journal Title

      Schizophr Res

      Volume: 118(1-3) Pages: 106-112

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] No association between DAO and schizophrenia in a Japanese patient population : A multicenter replication study2010

    • Author(s)
      Ohnuma T, Hashimoto R, et al.
    • Journal Title

      Schizophr Res

      Volume: 118(1-3) Pages: 300-302

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic association study of KREMEN1 and DKK1 and schizophrenia in Japanese population2010

    • Author(s)
      Aleksic B, Hashimoto R, et al.
    • Journal Title

      Schizophr Res

      Volume: 118(1-3) Pages: 113-117

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Genome-wide association study of cognitive decline in schizophrenia2013

    • Author(s)
      Hashimoto R, Ikeda M, Kazutaka O, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Dickinson D, Aleksic B, Iwase M, Kazui H, Ozaki N, Weinberger DR, Iwata N, Takeda M
    • Organizer
      The 3rd Asian Congress on Schizophrenia Research
    • Place of Presentation
      Bali, Indonesia
    • Related Report
      2012 Final Research Report
  • [Presentation] Genome-wide association study of cognitive decline in schizophrenia2013

    • Author(s)
      Hashimoto R,
    • Organizer
      The 3rd Asian Congress on Schizophrenia Research
    • Place of Presentation
      Indonesia
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The p250GAP Gene is Associated with Risk for Schizophrenia and Schizotypal Personality Trait2012

    • Author(s)
      Hashimoto R, Ohi K, Nakazawa T, Yasuda Y, Yamamori H, Fukumoto M, Iwase M, Kazui H, Yamamoto T, Kano M, Takeda M
    • Organizer
      CNIP 28th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2012 Final Research Report
  • [Presentation] 統合失調症入院プログラムにおける治療抵抗性統合失調症に対するclozapineの有用性2012

    • Author(s)
      橋本亮太、山森英長、安田由華、福本素由己、大井一高、井上頌子、竹上学、武田雅俊
    • Organizer
      第22回日本臨床精神神経薬理学会第42回日本神経精神薬理学会合同年会
    • Place of Presentation
      栃木
    • Related Report
      2012 Final Research Report
  • [Presentation] Variants of the RELA gene are associated with schizophrenia and their startleresponses2012

    • Author(s)
      Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Takahashi H, Iwase M, Okochi T, Kazui H, Saitoh O, Tatsumi M, Iwata N, OzakiN, Kamijima K, Kunugi H, Takeda M
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] 広汎性発達障害の原因遺伝子とその探索ストラテジーResearch strategy for identifying ASDgenes-2012

    • Author(s)
      橋本亮太、安田由華、山森英長、梅田知美、深井綾子、大井一高、福本素由己、毛利育子、谷池雅子、松本直通、武田雅俊
    • Organizer
      第34回日本生物学的精神医学会、第11回アジア太平洋神経化学会大会・第55回日本神経化学会大会合同シンポジウム
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] 「ゲノム研究による精神疾患診断は可能か?」、シンポジウム:バイオロジカルマーカー研究からDSM-Vに向けて2012

    • Author(s)
      橋本亮太、大井一高、安田由華、山森英長、梅田知美、福本素由己、武田雅俊
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] 統合失調症の分子メカニズム研究の新しい潮流:中間表現型を用いた統合失調症の病態解明2012

    • Author(s)
      橋本亮太、大井一高、安田由華、山森英長、梅田知美、岩瀬真生、数井裕光、武田雅俊
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      愛知
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒトにおける脳表現型の分子機構の解明:ヒト脳表現型コンソーシアムについて2012

    • Author(s)
      橋本亮太、大井一高、安田由華、梅田知美、山森英長、武田雅俊
    • Organizer
      2012年度包括脳ネットワーク夏のワークショップ
    • Place of Presentation
      仙台
    • Related Report
      2012 Final Research Report
  • [Presentation] 阪大病院における 20症例の治療抵抗性統合失調症患者へのクロザピンの使用経験2012

    • Author(s)
      橋本亮太、山森英長、安田由華、福本 素由己、大井 一高、梅田 知美、岡田 武也、武田雅俊
    • Organizer
      第108回日本精神神経学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] 統合失調症専門外来・入院プログラムによる地域医療と臨床研究の融合システムの構築2012

    • Author(s)
      橋本亮太、大井 一高、安田由華、山森英長、福本素由己、梅田 知美、岡田 武也、武田雅俊
    • Organizer
      第108回日本精神神経学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] The p250GAP Gene is Associated with Risk for Schizophrenia and Schizotypal Personality Trait.2012

    • Author(s)
      Hashimoto R,
    • Organizer
      28th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      Sweden
    • Related Report
      2012 Annual Research Report
  • [Presentation] 統合失調症入院プログラムにおける治療抵抗性統合失調症に対するclozapineの有用性、2012

    • Author(s)
      橋本亮太
    • Organizer
      第22回日本臨床精神神経薬理学会第42回日本神経精神薬理学会合同年会
    • Place of Presentation
      栃木
    • Related Report
      2012 Annual Research Report
  • [Presentation] Variants of the RELA gene are associated with schizophrenia and their startle responses.2012

    • Author(s)
      Hashimoto R,橋本亮太
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] 広汎性発達障害の原因遺伝子とその探索ストラテジー- Research strategy for identifying ASD genes-2012

    • Author(s)
      橋本亮太
    • Organizer
      第34回日本生物学的精神医学会、第11回アジア太平洋神経化学会大会・第55回日本神経化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] ゲノム研究による精神疾患診断は可能か?2012

    • Author(s)
      橋本亮太
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 統合失調症の分子メカニズム研究の新しい潮流:中間表現型を用いた統合失調症の病態解明2012

    • Author(s)
      橋本亮太
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      愛知
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ヒトにおける脳表現型の分子機構の解明:ヒト脳表現型コンソーシアムについて2012

    • Author(s)
      橋本亮太
    • Organizer
      2012年度包括脳ネットワーク夏のワークショップ
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] 阪大病院における20症例の治療抵抗性統合失調症患者へのクロザピンの使用経験2012

    • Author(s)
      橋本亮太
    • Organizer
      第108回日本精神神経学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] 統合失調症専門外来・入院プログラムによる地域医療と臨床研究の融合システムの構築、2012

    • Author(s)
      橋本亮太
    • Organizer
      第108回日本精神神経学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] The KCNH2 gene is associated with neurocognition and the risk of schizophrenia2011

    • Author(s)
      Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Takeda M
    • Organizer
      2nd Congress of AsCNP
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Variants of the RELA gene are associated with schizophrenia and their startle responses2011

    • Author(s)
      Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Takahashi H, Iwase M, Okochi T, Kazui H, Saitoh O, Tatsumi M, Iwata N, OzakiN, Kamijima K, Kunugi H, Takeda M
    • Organizer
      19th World Congress of Psychiatric Genetics
    • Place of Presentation
      Washington D.C., U.S.A.
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Dysbindin: Possible target molecule for antipsychotic development2011

    • Author(s)
      Hashimoto R, Yasuda Y, Ohi K, Fukumoto M, Yamamori H, Takeda M
    • Organizer
      10th World Congress of Biological Psychiatry
    • Place of Presentation
      Prague, Czech Republic
    • Related Report
      2012 Final Research Report
  • [Presentation] 統合失調症の候補遺伝子の精神生物学2011

    • Author(s)
      橋本亮太、安田由華、大井一高、福本素由己、山森英長、梅田知美、岡田武也、高雄啓三、小林克典、楯林義孝、宮川剛、貝淵弘三、岩田仲生、尾崎紀夫、武田雅俊
    • Organizer
      第54回日本神経化学会大会
    • Place of Presentation
      石川
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト脳表現型と分子を結ぶ新しいアプローチ:ヒト脳表現型コンソーシアム2011

    • Author(s)
      橋本亮太、大井一高、安田由華、福本素由己、山森英長、梅田知美、岡田武也、岩瀬真生、数井裕光、武田雅俊
    • Organizer
      第54回日本神経化学会大会
    • Place of Presentation
      石川
    • Related Report
      2012 Final Research Report
  • [Presentation] 統合失調症の中間表現型研究の最前線-The front line of intermediate phenotype study in schizophrenia-2011

    • Author(s)
      橋本亮太、大井一高、安田由華、福本素由己、山森英長、梅田知美、岩瀬真生、数井裕光、武田雅俊
    • Organizer
      第33回日本生物学的精神医学会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Dysbindin and Pathophysiology of Schizophrenia2011

    • Author(s)
      Hashimoto R, Yasuda Y, Ohi K, Fukumoto M, Yamamori H, and Takeda M
    • Organizer
      2nd Asian Congress on Schizophrenia Research
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Final Research Report
  • [Presentation] KCNH2 Gene is associated with Neurocognition and Risk for Schizophrenia2011

    • Author(s)
      Hashimoto R, Ohi K, Yasuda Y, Fukumoto M,Yamamori H,Kamino K, Morihara T, Iwase M, Kazui K, Takeda M
    • Organizer
      第6回日本統合失調症学会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] Dysbindin : Possible target molecule for antipsychotic development2011

    • Author(s)
      Hashimoto R
    • Organizer
      10th World Congress of Biological Psychiatry
    • Place of Presentation
      Prague, Czech Republic(invited speaker)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 統合失調症の候補遺伝子の精神生物学2011

    • Author(s)
      Hashimoto R
    • Organizer
      第54回日本神経化学会大会
    • Place of Presentation
      石川(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト脳表現型と分子を結ぶ新しいアプローチ:ヒト脳表現型コンソーシアム2011

    • Author(s)
      Hashimoto R
    • Organizer
      第54回日本神経化学会大会
    • Place of Presentation
      石川(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 統合失調症の中間表現型研究の最前線-The front line of intermediate pheno type study in schizophrenia-2011

    • Author(s)
      Hashimoto R
    • Organizer
      第33回日本生物学的精神医学会
    • Place of Presentation
      東京(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dysbindin and Pathophysiology of Schizophrenia2011

    • Author(s)
      Hashimoto R
    • Organizer
      The 2^<nd> Asian Congress on Schizophrenia Research
    • Place of Presentation
      Seoul, Korea(invited speaker)
    • Related Report
      2010 Annual Research Report
  • [Presentation] KCNH2 Gene is associated with Neurocognition and Risk for Schizophrenia2011

    • Author(s)
      Hashimoto R
    • Organizer
      第6回日本統合失調症学会
    • Place of Presentation
      福島
    • Related Report
      2010 Annual Research Report
  • [Presentation] Schizophrenia and Dysbindin, a Susceptibility Gene2010

    • Author(s)
      Hashimoto R, Takeda M
    • Organizer
      The 25th Anniversary Conference, Korean Society of Biological Psychiatry
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-10-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Schizophrenia and Dysbindin, a Susceptibility Gene2010

    • Author(s)
      Hashimoto R
    • Organizer
      The 25^<th> Anniversary Conference, Korean Society of Biological Psychiatry
    • Place of Presentation
      Seoul, Korea(invited speaker)
    • Year and Date
      2010-10-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia2010

    • Author(s)
      Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M,Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H,Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M
    • Organizer
      The 49th ACNP (American College of Neuropsychopharmacology) Annual Meeting
    • Place of Presentation
      Miami Beach, Florida, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Translational Research For Schizophrenia: Genes, Intermediate Phenotypes, and Function.2010

    • Author(s)
      Hashimoto R, Yasuda Y, Ohi K, Fukumoto M, Yamamori H, Takeda M
    • Organizer
      11th Australasian Schizophrenia Conference
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2012 Final Research Report
  • [Presentation] 統合失調症の中間表現型解析-その現状と展望2010

    • Author(s)
      橋本亮太、安田由華、大井一高、福本素由己、山森英長、岩瀬真生、数井裕光、武田雅俊
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] 統合失調症の新しい理解に向けて2010

    • Author(s)
      橋本亮太
    • Organizer
      日本心理学会第74回大会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] 発達障害治療薬の現状と展望2010

    • Author(s)
      橋本亮太
    • Organizer
      第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会合同年会
    • Place of Presentation
      仙台
    • Related Report
      2012 Final Research Report
  • [Presentation] 統合失調症の認知機能障害に対する遺伝子研究はどこまで到達したか?2010

    • Author(s)
      橋本亮太
    • Organizer
      統合失調症の認知機能障害のメカニズム-その到達点と将来の展望
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒトにおける脳表現型の分子機構の解明:ヒト脳表現型コンソーシアムについて2010

    • Author(s)
      橋本亮太、安田由華、大井一高、福本素由己、山森英長、岩瀬真生、数井裕光、高雄啓三、宮川剛、武田雅俊
    • Organizer
      包括脳ネットワーク 夏のワークショップ
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 統合失調症、精神医学研修コース「ここまでわかった精神疾患の脳内メカニズム」2010

    • Author(s)
      橋本亮太
    • Organizer
      第106回日本精神神経学会
    • Place of Presentation
      広島
    • Related Report
      2012 Final Research Report
  • [Presentation] 統合失調症のゲノムワイド関連解析にて見出されたZNF804A遺伝子のリスク多型は統合失調症の記憶機能と関連する2010

    • Author(s)
      橋本亮太、大井一高、安田由華、福本素由己、岩瀬真生、井池直美、疇地道代、池澤浩二、高屋雅彦、高橋秀俊、石井良平、数井裕光、岩田仲生、武田雅俊
    • Organizer
      第106回日本精神神経学会
    • Place of Presentation
      広島
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] The Impact of a Genome-Wide Supported Psychosis Variant in the ZNF804A Gene on Memory Function in Schizophrenia2010

    • Author(s)
      Hashimoto R
    • Organizer
      The 49th ACNP (American College of Neuropsych opharmacology) Annual Meeting
    • Place of Presentation
      Florida, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Translational Research For Schizophrenia : Genes, Intermediate Phenotypes, and Function2010

    • Author(s)
      Hashimoto R
    • Organizer
      11^<th> Australasian Schizophrenia Conference
    • Place of Presentation
      Sydney, Australia(invited speaker)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 統合失調症の中間表現型解析-その現状と展望2010

    • Author(s)
      橋本亮太
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      福岡(招待)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 統合失調症の新しい理解に向けて2010

    • Author(s)
      橋本亮太
    • Organizer
      日本心理学会第74回大会
    • Place of Presentation
      大阪(招待)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 発達障害治療薬の現状と展望2010

    • Author(s)
      橋本亮太
    • Organizer
      第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会合同年会
    • Place of Presentation
      仙台(パネリスト、招待)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 統合失調症の認知機能障害に対する遺伝子研究はどこまで到達したか?「統合失調症の認知機能障害のメカニズム-その到達点と将来の展望」2010

    • Author(s)
      橋本亮太
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸(招待)
    • Related Report
      2010 Annual Research Report
  • [Presentation] ここまでわかった精神疾患の脳内メカニズム2010

    • Author(s)
      橋本亮太
    • Organizer
      第106回日本精神神経学会
    • Place of Presentation
      広島(招待)
    • Related Report
      2010 Annual Research Report
  • [Book] 臨床精神薬理 152012

    • Author(s)
      橋本亮太、山森英長、安田由華、福本素由己、大井一高、井上頌子、竹上学、武田雅俊
    • Publisher
      星和書店
    • Related Report
      2012 Final Research Report
  • [Book] 統合失調症入院プログラムにおける治療抵抗性統合失調症に対するclozapineの有用性、2012

    • Author(s)
      橋本亮太
    • Publisher
      臨床精神薬理、星和書店
    • Related Report
      2012 Annual Research Report
  • [Book] 中間表現型、精神医学キーワード事典2011

    • Author(s)
      橋本亮太、武田雅俊
    • Publisher
      中山書
    • Related Report
      2012 Final Research Report
  • [Book] 中間表現型、精神医学キーワード事典2011

    • Author(s)
      橋本亮太、武田雅俊
    • Publisher
      中山書店
    • Related Report
      2011 Annual Research Report
  • [Book] 疾病と治療III2010

    • Author(s)
      橋本亮太、安田由華
    • Publisher
      南江堂
    • Related Report
      2012 Final Research Report
  • [Book] 疾病と治療III2010

    • Author(s)
      橋本亮太、大井一高
    • Publisher
      南江堂
    • Related Report
      2012 Final Research Report
  • [Book] 疾病と治療III(看護学テキスト)2010

    • Author(s)
      橋本亮太(共著)
    • Publisher
      南江堂
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.sp-web.sakura.ne.jp/lab/index.html

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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